Chili pepper extracts, capsaicin, and dihydrocapsaicin as potential anticancer agents targeting topoisomerases

Abstract DNA topoisomerases regulate conformational changes in DNA topology during normal cell growth, such as replication, transcription, recombination, and repair, and may be targeted for anticancer drugs. A DNA topology assay was used to investigate DNA-damaging/protective activities of extracts...
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Autor*in:	Terézia Hudáková [verfasserIn] Martina Šemeláková [verfasserIn] Peter Očenáš [verfasserIn] Mária Kožurková [verfasserIn] Kristína Krochtová [verfasserIn] Simona Sovová [verfasserIn] Zuzana Tóthová [verfasserIn] Zuzana Guľášová [verfasserIn] Peter Popelka [verfasserIn] Peter Solár [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Chili pepper extract Capsaicin Dihydrocapsaicin Topoisomerases inhibition

Übergeordnetes Werk:	In: BMC Complementary Medicine and Therapies - BMC, 2020, 24(2024), 1, Seite 11
Übergeordnetes Werk:	volume:24 ; year:2024 ; number:1 ; pages:11

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12906-024-04394-5

Katalog-ID:	DOAJ092189458

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spelling	10.1186/s12906-024-04394-5 doi (DE-627)DOAJ092189458 (DE-599)DOAJ1912b47f60754379b54fb7b761c8a955 DE-627 ger DE-627 rakwb eng RZ201-999 Terézia Hudáková verfasserin aut Chili pepper extracts, capsaicin, and dihydrocapsaicin as potential anticancer agents targeting topoisomerases 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract DNA topoisomerases regulate conformational changes in DNA topology during normal cell growth, such as replication, transcription, recombination, and repair, and may be targeted for anticancer drugs. A DNA topology assay was used to investigate DNA-damaging/protective activities of extracts from Habanero Red (HR), Habanero Maya Red (HMR), Trinidad Moruga Scorpion (TMS), Jalapeno (J), Serrano pepper (SP), Habanero Red Savina (HRS), Bhut Jolokia (BJ), and Jamaica Rosso (JR) peppers, demonstrating their inhibitory effect on the relaxation of pBR by Topo I. DNA topoisomerase II (Topo II) is proven therapeutic target of anticancer drugs. Complete inhibition of Topo II was observed for samples TMS, HR, and HMR. Extracts J and SP had the lowest capsaicin and dihydrocapsaicin content compared to other peppers. HR, HMR, TMS, J, S, HRS, BJ, JR extracts showed the anticancer effect, examined by MTS and xCell assay on the in vitro culture of human colon carcinoma cell line HCT116. Chili pepper extract Capsaicin Dihydrocapsaicin Topoisomerases inhibition Other systems of medicine Martina Šemeláková verfasserin aut Peter Očenáš verfasserin aut Mária Kožurková verfasserin aut Kristína Krochtová verfasserin aut Simona Sovová verfasserin aut Zuzana Tóthová verfasserin aut Zuzana Guľášová verfasserin aut Peter Popelka verfasserin aut Peter Solár verfasserin aut In BMC Complementary Medicine and Therapies BMC, 2020 24(2024), 1, Seite 11 (DE-627)1733118462 26627671 nnns volume:24 year:2024 number:1 pages:11 https://doi.org/10.1186/s12906-024-04394-5 kostenfrei https://doaj.org/article/1912b47f60754379b54fb7b761c8a955 kostenfrei https://doi.org/10.1186/s12906-024-04394-5 kostenfrei https://doaj.org/toc/2662-7671 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2024 1 11
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allfieldsSound	10.1186/s12906-024-04394-5 doi (DE-627)DOAJ092189458 (DE-599)DOAJ1912b47f60754379b54fb7b761c8a955 DE-627 ger DE-627 rakwb eng RZ201-999 Terézia Hudáková verfasserin aut Chili pepper extracts, capsaicin, and dihydrocapsaicin as potential anticancer agents targeting topoisomerases 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract DNA topoisomerases regulate conformational changes in DNA topology during normal cell growth, such as replication, transcription, recombination, and repair, and may be targeted for anticancer drugs. A DNA topology assay was used to investigate DNA-damaging/protective activities of extracts from Habanero Red (HR), Habanero Maya Red (HMR), Trinidad Moruga Scorpion (TMS), Jalapeno (J), Serrano pepper (SP), Habanero Red Savina (HRS), Bhut Jolokia (BJ), and Jamaica Rosso (JR) peppers, demonstrating their inhibitory effect on the relaxation of pBR by Topo I. DNA topoisomerase II (Topo II) is proven therapeutic target of anticancer drugs. Complete inhibition of Topo II was observed for samples TMS, HR, and HMR. Extracts J and SP had the lowest capsaicin and dihydrocapsaicin content compared to other peppers. HR, HMR, TMS, J, S, HRS, BJ, JR extracts showed the anticancer effect, examined by MTS and xCell assay on the in vitro culture of human colon carcinoma cell line HCT116. Chili pepper extract Capsaicin Dihydrocapsaicin Topoisomerases inhibition Other systems of medicine Martina Šemeláková verfasserin aut Peter Očenáš verfasserin aut Mária Kožurková verfasserin aut Kristína Krochtová verfasserin aut Simona Sovová verfasserin aut Zuzana Tóthová verfasserin aut Zuzana Guľášová verfasserin aut Peter Popelka verfasserin aut Peter Solár verfasserin aut In BMC Complementary Medicine and Therapies BMC, 2020 24(2024), 1, Seite 11 (DE-627)1733118462 26627671 nnns volume:24 year:2024 number:1 pages:11 https://doi.org/10.1186/s12906-024-04394-5 kostenfrei https://doaj.org/article/1912b47f60754379b54fb7b761c8a955 kostenfrei https://doi.org/10.1186/s12906-024-04394-5 kostenfrei https://doaj.org/toc/2662-7671 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2024 1 11
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callnumber-first	R - Medicine
author	Terézia Hudáková
spellingShingle	Terézia Hudáková misc RZ201-999 misc Chili pepper extract misc Capsaicin misc Dihydrocapsaicin misc Topoisomerases inhibition misc Other systems of medicine Chili pepper extracts, capsaicin, and dihydrocapsaicin as potential anticancer agents targeting topoisomerases
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topic_title	RZ201-999 Chili pepper extracts, capsaicin, and dihydrocapsaicin as potential anticancer agents targeting topoisomerases Chili pepper extract Capsaicin Dihydrocapsaicin Topoisomerases inhibition
topic	misc RZ201-999 misc Chili pepper extract misc Capsaicin misc Dihydrocapsaicin misc Topoisomerases inhibition misc Other systems of medicine
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title	Chili pepper extracts, capsaicin, and dihydrocapsaicin as potential anticancer agents targeting topoisomerases
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title_full	Chili pepper extracts, capsaicin, and dihydrocapsaicin as potential anticancer agents targeting topoisomerases
author_sort	Terézia Hudáková
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author_browse	Terézia Hudáková Martina Šemeláková Peter Očenáš Mária Kožurková Kristína Krochtová Simona Sovová Zuzana Tóthová Zuzana Guľášová Peter Popelka Peter Solár
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title_sort	chili pepper extracts, capsaicin, and dihydrocapsaicin as potential anticancer agents targeting topoisomerases
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title_auth	Chili pepper extracts, capsaicin, and dihydrocapsaicin as potential anticancer agents targeting topoisomerases
abstract	Abstract DNA topoisomerases regulate conformational changes in DNA topology during normal cell growth, such as replication, transcription, recombination, and repair, and may be targeted for anticancer drugs. A DNA topology assay was used to investigate DNA-damaging/protective activities of extracts from Habanero Red (HR), Habanero Maya Red (HMR), Trinidad Moruga Scorpion (TMS), Jalapeno (J), Serrano pepper (SP), Habanero Red Savina (HRS), Bhut Jolokia (BJ), and Jamaica Rosso (JR) peppers, demonstrating their inhibitory effect on the relaxation of pBR by Topo I. DNA topoisomerase II (Topo II) is proven therapeutic target of anticancer drugs. Complete inhibition of Topo II was observed for samples TMS, HR, and HMR. Extracts J and SP had the lowest capsaicin and dihydrocapsaicin content compared to other peppers. HR, HMR, TMS, J, S, HRS, BJ, JR extracts showed the anticancer effect, examined by MTS and xCell assay on the in vitro culture of human colon carcinoma cell line HCT116.
abstractGer	Abstract DNA topoisomerases regulate conformational changes in DNA topology during normal cell growth, such as replication, transcription, recombination, and repair, and may be targeted for anticancer drugs. A DNA topology assay was used to investigate DNA-damaging/protective activities of extracts from Habanero Red (HR), Habanero Maya Red (HMR), Trinidad Moruga Scorpion (TMS), Jalapeno (J), Serrano pepper (SP), Habanero Red Savina (HRS), Bhut Jolokia (BJ), and Jamaica Rosso (JR) peppers, demonstrating their inhibitory effect on the relaxation of pBR by Topo I. DNA topoisomerase II (Topo II) is proven therapeutic target of anticancer drugs. Complete inhibition of Topo II was observed for samples TMS, HR, and HMR. Extracts J and SP had the lowest capsaicin and dihydrocapsaicin content compared to other peppers. HR, HMR, TMS, J, S, HRS, BJ, JR extracts showed the anticancer effect, examined by MTS and xCell assay on the in vitro culture of human colon carcinoma cell line HCT116.
abstract_unstemmed	Abstract DNA topoisomerases regulate conformational changes in DNA topology during normal cell growth, such as replication, transcription, recombination, and repair, and may be targeted for anticancer drugs. A DNA topology assay was used to investigate DNA-damaging/protective activities of extracts from Habanero Red (HR), Habanero Maya Red (HMR), Trinidad Moruga Scorpion (TMS), Jalapeno (J), Serrano pepper (SP), Habanero Red Savina (HRS), Bhut Jolokia (BJ), and Jamaica Rosso (JR) peppers, demonstrating their inhibitory effect on the relaxation of pBR by Topo I. DNA topoisomerase II (Topo II) is proven therapeutic target of anticancer drugs. Complete inhibition of Topo II was observed for samples TMS, HR, and HMR. Extracts J and SP had the lowest capsaicin and dihydrocapsaicin content compared to other peppers. HR, HMR, TMS, J, S, HRS, BJ, JR extracts showed the anticancer effect, examined by MTS and xCell assay on the in vitro culture of human colon carcinoma cell line HCT116.
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title_short	Chili pepper extracts, capsaicin, and dihydrocapsaicin as potential anticancer agents targeting topoisomerases
url	https://doi.org/10.1186/s12906-024-04394-5 https://doaj.org/article/1912b47f60754379b54fb7b761c8a955 https://doaj.org/toc/2662-7671
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Chili pepper extracts, capsaicin, and dihydrocapsaicin as potential anticancer agents targeting topoisomerases

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