Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool

Abstract Cancer remains a serious burden in society and while the pace in the development of novel and more effective therapeutics is increasing, testing platforms that faithfully mimic the tumor microenvironment are lacking. With a clear shift from animal models to more complex in vitro 3D systems,...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Daniel B. Rodrigues [verfasserIn] Rui L. Reis [verfasserIn] Rogério P. Pirraco [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Spheroids 3D tumor models Cancer Tumor microenvironment

Übergeordnetes Werk:	In: Journal of Biomedical Science - BMC, 2002, 31(2024), 1, Seite 22
Übergeordnetes Werk:	volume:31 ; year:2024 ; number:1 ; pages:22

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12929-024-00997-9

Katalog-ID:	DOAJ092212174

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spelling	10.1186/s12929-024-00997-9 doi (DE-627)DOAJ092212174 (DE-599)DOAJ239a82f3f72a45e2ac331d69e2f3370d DE-627 ger DE-627 rakwb eng Daniel B. Rodrigues verfasserin aut Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Cancer remains a serious burden in society and while the pace in the development of novel and more effective therapeutics is increasing, testing platforms that faithfully mimic the tumor microenvironment are lacking. With a clear shift from animal models to more complex in vitro 3D systems, spheroids emerge as strong options in this regard. Years of development have allowed spheroid-based models to better reproduce the biomechanical cues that are observed in the tumor-associated extracellular matrix (ECM) and cellular interactions that occur in both a cell–cell and cell-ECM manner. Here, we summarize some of the key cellular interactions that drive tumor development, progression and invasion, and how successfully are these interactions recapitulated in 3D spheroid models currently in use in the field. We finish by speculating on future advancements in the field and on how these can shape the relevance of spherical 3D models for tumor modelling. Spheroids 3D tumor models Cancer Tumor microenvironment Medicine R Rui L. Reis verfasserin aut Rogério P. Pirraco verfasserin aut In Journal of Biomedical Science BMC, 2002 31(2024), 1, Seite 22 (DE-627)300593724 (DE-600)1482918-6 14230127 nnns volume:31 year:2024 number:1 pages:22 https://doi.org/10.1186/s12929-024-00997-9 kostenfrei https://doaj.org/article/239a82f3f72a45e2ac331d69e2f3370d kostenfrei https://doi.org/10.1186/s12929-024-00997-9 kostenfrei https://doaj.org/toc/1423-0127 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4328 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 31 2024 1 22
allfields_unstemmed	10.1186/s12929-024-00997-9 doi (DE-627)DOAJ092212174 (DE-599)DOAJ239a82f3f72a45e2ac331d69e2f3370d DE-627 ger DE-627 rakwb eng Daniel B. Rodrigues verfasserin aut Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Cancer remains a serious burden in society and while the pace in the development of novel and more effective therapeutics is increasing, testing platforms that faithfully mimic the tumor microenvironment are lacking. With a clear shift from animal models to more complex in vitro 3D systems, spheroids emerge as strong options in this regard. Years of development have allowed spheroid-based models to better reproduce the biomechanical cues that are observed in the tumor-associated extracellular matrix (ECM) and cellular interactions that occur in both a cell–cell and cell-ECM manner. Here, we summarize some of the key cellular interactions that drive tumor development, progression and invasion, and how successfully are these interactions recapitulated in 3D spheroid models currently in use in the field. We finish by speculating on future advancements in the field and on how these can shape the relevance of spherical 3D models for tumor modelling. Spheroids 3D tumor models Cancer Tumor microenvironment Medicine R Rui L. Reis verfasserin aut Rogério P. Pirraco verfasserin aut In Journal of Biomedical Science BMC, 2002 31(2024), 1, Seite 22 (DE-627)300593724 (DE-600)1482918-6 14230127 nnns volume:31 year:2024 number:1 pages:22 https://doi.org/10.1186/s12929-024-00997-9 kostenfrei https://doaj.org/article/239a82f3f72a45e2ac331d69e2f3370d kostenfrei https://doi.org/10.1186/s12929-024-00997-9 kostenfrei https://doaj.org/toc/1423-0127 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4328 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 31 2024 1 22
allfieldsGer	10.1186/s12929-024-00997-9 doi (DE-627)DOAJ092212174 (DE-599)DOAJ239a82f3f72a45e2ac331d69e2f3370d DE-627 ger DE-627 rakwb eng Daniel B. Rodrigues verfasserin aut Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Cancer remains a serious burden in society and while the pace in the development of novel and more effective therapeutics is increasing, testing platforms that faithfully mimic the tumor microenvironment are lacking. With a clear shift from animal models to more complex in vitro 3D systems, spheroids emerge as strong options in this regard. Years of development have allowed spheroid-based models to better reproduce the biomechanical cues that are observed in the tumor-associated extracellular matrix (ECM) and cellular interactions that occur in both a cell–cell and cell-ECM manner. Here, we summarize some of the key cellular interactions that drive tumor development, progression and invasion, and how successfully are these interactions recapitulated in 3D spheroid models currently in use in the field. We finish by speculating on future advancements in the field and on how these can shape the relevance of spherical 3D models for tumor modelling. Spheroids 3D tumor models Cancer Tumor microenvironment Medicine R Rui L. Reis verfasserin aut Rogério P. Pirraco verfasserin aut In Journal of Biomedical Science BMC, 2002 31(2024), 1, Seite 22 (DE-627)300593724 (DE-600)1482918-6 14230127 nnns volume:31 year:2024 number:1 pages:22 https://doi.org/10.1186/s12929-024-00997-9 kostenfrei https://doaj.org/article/239a82f3f72a45e2ac331d69e2f3370d kostenfrei https://doi.org/10.1186/s12929-024-00997-9 kostenfrei https://doaj.org/toc/1423-0127 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4328 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 31 2024 1 22
allfieldsSound	10.1186/s12929-024-00997-9 doi (DE-627)DOAJ092212174 (DE-599)DOAJ239a82f3f72a45e2ac331d69e2f3370d DE-627 ger DE-627 rakwb eng Daniel B. Rodrigues verfasserin aut Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Cancer remains a serious burden in society and while the pace in the development of novel and more effective therapeutics is increasing, testing platforms that faithfully mimic the tumor microenvironment are lacking. With a clear shift from animal models to more complex in vitro 3D systems, spheroids emerge as strong options in this regard. Years of development have allowed spheroid-based models to better reproduce the biomechanical cues that are observed in the tumor-associated extracellular matrix (ECM) and cellular interactions that occur in both a cell–cell and cell-ECM manner. Here, we summarize some of the key cellular interactions that drive tumor development, progression and invasion, and how successfully are these interactions recapitulated in 3D spheroid models currently in use in the field. We finish by speculating on future advancements in the field and on how these can shape the relevance of spherical 3D models for tumor modelling. Spheroids 3D tumor models Cancer Tumor microenvironment Medicine R Rui L. Reis verfasserin aut Rogério P. Pirraco verfasserin aut In Journal of Biomedical Science BMC, 2002 31(2024), 1, Seite 22 (DE-627)300593724 (DE-600)1482918-6 14230127 nnns volume:31 year:2024 number:1 pages:22 https://doi.org/10.1186/s12929-024-00997-9 kostenfrei https://doaj.org/article/239a82f3f72a45e2ac331d69e2f3370d kostenfrei https://doi.org/10.1186/s12929-024-00997-9 kostenfrei https://doaj.org/toc/1423-0127 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4328 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 31 2024 1 22
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author	Daniel B. Rodrigues
spellingShingle	Daniel B. Rodrigues misc Spheroids misc 3D tumor models misc Cancer misc Tumor microenvironment misc Medicine misc R Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool
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topic_title	Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool Spheroids 3D tumor models Cancer Tumor microenvironment
topic	misc Spheroids misc 3D tumor models misc Cancer misc Tumor microenvironment misc Medicine misc R
topic_unstemmed	misc Spheroids misc 3D tumor models misc Cancer misc Tumor microenvironment misc Medicine misc R
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title	Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool
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title_full	Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool
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author_browse	Daniel B. Rodrigues Rui L. Reis Rogério P. Pirraco
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title_sort	modelling the complex nature of the tumor microenvironment: 3d tumor spheroids as an evolving tool
title_auth	Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool
abstract	Abstract Cancer remains a serious burden in society and while the pace in the development of novel and more effective therapeutics is increasing, testing platforms that faithfully mimic the tumor microenvironment are lacking. With a clear shift from animal models to more complex in vitro 3D systems, spheroids emerge as strong options in this regard. Years of development have allowed spheroid-based models to better reproduce the biomechanical cues that are observed in the tumor-associated extracellular matrix (ECM) and cellular interactions that occur in both a cell–cell and cell-ECM manner. Here, we summarize some of the key cellular interactions that drive tumor development, progression and invasion, and how successfully are these interactions recapitulated in 3D spheroid models currently in use in the field. We finish by speculating on future advancements in the field and on how these can shape the relevance of spherical 3D models for tumor modelling.
abstractGer	Abstract Cancer remains a serious burden in society and while the pace in the development of novel and more effective therapeutics is increasing, testing platforms that faithfully mimic the tumor microenvironment are lacking. With a clear shift from animal models to more complex in vitro 3D systems, spheroids emerge as strong options in this regard. Years of development have allowed spheroid-based models to better reproduce the biomechanical cues that are observed in the tumor-associated extracellular matrix (ECM) and cellular interactions that occur in both a cell–cell and cell-ECM manner. Here, we summarize some of the key cellular interactions that drive tumor development, progression and invasion, and how successfully are these interactions recapitulated in 3D spheroid models currently in use in the field. We finish by speculating on future advancements in the field and on how these can shape the relevance of spherical 3D models for tumor modelling.
abstract_unstemmed	Abstract Cancer remains a serious burden in society and while the pace in the development of novel and more effective therapeutics is increasing, testing platforms that faithfully mimic the tumor microenvironment are lacking. With a clear shift from animal models to more complex in vitro 3D systems, spheroids emerge as strong options in this regard. Years of development have allowed spheroid-based models to better reproduce the biomechanical cues that are observed in the tumor-associated extracellular matrix (ECM) and cellular interactions that occur in both a cell–cell and cell-ECM manner. Here, we summarize some of the key cellular interactions that drive tumor development, progression and invasion, and how successfully are these interactions recapitulated in 3D spheroid models currently in use in the field. We finish by speculating on future advancements in the field and on how these can shape the relevance of spherical 3D models for tumor modelling.
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title_short	Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool
url	https://doi.org/10.1186/s12929-024-00997-9 https://doaj.org/article/239a82f3f72a45e2ac331d69e2f3370d https://doaj.org/toc/1423-0127
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up_date	2024-07-04T00:29:53.847Z
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Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool

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