Outcomes of cochlear implantation in 75 patients with auditory neuropathy

BackgroundCochlear implantation (CI) outcomes in patients with auditory neuropathy (AN) are variable, which hampers patients’ decisions on CI.ObjectiveThis study aims to assess the outcomes of CI in individuals diagnosed with AN and to examine the various factors that may influence the effectiveness...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Jie Wu [verfasserIn] Jiyue Chen [verfasserIn] Zhiwei Ding [verfasserIn] Jialin Fan [verfasserIn] Qiuquan Wang [verfasserIn] Pu Dai [verfasserIn] Dongyi Han [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	auditory neuropathy cochlear implantation impact factor cochlear nerve genetic testing

Übergeordnetes Werk:	In: Frontiers in Neuroscience - Frontiers Media S.A., 2008, 17(2023)
Übergeordnetes Werk:	volume:17 ; year:2023

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnins.2023.1281884

Katalog-ID:	DOAJ092078737

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520			\|a BackgroundCochlear implantation (CI) outcomes in patients with auditory neuropathy (AN) are variable, which hampers patients’ decisions on CI.ObjectiveThis study aims to assess the outcomes of CI in individuals diagnosed with AN and to examine the various factors that may influence the effectiveness of this intervention.MethodsA total of 75 patients diagnosed with AN were included in the study. The hearing threshold, the score of categories of auditory performance (CAP), speech intelligibility rating (SIR), and speech audiometry were tested. Genetic testing was conducted by medical exome sequencing in 46 patients.ResultsAfter CI, the average aided hearing threshold for patients with prelingual and post-lingual onset was 38.25 ± 6.63 dB and 32.58 ± 9.26 dB, respectively; CAP score improved to 5.52 ± 1.64 (p < 0.001) and 6.00 ± 0.96 (p < 0.001), respectively; SIR score increased to 3.57 ± 1.22 (p < 0.001) and 4.15 ± 0.95 (p < 0.001), respectively. Maximum speech recognition ranged from 58 to 93% for prelingual onset patients and 43 to 98% for those with post-lingual onset. Speech outcomes of CI in cases with cochlear nerve (CN) deficiency were significantly poorer (p = 0.008). Molecular etiologies, including TWIST1, ACTG1, m.A7445G, and a copy-number variant (CNV) carrying ACTB, were related to AN here.ConclusionCI is a viable therapy option for patients with AN; CN deficiency might impact outcomes of CI.
650		4	\|a auditory neuropathy
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allfields	10.3389/fnins.2023.1281884 doi (DE-627)DOAJ092078737 (DE-599)DOAJ11c243616e7d4a9c8a309d9f8683c059 DE-627 ger DE-627 rakwb eng RC321-571 Jie Wu verfasserin aut Outcomes of cochlear implantation in 75 patients with auditory neuropathy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundCochlear implantation (CI) outcomes in patients with auditory neuropathy (AN) are variable, which hampers patients’ decisions on CI.ObjectiveThis study aims to assess the outcomes of CI in individuals diagnosed with AN and to examine the various factors that may influence the effectiveness of this intervention.MethodsA total of 75 patients diagnosed with AN were included in the study. The hearing threshold, the score of categories of auditory performance (CAP), speech intelligibility rating (SIR), and speech audiometry were tested. Genetic testing was conducted by medical exome sequencing in 46 patients.ResultsAfter CI, the average aided hearing threshold for patients with prelingual and post-lingual onset was 38.25 ± 6.63 dB and 32.58 ± 9.26 dB, respectively; CAP score improved to 5.52 ± 1.64 (p < 0.001) and 6.00 ± 0.96 (p < 0.001), respectively; SIR score increased to 3.57 ± 1.22 (p < 0.001) and 4.15 ± 0.95 (p < 0.001), respectively. Maximum speech recognition ranged from 58 to 93% for prelingual onset patients and 43 to 98% for those with post-lingual onset. Speech outcomes of CI in cases with cochlear nerve (CN) deficiency were significantly poorer (p = 0.008). Molecular etiologies, including TWIST1, ACTG1, m.A7445G, and a copy-number variant (CNV) carrying ACTB, were related to AN here.ConclusionCI is a viable therapy option for patients with AN; CN deficiency might impact outcomes of CI. auditory neuropathy cochlear implantation impact factor cochlear nerve genetic testing Neurosciences. Biological psychiatry. Neuropsychiatry Jiyue Chen verfasserin aut Zhiwei Ding verfasserin aut Jialin Fan verfasserin aut Qiuquan Wang verfasserin aut Pu Dai verfasserin aut Dongyi Han verfasserin aut In Frontiers in Neuroscience Frontiers Media S.A., 2008 17(2023) (DE-627)55908109X (DE-600)2411902-7 1662453X nnns volume:17 year:2023 https://doi.org/10.3389/fnins.2023.1281884 kostenfrei https://doaj.org/article/11c243616e7d4a9c8a309d9f8683c059 kostenfrei https://www.frontiersin.org/articles/10.3389/fnins.2023.1281884/full kostenfrei https://doaj.org/toc/1662-453X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2023
spelling	10.3389/fnins.2023.1281884 doi (DE-627)DOAJ092078737 (DE-599)DOAJ11c243616e7d4a9c8a309d9f8683c059 DE-627 ger DE-627 rakwb eng RC321-571 Jie Wu verfasserin aut Outcomes of cochlear implantation in 75 patients with auditory neuropathy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundCochlear implantation (CI) outcomes in patients with auditory neuropathy (AN) are variable, which hampers patients’ decisions on CI.ObjectiveThis study aims to assess the outcomes of CI in individuals diagnosed with AN and to examine the various factors that may influence the effectiveness of this intervention.MethodsA total of 75 patients diagnosed with AN were included in the study. The hearing threshold, the score of categories of auditory performance (CAP), speech intelligibility rating (SIR), and speech audiometry were tested. Genetic testing was conducted by medical exome sequencing in 46 patients.ResultsAfter CI, the average aided hearing threshold for patients with prelingual and post-lingual onset was 38.25 ± 6.63 dB and 32.58 ± 9.26 dB, respectively; CAP score improved to 5.52 ± 1.64 (p < 0.001) and 6.00 ± 0.96 (p < 0.001), respectively; SIR score increased to 3.57 ± 1.22 (p < 0.001) and 4.15 ± 0.95 (p < 0.001), respectively. Maximum speech recognition ranged from 58 to 93% for prelingual onset patients and 43 to 98% for those with post-lingual onset. Speech outcomes of CI in cases with cochlear nerve (CN) deficiency were significantly poorer (p = 0.008). Molecular etiologies, including TWIST1, ACTG1, m.A7445G, and a copy-number variant (CNV) carrying ACTB, were related to AN here.ConclusionCI is a viable therapy option for patients with AN; CN deficiency might impact outcomes of CI. auditory neuropathy cochlear implantation impact factor cochlear nerve genetic testing Neurosciences. Biological psychiatry. Neuropsychiatry Jiyue Chen verfasserin aut Zhiwei Ding verfasserin aut Jialin Fan verfasserin aut Qiuquan Wang verfasserin aut Pu Dai verfasserin aut Dongyi Han verfasserin aut In Frontiers in Neuroscience Frontiers Media S.A., 2008 17(2023) (DE-627)55908109X (DE-600)2411902-7 1662453X nnns volume:17 year:2023 https://doi.org/10.3389/fnins.2023.1281884 kostenfrei https://doaj.org/article/11c243616e7d4a9c8a309d9f8683c059 kostenfrei https://www.frontiersin.org/articles/10.3389/fnins.2023.1281884/full kostenfrei https://doaj.org/toc/1662-453X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2023
allfields_unstemmed	10.3389/fnins.2023.1281884 doi (DE-627)DOAJ092078737 (DE-599)DOAJ11c243616e7d4a9c8a309d9f8683c059 DE-627 ger DE-627 rakwb eng RC321-571 Jie Wu verfasserin aut Outcomes of cochlear implantation in 75 patients with auditory neuropathy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundCochlear implantation (CI) outcomes in patients with auditory neuropathy (AN) are variable, which hampers patients’ decisions on CI.ObjectiveThis study aims to assess the outcomes of CI in individuals diagnosed with AN and to examine the various factors that may influence the effectiveness of this intervention.MethodsA total of 75 patients diagnosed with AN were included in the study. The hearing threshold, the score of categories of auditory performance (CAP), speech intelligibility rating (SIR), and speech audiometry were tested. Genetic testing was conducted by medical exome sequencing in 46 patients.ResultsAfter CI, the average aided hearing threshold for patients with prelingual and post-lingual onset was 38.25 ± 6.63 dB and 32.58 ± 9.26 dB, respectively; CAP score improved to 5.52 ± 1.64 (p < 0.001) and 6.00 ± 0.96 (p < 0.001), respectively; SIR score increased to 3.57 ± 1.22 (p < 0.001) and 4.15 ± 0.95 (p < 0.001), respectively. Maximum speech recognition ranged from 58 to 93% for prelingual onset patients and 43 to 98% for those with post-lingual onset. Speech outcomes of CI in cases with cochlear nerve (CN) deficiency were significantly poorer (p = 0.008). Molecular etiologies, including TWIST1, ACTG1, m.A7445G, and a copy-number variant (CNV) carrying ACTB, were related to AN here.ConclusionCI is a viable therapy option for patients with AN; CN deficiency might impact outcomes of CI. auditory neuropathy cochlear implantation impact factor cochlear nerve genetic testing Neurosciences. Biological psychiatry. Neuropsychiatry Jiyue Chen verfasserin aut Zhiwei Ding verfasserin aut Jialin Fan verfasserin aut Qiuquan Wang verfasserin aut Pu Dai verfasserin aut Dongyi Han verfasserin aut In Frontiers in Neuroscience Frontiers Media S.A., 2008 17(2023) (DE-627)55908109X (DE-600)2411902-7 1662453X nnns volume:17 year:2023 https://doi.org/10.3389/fnins.2023.1281884 kostenfrei https://doaj.org/article/11c243616e7d4a9c8a309d9f8683c059 kostenfrei https://www.frontiersin.org/articles/10.3389/fnins.2023.1281884/full kostenfrei https://doaj.org/toc/1662-453X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2023
allfieldsGer	10.3389/fnins.2023.1281884 doi (DE-627)DOAJ092078737 (DE-599)DOAJ11c243616e7d4a9c8a309d9f8683c059 DE-627 ger DE-627 rakwb eng RC321-571 Jie Wu verfasserin aut Outcomes of cochlear implantation in 75 patients with auditory neuropathy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundCochlear implantation (CI) outcomes in patients with auditory neuropathy (AN) are variable, which hampers patients’ decisions on CI.ObjectiveThis study aims to assess the outcomes of CI in individuals diagnosed with AN and to examine the various factors that may influence the effectiveness of this intervention.MethodsA total of 75 patients diagnosed with AN were included in the study. The hearing threshold, the score of categories of auditory performance (CAP), speech intelligibility rating (SIR), and speech audiometry were tested. Genetic testing was conducted by medical exome sequencing in 46 patients.ResultsAfter CI, the average aided hearing threshold for patients with prelingual and post-lingual onset was 38.25 ± 6.63 dB and 32.58 ± 9.26 dB, respectively; CAP score improved to 5.52 ± 1.64 (p < 0.001) and 6.00 ± 0.96 (p < 0.001), respectively; SIR score increased to 3.57 ± 1.22 (p < 0.001) and 4.15 ± 0.95 (p < 0.001), respectively. Maximum speech recognition ranged from 58 to 93% for prelingual onset patients and 43 to 98% for those with post-lingual onset. Speech outcomes of CI in cases with cochlear nerve (CN) deficiency were significantly poorer (p = 0.008). Molecular etiologies, including TWIST1, ACTG1, m.A7445G, and a copy-number variant (CNV) carrying ACTB, were related to AN here.ConclusionCI is a viable therapy option for patients with AN; CN deficiency might impact outcomes of CI. auditory neuropathy cochlear implantation impact factor cochlear nerve genetic testing Neurosciences. Biological psychiatry. Neuropsychiatry Jiyue Chen verfasserin aut Zhiwei Ding verfasserin aut Jialin Fan verfasserin aut Qiuquan Wang verfasserin aut Pu Dai verfasserin aut Dongyi Han verfasserin aut In Frontiers in Neuroscience Frontiers Media S.A., 2008 17(2023) (DE-627)55908109X (DE-600)2411902-7 1662453X nnns volume:17 year:2023 https://doi.org/10.3389/fnins.2023.1281884 kostenfrei https://doaj.org/article/11c243616e7d4a9c8a309d9f8683c059 kostenfrei https://www.frontiersin.org/articles/10.3389/fnins.2023.1281884/full kostenfrei https://doaj.org/toc/1662-453X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2023
allfieldsSound	10.3389/fnins.2023.1281884 doi (DE-627)DOAJ092078737 (DE-599)DOAJ11c243616e7d4a9c8a309d9f8683c059 DE-627 ger DE-627 rakwb eng RC321-571 Jie Wu verfasserin aut Outcomes of cochlear implantation in 75 patients with auditory neuropathy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundCochlear implantation (CI) outcomes in patients with auditory neuropathy (AN) are variable, which hampers patients’ decisions on CI.ObjectiveThis study aims to assess the outcomes of CI in individuals diagnosed with AN and to examine the various factors that may influence the effectiveness of this intervention.MethodsA total of 75 patients diagnosed with AN were included in the study. The hearing threshold, the score of categories of auditory performance (CAP), speech intelligibility rating (SIR), and speech audiometry were tested. Genetic testing was conducted by medical exome sequencing in 46 patients.ResultsAfter CI, the average aided hearing threshold for patients with prelingual and post-lingual onset was 38.25 ± 6.63 dB and 32.58 ± 9.26 dB, respectively; CAP score improved to 5.52 ± 1.64 (p < 0.001) and 6.00 ± 0.96 (p < 0.001), respectively; SIR score increased to 3.57 ± 1.22 (p < 0.001) and 4.15 ± 0.95 (p < 0.001), respectively. Maximum speech recognition ranged from 58 to 93% for prelingual onset patients and 43 to 98% for those with post-lingual onset. Speech outcomes of CI in cases with cochlear nerve (CN) deficiency were significantly poorer (p = 0.008). Molecular etiologies, including TWIST1, ACTG1, m.A7445G, and a copy-number variant (CNV) carrying ACTB, were related to AN here.ConclusionCI is a viable therapy option for patients with AN; CN deficiency might impact outcomes of CI. auditory neuropathy cochlear implantation impact factor cochlear nerve genetic testing Neurosciences. Biological psychiatry. Neuropsychiatry Jiyue Chen verfasserin aut Zhiwei Ding verfasserin aut Jialin Fan verfasserin aut Qiuquan Wang verfasserin aut Pu Dai verfasserin aut Dongyi Han verfasserin aut In Frontiers in Neuroscience Frontiers Media S.A., 2008 17(2023) (DE-627)55908109X (DE-600)2411902-7 1662453X nnns volume:17 year:2023 https://doi.org/10.3389/fnins.2023.1281884 kostenfrei https://doaj.org/article/11c243616e7d4a9c8a309d9f8683c059 kostenfrei https://www.frontiersin.org/articles/10.3389/fnins.2023.1281884/full kostenfrei https://doaj.org/toc/1662-453X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2023
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authorswithroles_txt_mv	Jie Wu @@aut@@ Jiyue Chen @@aut@@ Zhiwei Ding @@aut@@ Jialin Fan @@aut@@ Qiuquan Wang @@aut@@ Pu Dai @@aut@@ Dongyi Han @@aut@@
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The hearing threshold, the score of categories of auditory performance (CAP), speech intelligibility rating (SIR), and speech audiometry were tested. Genetic testing was conducted by medical exome sequencing in 46 patients.ResultsAfter CI, the average aided hearing threshold for patients with prelingual and post-lingual onset was 38.25 ± 6.63 dB and 32.58 ± 9.26 dB, respectively; CAP score improved to 5.52 ± 1.64 (p &lt; 0.001) and 6.00 ± 0.96 (p &lt; 0.001), respectively; SIR score increased to 3.57 ± 1.22 (p &lt; 0.001) and 4.15 ± 0.95 (p &lt; 0.001), respectively. Maximum speech recognition ranged from 58 to 93% for prelingual onset patients and 43 to 98% for those with post-lingual onset. Speech outcomes of CI in cases with cochlear nerve (CN) deficiency were significantly poorer (p = 0.008). Molecular etiologies, including TWIST1, ACTG1, m.A7445G, and a copy-number variant (CNV) carrying ACTB, were related to AN here.ConclusionCI is a viable therapy option for patients with AN; CN deficiency might impact outcomes of CI.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">auditory neuropathy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">cochlear implantation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">impact factor</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">cochlear nerve</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">genetic testing</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Neurosciences. Biological psychiatry. 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callnumber-first	R - Medicine
author	Jie Wu
spellingShingle	Jie Wu misc RC321-571 misc auditory neuropathy misc cochlear implantation misc impact factor misc cochlear nerve misc genetic testing misc Neurosciences. Biological psychiatry. Neuropsychiatry Outcomes of cochlear implantation in 75 patients with auditory neuropathy
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topic_title	RC321-571 Outcomes of cochlear implantation in 75 patients with auditory neuropathy auditory neuropathy cochlear implantation impact factor cochlear nerve genetic testing
topic	misc RC321-571 misc auditory neuropathy misc cochlear implantation misc impact factor misc cochlear nerve misc genetic testing misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc auditory neuropathy misc cochlear implantation misc impact factor misc cochlear nerve misc genetic testing misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_browse	misc RC321-571 misc auditory neuropathy misc cochlear implantation misc impact factor misc cochlear nerve misc genetic testing misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Outcomes of cochlear implantation in 75 patients with auditory neuropathy
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title_full	Outcomes of cochlear implantation in 75 patients with auditory neuropathy
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author_browse	Jie Wu Jiyue Chen Zhiwei Ding Jialin Fan Qiuquan Wang Pu Dai Dongyi Han
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title_sort	outcomes of cochlear implantation in 75 patients with auditory neuropathy
callnumber	RC321-571
title_auth	Outcomes of cochlear implantation in 75 patients with auditory neuropathy
abstract	BackgroundCochlear implantation (CI) outcomes in patients with auditory neuropathy (AN) are variable, which hampers patients’ decisions on CI.ObjectiveThis study aims to assess the outcomes of CI in individuals diagnosed with AN and to examine the various factors that may influence the effectiveness of this intervention.MethodsA total of 75 patients diagnosed with AN were included in the study. The hearing threshold, the score of categories of auditory performance (CAP), speech intelligibility rating (SIR), and speech audiometry were tested. Genetic testing was conducted by medical exome sequencing in 46 patients.ResultsAfter CI, the average aided hearing threshold for patients with prelingual and post-lingual onset was 38.25 ± 6.63 dB and 32.58 ± 9.26 dB, respectively; CAP score improved to 5.52 ± 1.64 (p < 0.001) and 6.00 ± 0.96 (p < 0.001), respectively; SIR score increased to 3.57 ± 1.22 (p < 0.001) and 4.15 ± 0.95 (p < 0.001), respectively. Maximum speech recognition ranged from 58 to 93% for prelingual onset patients and 43 to 98% for those with post-lingual onset. Speech outcomes of CI in cases with cochlear nerve (CN) deficiency were significantly poorer (p = 0.008). Molecular etiologies, including TWIST1, ACTG1, m.A7445G, and a copy-number variant (CNV) carrying ACTB, were related to AN here.ConclusionCI is a viable therapy option for patients with AN; CN deficiency might impact outcomes of CI.
abstractGer	BackgroundCochlear implantation (CI) outcomes in patients with auditory neuropathy (AN) are variable, which hampers patients’ decisions on CI.ObjectiveThis study aims to assess the outcomes of CI in individuals diagnosed with AN and to examine the various factors that may influence the effectiveness of this intervention.MethodsA total of 75 patients diagnosed with AN were included in the study. The hearing threshold, the score of categories of auditory performance (CAP), speech intelligibility rating (SIR), and speech audiometry were tested. Genetic testing was conducted by medical exome sequencing in 46 patients.ResultsAfter CI, the average aided hearing threshold for patients with prelingual and post-lingual onset was 38.25 ± 6.63 dB and 32.58 ± 9.26 dB, respectively; CAP score improved to 5.52 ± 1.64 (p < 0.001) and 6.00 ± 0.96 (p < 0.001), respectively; SIR score increased to 3.57 ± 1.22 (p < 0.001) and 4.15 ± 0.95 (p < 0.001), respectively. Maximum speech recognition ranged from 58 to 93% for prelingual onset patients and 43 to 98% for those with post-lingual onset. Speech outcomes of CI in cases with cochlear nerve (CN) deficiency were significantly poorer (p = 0.008). Molecular etiologies, including TWIST1, ACTG1, m.A7445G, and a copy-number variant (CNV) carrying ACTB, were related to AN here.ConclusionCI is a viable therapy option for patients with AN; CN deficiency might impact outcomes of CI.
abstract_unstemmed	BackgroundCochlear implantation (CI) outcomes in patients with auditory neuropathy (AN) are variable, which hampers patients’ decisions on CI.ObjectiveThis study aims to assess the outcomes of CI in individuals diagnosed with AN and to examine the various factors that may influence the effectiveness of this intervention.MethodsA total of 75 patients diagnosed with AN were included in the study. The hearing threshold, the score of categories of auditory performance (CAP), speech intelligibility rating (SIR), and speech audiometry were tested. Genetic testing was conducted by medical exome sequencing in 46 patients.ResultsAfter CI, the average aided hearing threshold for patients with prelingual and post-lingual onset was 38.25 ± 6.63 dB and 32.58 ± 9.26 dB, respectively; CAP score improved to 5.52 ± 1.64 (p < 0.001) and 6.00 ± 0.96 (p < 0.001), respectively; SIR score increased to 3.57 ± 1.22 (p < 0.001) and 4.15 ± 0.95 (p < 0.001), respectively. Maximum speech recognition ranged from 58 to 93% for prelingual onset patients and 43 to 98% for those with post-lingual onset. Speech outcomes of CI in cases with cochlear nerve (CN) deficiency were significantly poorer (p = 0.008). Molecular etiologies, including TWIST1, ACTG1, m.A7445G, and a copy-number variant (CNV) carrying ACTB, were related to AN here.ConclusionCI is a viable therapy option for patients with AN; CN deficiency might impact outcomes of CI.
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title_short	Outcomes of cochlear implantation in 75 patients with auditory neuropathy
url	https://doi.org/10.3389/fnins.2023.1281884 https://doaj.org/article/11c243616e7d4a9c8a309d9f8683c059 https://www.frontiersin.org/articles/10.3389/fnins.2023.1281884/full https://doaj.org/toc/1662-453X
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author2	Jiyue Chen Zhiwei Ding Jialin Fan Qiuquan Wang Pu Dai Dongyi Han
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up_date	2024-07-03T23:48:05.158Z
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The hearing threshold, the score of categories of auditory performance (CAP), speech intelligibility rating (SIR), and speech audiometry were tested. Genetic testing was conducted by medical exome sequencing in 46 patients.ResultsAfter CI, the average aided hearing threshold for patients with prelingual and post-lingual onset was 38.25 ± 6.63 dB and 32.58 ± 9.26 dB, respectively; CAP score improved to 5.52 ± 1.64 (p &lt; 0.001) and 6.00 ± 0.96 (p &lt; 0.001), respectively; SIR score increased to 3.57 ± 1.22 (p &lt; 0.001) and 4.15 ± 0.95 (p &lt; 0.001), respectively. Maximum speech recognition ranged from 58 to 93% for prelingual onset patients and 43 to 98% for those with post-lingual onset. Speech outcomes of CI in cases with cochlear nerve (CN) deficiency were significantly poorer (p = 0.008). Molecular etiologies, including TWIST1, ACTG1, m.A7445G, and a copy-number variant (CNV) carrying ACTB, were related to AN here.ConclusionCI is a viable therapy option for patients with AN; CN deficiency might impact outcomes of CI.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">auditory neuropathy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">cochlear implantation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">impact factor</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">cochlear nerve</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">genetic testing</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Neurosciences. Biological psychiatry. 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Outcomes of cochlear implantation in 75 patients with auditory neuropathy

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