Association between resting-state connectivity patterns in the defensive system network and treatment response in spider phobia—a replication approach
Abstract Although highly effective on average, exposure-based treatments do not work equally well for all patients with anxiety disorders. The identification of pre-treatment response-predicting patient characteristics may enable patient stratification. Preliminary research highlights the relevance...
Ausführliche Beschreibung
Autor*in: |
Elisabeth J. Leehr [verfasserIn] Fabian R. Seeger [verfasserIn] Joscha Böhnlein [verfasserIn] Bettina Gathmann [verfasserIn] Thomas Straube [verfasserIn] Kati Roesmann [verfasserIn] Markus Junghöfer [verfasserIn] Hanna Schwarzmeier [verfasserIn] Niklas Siminski [verfasserIn] Martin J. Herrmann [verfasserIn] Till Langhammer [verfasserIn] Janik Goltermann [verfasserIn] Dominik Grotegerd [verfasserIn] Susanne Meinert [verfasserIn] Nils R. Winter [verfasserIn] Udo Dannlowski [verfasserIn] Ulrike Lueken [verfasserIn] |
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E-Artikel |
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Englisch |
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2024 |
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Übergeordnetes Werk: |
In: Translational Psychiatry - Nature Publishing Group, 2012, 14(2024), 1, Seite 12 |
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Übergeordnetes Werk: |
volume:14 ; year:2024 ; number:1 ; pages:12 |
Links: |
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DOI / URN: |
10.1038/s41398-024-02799-x |
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Katalog-ID: |
DOAJ092304389 |
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520 | |a Abstract Although highly effective on average, exposure-based treatments do not work equally well for all patients with anxiety disorders. The identification of pre-treatment response-predicting patient characteristics may enable patient stratification. Preliminary research highlights the relevance of inhibitory fronto-limbic networks as such. We aimed to identify pre-treatment neural signatures differing between exposure treatment responders and non-responders in spider phobia and to validate results through rigorous replication. Data of a bi-centric intervention study comprised clinical phenotyping and pre-treatment resting-state functional connectivity (rsFC) data of n = 79 patients with spider phobia (discovery sample) and n = 69 patients (replication sample). RsFC data analyses were accomplished using the Matlab-based CONN-toolbox with harmonized analyses protocols at both sites. Treatment response was defined by a reduction of <30% symptom severity from pre- to post-treatment (Spider Phobia Questionnaire Score, primary outcome). Secondary outcome was defined by a reduction of <50% in a Behavioral Avoidance Test (BAT). Mean within-session fear reduction functioned as a process measure for exposure. Compared to non-responders and pre-treatment, results in the discovery sample seemed to indicate that responders exhibited stronger negative connectivity between frontal and limbic structures and were characterized by heightened connectivity between the amygdala and ventral visual pathway regions. Patients exhibiting high within-session fear reduction showed stronger excitatory connectivity within the prefrontal cortex than patients with low within-session fear reduction. Whereas these results could be replicated by another team using the same data (cross-team replication), cross-site replication of the discovery sample findings in the independent replication sample was unsuccessful. Results seem to support negative fronto-limbic connectivity as promising ingredient to enhance response rates in specific phobia but lack sufficient replication. Further research is needed to obtain a valid basis for clinical decision-making and the development of individually tailored treatment options. Notably, future studies should regularly include replication approaches in their protocols. | ||
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10.1038/s41398-024-02799-x doi (DE-627)DOAJ092304389 (DE-599)DOAJ8d42f308e5134d80be98e2d2d41d5a8f DE-627 ger DE-627 rakwb eng RC321-571 Elisabeth J. Leehr verfasserin aut Association between resting-state connectivity patterns in the defensive system network and treatment response in spider phobia—a replication approach 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Although highly effective on average, exposure-based treatments do not work equally well for all patients with anxiety disorders. The identification of pre-treatment response-predicting patient characteristics may enable patient stratification. Preliminary research highlights the relevance of inhibitory fronto-limbic networks as such. We aimed to identify pre-treatment neural signatures differing between exposure treatment responders and non-responders in spider phobia and to validate results through rigorous replication. Data of a bi-centric intervention study comprised clinical phenotyping and pre-treatment resting-state functional connectivity (rsFC) data of n = 79 patients with spider phobia (discovery sample) and n = 69 patients (replication sample). RsFC data analyses were accomplished using the Matlab-based CONN-toolbox with harmonized analyses protocols at both sites. Treatment response was defined by a reduction of <30% symptom severity from pre- to post-treatment (Spider Phobia Questionnaire Score, primary outcome). Secondary outcome was defined by a reduction of <50% in a Behavioral Avoidance Test (BAT). Mean within-session fear reduction functioned as a process measure for exposure. Compared to non-responders and pre-treatment, results in the discovery sample seemed to indicate that responders exhibited stronger negative connectivity between frontal and limbic structures and were characterized by heightened connectivity between the amygdala and ventral visual pathway regions. Patients exhibiting high within-session fear reduction showed stronger excitatory connectivity within the prefrontal cortex than patients with low within-session fear reduction. Whereas these results could be replicated by another team using the same data (cross-team replication), cross-site replication of the discovery sample findings in the independent replication sample was unsuccessful. Results seem to support negative fronto-limbic connectivity as promising ingredient to enhance response rates in specific phobia but lack sufficient replication. Further research is needed to obtain a valid basis for clinical decision-making and the development of individually tailored treatment options. Notably, future studies should regularly include replication approaches in their protocols. Neurosciences. Biological psychiatry. Neuropsychiatry Fabian R. Seeger verfasserin aut Joscha Böhnlein verfasserin aut Bettina Gathmann verfasserin aut Thomas Straube verfasserin aut Kati Roesmann verfasserin aut Markus Junghöfer verfasserin aut Hanna Schwarzmeier verfasserin aut Niklas Siminski verfasserin aut Martin J. Herrmann verfasserin aut Till Langhammer verfasserin aut Janik Goltermann verfasserin aut Dominik Grotegerd verfasserin aut Susanne Meinert verfasserin aut Nils R. Winter verfasserin aut Udo Dannlowski verfasserin aut Ulrike Lueken verfasserin aut In Translational Psychiatry Nature Publishing Group, 2012 14(2024), 1, Seite 12 (DE-627)660807378 (DE-600)2609311-X 21583188 nnns volume:14 year:2024 number:1 pages:12 https://doi.org/10.1038/s41398-024-02799-x kostenfrei https://doaj.org/article/8d42f308e5134d80be98e2d2d41d5a8f kostenfrei https://doi.org/10.1038/s41398-024-02799-x kostenfrei https://doaj.org/toc/2158-3188 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 1 12 |
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10.1038/s41398-024-02799-x doi (DE-627)DOAJ092304389 (DE-599)DOAJ8d42f308e5134d80be98e2d2d41d5a8f DE-627 ger DE-627 rakwb eng RC321-571 Elisabeth J. Leehr verfasserin aut Association between resting-state connectivity patterns in the defensive system network and treatment response in spider phobia—a replication approach 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Although highly effective on average, exposure-based treatments do not work equally well for all patients with anxiety disorders. The identification of pre-treatment response-predicting patient characteristics may enable patient stratification. Preliminary research highlights the relevance of inhibitory fronto-limbic networks as such. We aimed to identify pre-treatment neural signatures differing between exposure treatment responders and non-responders in spider phobia and to validate results through rigorous replication. Data of a bi-centric intervention study comprised clinical phenotyping and pre-treatment resting-state functional connectivity (rsFC) data of n = 79 patients with spider phobia (discovery sample) and n = 69 patients (replication sample). RsFC data analyses were accomplished using the Matlab-based CONN-toolbox with harmonized analyses protocols at both sites. Treatment response was defined by a reduction of <30% symptom severity from pre- to post-treatment (Spider Phobia Questionnaire Score, primary outcome). Secondary outcome was defined by a reduction of <50% in a Behavioral Avoidance Test (BAT). Mean within-session fear reduction functioned as a process measure for exposure. Compared to non-responders and pre-treatment, results in the discovery sample seemed to indicate that responders exhibited stronger negative connectivity between frontal and limbic structures and were characterized by heightened connectivity between the amygdala and ventral visual pathway regions. Patients exhibiting high within-session fear reduction showed stronger excitatory connectivity within the prefrontal cortex than patients with low within-session fear reduction. Whereas these results could be replicated by another team using the same data (cross-team replication), cross-site replication of the discovery sample findings in the independent replication sample was unsuccessful. Results seem to support negative fronto-limbic connectivity as promising ingredient to enhance response rates in specific phobia but lack sufficient replication. Further research is needed to obtain a valid basis for clinical decision-making and the development of individually tailored treatment options. Notably, future studies should regularly include replication approaches in their protocols. Neurosciences. Biological psychiatry. Neuropsychiatry Fabian R. Seeger verfasserin aut Joscha Böhnlein verfasserin aut Bettina Gathmann verfasserin aut Thomas Straube verfasserin aut Kati Roesmann verfasserin aut Markus Junghöfer verfasserin aut Hanna Schwarzmeier verfasserin aut Niklas Siminski verfasserin aut Martin J. Herrmann verfasserin aut Till Langhammer verfasserin aut Janik Goltermann verfasserin aut Dominik Grotegerd verfasserin aut Susanne Meinert verfasserin aut Nils R. Winter verfasserin aut Udo Dannlowski verfasserin aut Ulrike Lueken verfasserin aut In Translational Psychiatry Nature Publishing Group, 2012 14(2024), 1, Seite 12 (DE-627)660807378 (DE-600)2609311-X 21583188 nnns volume:14 year:2024 number:1 pages:12 https://doi.org/10.1038/s41398-024-02799-x kostenfrei https://doaj.org/article/8d42f308e5134d80be98e2d2d41d5a8f kostenfrei https://doi.org/10.1038/s41398-024-02799-x kostenfrei https://doaj.org/toc/2158-3188 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 1 12 |
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Association between resting-state connectivity patterns in the defensive system network and treatment response in spider phobia—a replication approach |
abstract |
Abstract Although highly effective on average, exposure-based treatments do not work equally well for all patients with anxiety disorders. The identification of pre-treatment response-predicting patient characteristics may enable patient stratification. Preliminary research highlights the relevance of inhibitory fronto-limbic networks as such. We aimed to identify pre-treatment neural signatures differing between exposure treatment responders and non-responders in spider phobia and to validate results through rigorous replication. Data of a bi-centric intervention study comprised clinical phenotyping and pre-treatment resting-state functional connectivity (rsFC) data of n = 79 patients with spider phobia (discovery sample) and n = 69 patients (replication sample). RsFC data analyses were accomplished using the Matlab-based CONN-toolbox with harmonized analyses protocols at both sites. Treatment response was defined by a reduction of <30% symptom severity from pre- to post-treatment (Spider Phobia Questionnaire Score, primary outcome). Secondary outcome was defined by a reduction of <50% in a Behavioral Avoidance Test (BAT). Mean within-session fear reduction functioned as a process measure for exposure. Compared to non-responders and pre-treatment, results in the discovery sample seemed to indicate that responders exhibited stronger negative connectivity between frontal and limbic structures and were characterized by heightened connectivity between the amygdala and ventral visual pathway regions. Patients exhibiting high within-session fear reduction showed stronger excitatory connectivity within the prefrontal cortex than patients with low within-session fear reduction. Whereas these results could be replicated by another team using the same data (cross-team replication), cross-site replication of the discovery sample findings in the independent replication sample was unsuccessful. Results seem to support negative fronto-limbic connectivity as promising ingredient to enhance response rates in specific phobia but lack sufficient replication. Further research is needed to obtain a valid basis for clinical decision-making and the development of individually tailored treatment options. Notably, future studies should regularly include replication approaches in their protocols. |
abstractGer |
Abstract Although highly effective on average, exposure-based treatments do not work equally well for all patients with anxiety disorders. The identification of pre-treatment response-predicting patient characteristics may enable patient stratification. Preliminary research highlights the relevance of inhibitory fronto-limbic networks as such. We aimed to identify pre-treatment neural signatures differing between exposure treatment responders and non-responders in spider phobia and to validate results through rigorous replication. Data of a bi-centric intervention study comprised clinical phenotyping and pre-treatment resting-state functional connectivity (rsFC) data of n = 79 patients with spider phobia (discovery sample) and n = 69 patients (replication sample). RsFC data analyses were accomplished using the Matlab-based CONN-toolbox with harmonized analyses protocols at both sites. Treatment response was defined by a reduction of <30% symptom severity from pre- to post-treatment (Spider Phobia Questionnaire Score, primary outcome). Secondary outcome was defined by a reduction of <50% in a Behavioral Avoidance Test (BAT). Mean within-session fear reduction functioned as a process measure for exposure. Compared to non-responders and pre-treatment, results in the discovery sample seemed to indicate that responders exhibited stronger negative connectivity between frontal and limbic structures and were characterized by heightened connectivity between the amygdala and ventral visual pathway regions. Patients exhibiting high within-session fear reduction showed stronger excitatory connectivity within the prefrontal cortex than patients with low within-session fear reduction. Whereas these results could be replicated by another team using the same data (cross-team replication), cross-site replication of the discovery sample findings in the independent replication sample was unsuccessful. Results seem to support negative fronto-limbic connectivity as promising ingredient to enhance response rates in specific phobia but lack sufficient replication. Further research is needed to obtain a valid basis for clinical decision-making and the development of individually tailored treatment options. Notably, future studies should regularly include replication approaches in their protocols. |
abstract_unstemmed |
Abstract Although highly effective on average, exposure-based treatments do not work equally well for all patients with anxiety disorders. The identification of pre-treatment response-predicting patient characteristics may enable patient stratification. Preliminary research highlights the relevance of inhibitory fronto-limbic networks as such. We aimed to identify pre-treatment neural signatures differing between exposure treatment responders and non-responders in spider phobia and to validate results through rigorous replication. Data of a bi-centric intervention study comprised clinical phenotyping and pre-treatment resting-state functional connectivity (rsFC) data of n = 79 patients with spider phobia (discovery sample) and n = 69 patients (replication sample). RsFC data analyses were accomplished using the Matlab-based CONN-toolbox with harmonized analyses protocols at both sites. Treatment response was defined by a reduction of <30% symptom severity from pre- to post-treatment (Spider Phobia Questionnaire Score, primary outcome). Secondary outcome was defined by a reduction of <50% in a Behavioral Avoidance Test (BAT). Mean within-session fear reduction functioned as a process measure for exposure. Compared to non-responders and pre-treatment, results in the discovery sample seemed to indicate that responders exhibited stronger negative connectivity between frontal and limbic structures and were characterized by heightened connectivity between the amygdala and ventral visual pathway regions. Patients exhibiting high within-session fear reduction showed stronger excitatory connectivity within the prefrontal cortex than patients with low within-session fear reduction. Whereas these results could be replicated by another team using the same data (cross-team replication), cross-site replication of the discovery sample findings in the independent replication sample was unsuccessful. Results seem to support negative fronto-limbic connectivity as promising ingredient to enhance response rates in specific phobia but lack sufficient replication. Further research is needed to obtain a valid basis for clinical decision-making and the development of individually tailored treatment options. Notably, future studies should regularly include replication approaches in their protocols. |
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title_short |
Association between resting-state connectivity patterns in the defensive system network and treatment response in spider phobia—a replication approach |
url |
https://doi.org/10.1038/s41398-024-02799-x https://doaj.org/article/8d42f308e5134d80be98e2d2d41d5a8f https://doaj.org/toc/2158-3188 |
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author2 |
Fabian R. Seeger Joscha Böhnlein Bettina Gathmann Thomas Straube Kati Roesmann Markus Junghöfer Hanna Schwarzmeier Niklas Siminski Martin J. Herrmann Till Langhammer Janik Goltermann Dominik Grotegerd Susanne Meinert Nils R. Winter Udo Dannlowski Ulrike Lueken |
author2Str |
Fabian R. Seeger Joscha Böhnlein Bettina Gathmann Thomas Straube Kati Roesmann Markus Junghöfer Hanna Schwarzmeier Niklas Siminski Martin J. Herrmann Till Langhammer Janik Goltermann Dominik Grotegerd Susanne Meinert Nils R. Winter Udo Dannlowski Ulrike Lueken |
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doi_str |
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callnumber-a |
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up_date |
2024-07-04T00:52:35.277Z |
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