Roles of organokines in intervertebral disc homeostasis and degeneration

The intervertebral disc is not isolated from other tissues. Recently, abundant research has linked intervertebral disc homeostasis and degeneration to various systemic diseases, including obesity, metabolic syndrome, and diabetes. Organokines are a group of diverse factors named for the tissue of or...
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Autor*in:	Yuxin He [verfasserIn] Sheng Liu [verfasserIn] Hui Lin [verfasserIn] Fan Ding [verfasserIn] Zengwu Shao [verfasserIn] Liming Xiong [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	intervertebral disc homeostasis intervertebral disc degeneration organokines organ crosstalk signaling pathway

Übergeordnetes Werk:	In: Frontiers in Endocrinology - Frontiers Media S.A., 2011, 15(2024)
Übergeordnetes Werk:	volume:15 ; year:2024

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fendo.2024.1340625

Katalog-ID:	DOAJ092248594

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520			\|a The intervertebral disc is not isolated from other tissues. Recently, abundant research has linked intervertebral disc homeostasis and degeneration to various systemic diseases, including obesity, metabolic syndrome, and diabetes. Organokines are a group of diverse factors named for the tissue of origin, including adipokines, osteokines, myokines, cardiokines, gastrointestinal hormones, and hepatokines. Through endocrine, paracrine, and autocrine mechanisms, organokines modulate energy homeostasis, oxidative stress, and metabolic balance in various tissues to mediate cross-organ communication. These molecules are involved in the regulation of cellular behavior, inflammation, and matrix metabolism under physiological and pathological conditions. In this review, we aimed to summarize the impact of organokines on disc homeostasis and degeneration and the underlying signaling mechanism. We focused on the regulatory mechanisms of organokines to provide a basis for the development of early diagnostic and therapeutic strategies for disc degeneration.
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topic_facet	intervertebral disc homeostasis intervertebral disc degeneration organokines organ crosstalk signaling pathway Diseases of the endocrine glands. Clinical endocrinology
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container_title	Frontiers in Endocrinology
authorswithroles_txt_mv	Yuxin He @@aut@@ Sheng Liu @@aut@@ Hui Lin @@aut@@ Fan Ding @@aut@@ Zengwu Shao @@aut@@ Liming Xiong @@aut@@
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callnumber-first	R - Medicine
author	Yuxin He
spellingShingle	Yuxin He misc RC648-665 misc intervertebral disc homeostasis misc intervertebral disc degeneration misc organokines misc organ crosstalk misc signaling pathway misc Diseases of the endocrine glands. Clinical endocrinology Roles of organokines in intervertebral disc homeostasis and degeneration
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topic_title	RC648-665 Roles of organokines in intervertebral disc homeostasis and degeneration intervertebral disc homeostasis intervertebral disc degeneration organokines organ crosstalk signaling pathway
topic	misc RC648-665 misc intervertebral disc homeostasis misc intervertebral disc degeneration misc organokines misc organ crosstalk misc signaling pathway misc Diseases of the endocrine glands. Clinical endocrinology
topic_unstemmed	misc RC648-665 misc intervertebral disc homeostasis misc intervertebral disc degeneration misc organokines misc organ crosstalk misc signaling pathway misc Diseases of the endocrine glands. Clinical endocrinology
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title	Roles of organokines in intervertebral disc homeostasis and degeneration
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title_full	Roles of organokines in intervertebral disc homeostasis and degeneration
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title_sort	roles of organokines in intervertebral disc homeostasis and degeneration
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title_auth	Roles of organokines in intervertebral disc homeostasis and degeneration
abstract	The intervertebral disc is not isolated from other tissues. Recently, abundant research has linked intervertebral disc homeostasis and degeneration to various systemic diseases, including obesity, metabolic syndrome, and diabetes. Organokines are a group of diverse factors named for the tissue of origin, including adipokines, osteokines, myokines, cardiokines, gastrointestinal hormones, and hepatokines. Through endocrine, paracrine, and autocrine mechanisms, organokines modulate energy homeostasis, oxidative stress, and metabolic balance in various tissues to mediate cross-organ communication. These molecules are involved in the regulation of cellular behavior, inflammation, and matrix metabolism under physiological and pathological conditions. In this review, we aimed to summarize the impact of organokines on disc homeostasis and degeneration and the underlying signaling mechanism. We focused on the regulatory mechanisms of organokines to provide a basis for the development of early diagnostic and therapeutic strategies for disc degeneration.
abstractGer	The intervertebral disc is not isolated from other tissues. Recently, abundant research has linked intervertebral disc homeostasis and degeneration to various systemic diseases, including obesity, metabolic syndrome, and diabetes. Organokines are a group of diverse factors named for the tissue of origin, including adipokines, osteokines, myokines, cardiokines, gastrointestinal hormones, and hepatokines. Through endocrine, paracrine, and autocrine mechanisms, organokines modulate energy homeostasis, oxidative stress, and metabolic balance in various tissues to mediate cross-organ communication. These molecules are involved in the regulation of cellular behavior, inflammation, and matrix metabolism under physiological and pathological conditions. In this review, we aimed to summarize the impact of organokines on disc homeostasis and degeneration and the underlying signaling mechanism. We focused on the regulatory mechanisms of organokines to provide a basis for the development of early diagnostic and therapeutic strategies for disc degeneration.
abstract_unstemmed	The intervertebral disc is not isolated from other tissues. Recently, abundant research has linked intervertebral disc homeostasis and degeneration to various systemic diseases, including obesity, metabolic syndrome, and diabetes. Organokines are a group of diverse factors named for the tissue of origin, including adipokines, osteokines, myokines, cardiokines, gastrointestinal hormones, and hepatokines. Through endocrine, paracrine, and autocrine mechanisms, organokines modulate energy homeostasis, oxidative stress, and metabolic balance in various tissues to mediate cross-organ communication. These molecules are involved in the regulation of cellular behavior, inflammation, and matrix metabolism under physiological and pathological conditions. In this review, we aimed to summarize the impact of organokines on disc homeostasis and degeneration and the underlying signaling mechanism. We focused on the regulatory mechanisms of organokines to provide a basis for the development of early diagnostic and therapeutic strategies for disc degeneration.
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title_short	Roles of organokines in intervertebral disc homeostasis and degeneration
url	https://doi.org/10.3389/fendo.2024.1340625 https://doaj.org/article/6aee13b7427c4208a19de110db9e624e https://www.frontiersin.org/articles/10.3389/fendo.2024.1340625/full https://doaj.org/toc/1664-2392
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Roles of organokines in intervertebral disc homeostasis and degeneration

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