A System‐Level Feasibility Study of a Lead‐Free Ultrasonically Powered Light Delivery Implant for Optogenetics

Body implants play a crucial role in clinical applications, encompassing data acquisition, diagnosis, and disease treatment. However, challenges in size, power consumption, and biocompatibility, particularly in brain applications requiring small, battery‐free devices for deep areas, hinder their dev...
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Autor*in:	Saeed Baghaee Ivriq [verfasserIn] Kjeld Laursen [verfasserIn] Aske Møller Jørgensen [verfasserIn] Tanmay Mondal [verfasserIn] Milad Zamani [verfasserIn] Yasser Rezaeiyan [verfasserIn] Brian Corbett [verfasserIn] Bo Brummerstedt Iversen [verfasserIn] Farshad Moradi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	biocompatible materials brain implants CMOS piezoelectric ultrasonic

Übergeordnetes Werk:	In: Advanced Intelligent Systems - Wiley, 2019, 6(2024), 3, Seite n/a-n/a
Übergeordnetes Werk:	volume:6 ; year:2024 ; number:3 ; pages:n/a-n/a

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1002/aisy.202300527

Katalog-ID:	DOAJ092421466

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allfields_unstemmed	10.1002/aisy.202300527 doi (DE-627)DOAJ092421466 (DE-599)DOAJ35d4475c496a4e02b2cb09b3fe6e2126 DE-627 ger DE-627 rakwb eng TK7885-7895 TJ212-225 Saeed Baghaee Ivriq verfasserin aut A System‐Level Feasibility Study of a Lead‐Free Ultrasonically Powered Light Delivery Implant for Optogenetics 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Body implants play a crucial role in clinical applications, encompassing data acquisition, diagnosis, and disease treatment. However, challenges in size, power consumption, and biocompatibility, particularly in brain applications requiring small, battery‐free devices for deep areas, hinder their development. Despite potential advances through simplified, single‐purpose devices, such as recording or stimulation, overcoming the power and biocompatibility issues remains a hurdle. Addressing this, the article introduces an ultrasonically powered light delivery implant (LDI) utilizing lead‐free piezoelectric material (Li0.08K0.46Na0.46) NbO3 to harvest energy from external ultrasonic waves. The prototype includes a piezoelectric cube, a chip fabricated in 180 nm CMOS technology, and a microscale light‐emitting diode (μ‐LED) for optogenetics. Achieving an end‐to‐end efficiency of 0.75%, the LDI holds promise for various optogenetic studies, particularly in animal studies targeting specific brain areas for treating Parkinson's disease. The delivered optical power on the μ‐LED surface, at 14.1 mW mm−2, presents applicability to diverse studies involving specific opsins. biocompatible materials brain implants CMOS piezoelectric ultrasonic Computer engineering. Computer hardware Control engineering systems. Automatic machinery (General) Kjeld Laursen verfasserin aut Aske Møller Jørgensen verfasserin aut Tanmay Mondal verfasserin aut Milad Zamani verfasserin aut Yasser Rezaeiyan verfasserin aut Brian Corbett verfasserin aut Bo Brummerstedt Iversen verfasserin aut Farshad Moradi verfasserin aut In Advanced Intelligent Systems Wiley, 2019 6(2024), 3, Seite n/a-n/a (DE-627)166775601X (DE-600)2975566-9 26404567 nnns volume:6 year:2024 number:3 pages:n/a-n/a https://doi.org/10.1002/aisy.202300527 kostenfrei https://doaj.org/article/35d4475c496a4e02b2cb09b3fe6e2126 kostenfrei https://doi.org/10.1002/aisy.202300527 kostenfrei https://doaj.org/toc/2640-4567 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2024 3 n/a-n/a
allfieldsGer	10.1002/aisy.202300527 doi (DE-627)DOAJ092421466 (DE-599)DOAJ35d4475c496a4e02b2cb09b3fe6e2126 DE-627 ger DE-627 rakwb eng TK7885-7895 TJ212-225 Saeed Baghaee Ivriq verfasserin aut A System‐Level Feasibility Study of a Lead‐Free Ultrasonically Powered Light Delivery Implant for Optogenetics 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Body implants play a crucial role in clinical applications, encompassing data acquisition, diagnosis, and disease treatment. However, challenges in size, power consumption, and biocompatibility, particularly in brain applications requiring small, battery‐free devices for deep areas, hinder their development. Despite potential advances through simplified, single‐purpose devices, such as recording or stimulation, overcoming the power and biocompatibility issues remains a hurdle. Addressing this, the article introduces an ultrasonically powered light delivery implant (LDI) utilizing lead‐free piezoelectric material (Li0.08K0.46Na0.46) NbO3 to harvest energy from external ultrasonic waves. The prototype includes a piezoelectric cube, a chip fabricated in 180 nm CMOS technology, and a microscale light‐emitting diode (μ‐LED) for optogenetics. Achieving an end‐to‐end efficiency of 0.75%, the LDI holds promise for various optogenetic studies, particularly in animal studies targeting specific brain areas for treating Parkinson's disease. The delivered optical power on the μ‐LED surface, at 14.1 mW mm−2, presents applicability to diverse studies involving specific opsins. biocompatible materials brain implants CMOS piezoelectric ultrasonic Computer engineering. Computer hardware Control engineering systems. Automatic machinery (General) Kjeld Laursen verfasserin aut Aske Møller Jørgensen verfasserin aut Tanmay Mondal verfasserin aut Milad Zamani verfasserin aut Yasser Rezaeiyan verfasserin aut Brian Corbett verfasserin aut Bo Brummerstedt Iversen verfasserin aut Farshad Moradi verfasserin aut In Advanced Intelligent Systems Wiley, 2019 6(2024), 3, Seite n/a-n/a (DE-627)166775601X (DE-600)2975566-9 26404567 nnns volume:6 year:2024 number:3 pages:n/a-n/a https://doi.org/10.1002/aisy.202300527 kostenfrei https://doaj.org/article/35d4475c496a4e02b2cb09b3fe6e2126 kostenfrei https://doi.org/10.1002/aisy.202300527 kostenfrei https://doaj.org/toc/2640-4567 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2024 3 n/a-n/a
allfieldsSound	10.1002/aisy.202300527 doi (DE-627)DOAJ092421466 (DE-599)DOAJ35d4475c496a4e02b2cb09b3fe6e2126 DE-627 ger DE-627 rakwb eng TK7885-7895 TJ212-225 Saeed Baghaee Ivriq verfasserin aut A System‐Level Feasibility Study of a Lead‐Free Ultrasonically Powered Light Delivery Implant for Optogenetics 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Body implants play a crucial role in clinical applications, encompassing data acquisition, diagnosis, and disease treatment. However, challenges in size, power consumption, and biocompatibility, particularly in brain applications requiring small, battery‐free devices for deep areas, hinder their development. Despite potential advances through simplified, single‐purpose devices, such as recording or stimulation, overcoming the power and biocompatibility issues remains a hurdle. Addressing this, the article introduces an ultrasonically powered light delivery implant (LDI) utilizing lead‐free piezoelectric material (Li0.08K0.46Na0.46) NbO3 to harvest energy from external ultrasonic waves. The prototype includes a piezoelectric cube, a chip fabricated in 180 nm CMOS technology, and a microscale light‐emitting diode (μ‐LED) for optogenetics. Achieving an end‐to‐end efficiency of 0.75%, the LDI holds promise for various optogenetic studies, particularly in animal studies targeting specific brain areas for treating Parkinson's disease. The delivered optical power on the μ‐LED surface, at 14.1 mW mm−2, presents applicability to diverse studies involving specific opsins. biocompatible materials brain implants CMOS piezoelectric ultrasonic Computer engineering. Computer hardware Control engineering systems. Automatic machinery (General) Kjeld Laursen verfasserin aut Aske Møller Jørgensen verfasserin aut Tanmay Mondal verfasserin aut Milad Zamani verfasserin aut Yasser Rezaeiyan verfasserin aut Brian Corbett verfasserin aut Bo Brummerstedt Iversen verfasserin aut Farshad Moradi verfasserin aut In Advanced Intelligent Systems Wiley, 2019 6(2024), 3, Seite n/a-n/a (DE-627)166775601X (DE-600)2975566-9 26404567 nnns volume:6 year:2024 number:3 pages:n/a-n/a https://doi.org/10.1002/aisy.202300527 kostenfrei https://doaj.org/article/35d4475c496a4e02b2cb09b3fe6e2126 kostenfrei https://doi.org/10.1002/aisy.202300527 kostenfrei https://doaj.org/toc/2640-4567 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2024 3 n/a-n/a
language	English
source	In Advanced Intelligent Systems 6(2024), 3, Seite n/a-n/a volume:6 year:2024 number:3 pages:n/a-n/a
sourceStr	In Advanced Intelligent Systems 6(2024), 3, Seite n/a-n/a volume:6 year:2024 number:3 pages:n/a-n/a
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	biocompatible materials brain implants CMOS piezoelectric ultrasonic Computer engineering. Computer hardware Control engineering systems. Automatic machinery (General)
isfreeaccess_bool	true
container_title	Advanced Intelligent Systems
authorswithroles_txt_mv	Saeed Baghaee Ivriq @@aut@@ Kjeld Laursen @@aut@@ Aske Møller Jørgensen @@aut@@ Tanmay Mondal @@aut@@ Milad Zamani @@aut@@ Yasser Rezaeiyan @@aut@@ Brian Corbett @@aut@@ Bo Brummerstedt Iversen @@aut@@ Farshad Moradi @@aut@@
publishDateDaySort_date	2024-01-01T00:00:00Z
hierarchy_top_id	166775601X
id	DOAJ092421466
language_de	englisch
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callnumber-first	T - Technology
author	Saeed Baghaee Ivriq
spellingShingle	Saeed Baghaee Ivriq misc TK7885-7895 misc TJ212-225 misc biocompatible materials misc brain implants misc CMOS misc piezoelectric misc ultrasonic misc Computer engineering. Computer hardware misc Control engineering systems. Automatic machinery (General) A System‐Level Feasibility Study of a Lead‐Free Ultrasonically Powered Light Delivery Implant for Optogenetics
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topic_title	TK7885-7895 TJ212-225 A System‐Level Feasibility Study of a Lead‐Free Ultrasonically Powered Light Delivery Implant for Optogenetics biocompatible materials brain implants CMOS piezoelectric ultrasonic
topic	misc TK7885-7895 misc TJ212-225 misc biocompatible materials misc brain implants misc CMOS misc piezoelectric misc ultrasonic misc Computer engineering. Computer hardware misc Control engineering systems. Automatic machinery (General)
topic_unstemmed	misc TK7885-7895 misc TJ212-225 misc biocompatible materials misc brain implants misc CMOS misc piezoelectric misc ultrasonic misc Computer engineering. Computer hardware misc Control engineering systems. Automatic machinery (General)
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title	A System‐Level Feasibility Study of a Lead‐Free Ultrasonically Powered Light Delivery Implant for Optogenetics
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title_full	A System‐Level Feasibility Study of a Lead‐Free Ultrasonically Powered Light Delivery Implant for Optogenetics
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title_sort	system‐level feasibility study of a lead‐free ultrasonically powered light delivery implant for optogenetics
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title_auth	A System‐Level Feasibility Study of a Lead‐Free Ultrasonically Powered Light Delivery Implant for Optogenetics
abstract	Body implants play a crucial role in clinical applications, encompassing data acquisition, diagnosis, and disease treatment. However, challenges in size, power consumption, and biocompatibility, particularly in brain applications requiring small, battery‐free devices for deep areas, hinder their development. Despite potential advances through simplified, single‐purpose devices, such as recording or stimulation, overcoming the power and biocompatibility issues remains a hurdle. Addressing this, the article introduces an ultrasonically powered light delivery implant (LDI) utilizing lead‐free piezoelectric material (Li0.08K0.46Na0.46) NbO3 to harvest energy from external ultrasonic waves. The prototype includes a piezoelectric cube, a chip fabricated in 180 nm CMOS technology, and a microscale light‐emitting diode (μ‐LED) for optogenetics. Achieving an end‐to‐end efficiency of 0.75%, the LDI holds promise for various optogenetic studies, particularly in animal studies targeting specific brain areas for treating Parkinson's disease. The delivered optical power on the μ‐LED surface, at 14.1 mW mm−2, presents applicability to diverse studies involving specific opsins.
abstractGer	Body implants play a crucial role in clinical applications, encompassing data acquisition, diagnosis, and disease treatment. However, challenges in size, power consumption, and biocompatibility, particularly in brain applications requiring small, battery‐free devices for deep areas, hinder their development. Despite potential advances through simplified, single‐purpose devices, such as recording or stimulation, overcoming the power and biocompatibility issues remains a hurdle. Addressing this, the article introduces an ultrasonically powered light delivery implant (LDI) utilizing lead‐free piezoelectric material (Li0.08K0.46Na0.46) NbO3 to harvest energy from external ultrasonic waves. The prototype includes a piezoelectric cube, a chip fabricated in 180 nm CMOS technology, and a microscale light‐emitting diode (μ‐LED) for optogenetics. Achieving an end‐to‐end efficiency of 0.75%, the LDI holds promise for various optogenetic studies, particularly in animal studies targeting specific brain areas for treating Parkinson's disease. The delivered optical power on the μ‐LED surface, at 14.1 mW mm−2, presents applicability to diverse studies involving specific opsins.
abstract_unstemmed	Body implants play a crucial role in clinical applications, encompassing data acquisition, diagnosis, and disease treatment. However, challenges in size, power consumption, and biocompatibility, particularly in brain applications requiring small, battery‐free devices for deep areas, hinder their development. Despite potential advances through simplified, single‐purpose devices, such as recording or stimulation, overcoming the power and biocompatibility issues remains a hurdle. Addressing this, the article introduces an ultrasonically powered light delivery implant (LDI) utilizing lead‐free piezoelectric material (Li0.08K0.46Na0.46) NbO3 to harvest energy from external ultrasonic waves. The prototype includes a piezoelectric cube, a chip fabricated in 180 nm CMOS technology, and a microscale light‐emitting diode (μ‐LED) for optogenetics. Achieving an end‐to‐end efficiency of 0.75%, the LDI holds promise for various optogenetic studies, particularly in animal studies targeting specific brain areas for treating Parkinson's disease. The delivered optical power on the μ‐LED surface, at 14.1 mW mm−2, presents applicability to diverse studies involving specific opsins.
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title_short	A System‐Level Feasibility Study of a Lead‐Free Ultrasonically Powered Light Delivery Implant for Optogenetics
url	https://doi.org/10.1002/aisy.202300527 https://doaj.org/article/35d4475c496a4e02b2cb09b3fe6e2126 https://doaj.org/toc/2640-4567
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up_date	2024-07-04T01:15:52.820Z
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A System‐Level Feasibility Study of a Lead‐Free Ultrasonically Powered Light Delivery Implant for Optogenetics

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