Risk factors for health impairments in children after hospitalization for acute COVID-19 or MIS-C
ObjectiveTo identify risk factors for persistent impairments after pediatric hospitalization for acute coronavirus disease 2019 (COVID-19) or multisystem inflammatory syndrome in children (MIS-C) during the SARS-CoV-2 pandemic.MethodsAcross 25 U.S. Overcoming COVID-19 Network hospitals, we conducted...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Aline B. Maddux [verfasserIn] Cameron C. Young [verfasserIn] Suden Kucukak [verfasserIn] Laura D. Zambrano [verfasserIn] Margaret M. Newhams [verfasserIn] Caitlin K. Rollins [verfasserIn] Natasha B. Halasa [verfasserIn] Shira J. Gertz [verfasserIn] Elizabeth H. Mack [verfasserIn] Stephanie Schwartz [verfasserIn] Michele Kong [verfasserIn] Laura L. Loftis [verfasserIn] Katherine Irby [verfasserIn] Courtney M. Rowan [verfasserIn] Keiko M. Tarquinio [verfasserIn] Matt S. Zinter [verfasserIn] Hillary Crandall [verfasserIn] Natalie Z. Cvijanovich [verfasserIn] Jennifer E. Schuster [verfasserIn] Julie C. Fitzgerald [verfasserIn] Mary A. Staat [verfasserIn] Charlotte V. Hobbs [verfasserIn] Ryan A. Nofziger [verfasserIn] Steven Shein [verfasserIn] Heidi Flori [verfasserIn] Melissa L. Cullimore [verfasserIn] Brandon M. Chatani [verfasserIn] Emily R. Levy [verfasserIn] Katri V. Typpo [verfasserIn] Janet R. Hume [verfasserIn] Angela P. Campbell [verfasserIn] Adrienne G. Randolph [verfasserIn] the Overcoming COVID-19 Investigators [verfasserIn] Meghan Murdock [verfasserIn] Heather Kelley [verfasserIn] Candice Colston [verfasserIn] Mary Glas Gaspers [verfasserIn] Ronald C. Sanders [verfasserIn] Emily Port [verfasserIn] Rachel Mansour [verfasserIn] Sara Shankman [verfasserIn] Kaitlin Jones [verfasserIn] Caitlin Rollins [verfasserIn] Tanya Novak [verfasserIn] Janet Chou [verfasserIn] Mary Beth Son [verfasserIn] Julia Clarke [verfasserIn] Brooke Sens [verfasserIn] Eve Listerud [verfasserIn] Sabrina Chen [verfasserIn] Kasey Stewart [verfasserIn] Heidi R. Flori [verfasserIn] Mary K. Dahmer [verfasserIn] Supriya Behl [verfasserIn] Noelle M. Drapeau [verfasserIn] Lora Martin [verfasserIn] Lacy Malloch [verfasserIn] Maygan Martin [verfasserIn] Kayla Patterson [verfasserIn] Cameron Sanders [verfasserIn] Kengo Inagaki [verfasserIn] Sarah McGraw [verfasserIn] Anita Dhanrajani [verfasserIn] Abigail Kietzman [verfasserIn] Shannon Hill [verfasserIn] Russell J. McCulloh [verfasserIn] Stephanie P. Schwartz [verfasserIn] Tracie C. Walker [verfasserIn] Mary Allen Staat [verfasserIn] Rajashri Rasal [verfasserIn] Ryan Burnett [verfasserIn] Jenny Bush [verfasserIn] Meena Golcha [verfasserIn] Laura Stewart [verfasserIn] Krow Ampofo [verfasserIn] Manish M. Patel [verfasserIn] Leora R. Feldstein [verfasserIn] Mark W. Tenforde [verfasserIn] Ashley M. Jackson [verfasserIn] Angela Campbell [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
COVID-19 post-intensive care syndrome |
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| Übergeordnetes Werk: |
In: Frontiers in Pediatrics - Frontiers Media S.A., 2013, 11(2023) |
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| Übergeordnetes Werk: |
volume:11 ; year:2023 |
| Links: |
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| DOI / URN: |
10.3389/fped.2023.1260372 |
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| Katalog-ID: |
DOAJ092703062 |
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| 100 | 0 | |a Aline B. Maddux |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Risk factors for health impairments in children after hospitalization for acute COVID-19 or MIS-C |
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| 520 | |a ObjectiveTo identify risk factors for persistent impairments after pediatric hospitalization for acute coronavirus disease 2019 (COVID-19) or multisystem inflammatory syndrome in children (MIS-C) during the SARS-CoV-2 pandemic.MethodsAcross 25 U.S. Overcoming COVID-19 Network hospitals, we conducted a prospective cohort study of patients <21-years-old hospitalized for acute COVID-19 or MIS-C (May 2020 to March 2022) surveyed 2- to 4-months post-admission. Multivariable regression was used to calculate adjusted risk ratios (aRR) and 95% confidence intervals (CI).ResultsOf 232 children with acute COVID-19, 71 (30.6%) had persistent symptoms and 50 (21.6%) had activity impairments at follow-up; for MIS-C (n = 241), 56 (23.2%) had persistent symptoms and 58 (24.1%) had activity impairments. In adjusted analyses of patients with acute COVID-19, receipt of mechanical ventilation was associated with persistent symptoms [aRR 1.83 (95% CI: 1.07, 3.13)] whereas obesity [aRR 2.18 (95% CI: 1.05, 4.51)] and greater organ system involvement [aRR 1.35 (95% CI: 1.13, 1.61)] were associated with activity impairment. For patients with MIS-C, having a pre-existing respiratory condition was associated with persistent symptoms [aRR 3.04 (95% CI: 1.70, 5.41)] whereas obesity [aRR 1.86 (95% CI: 1.09, 3.15)] and greater organ system involvement [aRR 1.26 (1.00, 1.58)] were associated with activity impairments.DiscussionAmong patients hospitalized, nearly one in three hospitalized with acute COVID-19 and one in four hospitalized with MIS-C had persistent impairments for ≥2 months post-hospitalization. Persistent impairments were associated with more severe illness and underlying health conditions, identifying populations to target for follow-up. | ||
| 650 | 4 | |a post-acute COVID-19 syndrome | |
| 650 | 4 | |a COVID-19 post-intensive care syndrome | |
| 650 | 4 | |a critical care outcomes | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a multisystem inflammatory syndrome in children | |
| 650 | 4 | |a MIS-C | |
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| 700 | 0 | |a Shira J. Gertz |e verfasserin |4 aut | |
| 700 | 0 | |a Elizabeth H. Mack |e verfasserin |4 aut | |
| 700 | 0 | |a Stephanie Schwartz |e verfasserin |4 aut | |
| 700 | 0 | |a Michele Kong |e verfasserin |4 aut | |
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| 700 | 0 | |a Mary A. Staat |e verfasserin |4 aut | |
| 700 | 0 | |a Charlotte V. Hobbs |e verfasserin |4 aut | |
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| 700 | 0 | |a Angela P. Campbell |e verfasserin |4 aut | |
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| 700 | 0 | |a Natalie Z. Cvijanovich |e verfasserin |4 aut | |
| 700 | 0 | |a Matt S. Zinter |e verfasserin |4 aut | |
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| 700 | 0 | |a Mary K. Dahmer |e verfasserin |4 aut | |
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| 700 | 0 | |a Melissa L. Cullimore |e verfasserin |4 aut | |
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10.3389/fped.2023.1260372 doi (DE-627)DOAJ092703062 (DE-599)DOAJ1e2f7cbc16d047dbab50b8aeff084f5e DE-627 ger DE-627 rakwb eng RJ1-570 Aline B. Maddux verfasserin aut Risk factors for health impairments in children after hospitalization for acute COVID-19 or MIS-C 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ObjectiveTo identify risk factors for persistent impairments after pediatric hospitalization for acute coronavirus disease 2019 (COVID-19) or multisystem inflammatory syndrome in children (MIS-C) during the SARS-CoV-2 pandemic.MethodsAcross 25 U.S. Overcoming COVID-19 Network hospitals, we conducted a prospective cohort study of patients <21-years-old hospitalized for acute COVID-19 or MIS-C (May 2020 to March 2022) surveyed 2- to 4-months post-admission. Multivariable regression was used to calculate adjusted risk ratios (aRR) and 95% confidence intervals (CI).ResultsOf 232 children with acute COVID-19, 71 (30.6%) had persistent symptoms and 50 (21.6%) had activity impairments at follow-up; for MIS-C (n = 241), 56 (23.2%) had persistent symptoms and 58 (24.1%) had activity impairments. In adjusted analyses of patients with acute COVID-19, receipt of mechanical ventilation was associated with persistent symptoms [aRR 1.83 (95% CI: 1.07, 3.13)] whereas obesity [aRR 2.18 (95% CI: 1.05, 4.51)] and greater organ system involvement [aRR 1.35 (95% CI: 1.13, 1.61)] were associated with activity impairment. For patients with MIS-C, having a pre-existing respiratory condition was associated with persistent symptoms [aRR 3.04 (95% CI: 1.70, 5.41)] whereas obesity [aRR 1.86 (95% CI: 1.09, 3.15)] and greater organ system involvement [aRR 1.26 (1.00, 1.58)] were associated with activity impairments.DiscussionAmong patients hospitalized, nearly one in three hospitalized with acute COVID-19 and one in four hospitalized with MIS-C had persistent impairments for ≥2 months post-hospitalization. Persistent impairments were associated with more severe illness and underlying health conditions, identifying populations to target for follow-up. post-acute COVID-19 syndrome COVID-19 post-intensive care syndrome critical care outcomes SARS-CoV-2 multisystem inflammatory syndrome in children MIS-C Pediatrics Cameron C. Young verfasserin aut Suden Kucukak verfasserin aut Laura D. Zambrano verfasserin aut Margaret M. Newhams verfasserin aut Caitlin K. Rollins verfasserin aut Natasha B. Halasa verfasserin aut Shira J. Gertz verfasserin aut Elizabeth H. Mack verfasserin aut Stephanie Schwartz verfasserin aut Michele Kong verfasserin aut Laura L. Loftis verfasserin aut Katherine Irby verfasserin aut Courtney M. Rowan verfasserin aut Keiko M. Tarquinio verfasserin aut Matt S. Zinter verfasserin aut Hillary Crandall verfasserin aut Natalie Z. Cvijanovich verfasserin aut Jennifer E. Schuster verfasserin aut Julie C. Fitzgerald verfasserin aut Mary A. Staat verfasserin aut Charlotte V. Hobbs verfasserin aut Ryan A. Nofziger verfasserin aut Steven Shein verfasserin aut Heidi Flori verfasserin aut Melissa L. Cullimore verfasserin aut Brandon M. Chatani verfasserin aut Emily R. Levy verfasserin aut Katri V. Typpo verfasserin aut Janet R. Hume verfasserin aut Angela P. Campbell verfasserin aut Adrienne G. Randolph verfasserin aut the Overcoming COVID-19 Investigators verfasserin aut Michele Kong verfasserin aut Meghan Murdock verfasserin aut Heather Kelley verfasserin aut Candice Colston verfasserin aut Mary Glas Gaspers verfasserin aut Katri V. Typpo verfasserin aut Ronald C. Sanders verfasserin aut Katherine Irby verfasserin aut Natalie Z. Cvijanovich verfasserin aut Matt S. Zinter verfasserin aut Aline B. Maddux verfasserin aut Emily Port verfasserin aut Rachel Mansour verfasserin aut Sara Shankman verfasserin aut Brandon M. Chatani verfasserin aut Keiko M. Tarquinio verfasserin aut Kaitlin Jones verfasserin aut Courtney M. Rowan verfasserin aut Adrienne G. Randolph verfasserin aut Margaret M. Newhams verfasserin aut Cameron C. Young verfasserin aut Suden Kucukak verfasserin aut Caitlin Rollins verfasserin aut Tanya Novak verfasserin aut Janet Chou verfasserin aut Mary Beth Son verfasserin aut Julia Clarke verfasserin aut Brooke Sens verfasserin aut Eve Listerud verfasserin aut Sabrina Chen verfasserin aut Kasey Stewart verfasserin aut Heidi R. Flori verfasserin aut Mary K. Dahmer verfasserin aut Janet R. Hume verfasserin aut Emily R. Levy verfasserin aut Supriya Behl verfasserin aut Noelle M. Drapeau verfasserin aut Charlotte V. Hobbs verfasserin aut Lora Martin verfasserin aut Lacy Malloch verfasserin aut Maygan Martin verfasserin aut Kayla Patterson verfasserin aut Cameron Sanders verfasserin aut Kengo Inagaki verfasserin aut Sarah McGraw verfasserin aut Anita Dhanrajani verfasserin aut Jennifer E. Schuster verfasserin aut Abigail Kietzman verfasserin aut Shannon Hill verfasserin aut Melissa L. Cullimore verfasserin aut Russell J. McCulloh verfasserin aut Shira J. Gertz verfasserin aut Stephanie P. Schwartz verfasserin aut Tracie C. Walker verfasserin aut Ryan A. Nofziger verfasserin aut Mary Allen Staat verfasserin aut Steven Shein verfasserin aut Rajashri Rasal verfasserin aut Julie C. Fitzgerald verfasserin aut Ryan Burnett verfasserin aut Jenny Bush verfasserin aut Elizabeth H. Mack verfasserin aut Natasha B. Halasa verfasserin aut Meena Golcha verfasserin aut Laura Stewart verfasserin aut Laura L. Loftis verfasserin aut Hillary Crandall verfasserin aut Krow Ampofo verfasserin aut Manish M. Patel verfasserin aut Leora R. Feldstein verfasserin aut Mark W. Tenforde verfasserin aut Ashley M. Jackson verfasserin aut Angela Campbell verfasserin aut Laura D. Zambrano verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 11(2023) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:11 year:2023 https://doi.org/10.3389/fped.2023.1260372 kostenfrei https://doaj.org/article/1e2f7cbc16d047dbab50b8aeff084f5e kostenfrei https://www.frontiersin.org/articles/10.3389/fped.2023.1260372/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2023 |
| spelling |
10.3389/fped.2023.1260372 doi (DE-627)DOAJ092703062 (DE-599)DOAJ1e2f7cbc16d047dbab50b8aeff084f5e DE-627 ger DE-627 rakwb eng RJ1-570 Aline B. Maddux verfasserin aut Risk factors for health impairments in children after hospitalization for acute COVID-19 or MIS-C 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ObjectiveTo identify risk factors for persistent impairments after pediatric hospitalization for acute coronavirus disease 2019 (COVID-19) or multisystem inflammatory syndrome in children (MIS-C) during the SARS-CoV-2 pandemic.MethodsAcross 25 U.S. Overcoming COVID-19 Network hospitals, we conducted a prospective cohort study of patients <21-years-old hospitalized for acute COVID-19 or MIS-C (May 2020 to March 2022) surveyed 2- to 4-months post-admission. Multivariable regression was used to calculate adjusted risk ratios (aRR) and 95% confidence intervals (CI).ResultsOf 232 children with acute COVID-19, 71 (30.6%) had persistent symptoms and 50 (21.6%) had activity impairments at follow-up; for MIS-C (n = 241), 56 (23.2%) had persistent symptoms and 58 (24.1%) had activity impairments. In adjusted analyses of patients with acute COVID-19, receipt of mechanical ventilation was associated with persistent symptoms [aRR 1.83 (95% CI: 1.07, 3.13)] whereas obesity [aRR 2.18 (95% CI: 1.05, 4.51)] and greater organ system involvement [aRR 1.35 (95% CI: 1.13, 1.61)] were associated with activity impairment. For patients with MIS-C, having a pre-existing respiratory condition was associated with persistent symptoms [aRR 3.04 (95% CI: 1.70, 5.41)] whereas obesity [aRR 1.86 (95% CI: 1.09, 3.15)] and greater organ system involvement [aRR 1.26 (1.00, 1.58)] were associated with activity impairments.DiscussionAmong patients hospitalized, nearly one in three hospitalized with acute COVID-19 and one in four hospitalized with MIS-C had persistent impairments for ≥2 months post-hospitalization. Persistent impairments were associated with more severe illness and underlying health conditions, identifying populations to target for follow-up. post-acute COVID-19 syndrome COVID-19 post-intensive care syndrome critical care outcomes SARS-CoV-2 multisystem inflammatory syndrome in children MIS-C Pediatrics Cameron C. Young verfasserin aut Suden Kucukak verfasserin aut Laura D. Zambrano verfasserin aut Margaret M. Newhams verfasserin aut Caitlin K. Rollins verfasserin aut Natasha B. Halasa verfasserin aut Shira J. Gertz verfasserin aut Elizabeth H. Mack verfasserin aut Stephanie Schwartz verfasserin aut Michele Kong verfasserin aut Laura L. Loftis verfasserin aut Katherine Irby verfasserin aut Courtney M. Rowan verfasserin aut Keiko M. Tarquinio verfasserin aut Matt S. Zinter verfasserin aut Hillary Crandall verfasserin aut Natalie Z. Cvijanovich verfasserin aut Jennifer E. Schuster verfasserin aut Julie C. Fitzgerald verfasserin aut Mary A. Staat verfasserin aut Charlotte V. Hobbs verfasserin aut Ryan A. Nofziger verfasserin aut Steven Shein verfasserin aut Heidi Flori verfasserin aut Melissa L. Cullimore verfasserin aut Brandon M. Chatani verfasserin aut Emily R. Levy verfasserin aut Katri V. Typpo verfasserin aut Janet R. Hume verfasserin aut Angela P. Campbell verfasserin aut Adrienne G. Randolph verfasserin aut the Overcoming COVID-19 Investigators verfasserin aut Michele Kong verfasserin aut Meghan Murdock verfasserin aut Heather Kelley verfasserin aut Candice Colston verfasserin aut Mary Glas Gaspers verfasserin aut Katri V. Typpo verfasserin aut Ronald C. Sanders verfasserin aut Katherine Irby verfasserin aut Natalie Z. Cvijanovich verfasserin aut Matt S. Zinter verfasserin aut Aline B. Maddux verfasserin aut Emily Port verfasserin aut Rachel Mansour verfasserin aut Sara Shankman verfasserin aut Brandon M. Chatani verfasserin aut Keiko M. Tarquinio verfasserin aut Kaitlin Jones verfasserin aut Courtney M. Rowan verfasserin aut Adrienne G. Randolph verfasserin aut Margaret M. Newhams verfasserin aut Cameron C. Young verfasserin aut Suden Kucukak verfasserin aut Caitlin Rollins verfasserin aut Tanya Novak verfasserin aut Janet Chou verfasserin aut Mary Beth Son verfasserin aut Julia Clarke verfasserin aut Brooke Sens verfasserin aut Eve Listerud verfasserin aut Sabrina Chen verfasserin aut Kasey Stewart verfasserin aut Heidi R. Flori verfasserin aut Mary K. Dahmer verfasserin aut Janet R. Hume verfasserin aut Emily R. Levy verfasserin aut Supriya Behl verfasserin aut Noelle M. Drapeau verfasserin aut Charlotte V. Hobbs verfasserin aut Lora Martin verfasserin aut Lacy Malloch verfasserin aut Maygan Martin verfasserin aut Kayla Patterson verfasserin aut Cameron Sanders verfasserin aut Kengo Inagaki verfasserin aut Sarah McGraw verfasserin aut Anita Dhanrajani verfasserin aut Jennifer E. Schuster verfasserin aut Abigail Kietzman verfasserin aut Shannon Hill verfasserin aut Melissa L. Cullimore verfasserin aut Russell J. McCulloh verfasserin aut Shira J. Gertz verfasserin aut Stephanie P. Schwartz verfasserin aut Tracie C. Walker verfasserin aut Ryan A. Nofziger verfasserin aut Mary Allen Staat verfasserin aut Steven Shein verfasserin aut Rajashri Rasal verfasserin aut Julie C. Fitzgerald verfasserin aut Ryan Burnett verfasserin aut Jenny Bush verfasserin aut Elizabeth H. Mack verfasserin aut Natasha B. Halasa verfasserin aut Meena Golcha verfasserin aut Laura Stewart verfasserin aut Laura L. Loftis verfasserin aut Hillary Crandall verfasserin aut Krow Ampofo verfasserin aut Manish M. Patel verfasserin aut Leora R. Feldstein verfasserin aut Mark W. Tenforde verfasserin aut Ashley M. Jackson verfasserin aut Angela Campbell verfasserin aut Laura D. Zambrano verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 11(2023) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:11 year:2023 https://doi.org/10.3389/fped.2023.1260372 kostenfrei https://doaj.org/article/1e2f7cbc16d047dbab50b8aeff084f5e kostenfrei https://www.frontiersin.org/articles/10.3389/fped.2023.1260372/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2023 |
| allfields_unstemmed |
10.3389/fped.2023.1260372 doi (DE-627)DOAJ092703062 (DE-599)DOAJ1e2f7cbc16d047dbab50b8aeff084f5e DE-627 ger DE-627 rakwb eng RJ1-570 Aline B. Maddux verfasserin aut Risk factors for health impairments in children after hospitalization for acute COVID-19 or MIS-C 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ObjectiveTo identify risk factors for persistent impairments after pediatric hospitalization for acute coronavirus disease 2019 (COVID-19) or multisystem inflammatory syndrome in children (MIS-C) during the SARS-CoV-2 pandemic.MethodsAcross 25 U.S. Overcoming COVID-19 Network hospitals, we conducted a prospective cohort study of patients <21-years-old hospitalized for acute COVID-19 or MIS-C (May 2020 to March 2022) surveyed 2- to 4-months post-admission. Multivariable regression was used to calculate adjusted risk ratios (aRR) and 95% confidence intervals (CI).ResultsOf 232 children with acute COVID-19, 71 (30.6%) had persistent symptoms and 50 (21.6%) had activity impairments at follow-up; for MIS-C (n = 241), 56 (23.2%) had persistent symptoms and 58 (24.1%) had activity impairments. In adjusted analyses of patients with acute COVID-19, receipt of mechanical ventilation was associated with persistent symptoms [aRR 1.83 (95% CI: 1.07, 3.13)] whereas obesity [aRR 2.18 (95% CI: 1.05, 4.51)] and greater organ system involvement [aRR 1.35 (95% CI: 1.13, 1.61)] were associated with activity impairment. For patients with MIS-C, having a pre-existing respiratory condition was associated with persistent symptoms [aRR 3.04 (95% CI: 1.70, 5.41)] whereas obesity [aRR 1.86 (95% CI: 1.09, 3.15)] and greater organ system involvement [aRR 1.26 (1.00, 1.58)] were associated with activity impairments.DiscussionAmong patients hospitalized, nearly one in three hospitalized with acute COVID-19 and one in four hospitalized with MIS-C had persistent impairments for ≥2 months post-hospitalization. Persistent impairments were associated with more severe illness and underlying health conditions, identifying populations to target for follow-up. post-acute COVID-19 syndrome COVID-19 post-intensive care syndrome critical care outcomes SARS-CoV-2 multisystem inflammatory syndrome in children MIS-C Pediatrics Cameron C. Young verfasserin aut Suden Kucukak verfasserin aut Laura D. Zambrano verfasserin aut Margaret M. Newhams verfasserin aut Caitlin K. Rollins verfasserin aut Natasha B. Halasa verfasserin aut Shira J. Gertz verfasserin aut Elizabeth H. Mack verfasserin aut Stephanie Schwartz verfasserin aut Michele Kong verfasserin aut Laura L. Loftis verfasserin aut Katherine Irby verfasserin aut Courtney M. Rowan verfasserin aut Keiko M. Tarquinio verfasserin aut Matt S. Zinter verfasserin aut Hillary Crandall verfasserin aut Natalie Z. Cvijanovich verfasserin aut Jennifer E. Schuster verfasserin aut Julie C. Fitzgerald verfasserin aut Mary A. Staat verfasserin aut Charlotte V. Hobbs verfasserin aut Ryan A. Nofziger verfasserin aut Steven Shein verfasserin aut Heidi Flori verfasserin aut Melissa L. Cullimore verfasserin aut Brandon M. Chatani verfasserin aut Emily R. Levy verfasserin aut Katri V. Typpo verfasserin aut Janet R. Hume verfasserin aut Angela P. Campbell verfasserin aut Adrienne G. Randolph verfasserin aut the Overcoming COVID-19 Investigators verfasserin aut Michele Kong verfasserin aut Meghan Murdock verfasserin aut Heather Kelley verfasserin aut Candice Colston verfasserin aut Mary Glas Gaspers verfasserin aut Katri V. Typpo verfasserin aut Ronald C. Sanders verfasserin aut Katherine Irby verfasserin aut Natalie Z. Cvijanovich verfasserin aut Matt S. Zinter verfasserin aut Aline B. Maddux verfasserin aut Emily Port verfasserin aut Rachel Mansour verfasserin aut Sara Shankman verfasserin aut Brandon M. Chatani verfasserin aut Keiko M. Tarquinio verfasserin aut Kaitlin Jones verfasserin aut Courtney M. Rowan verfasserin aut Adrienne G. Randolph verfasserin aut Margaret M. Newhams verfasserin aut Cameron C. Young verfasserin aut Suden Kucukak verfasserin aut Caitlin Rollins verfasserin aut Tanya Novak verfasserin aut Janet Chou verfasserin aut Mary Beth Son verfasserin aut Julia Clarke verfasserin aut Brooke Sens verfasserin aut Eve Listerud verfasserin aut Sabrina Chen verfasserin aut Kasey Stewart verfasserin aut Heidi R. Flori verfasserin aut Mary K. Dahmer verfasserin aut Janet R. Hume verfasserin aut Emily R. Levy verfasserin aut Supriya Behl verfasserin aut Noelle M. Drapeau verfasserin aut Charlotte V. Hobbs verfasserin aut Lora Martin verfasserin aut Lacy Malloch verfasserin aut Maygan Martin verfasserin aut Kayla Patterson verfasserin aut Cameron Sanders verfasserin aut Kengo Inagaki verfasserin aut Sarah McGraw verfasserin aut Anita Dhanrajani verfasserin aut Jennifer E. Schuster verfasserin aut Abigail Kietzman verfasserin aut Shannon Hill verfasserin aut Melissa L. Cullimore verfasserin aut Russell J. McCulloh verfasserin aut Shira J. Gertz verfasserin aut Stephanie P. Schwartz verfasserin aut Tracie C. Walker verfasserin aut Ryan A. Nofziger verfasserin aut Mary Allen Staat verfasserin aut Steven Shein verfasserin aut Rajashri Rasal verfasserin aut Julie C. Fitzgerald verfasserin aut Ryan Burnett verfasserin aut Jenny Bush verfasserin aut Elizabeth H. Mack verfasserin aut Natasha B. Halasa verfasserin aut Meena Golcha verfasserin aut Laura Stewart verfasserin aut Laura L. Loftis verfasserin aut Hillary Crandall verfasserin aut Krow Ampofo verfasserin aut Manish M. Patel verfasserin aut Leora R. Feldstein verfasserin aut Mark W. Tenforde verfasserin aut Ashley M. Jackson verfasserin aut Angela Campbell verfasserin aut Laura D. Zambrano verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 11(2023) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:11 year:2023 https://doi.org/10.3389/fped.2023.1260372 kostenfrei https://doaj.org/article/1e2f7cbc16d047dbab50b8aeff084f5e kostenfrei https://www.frontiersin.org/articles/10.3389/fped.2023.1260372/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2023 |
| allfieldsGer |
10.3389/fped.2023.1260372 doi (DE-627)DOAJ092703062 (DE-599)DOAJ1e2f7cbc16d047dbab50b8aeff084f5e DE-627 ger DE-627 rakwb eng RJ1-570 Aline B. Maddux verfasserin aut Risk factors for health impairments in children after hospitalization for acute COVID-19 or MIS-C 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ObjectiveTo identify risk factors for persistent impairments after pediatric hospitalization for acute coronavirus disease 2019 (COVID-19) or multisystem inflammatory syndrome in children (MIS-C) during the SARS-CoV-2 pandemic.MethodsAcross 25 U.S. Overcoming COVID-19 Network hospitals, we conducted a prospective cohort study of patients <21-years-old hospitalized for acute COVID-19 or MIS-C (May 2020 to March 2022) surveyed 2- to 4-months post-admission. Multivariable regression was used to calculate adjusted risk ratios (aRR) and 95% confidence intervals (CI).ResultsOf 232 children with acute COVID-19, 71 (30.6%) had persistent symptoms and 50 (21.6%) had activity impairments at follow-up; for MIS-C (n = 241), 56 (23.2%) had persistent symptoms and 58 (24.1%) had activity impairments. In adjusted analyses of patients with acute COVID-19, receipt of mechanical ventilation was associated with persistent symptoms [aRR 1.83 (95% CI: 1.07, 3.13)] whereas obesity [aRR 2.18 (95% CI: 1.05, 4.51)] and greater organ system involvement [aRR 1.35 (95% CI: 1.13, 1.61)] were associated with activity impairment. For patients with MIS-C, having a pre-existing respiratory condition was associated with persistent symptoms [aRR 3.04 (95% CI: 1.70, 5.41)] whereas obesity [aRR 1.86 (95% CI: 1.09, 3.15)] and greater organ system involvement [aRR 1.26 (1.00, 1.58)] were associated with activity impairments.DiscussionAmong patients hospitalized, nearly one in three hospitalized with acute COVID-19 and one in four hospitalized with MIS-C had persistent impairments for ≥2 months post-hospitalization. Persistent impairments were associated with more severe illness and underlying health conditions, identifying populations to target for follow-up. post-acute COVID-19 syndrome COVID-19 post-intensive care syndrome critical care outcomes SARS-CoV-2 multisystem inflammatory syndrome in children MIS-C Pediatrics Cameron C. Young verfasserin aut Suden Kucukak verfasserin aut Laura D. Zambrano verfasserin aut Margaret M. Newhams verfasserin aut Caitlin K. Rollins verfasserin aut Natasha B. Halasa verfasserin aut Shira J. Gertz verfasserin aut Elizabeth H. Mack verfasserin aut Stephanie Schwartz verfasserin aut Michele Kong verfasserin aut Laura L. Loftis verfasserin aut Katherine Irby verfasserin aut Courtney M. Rowan verfasserin aut Keiko M. Tarquinio verfasserin aut Matt S. Zinter verfasserin aut Hillary Crandall verfasserin aut Natalie Z. Cvijanovich verfasserin aut Jennifer E. Schuster verfasserin aut Julie C. Fitzgerald verfasserin aut Mary A. Staat verfasserin aut Charlotte V. Hobbs verfasserin aut Ryan A. Nofziger verfasserin aut Steven Shein verfasserin aut Heidi Flori verfasserin aut Melissa L. Cullimore verfasserin aut Brandon M. Chatani verfasserin aut Emily R. Levy verfasserin aut Katri V. Typpo verfasserin aut Janet R. Hume verfasserin aut Angela P. Campbell verfasserin aut Adrienne G. Randolph verfasserin aut the Overcoming COVID-19 Investigators verfasserin aut Michele Kong verfasserin aut Meghan Murdock verfasserin aut Heather Kelley verfasserin aut Candice Colston verfasserin aut Mary Glas Gaspers verfasserin aut Katri V. Typpo verfasserin aut Ronald C. Sanders verfasserin aut Katherine Irby verfasserin aut Natalie Z. Cvijanovich verfasserin aut Matt S. Zinter verfasserin aut Aline B. Maddux verfasserin aut Emily Port verfasserin aut Rachel Mansour verfasserin aut Sara Shankman verfasserin aut Brandon M. Chatani verfasserin aut Keiko M. Tarquinio verfasserin aut Kaitlin Jones verfasserin aut Courtney M. Rowan verfasserin aut Adrienne G. Randolph verfasserin aut Margaret M. Newhams verfasserin aut Cameron C. Young verfasserin aut Suden Kucukak verfasserin aut Caitlin Rollins verfasserin aut Tanya Novak verfasserin aut Janet Chou verfasserin aut Mary Beth Son verfasserin aut Julia Clarke verfasserin aut Brooke Sens verfasserin aut Eve Listerud verfasserin aut Sabrina Chen verfasserin aut Kasey Stewart verfasserin aut Heidi R. Flori verfasserin aut Mary K. Dahmer verfasserin aut Janet R. Hume verfasserin aut Emily R. Levy verfasserin aut Supriya Behl verfasserin aut Noelle M. Drapeau verfasserin aut Charlotte V. Hobbs verfasserin aut Lora Martin verfasserin aut Lacy Malloch verfasserin aut Maygan Martin verfasserin aut Kayla Patterson verfasserin aut Cameron Sanders verfasserin aut Kengo Inagaki verfasserin aut Sarah McGraw verfasserin aut Anita Dhanrajani verfasserin aut Jennifer E. Schuster verfasserin aut Abigail Kietzman verfasserin aut Shannon Hill verfasserin aut Melissa L. Cullimore verfasserin aut Russell J. McCulloh verfasserin aut Shira J. Gertz verfasserin aut Stephanie P. Schwartz verfasserin aut Tracie C. Walker verfasserin aut Ryan A. Nofziger verfasserin aut Mary Allen Staat verfasserin aut Steven Shein verfasserin aut Rajashri Rasal verfasserin aut Julie C. Fitzgerald verfasserin aut Ryan Burnett verfasserin aut Jenny Bush verfasserin aut Elizabeth H. Mack verfasserin aut Natasha B. Halasa verfasserin aut Meena Golcha verfasserin aut Laura Stewart verfasserin aut Laura L. Loftis verfasserin aut Hillary Crandall verfasserin aut Krow Ampofo verfasserin aut Manish M. Patel verfasserin aut Leora R. Feldstein verfasserin aut Mark W. Tenforde verfasserin aut Ashley M. Jackson verfasserin aut Angela Campbell verfasserin aut Laura D. Zambrano verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 11(2023) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:11 year:2023 https://doi.org/10.3389/fped.2023.1260372 kostenfrei https://doaj.org/article/1e2f7cbc16d047dbab50b8aeff084f5e kostenfrei https://www.frontiersin.org/articles/10.3389/fped.2023.1260372/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2023 |
| allfieldsSound |
10.3389/fped.2023.1260372 doi (DE-627)DOAJ092703062 (DE-599)DOAJ1e2f7cbc16d047dbab50b8aeff084f5e DE-627 ger DE-627 rakwb eng RJ1-570 Aline B. Maddux verfasserin aut Risk factors for health impairments in children after hospitalization for acute COVID-19 or MIS-C 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ObjectiveTo identify risk factors for persistent impairments after pediatric hospitalization for acute coronavirus disease 2019 (COVID-19) or multisystem inflammatory syndrome in children (MIS-C) during the SARS-CoV-2 pandemic.MethodsAcross 25 U.S. Overcoming COVID-19 Network hospitals, we conducted a prospective cohort study of patients <21-years-old hospitalized for acute COVID-19 or MIS-C (May 2020 to March 2022) surveyed 2- to 4-months post-admission. Multivariable regression was used to calculate adjusted risk ratios (aRR) and 95% confidence intervals (CI).ResultsOf 232 children with acute COVID-19, 71 (30.6%) had persistent symptoms and 50 (21.6%) had activity impairments at follow-up; for MIS-C (n = 241), 56 (23.2%) had persistent symptoms and 58 (24.1%) had activity impairments. In adjusted analyses of patients with acute COVID-19, receipt of mechanical ventilation was associated with persistent symptoms [aRR 1.83 (95% CI: 1.07, 3.13)] whereas obesity [aRR 2.18 (95% CI: 1.05, 4.51)] and greater organ system involvement [aRR 1.35 (95% CI: 1.13, 1.61)] were associated with activity impairment. For patients with MIS-C, having a pre-existing respiratory condition was associated with persistent symptoms [aRR 3.04 (95% CI: 1.70, 5.41)] whereas obesity [aRR 1.86 (95% CI: 1.09, 3.15)] and greater organ system involvement [aRR 1.26 (1.00, 1.58)] were associated with activity impairments.DiscussionAmong patients hospitalized, nearly one in three hospitalized with acute COVID-19 and one in four hospitalized with MIS-C had persistent impairments for ≥2 months post-hospitalization. Persistent impairments were associated with more severe illness and underlying health conditions, identifying populations to target for follow-up. post-acute COVID-19 syndrome COVID-19 post-intensive care syndrome critical care outcomes SARS-CoV-2 multisystem inflammatory syndrome in children MIS-C Pediatrics Cameron C. Young verfasserin aut Suden Kucukak verfasserin aut Laura D. Zambrano verfasserin aut Margaret M. Newhams verfasserin aut Caitlin K. Rollins verfasserin aut Natasha B. Halasa verfasserin aut Shira J. Gertz verfasserin aut Elizabeth H. Mack verfasserin aut Stephanie Schwartz verfasserin aut Michele Kong verfasserin aut Laura L. Loftis verfasserin aut Katherine Irby verfasserin aut Courtney M. Rowan verfasserin aut Keiko M. Tarquinio verfasserin aut Matt S. Zinter verfasserin aut Hillary Crandall verfasserin aut Natalie Z. Cvijanovich verfasserin aut Jennifer E. Schuster verfasserin aut Julie C. Fitzgerald verfasserin aut Mary A. Staat verfasserin aut Charlotte V. Hobbs verfasserin aut Ryan A. Nofziger verfasserin aut Steven Shein verfasserin aut Heidi Flori verfasserin aut Melissa L. Cullimore verfasserin aut Brandon M. Chatani verfasserin aut Emily R. Levy verfasserin aut Katri V. Typpo verfasserin aut Janet R. Hume verfasserin aut Angela P. Campbell verfasserin aut Adrienne G. Randolph verfasserin aut the Overcoming COVID-19 Investigators verfasserin aut Michele Kong verfasserin aut Meghan Murdock verfasserin aut Heather Kelley verfasserin aut Candice Colston verfasserin aut Mary Glas Gaspers verfasserin aut Katri V. Typpo verfasserin aut Ronald C. Sanders verfasserin aut Katherine Irby verfasserin aut Natalie Z. Cvijanovich verfasserin aut Matt S. Zinter verfasserin aut Aline B. Maddux verfasserin aut Emily Port verfasserin aut Rachel Mansour verfasserin aut Sara Shankman verfasserin aut Brandon M. Chatani verfasserin aut Keiko M. Tarquinio verfasserin aut Kaitlin Jones verfasserin aut Courtney M. Rowan verfasserin aut Adrienne G. Randolph verfasserin aut Margaret M. Newhams verfasserin aut Cameron C. Young verfasserin aut Suden Kucukak verfasserin aut Caitlin Rollins verfasserin aut Tanya Novak verfasserin aut Janet Chou verfasserin aut Mary Beth Son verfasserin aut Julia Clarke verfasserin aut Brooke Sens verfasserin aut Eve Listerud verfasserin aut Sabrina Chen verfasserin aut Kasey Stewart verfasserin aut Heidi R. Flori verfasserin aut Mary K. Dahmer verfasserin aut Janet R. Hume verfasserin aut Emily R. Levy verfasserin aut Supriya Behl verfasserin aut Noelle M. Drapeau verfasserin aut Charlotte V. Hobbs verfasserin aut Lora Martin verfasserin aut Lacy Malloch verfasserin aut Maygan Martin verfasserin aut Kayla Patterson verfasserin aut Cameron Sanders verfasserin aut Kengo Inagaki verfasserin aut Sarah McGraw verfasserin aut Anita Dhanrajani verfasserin aut Jennifer E. Schuster verfasserin aut Abigail Kietzman verfasserin aut Shannon Hill verfasserin aut Melissa L. Cullimore verfasserin aut Russell J. McCulloh verfasserin aut Shira J. Gertz verfasserin aut Stephanie P. Schwartz verfasserin aut Tracie C. Walker verfasserin aut Ryan A. Nofziger verfasserin aut Mary Allen Staat verfasserin aut Steven Shein verfasserin aut Rajashri Rasal verfasserin aut Julie C. Fitzgerald verfasserin aut Ryan Burnett verfasserin aut Jenny Bush verfasserin aut Elizabeth H. Mack verfasserin aut Natasha B. Halasa verfasserin aut Meena Golcha verfasserin aut Laura Stewart verfasserin aut Laura L. Loftis verfasserin aut Hillary Crandall verfasserin aut Krow Ampofo verfasserin aut Manish M. Patel verfasserin aut Leora R. Feldstein verfasserin aut Mark W. Tenforde verfasserin aut Ashley M. Jackson verfasserin aut Angela Campbell verfasserin aut Laura D. Zambrano verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 11(2023) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:11 year:2023 https://doi.org/10.3389/fped.2023.1260372 kostenfrei https://doaj.org/article/1e2f7cbc16d047dbab50b8aeff084f5e kostenfrei https://www.frontiersin.org/articles/10.3389/fped.2023.1260372/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2023 |
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English |
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In Frontiers in Pediatrics 11(2023) volume:11 year:2023 |
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In Frontiers in Pediatrics 11(2023) volume:11 year:2023 |
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findex.gbv.de |
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post-acute COVID-19 syndrome COVID-19 post-intensive care syndrome critical care outcomes SARS-CoV-2 multisystem inflammatory syndrome in children MIS-C Pediatrics |
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Frontiers in Pediatrics |
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Aline B. Maddux @@aut@@ Cameron C. Young @@aut@@ Suden Kucukak @@aut@@ Laura D. Zambrano @@aut@@ Margaret M. Newhams @@aut@@ Caitlin K. Rollins @@aut@@ Natasha B. Halasa @@aut@@ Shira J. Gertz @@aut@@ Elizabeth H. Mack @@aut@@ Stephanie Schwartz @@aut@@ Michele Kong @@aut@@ Laura L. Loftis @@aut@@ Katherine Irby @@aut@@ Courtney M. Rowan @@aut@@ Keiko M. Tarquinio @@aut@@ Matt S. Zinter @@aut@@ Hillary Crandall @@aut@@ Natalie Z. Cvijanovich @@aut@@ Jennifer E. Schuster @@aut@@ Julie C. Fitzgerald @@aut@@ Mary A. Staat @@aut@@ Charlotte V. Hobbs @@aut@@ Ryan A. Nofziger @@aut@@ Steven Shein @@aut@@ Heidi Flori @@aut@@ Melissa L. Cullimore @@aut@@ Brandon M. Chatani @@aut@@ Emily R. Levy @@aut@@ Katri V. Typpo @@aut@@ Janet R. Hume @@aut@@ Angela P. Campbell @@aut@@ Adrienne G. Randolph @@aut@@ the Overcoming COVID-19 Investigators @@aut@@ Meghan Murdock @@aut@@ Heather Kelley @@aut@@ Candice Colston @@aut@@ Mary Glas Gaspers @@aut@@ Ronald C. Sanders @@aut@@ Emily Port @@aut@@ Rachel Mansour @@aut@@ Sara Shankman @@aut@@ Kaitlin Jones @@aut@@ Caitlin Rollins @@aut@@ Tanya Novak @@aut@@ Janet Chou @@aut@@ Mary Beth Son @@aut@@ Julia Clarke @@aut@@ Brooke Sens @@aut@@ Eve Listerud @@aut@@ Sabrina Chen @@aut@@ Kasey Stewart @@aut@@ Heidi R. Flori @@aut@@ Mary K. Dahmer @@aut@@ Supriya Behl @@aut@@ Noelle M. Drapeau @@aut@@ Lora Martin @@aut@@ Lacy Malloch @@aut@@ Maygan Martin @@aut@@ Kayla Patterson @@aut@@ Cameron Sanders @@aut@@ Kengo Inagaki @@aut@@ Sarah McGraw @@aut@@ Anita Dhanrajani @@aut@@ Abigail Kietzman @@aut@@ Shannon Hill @@aut@@ Russell J. McCulloh @@aut@@ Stephanie P. Schwartz @@aut@@ Tracie C. Walker @@aut@@ Mary Allen Staat @@aut@@ Rajashri Rasal @@aut@@ Ryan Burnett @@aut@@ Jenny Bush @@aut@@ Meena Golcha @@aut@@ Laura Stewart @@aut@@ Krow Ampofo @@aut@@ Manish M. Patel @@aut@@ Leora R. Feldstein @@aut@@ Mark W. Tenforde @@aut@@ Ashley M. Jackson @@aut@@ Angela Campbell @@aut@@ |
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2023-01-01T00:00:00Z |
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englisch |
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Maddux</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Risk factors for health impairments in children after hospitalization for acute COVID-19 or MIS-C</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">ObjectiveTo identify risk factors for persistent impairments after pediatric hospitalization for acute coronavirus disease 2019 (COVID-19) or multisystem inflammatory syndrome in children (MIS-C) during the SARS-CoV-2 pandemic.MethodsAcross 25 U.S. Overcoming COVID-19 Network hospitals, we conducted a prospective cohort study of patients &lt;21-years-old hospitalized for acute COVID-19 or MIS-C (May 2020 to March 2022) surveyed 2- to 4-months post-admission. Multivariable regression was used to calculate adjusted risk ratios (aRR) and 95% confidence intervals (CI).ResultsOf 232 children with acute COVID-19, 71 (30.6%) had persistent symptoms and 50 (21.6%) had activity impairments at follow-up; for MIS-C (n = 241), 56 (23.2%) had persistent symptoms and 58 (24.1%) had activity impairments. In adjusted analyses of patients with acute COVID-19, receipt of mechanical ventilation was associated with persistent symptoms [aRR 1.83 (95% CI: 1.07, 3.13)] whereas obesity [aRR 2.18 (95% CI: 1.05, 4.51)] and greater organ system involvement [aRR 1.35 (95% CI: 1.13, 1.61)] were associated with activity impairment. For patients with MIS-C, having a pre-existing respiratory condition was associated with persistent symptoms [aRR 3.04 (95% CI: 1.70, 5.41)] whereas obesity [aRR 1.86 (95% CI: 1.09, 3.15)] and greater organ system involvement [aRR 1.26 (1.00, 1.58)] were associated with activity impairments.DiscussionAmong patients hospitalized, nearly one in three hospitalized with acute COVID-19 and one in four hospitalized with MIS-C had persistent impairments for ≥2 months post-hospitalization. Persistent impairments were associated with more severe illness and underlying health conditions, identifying populations to target for follow-up.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">post-acute COVID-19 syndrome</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">COVID-19 post-intensive care syndrome</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">critical care outcomes</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">SARS-CoV-2</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">multisystem inflammatory syndrome in children</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">MIS-C</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Pediatrics</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Cameron C. 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RJ1-570 Risk factors for health impairments in children after hospitalization for acute COVID-19 or MIS-C post-acute COVID-19 syndrome COVID-19 post-intensive care syndrome critical care outcomes SARS-CoV-2 multisystem inflammatory syndrome in children MIS-C |
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Aline B. Maddux Cameron C. Young Suden Kucukak Laura D. Zambrano Margaret M. Newhams Caitlin K. Rollins Natasha B. Halasa Shira J. Gertz Elizabeth H. Mack Stephanie Schwartz Michele Kong Laura L. Loftis Katherine Irby Courtney M. Rowan Keiko M. Tarquinio Matt S. Zinter Hillary Crandall Natalie Z. Cvijanovich Jennifer E. Schuster Julie C. Fitzgerald Mary A. Staat Charlotte V. Hobbs Ryan A. Nofziger Steven Shein Heidi Flori Melissa L. Cullimore Brandon M. Chatani Emily R. Levy Katri V. Typpo Janet R. Hume Angela P. Campbell Adrienne G. Randolph the Overcoming COVID-19 Investigators Meghan Murdock Heather Kelley Candice Colston Mary Glas Gaspers Ronald C. Sanders Emily Port Rachel Mansour Sara Shankman Kaitlin Jones Caitlin Rollins Tanya Novak Janet Chou Mary Beth Son Julia Clarke Brooke Sens Eve Listerud Sabrina Chen Kasey Stewart Heidi R. Flori Mary K. Dahmer Supriya Behl Noelle M. Drapeau Lora Martin Lacy Malloch Maygan Martin Kayla Patterson Cameron Sanders Kengo Inagaki Sarah McGraw Anita Dhanrajani Abigail Kietzman Shannon Hill Russell J. McCulloh Stephanie P. Schwartz Tracie C. Walker Mary Allen Staat Rajashri Rasal Ryan Burnett Jenny Bush Meena Golcha Laura Stewart Krow Ampofo Manish M. Patel Leora R. Feldstein Mark W. Tenforde Ashley M. Jackson Angela Campbell |
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10.3389/fped.2023.1260372 |
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risk factors for health impairments in children after hospitalization for acute covid-19 or mis-c |
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Risk factors for health impairments in children after hospitalization for acute COVID-19 or MIS-C |
| abstract |
ObjectiveTo identify risk factors for persistent impairments after pediatric hospitalization for acute coronavirus disease 2019 (COVID-19) or multisystem inflammatory syndrome in children (MIS-C) during the SARS-CoV-2 pandemic.MethodsAcross 25 U.S. Overcoming COVID-19 Network hospitals, we conducted a prospective cohort study of patients <21-years-old hospitalized for acute COVID-19 or MIS-C (May 2020 to March 2022) surveyed 2- to 4-months post-admission. Multivariable regression was used to calculate adjusted risk ratios (aRR) and 95% confidence intervals (CI).ResultsOf 232 children with acute COVID-19, 71 (30.6%) had persistent symptoms and 50 (21.6%) had activity impairments at follow-up; for MIS-C (n = 241), 56 (23.2%) had persistent symptoms and 58 (24.1%) had activity impairments. In adjusted analyses of patients with acute COVID-19, receipt of mechanical ventilation was associated with persistent symptoms [aRR 1.83 (95% CI: 1.07, 3.13)] whereas obesity [aRR 2.18 (95% CI: 1.05, 4.51)] and greater organ system involvement [aRR 1.35 (95% CI: 1.13, 1.61)] were associated with activity impairment. For patients with MIS-C, having a pre-existing respiratory condition was associated with persistent symptoms [aRR 3.04 (95% CI: 1.70, 5.41)] whereas obesity [aRR 1.86 (95% CI: 1.09, 3.15)] and greater organ system involvement [aRR 1.26 (1.00, 1.58)] were associated with activity impairments.DiscussionAmong patients hospitalized, nearly one in three hospitalized with acute COVID-19 and one in four hospitalized with MIS-C had persistent impairments for ≥2 months post-hospitalization. Persistent impairments were associated with more severe illness and underlying health conditions, identifying populations to target for follow-up. |
| abstractGer |
ObjectiveTo identify risk factors for persistent impairments after pediatric hospitalization for acute coronavirus disease 2019 (COVID-19) or multisystem inflammatory syndrome in children (MIS-C) during the SARS-CoV-2 pandemic.MethodsAcross 25 U.S. Overcoming COVID-19 Network hospitals, we conducted a prospective cohort study of patients <21-years-old hospitalized for acute COVID-19 or MIS-C (May 2020 to March 2022) surveyed 2- to 4-months post-admission. Multivariable regression was used to calculate adjusted risk ratios (aRR) and 95% confidence intervals (CI).ResultsOf 232 children with acute COVID-19, 71 (30.6%) had persistent symptoms and 50 (21.6%) had activity impairments at follow-up; for MIS-C (n = 241), 56 (23.2%) had persistent symptoms and 58 (24.1%) had activity impairments. In adjusted analyses of patients with acute COVID-19, receipt of mechanical ventilation was associated with persistent symptoms [aRR 1.83 (95% CI: 1.07, 3.13)] whereas obesity [aRR 2.18 (95% CI: 1.05, 4.51)] and greater organ system involvement [aRR 1.35 (95% CI: 1.13, 1.61)] were associated with activity impairment. For patients with MIS-C, having a pre-existing respiratory condition was associated with persistent symptoms [aRR 3.04 (95% CI: 1.70, 5.41)] whereas obesity [aRR 1.86 (95% CI: 1.09, 3.15)] and greater organ system involvement [aRR 1.26 (1.00, 1.58)] were associated with activity impairments.DiscussionAmong patients hospitalized, nearly one in three hospitalized with acute COVID-19 and one in four hospitalized with MIS-C had persistent impairments for ≥2 months post-hospitalization. Persistent impairments were associated with more severe illness and underlying health conditions, identifying populations to target for follow-up. |
| abstract_unstemmed |
ObjectiveTo identify risk factors for persistent impairments after pediatric hospitalization for acute coronavirus disease 2019 (COVID-19) or multisystem inflammatory syndrome in children (MIS-C) during the SARS-CoV-2 pandemic.MethodsAcross 25 U.S. Overcoming COVID-19 Network hospitals, we conducted a prospective cohort study of patients <21-years-old hospitalized for acute COVID-19 or MIS-C (May 2020 to March 2022) surveyed 2- to 4-months post-admission. Multivariable regression was used to calculate adjusted risk ratios (aRR) and 95% confidence intervals (CI).ResultsOf 232 children with acute COVID-19, 71 (30.6%) had persistent symptoms and 50 (21.6%) had activity impairments at follow-up; for MIS-C (n = 241), 56 (23.2%) had persistent symptoms and 58 (24.1%) had activity impairments. In adjusted analyses of patients with acute COVID-19, receipt of mechanical ventilation was associated with persistent symptoms [aRR 1.83 (95% CI: 1.07, 3.13)] whereas obesity [aRR 2.18 (95% CI: 1.05, 4.51)] and greater organ system involvement [aRR 1.35 (95% CI: 1.13, 1.61)] were associated with activity impairment. For patients with MIS-C, having a pre-existing respiratory condition was associated with persistent symptoms [aRR 3.04 (95% CI: 1.70, 5.41)] whereas obesity [aRR 1.86 (95% CI: 1.09, 3.15)] and greater organ system involvement [aRR 1.26 (1.00, 1.58)] were associated with activity impairments.DiscussionAmong patients hospitalized, nearly one in three hospitalized with acute COVID-19 and one in four hospitalized with MIS-C had persistent impairments for ≥2 months post-hospitalization. Persistent impairments were associated with more severe illness and underlying health conditions, identifying populations to target for follow-up. |
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Risk factors for health impairments in children after hospitalization for acute COVID-19 or MIS-C |
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Cameron C. Young Suden Kucukak Laura D. Zambrano Margaret M. Newhams Caitlin K. Rollins Natasha B. Halasa Shira J. Gertz Elizabeth H. Mack Stephanie Schwartz Michele Kong Laura L. Loftis Katherine Irby Courtney M. Rowan Keiko M. Tarquinio Matt S. Zinter Hillary Crandall Natalie Z. Cvijanovich Jennifer E. Schuster Julie C. Fitzgerald Mary A. Staat Charlotte V. Hobbs Ryan A. Nofziger Steven Shein Heidi Flori Melissa L. Cullimore Brandon M. Chatani Emily R. Levy Katri V. Typpo Janet R. Hume Angela P. Campbell Adrienne G. Randolph the Overcoming COVID-19 Investigators Meghan Murdock Heather Kelley Candice Colston Mary Glas Gaspers Ronald C. Sanders Aline B. Maddux Emily Port Rachel Mansour Sara Shankman Kaitlin Jones Caitlin Rollins Tanya Novak Janet Chou Mary Beth Son Julia Clarke Brooke Sens Eve Listerud Sabrina Chen Kasey Stewart Heidi R. Flori Mary K. Dahmer Supriya Behl Noelle M. Drapeau Lora Martin Lacy Malloch Maygan Martin Kayla Patterson Cameron Sanders Kengo Inagaki Sarah McGraw Anita Dhanrajani Abigail Kietzman Shannon Hill Russell J. McCulloh Stephanie P. Schwartz Tracie C. Walker Mary Allen Staat Rajashri Rasal Ryan Burnett Jenny Bush Meena Golcha Laura Stewart Krow Ampofo Manish M. Patel Leora R. Feldstein Mark W. Tenforde Ashley M. Jackson Angela Campbell |
| author2Str |
Cameron C. Young Suden Kucukak Laura D. Zambrano Margaret M. Newhams Caitlin K. Rollins Natasha B. Halasa Shira J. Gertz Elizabeth H. Mack Stephanie Schwartz Michele Kong Laura L. Loftis Katherine Irby Courtney M. Rowan Keiko M. Tarquinio Matt S. Zinter Hillary Crandall Natalie Z. Cvijanovich Jennifer E. Schuster Julie C. Fitzgerald Mary A. Staat Charlotte V. Hobbs Ryan A. Nofziger Steven Shein Heidi Flori Melissa L. Cullimore Brandon M. Chatani Emily R. Levy Katri V. Typpo Janet R. Hume Angela P. Campbell Adrienne G. Randolph the Overcoming COVID-19 Investigators Meghan Murdock Heather Kelley Candice Colston Mary Glas Gaspers Ronald C. Sanders Aline B. Maddux Emily Port Rachel Mansour Sara Shankman Kaitlin Jones Caitlin Rollins Tanya Novak Janet Chou Mary Beth Son Julia Clarke Brooke Sens Eve Listerud Sabrina Chen Kasey Stewart Heidi R. Flori Mary K. Dahmer Supriya Behl Noelle M. Drapeau Lora Martin Lacy Malloch Maygan Martin Kayla Patterson Cameron Sanders Kengo Inagaki Sarah McGraw Anita Dhanrajani Abigail Kietzman Shannon Hill Russell J. McCulloh Stephanie P. Schwartz Tracie C. Walker Mary Allen Staat Rajashri Rasal Ryan Burnett Jenny Bush Meena Golcha Laura Stewart Krow Ampofo Manish M. Patel Leora R. Feldstein Mark W. Tenforde Ashley M. Jackson Angela Campbell |
| ppnlink |
742738744 |
| callnumber-subject |
RJ - Pediatrics |
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c |
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true |
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false |
| doi_str |
10.3389/fped.2023.1260372 |
| callnumber-a |
RJ1-570 |
| up_date |
2024-07-03T13:16:51.057Z |
| _version_ |
1803563943659044864 |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">DOAJ092703062</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240412202241.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">240412s2023 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3389/fped.2023.1260372</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ092703062</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ1e2f7cbc16d047dbab50b8aeff084f5e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RJ1-570</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Aline B. Maddux</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Risk factors for health impairments in children after hospitalization for acute COVID-19 or MIS-C</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">ObjectiveTo identify risk factors for persistent impairments after pediatric hospitalization for acute coronavirus disease 2019 (COVID-19) or multisystem inflammatory syndrome in children (MIS-C) during the SARS-CoV-2 pandemic.MethodsAcross 25 U.S. Overcoming COVID-19 Network hospitals, we conducted a prospective cohort study of patients &lt;21-years-old hospitalized for acute COVID-19 or MIS-C (May 2020 to March 2022) surveyed 2- to 4-months post-admission. Multivariable regression was used to calculate adjusted risk ratios (aRR) and 95% confidence intervals (CI).ResultsOf 232 children with acute COVID-19, 71 (30.6%) had persistent symptoms and 50 (21.6%) had activity impairments at follow-up; for MIS-C (n = 241), 56 (23.2%) had persistent symptoms and 58 (24.1%) had activity impairments. In adjusted analyses of patients with acute COVID-19, receipt of mechanical ventilation was associated with persistent symptoms [aRR 1.83 (95% CI: 1.07, 3.13)] whereas obesity [aRR 2.18 (95% CI: 1.05, 4.51)] and greater organ system involvement [aRR 1.35 (95% CI: 1.13, 1.61)] were associated with activity impairment. For patients with MIS-C, having a pre-existing respiratory condition was associated with persistent symptoms [aRR 3.04 (95% CI: 1.70, 5.41)] whereas obesity [aRR 1.86 (95% CI: 1.09, 3.15)] and greater organ system involvement [aRR 1.26 (1.00, 1.58)] were associated with activity impairments.DiscussionAmong patients hospitalized, nearly one in three hospitalized with acute COVID-19 and one in four hospitalized with MIS-C had persistent impairments for ≥2 months post-hospitalization. Persistent impairments were associated with more severe illness and underlying health conditions, identifying populations to target for follow-up.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">post-acute COVID-19 syndrome</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">COVID-19 post-intensive care syndrome</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">critical care outcomes</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">SARS-CoV-2</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">multisystem inflammatory syndrome in children</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">MIS-C</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Pediatrics</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Cameron C. Young</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Suden Kucukak</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Laura D. Zambrano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Margaret M. Newhams</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Caitlin K. Rollins</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Natasha B. Halasa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shira J. Gertz</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elizabeth H. Mack</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stephanie Schwartz</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Michele Kong</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Laura L. Loftis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Katherine Irby</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Courtney M. Rowan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Keiko M. Tarquinio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Matt S. Zinter</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hillary Crandall</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Natalie Z. Cvijanovich</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jennifer E. Schuster</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Julie C. Fitzgerald</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mary A. 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Cullimore</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Brandon M. Chatani</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Emily R. Levy</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Katri V. Typpo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Janet R. Hume</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Angela P. 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Randolph</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">the Overcoming COVID-19 Investigators</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Michele Kong</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Meghan Murdock</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Heather Kelley</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Candice Colston</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mary Glas Gaspers</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Katri V. 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