FEATURES OF CYTOKINE PRODUCTION DURING REHABILITATION AFTER COVID-19 IN PEOPLE LIVING IN THE NORTHERN REGIONS OF SIBERIA
The coronavirus infection of 2019 (COVID-19) has significantly affected the modern world. Recently, it has been proven that IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IFN-γ and TNF-α play an important role in the inflammatory response of the body to SARS-CoV-2 infection. Purpose. To study the features...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Vasilii D. Belenyuk [verfasserIn] Alexander A. Sinyakov [verfasserIn] Ekaterina O. Shavrina [verfasserIn] Olga L. Moskalenko [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch ; Russisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Siberian Journal of Life Sciences and Agriculture - Science and Innovation Center Publishing House, 2019, 15(2023), 6, Seite 343-359 |
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| Übergeordnetes Werk: |
volume:15 ; year:2023 ; number:6 ; pages:343-359 |
| Links: |
Link aufrufen |
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| DOI / URN: |
10.12731/2658-6649-2023-15-6-967 |
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| Katalog-ID: |
DOAJ092439446 |
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| 520 | |a The coronavirus infection of 2019 (COVID-19) has significantly affected the modern world. Recently, it has been proven that IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IFN-γ and TNF-α play an important role in the inflammatory response of the body to SARS-CoV-2 infection. Purpose. To study the features of the synthesis of key cytokines in residents of the Turukhansky district of the Krasnoyarsk Territory who underwent COVID-19. Materials and methods. On the basis of "Turukhanskaya RB", village. Turukhansk, in February 2023, 98 patients were examined, the average age was 58 (± 5 years). Of the 98 participants interviewed, 76 people had an official diagnosis of COVID-19 in the period from October 2020. The study was conducted with the permission of the ethical committee of the Research Institute of Medical Problems of the North. Each participant signed an informed consent form for the examination, according to the Helsinki Declaration of the World Medical Association regulating the conduct of scientific research. Results. A high IgG titer to SARS-Cov-2 was observed in 99% of the examined, a positive IdM titer to SARS-Cov-2 was in 1% of the examined. In the course of studying the features of the cytokine network in patients with Turukhansk there was a significant decrease in the concentration of α-TNF, IL-1b and IL-10, as well as an increase in IL-2, IL-6 and IL-8 relative to the control group of Krasnoyarsk. α-IFN and IL-4 showed no significant changes and remained within the control range. At the same time, no differences were found between the groups of patients with a confirmed diagnosis of COVID-19 and without it. Conclusion. The data obtained indicate a high level of homogeneity of the sample in the village . Turukhansk, regardless of the presence of the disease, about the low level of detection and control over the course of COVID-19. We observe the formation of a chronic inflammatory process against the background of the prevalence of pro-inflammatory function and an increase in the concentration of pro-inflammatory cytokines, which can subsequently deplete the body's resources and contribute to the development of additional complications. | ||
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10.12731/2658-6649-2023-15-6-967 doi (DE-627)DOAJ092439446 (DE-599)DOAJ548186ccf5ba4b6188e8d2d61a416dda DE-627 ger DE-627 rakwb eng rus Vasilii D. Belenyuk verfasserin aut FEATURES OF CYTOKINE PRODUCTION DURING REHABILITATION AFTER COVID-19 IN PEOPLE LIVING IN THE NORTHERN REGIONS OF SIBERIA 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The coronavirus infection of 2019 (COVID-19) has significantly affected the modern world. Recently, it has been proven that IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IFN-γ and TNF-α play an important role in the inflammatory response of the body to SARS-CoV-2 infection. Purpose. To study the features of the synthesis of key cytokines in residents of the Turukhansky district of the Krasnoyarsk Territory who underwent COVID-19. Materials and methods. On the basis of "Turukhanskaya RB", village. Turukhansk, in February 2023, 98 patients were examined, the average age was 58 (± 5 years). Of the 98 participants interviewed, 76 people had an official diagnosis of COVID-19 in the period from October 2020. The study was conducted with the permission of the ethical committee of the Research Institute of Medical Problems of the North. Each participant signed an informed consent form for the examination, according to the Helsinki Declaration of the World Medical Association regulating the conduct of scientific research. Results. A high IgG titer to SARS-Cov-2 was observed in 99% of the examined, a positive IdM titer to SARS-Cov-2 was in 1% of the examined. In the course of studying the features of the cytokine network in patients with Turukhansk there was a significant decrease in the concentration of α-TNF, IL-1b and IL-10, as well as an increase in IL-2, IL-6 and IL-8 relative to the control group of Krasnoyarsk. α-IFN and IL-4 showed no significant changes and remained within the control range. At the same time, no differences were found between the groups of patients with a confirmed diagnosis of COVID-19 and without it. Conclusion. The data obtained indicate a high level of homogeneity of the sample in the village . Turukhansk, regardless of the presence of the disease, about the low level of detection and control over the course of COVID-19. We observe the formation of a chronic inflammatory process against the background of the prevalence of pro-inflammatory function and an increase in the concentration of pro-inflammatory cytokines, which can subsequently deplete the body's resources and contribute to the development of additional complications. covid-19 cytokines chemokines interferons Agriculture S Science Q Alexander A. Sinyakov verfasserin aut Ekaterina O. Shavrina verfasserin aut Olga L. Moskalenko verfasserin aut In Siberian Journal of Life Sciences and Agriculture Science and Innovation Center Publishing House, 2019 15(2023), 6, Seite 343-359 (DE-627)175765996X 26586657 nnns volume:15 year:2023 number:6 pages:343-359 https://doi.org/10.12731/2658-6649-2023-15-6-967 kostenfrei https://doaj.org/article/548186ccf5ba4b6188e8d2d61a416dda kostenfrei http://discover-journal.ru/jour/index.php/sjlsa/article/view/967 kostenfrei https://doaj.org/toc/2658-6649 Journal toc kostenfrei https://doaj.org/toc/2658-6657 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 6 343-359 |
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10.12731/2658-6649-2023-15-6-967 doi (DE-627)DOAJ092439446 (DE-599)DOAJ548186ccf5ba4b6188e8d2d61a416dda DE-627 ger DE-627 rakwb eng rus Vasilii D. Belenyuk verfasserin aut FEATURES OF CYTOKINE PRODUCTION DURING REHABILITATION AFTER COVID-19 IN PEOPLE LIVING IN THE NORTHERN REGIONS OF SIBERIA 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The coronavirus infection of 2019 (COVID-19) has significantly affected the modern world. Recently, it has been proven that IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IFN-γ and TNF-α play an important role in the inflammatory response of the body to SARS-CoV-2 infection. Purpose. To study the features of the synthesis of key cytokines in residents of the Turukhansky district of the Krasnoyarsk Territory who underwent COVID-19. Materials and methods. On the basis of "Turukhanskaya RB", village. Turukhansk, in February 2023, 98 patients were examined, the average age was 58 (± 5 years). Of the 98 participants interviewed, 76 people had an official diagnosis of COVID-19 in the period from October 2020. The study was conducted with the permission of the ethical committee of the Research Institute of Medical Problems of the North. Each participant signed an informed consent form for the examination, according to the Helsinki Declaration of the World Medical Association regulating the conduct of scientific research. Results. A high IgG titer to SARS-Cov-2 was observed in 99% of the examined, a positive IdM titer to SARS-Cov-2 was in 1% of the examined. In the course of studying the features of the cytokine network in patients with Turukhansk there was a significant decrease in the concentration of α-TNF, IL-1b and IL-10, as well as an increase in IL-2, IL-6 and IL-8 relative to the control group of Krasnoyarsk. α-IFN and IL-4 showed no significant changes and remained within the control range. At the same time, no differences were found between the groups of patients with a confirmed diagnosis of COVID-19 and without it. Conclusion. The data obtained indicate a high level of homogeneity of the sample in the village . Turukhansk, regardless of the presence of the disease, about the low level of detection and control over the course of COVID-19. We observe the formation of a chronic inflammatory process against the background of the prevalence of pro-inflammatory function and an increase in the concentration of pro-inflammatory cytokines, which can subsequently deplete the body's resources and contribute to the development of additional complications. covid-19 cytokines chemokines interferons Agriculture S Science Q Alexander A. Sinyakov verfasserin aut Ekaterina O. Shavrina verfasserin aut Olga L. Moskalenko verfasserin aut In Siberian Journal of Life Sciences and Agriculture Science and Innovation Center Publishing House, 2019 15(2023), 6, Seite 343-359 (DE-627)175765996X 26586657 nnns volume:15 year:2023 number:6 pages:343-359 https://doi.org/10.12731/2658-6649-2023-15-6-967 kostenfrei https://doaj.org/article/548186ccf5ba4b6188e8d2d61a416dda kostenfrei http://discover-journal.ru/jour/index.php/sjlsa/article/view/967 kostenfrei https://doaj.org/toc/2658-6649 Journal toc kostenfrei https://doaj.org/toc/2658-6657 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 6 343-359 |
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10.12731/2658-6649-2023-15-6-967 doi (DE-627)DOAJ092439446 (DE-599)DOAJ548186ccf5ba4b6188e8d2d61a416dda DE-627 ger DE-627 rakwb eng rus Vasilii D. Belenyuk verfasserin aut FEATURES OF CYTOKINE PRODUCTION DURING REHABILITATION AFTER COVID-19 IN PEOPLE LIVING IN THE NORTHERN REGIONS OF SIBERIA 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The coronavirus infection of 2019 (COVID-19) has significantly affected the modern world. Recently, it has been proven that IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IFN-γ and TNF-α play an important role in the inflammatory response of the body to SARS-CoV-2 infection. Purpose. To study the features of the synthesis of key cytokines in residents of the Turukhansky district of the Krasnoyarsk Territory who underwent COVID-19. Materials and methods. On the basis of "Turukhanskaya RB", village. Turukhansk, in February 2023, 98 patients were examined, the average age was 58 (± 5 years). Of the 98 participants interviewed, 76 people had an official diagnosis of COVID-19 in the period from October 2020. The study was conducted with the permission of the ethical committee of the Research Institute of Medical Problems of the North. Each participant signed an informed consent form for the examination, according to the Helsinki Declaration of the World Medical Association regulating the conduct of scientific research. Results. A high IgG titer to SARS-Cov-2 was observed in 99% of the examined, a positive IdM titer to SARS-Cov-2 was in 1% of the examined. In the course of studying the features of the cytokine network in patients with Turukhansk there was a significant decrease in the concentration of α-TNF, IL-1b and IL-10, as well as an increase in IL-2, IL-6 and IL-8 relative to the control group of Krasnoyarsk. α-IFN and IL-4 showed no significant changes and remained within the control range. At the same time, no differences were found between the groups of patients with a confirmed diagnosis of COVID-19 and without it. Conclusion. The data obtained indicate a high level of homogeneity of the sample in the village . Turukhansk, regardless of the presence of the disease, about the low level of detection and control over the course of COVID-19. We observe the formation of a chronic inflammatory process against the background of the prevalence of pro-inflammatory function and an increase in the concentration of pro-inflammatory cytokines, which can subsequently deplete the body's resources and contribute to the development of additional complications. covid-19 cytokines chemokines interferons Agriculture S Science Q Alexander A. Sinyakov verfasserin aut Ekaterina O. Shavrina verfasserin aut Olga L. Moskalenko verfasserin aut In Siberian Journal of Life Sciences and Agriculture Science and Innovation Center Publishing House, 2019 15(2023), 6, Seite 343-359 (DE-627)175765996X 26586657 nnns volume:15 year:2023 number:6 pages:343-359 https://doi.org/10.12731/2658-6649-2023-15-6-967 kostenfrei https://doaj.org/article/548186ccf5ba4b6188e8d2d61a416dda kostenfrei http://discover-journal.ru/jour/index.php/sjlsa/article/view/967 kostenfrei https://doaj.org/toc/2658-6649 Journal toc kostenfrei https://doaj.org/toc/2658-6657 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 6 343-359 |
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10.12731/2658-6649-2023-15-6-967 doi (DE-627)DOAJ092439446 (DE-599)DOAJ548186ccf5ba4b6188e8d2d61a416dda DE-627 ger DE-627 rakwb eng rus Vasilii D. Belenyuk verfasserin aut FEATURES OF CYTOKINE PRODUCTION DURING REHABILITATION AFTER COVID-19 IN PEOPLE LIVING IN THE NORTHERN REGIONS OF SIBERIA 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The coronavirus infection of 2019 (COVID-19) has significantly affected the modern world. Recently, it has been proven that IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IFN-γ and TNF-α play an important role in the inflammatory response of the body to SARS-CoV-2 infection. Purpose. To study the features of the synthesis of key cytokines in residents of the Turukhansky district of the Krasnoyarsk Territory who underwent COVID-19. Materials and methods. On the basis of "Turukhanskaya RB", village. Turukhansk, in February 2023, 98 patients were examined, the average age was 58 (± 5 years). Of the 98 participants interviewed, 76 people had an official diagnosis of COVID-19 in the period from October 2020. The study was conducted with the permission of the ethical committee of the Research Institute of Medical Problems of the North. Each participant signed an informed consent form for the examination, according to the Helsinki Declaration of the World Medical Association regulating the conduct of scientific research. Results. A high IgG titer to SARS-Cov-2 was observed in 99% of the examined, a positive IdM titer to SARS-Cov-2 was in 1% of the examined. In the course of studying the features of the cytokine network in patients with Turukhansk there was a significant decrease in the concentration of α-TNF, IL-1b and IL-10, as well as an increase in IL-2, IL-6 and IL-8 relative to the control group of Krasnoyarsk. α-IFN and IL-4 showed no significant changes and remained within the control range. At the same time, no differences were found between the groups of patients with a confirmed diagnosis of COVID-19 and without it. Conclusion. The data obtained indicate a high level of homogeneity of the sample in the village . Turukhansk, regardless of the presence of the disease, about the low level of detection and control over the course of COVID-19. We observe the formation of a chronic inflammatory process against the background of the prevalence of pro-inflammatory function and an increase in the concentration of pro-inflammatory cytokines, which can subsequently deplete the body's resources and contribute to the development of additional complications. covid-19 cytokines chemokines interferons Agriculture S Science Q Alexander A. Sinyakov verfasserin aut Ekaterina O. Shavrina verfasserin aut Olga L. Moskalenko verfasserin aut In Siberian Journal of Life Sciences and Agriculture Science and Innovation Center Publishing House, 2019 15(2023), 6, Seite 343-359 (DE-627)175765996X 26586657 nnns volume:15 year:2023 number:6 pages:343-359 https://doi.org/10.12731/2658-6649-2023-15-6-967 kostenfrei https://doaj.org/article/548186ccf5ba4b6188e8d2d61a416dda kostenfrei http://discover-journal.ru/jour/index.php/sjlsa/article/view/967 kostenfrei https://doaj.org/toc/2658-6649 Journal toc kostenfrei https://doaj.org/toc/2658-6657 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 6 343-359 |
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FEATURES OF CYTOKINE PRODUCTION DURING REHABILITATION AFTER COVID-19 IN PEOPLE LIVING IN THE NORTHERN REGIONS OF SIBERIA |
| abstract |
The coronavirus infection of 2019 (COVID-19) has significantly affected the modern world. Recently, it has been proven that IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IFN-γ and TNF-α play an important role in the inflammatory response of the body to SARS-CoV-2 infection. Purpose. To study the features of the synthesis of key cytokines in residents of the Turukhansky district of the Krasnoyarsk Territory who underwent COVID-19. Materials and methods. On the basis of "Turukhanskaya RB", village. Turukhansk, in February 2023, 98 patients were examined, the average age was 58 (± 5 years). Of the 98 participants interviewed, 76 people had an official diagnosis of COVID-19 in the period from October 2020. The study was conducted with the permission of the ethical committee of the Research Institute of Medical Problems of the North. Each participant signed an informed consent form for the examination, according to the Helsinki Declaration of the World Medical Association regulating the conduct of scientific research. Results. A high IgG titer to SARS-Cov-2 was observed in 99% of the examined, a positive IdM titer to SARS-Cov-2 was in 1% of the examined. In the course of studying the features of the cytokine network in patients with Turukhansk there was a significant decrease in the concentration of α-TNF, IL-1b and IL-10, as well as an increase in IL-2, IL-6 and IL-8 relative to the control group of Krasnoyarsk. α-IFN and IL-4 showed no significant changes and remained within the control range. At the same time, no differences were found between the groups of patients with a confirmed diagnosis of COVID-19 and without it. Conclusion. The data obtained indicate a high level of homogeneity of the sample in the village . Turukhansk, regardless of the presence of the disease, about the low level of detection and control over the course of COVID-19. We observe the formation of a chronic inflammatory process against the background of the prevalence of pro-inflammatory function and an increase in the concentration of pro-inflammatory cytokines, which can subsequently deplete the body's resources and contribute to the development of additional complications. |
| abstractGer |
The coronavirus infection of 2019 (COVID-19) has significantly affected the modern world. Recently, it has been proven that IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IFN-γ and TNF-α play an important role in the inflammatory response of the body to SARS-CoV-2 infection. Purpose. To study the features of the synthesis of key cytokines in residents of the Turukhansky district of the Krasnoyarsk Territory who underwent COVID-19. Materials and methods. On the basis of "Turukhanskaya RB", village. Turukhansk, in February 2023, 98 patients were examined, the average age was 58 (± 5 years). Of the 98 participants interviewed, 76 people had an official diagnosis of COVID-19 in the period from October 2020. The study was conducted with the permission of the ethical committee of the Research Institute of Medical Problems of the North. Each participant signed an informed consent form for the examination, according to the Helsinki Declaration of the World Medical Association regulating the conduct of scientific research. Results. A high IgG titer to SARS-Cov-2 was observed in 99% of the examined, a positive IdM titer to SARS-Cov-2 was in 1% of the examined. In the course of studying the features of the cytokine network in patients with Turukhansk there was a significant decrease in the concentration of α-TNF, IL-1b and IL-10, as well as an increase in IL-2, IL-6 and IL-8 relative to the control group of Krasnoyarsk. α-IFN and IL-4 showed no significant changes and remained within the control range. At the same time, no differences were found between the groups of patients with a confirmed diagnosis of COVID-19 and without it. Conclusion. The data obtained indicate a high level of homogeneity of the sample in the village . Turukhansk, regardless of the presence of the disease, about the low level of detection and control over the course of COVID-19. We observe the formation of a chronic inflammatory process against the background of the prevalence of pro-inflammatory function and an increase in the concentration of pro-inflammatory cytokines, which can subsequently deplete the body's resources and contribute to the development of additional complications. |
| abstract_unstemmed |
The coronavirus infection of 2019 (COVID-19) has significantly affected the modern world. Recently, it has been proven that IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IFN-γ and TNF-α play an important role in the inflammatory response of the body to SARS-CoV-2 infection. Purpose. To study the features of the synthesis of key cytokines in residents of the Turukhansky district of the Krasnoyarsk Territory who underwent COVID-19. Materials and methods. On the basis of "Turukhanskaya RB", village. Turukhansk, in February 2023, 98 patients were examined, the average age was 58 (± 5 years). Of the 98 participants interviewed, 76 people had an official diagnosis of COVID-19 in the period from October 2020. The study was conducted with the permission of the ethical committee of the Research Institute of Medical Problems of the North. Each participant signed an informed consent form for the examination, according to the Helsinki Declaration of the World Medical Association regulating the conduct of scientific research. Results. A high IgG titer to SARS-Cov-2 was observed in 99% of the examined, a positive IdM titer to SARS-Cov-2 was in 1% of the examined. In the course of studying the features of the cytokine network in patients with Turukhansk there was a significant decrease in the concentration of α-TNF, IL-1b and IL-10, as well as an increase in IL-2, IL-6 and IL-8 relative to the control group of Krasnoyarsk. α-IFN and IL-4 showed no significant changes and remained within the control range. At the same time, no differences were found between the groups of patients with a confirmed diagnosis of COVID-19 and without it. Conclusion. The data obtained indicate a high level of homogeneity of the sample in the village . Turukhansk, regardless of the presence of the disease, about the low level of detection and control over the course of COVID-19. We observe the formation of a chronic inflammatory process against the background of the prevalence of pro-inflammatory function and an increase in the concentration of pro-inflammatory cytokines, which can subsequently deplete the body's resources and contribute to the development of additional complications. |
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| title_short |
FEATURES OF CYTOKINE PRODUCTION DURING REHABILITATION AFTER COVID-19 IN PEOPLE LIVING IN THE NORTHERN REGIONS OF SIBERIA |
| url |
https://doi.org/10.12731/2658-6649-2023-15-6-967 https://doaj.org/article/548186ccf5ba4b6188e8d2d61a416dda http://discover-journal.ru/jour/index.php/sjlsa/article/view/967 https://doaj.org/toc/2658-6649 https://doaj.org/toc/2658-6657 |
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Alexander A. Sinyakov Ekaterina O. Shavrina Olga L. Moskalenko |
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| up_date |
2024-07-04T01:20:04.704Z |
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