Pain at chronic pancreatitis: origin and treatment options

The aim of review. To present basic mechanisms of pain at pancreatitis and determine main management approaches in pain-predominant cases.Summary. Direct toxic action of damaging factors (first of all — alcohol), pancreatic enzyme deviation phenomenon, parenchymal damage by overflow of free radicals...
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Gespeichert in:

Autor*in:	V. T. Ivashkin [verfasserIn] K. V. Ivashkin [verfasserIn] A. V. Okhlobystin [verfasserIn]

Format:	E-Artikel
Sprache:	Russisch

Erschienen:	2024

Schlagwörter:	pain chronic pancreatitis the pancreas

Übergeordnetes Werk:	In: Российский журнал гастроэнтерологии, гепатологии, колопроктологии - Gastro LLC, 2020, 25(2024), 3, Seite 4-11
Übergeordnetes Werk:	volume:25 ; year:2024 ; number:3 ; pages:4-11

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Katalog-ID:	DOAJ092422438

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520			\|a The aim of review. To present basic mechanisms of pain at pancreatitis and determine main management approaches in pain-predominant cases.Summary. Direct toxic action of damaging factors (first of all — alcohol), pancreatic enzyme deviation phenomenon, parenchymal damage by overflow of free radicals, elevation of intraductal pressure, damage of nerves (neuropathic pain) and compression of adjacent organs play primary role in development of pain. Enzyme supplements at chronic pancreatitis can be indicated not only as replacement treatment, but also as addition to complex treatment of patients with severe abdominal pain. Proton pump inhibitors, spasmolytics or prokinetics are recommended as additional therapy. At absence of desirable results application of nonsteroid anti-inflammatory drugs and analgetics, in resistant pain — non-narcotic opiates or pregabalin are indicated. Efficacy of analgetics can be increased by coadministration of psychotropic agents, most often — tricyclic antidepressants. In severe cases intractable pain at a chronic pancreatitis itself can become indication to surgical intervention.Conclusion. Treatment efficacy in each given case depends on duly establishment and adequate treatment of complications, motivation for abstain of alcohol intake and smoking; strict diet restriction for relapse period, and functional rest for the pancreas.
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allfields	(DE-627)DOAJ092422438 (DE-599)DOAJdfe52fe1ed45464db2d7504d5fdda752 DE-627 ger DE-627 rakwb rus RC799-869 V. T. Ivashkin verfasserin aut Pain at chronic pancreatitis: origin and treatment options 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of review. To present basic mechanisms of pain at pancreatitis and determine main management approaches in pain-predominant cases.Summary. Direct toxic action of damaging factors (first of all — alcohol), pancreatic enzyme deviation phenomenon, parenchymal damage by overflow of free radicals, elevation of intraductal pressure, damage of nerves (neuropathic pain) and compression of adjacent organs play primary role in development of pain. Enzyme supplements at chronic pancreatitis can be indicated not only as replacement treatment, but also as addition to complex treatment of patients with severe abdominal pain. Proton pump inhibitors, spasmolytics or prokinetics are recommended as additional therapy. At absence of desirable results application of nonsteroid anti-inflammatory drugs and analgetics, in resistant pain — non-narcotic opiates or pregabalin are indicated. Efficacy of analgetics can be increased by coadministration of psychotropic agents, most often — tricyclic antidepressants. In severe cases intractable pain at a chronic pancreatitis itself can become indication to surgical intervention.Conclusion. Treatment efficacy in each given case depends on duly establishment and adequate treatment of complications, motivation for abstain of alcohol intake and smoking; strict diet restriction for relapse period, and functional rest for the pancreas. pain chronic pancreatitis the pancreas Diseases of the digestive system. Gastroenterology K. V. Ivashkin verfasserin aut A. V. Okhlobystin verfasserin aut In Российский журнал гастроэнтерологии, гепатологии, колопроктологии Gastro LLC, 2020 25(2024), 3, Seite 4-11 (DE-627)1698164203 26586673 nnns volume:25 year:2024 number:3 pages:4-11 https://doaj.org/article/dfe52fe1ed45464db2d7504d5fdda752 kostenfrei https://www.gastro-j.ru/jour/article/view/1007 kostenfrei https://doaj.org/toc/1382-4376 Journal toc kostenfrei https://doaj.org/toc/2658-6673 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2024 3 4-11
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allfieldsGer	(DE-627)DOAJ092422438 (DE-599)DOAJdfe52fe1ed45464db2d7504d5fdda752 DE-627 ger DE-627 rakwb rus RC799-869 V. T. Ivashkin verfasserin aut Pain at chronic pancreatitis: origin and treatment options 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of review. To present basic mechanisms of pain at pancreatitis and determine main management approaches in pain-predominant cases.Summary. Direct toxic action of damaging factors (first of all — alcohol), pancreatic enzyme deviation phenomenon, parenchymal damage by overflow of free radicals, elevation of intraductal pressure, damage of nerves (neuropathic pain) and compression of adjacent organs play primary role in development of pain. Enzyme supplements at chronic pancreatitis can be indicated not only as replacement treatment, but also as addition to complex treatment of patients with severe abdominal pain. Proton pump inhibitors, spasmolytics or prokinetics are recommended as additional therapy. At absence of desirable results application of nonsteroid anti-inflammatory drugs and analgetics, in resistant pain — non-narcotic opiates or pregabalin are indicated. Efficacy of analgetics can be increased by coadministration of psychotropic agents, most often — tricyclic antidepressants. In severe cases intractable pain at a chronic pancreatitis itself can become indication to surgical intervention.Conclusion. Treatment efficacy in each given case depends on duly establishment and adequate treatment of complications, motivation for abstain of alcohol intake and smoking; strict diet restriction for relapse period, and functional rest for the pancreas. pain chronic pancreatitis the pancreas Diseases of the digestive system. Gastroenterology K. V. Ivashkin verfasserin aut A. V. Okhlobystin verfasserin aut In Российский журнал гастроэнтерологии, гепатологии, колопроктологии Gastro LLC, 2020 25(2024), 3, Seite 4-11 (DE-627)1698164203 26586673 nnns volume:25 year:2024 number:3 pages:4-11 https://doaj.org/article/dfe52fe1ed45464db2d7504d5fdda752 kostenfrei https://www.gastro-j.ru/jour/article/view/1007 kostenfrei https://doaj.org/toc/1382-4376 Journal toc kostenfrei https://doaj.org/toc/2658-6673 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2024 3 4-11
allfieldsSound	(DE-627)DOAJ092422438 (DE-599)DOAJdfe52fe1ed45464db2d7504d5fdda752 DE-627 ger DE-627 rakwb rus RC799-869 V. T. Ivashkin verfasserin aut Pain at chronic pancreatitis: origin and treatment options 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of review. To present basic mechanisms of pain at pancreatitis and determine main management approaches in pain-predominant cases.Summary. Direct toxic action of damaging factors (first of all — alcohol), pancreatic enzyme deviation phenomenon, parenchymal damage by overflow of free radicals, elevation of intraductal pressure, damage of nerves (neuropathic pain) and compression of adjacent organs play primary role in development of pain. Enzyme supplements at chronic pancreatitis can be indicated not only as replacement treatment, but also as addition to complex treatment of patients with severe abdominal pain. Proton pump inhibitors, spasmolytics or prokinetics are recommended as additional therapy. At absence of desirable results application of nonsteroid anti-inflammatory drugs and analgetics, in resistant pain — non-narcotic opiates or pregabalin are indicated. Efficacy of analgetics can be increased by coadministration of psychotropic agents, most often — tricyclic antidepressants. In severe cases intractable pain at a chronic pancreatitis itself can become indication to surgical intervention.Conclusion. Treatment efficacy in each given case depends on duly establishment and adequate treatment of complications, motivation for abstain of alcohol intake and smoking; strict diet restriction for relapse period, and functional rest for the pancreas. pain chronic pancreatitis the pancreas Diseases of the digestive system. Gastroenterology K. V. Ivashkin verfasserin aut A. V. Okhlobystin verfasserin aut In Российский журнал гастроэнтерологии, гепатологии, колопроктологии Gastro LLC, 2020 25(2024), 3, Seite 4-11 (DE-627)1698164203 26586673 nnns volume:25 year:2024 number:3 pages:4-11 https://doaj.org/article/dfe52fe1ed45464db2d7504d5fdda752 kostenfrei https://www.gastro-j.ru/jour/article/view/1007 kostenfrei https://doaj.org/toc/1382-4376 Journal toc kostenfrei https://doaj.org/toc/2658-6673 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2024 3 4-11
language	Russian
source	In Российский журнал гастроэнтерологии, гепатологии, колопроктологии 25(2024), 3, Seite 4-11 volume:25 year:2024 number:3 pages:4-11
sourceStr	In Российский журнал гастроэнтерологии, гепатологии, колопроктологии 25(2024), 3, Seite 4-11 volume:25 year:2024 number:3 pages:4-11
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topic_facet	pain chronic pancreatitis the pancreas Diseases of the digestive system. Gastroenterology
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callnumber-first	R - Medicine
author	V. T. Ivashkin
spellingShingle	V. T. Ivashkin misc RC799-869 misc pain misc chronic pancreatitis misc the pancreas misc Diseases of the digestive system. Gastroenterology Pain at chronic pancreatitis: origin and treatment options
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topic_title	RC799-869 Pain at chronic pancreatitis: origin and treatment options pain chronic pancreatitis the pancreas
topic	misc RC799-869 misc pain misc chronic pancreatitis misc the pancreas misc Diseases of the digestive system. Gastroenterology
topic_unstemmed	misc RC799-869 misc pain misc chronic pancreatitis misc the pancreas misc Diseases of the digestive system. Gastroenterology
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title	Pain at chronic pancreatitis: origin and treatment options
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title_full	Pain at chronic pancreatitis: origin and treatment options
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title_sort	pain at chronic pancreatitis: origin and treatment options
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title_auth	Pain at chronic pancreatitis: origin and treatment options
abstract	The aim of review. To present basic mechanisms of pain at pancreatitis and determine main management approaches in pain-predominant cases.Summary. Direct toxic action of damaging factors (first of all — alcohol), pancreatic enzyme deviation phenomenon, parenchymal damage by overflow of free radicals, elevation of intraductal pressure, damage of nerves (neuropathic pain) and compression of adjacent organs play primary role in development of pain. Enzyme supplements at chronic pancreatitis can be indicated not only as replacement treatment, but also as addition to complex treatment of patients with severe abdominal pain. Proton pump inhibitors, spasmolytics or prokinetics are recommended as additional therapy. At absence of desirable results application of nonsteroid anti-inflammatory drugs and analgetics, in resistant pain — non-narcotic opiates or pregabalin are indicated. Efficacy of analgetics can be increased by coadministration of psychotropic agents, most often — tricyclic antidepressants. In severe cases intractable pain at a chronic pancreatitis itself can become indication to surgical intervention.Conclusion. Treatment efficacy in each given case depends on duly establishment and adequate treatment of complications, motivation for abstain of alcohol intake and smoking; strict diet restriction for relapse period, and functional rest for the pancreas.
abstractGer	The aim of review. To present basic mechanisms of pain at pancreatitis and determine main management approaches in pain-predominant cases.Summary. Direct toxic action of damaging factors (first of all — alcohol), pancreatic enzyme deviation phenomenon, parenchymal damage by overflow of free radicals, elevation of intraductal pressure, damage of nerves (neuropathic pain) and compression of adjacent organs play primary role in development of pain. Enzyme supplements at chronic pancreatitis can be indicated not only as replacement treatment, but also as addition to complex treatment of patients with severe abdominal pain. Proton pump inhibitors, spasmolytics or prokinetics are recommended as additional therapy. At absence of desirable results application of nonsteroid anti-inflammatory drugs and analgetics, in resistant pain — non-narcotic opiates or pregabalin are indicated. Efficacy of analgetics can be increased by coadministration of psychotropic agents, most often — tricyclic antidepressants. In severe cases intractable pain at a chronic pancreatitis itself can become indication to surgical intervention.Conclusion. Treatment efficacy in each given case depends on duly establishment and adequate treatment of complications, motivation for abstain of alcohol intake and smoking; strict diet restriction for relapse period, and functional rest for the pancreas.
abstract_unstemmed	The aim of review. To present basic mechanisms of pain at pancreatitis and determine main management approaches in pain-predominant cases.Summary. Direct toxic action of damaging factors (first of all — alcohol), pancreatic enzyme deviation phenomenon, parenchymal damage by overflow of free radicals, elevation of intraductal pressure, damage of nerves (neuropathic pain) and compression of adjacent organs play primary role in development of pain. Enzyme supplements at chronic pancreatitis can be indicated not only as replacement treatment, but also as addition to complex treatment of patients with severe abdominal pain. Proton pump inhibitors, spasmolytics or prokinetics are recommended as additional therapy. At absence of desirable results application of nonsteroid anti-inflammatory drugs and analgetics, in resistant pain — non-narcotic opiates or pregabalin are indicated. Efficacy of analgetics can be increased by coadministration of psychotropic agents, most often — tricyclic antidepressants. In severe cases intractable pain at a chronic pancreatitis itself can become indication to surgical intervention.Conclusion. Treatment efficacy in each given case depends on duly establishment and adequate treatment of complications, motivation for abstain of alcohol intake and smoking; strict diet restriction for relapse period, and functional rest for the pancreas.
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title_short	Pain at chronic pancreatitis: origin and treatment options
url	https://doaj.org/article/dfe52fe1ed45464db2d7504d5fdda752 https://www.gastro-j.ru/jour/article/view/1007 https://doaj.org/toc/1382-4376 https://doaj.org/toc/2658-6673
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