Non-coding RNAs: targets for Chinese herbal medicine in treating myocardial fibrosis

Cardiovascular diseases have become the leading cause of death in urban and rural areas. Myocardial fibrosis is a common pathological manifestation at the adaptive and repair stage of cardiovascular diseases, easily predisposing to cardiac death. Non-coding RNAs (ncRNAs), RNA molecules with no codin...
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Gespeichert in:

Autor*in:	Minghui Wang [verfasserIn] Maocai Yan [verfasserIn] Liqiang Tan [verfasserIn] Xiaona Zhao [verfasserIn] Guoqing Liu [verfasserIn] Zejin Zhang [verfasserIn] Jing Zhang [verfasserIn] Honggang Gao [verfasserIn] Wei Qin [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	myocardial fibrosis Chinese herbal medicine ncRNAs miRNAs lncRNAs circRNAs

Übergeordnetes Werk:	In: Frontiers in Pharmacology - Frontiers Media S.A., 2010, 15(2024)
Übergeordnetes Werk:	volume:15 ; year:2024

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fphar.2024.1337623

Katalog-ID:	DOAJ09282286X

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520			\|a Cardiovascular diseases have become the leading cause of death in urban and rural areas. Myocardial fibrosis is a common pathological manifestation at the adaptive and repair stage of cardiovascular diseases, easily predisposing to cardiac death. Non-coding RNAs (ncRNAs), RNA molecules with no coding potential, can regulate gene expression in the occurrence and development of myocardial fibrosis. Recent studies have suggested that Chinese herbal medicine can relieve myocardial fibrosis through targeting various ncRNAs, mainly including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). Thus, ncRNAs are novel drug targets for Chinese herbal medicine. Herein, we summarized the current understanding of ncRNAs in the pathogenesis of myocardial fibrosis, and highlighted the contribution of ncRNAs to the therapeutic effect of Chinese herbal medicine on myocardial fibrosis. Further, we discussed the future directions regarding the potential applications of ncRNA-based drug screening platform to screen drugs for myocardial fibrosis.
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allfieldsSound	10.3389/fphar.2024.1337623 doi (DE-627)DOAJ09282286X (DE-599)DOAJfdeccf97d066488bbf987e41f7b4336b DE-627 ger DE-627 rakwb eng RM1-950 Minghui Wang verfasserin aut Non-coding RNAs: targets for Chinese herbal medicine in treating myocardial fibrosis 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cardiovascular diseases have become the leading cause of death in urban and rural areas. Myocardial fibrosis is a common pathological manifestation at the adaptive and repair stage of cardiovascular diseases, easily predisposing to cardiac death. Non-coding RNAs (ncRNAs), RNA molecules with no coding potential, can regulate gene expression in the occurrence and development of myocardial fibrosis. Recent studies have suggested that Chinese herbal medicine can relieve myocardial fibrosis through targeting various ncRNAs, mainly including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). Thus, ncRNAs are novel drug targets for Chinese herbal medicine. Herein, we summarized the current understanding of ncRNAs in the pathogenesis of myocardial fibrosis, and highlighted the contribution of ncRNAs to the therapeutic effect of Chinese herbal medicine on myocardial fibrosis. Further, we discussed the future directions regarding the potential applications of ncRNA-based drug screening platform to screen drugs for myocardial fibrosis. myocardial fibrosis Chinese herbal medicine ncRNAs miRNAs lncRNAs circRNAs Therapeutics. Pharmacology Minghui Wang verfasserin aut Maocai Yan verfasserin aut Liqiang Tan verfasserin aut Xiaona Zhao verfasserin aut Xiaona Zhao verfasserin aut Guoqing Liu verfasserin aut Guoqing Liu verfasserin aut Zejin Zhang verfasserin aut Zejin Zhang verfasserin aut Jing Zhang verfasserin aut Honggang Gao verfasserin aut Wei Qin verfasserin aut In Frontiers in Pharmacology Frontiers Media S.A., 2010 15(2024) (DE-627)642889392 (DE-600)2587355-6 16639812 nnns volume:15 year:2024 https://doi.org/10.3389/fphar.2024.1337623 kostenfrei https://doaj.org/article/fdeccf97d066488bbf987e41f7b4336b kostenfrei https://www.frontiersin.org/articles/10.3389/fphar.2024.1337623/full kostenfrei https://doaj.org/toc/1663-9812 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2024
language	English
source	In Frontiers in Pharmacology 15(2024) volume:15 year:2024
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format_phy_str_mv	Article
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topic_facet	myocardial fibrosis Chinese herbal medicine ncRNAs miRNAs lncRNAs circRNAs Therapeutics. Pharmacology
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container_title	Frontiers in Pharmacology
authorswithroles_txt_mv	Minghui Wang @@aut@@ Maocai Yan @@aut@@ Liqiang Tan @@aut@@ Xiaona Zhao @@aut@@ Guoqing Liu @@aut@@ Zejin Zhang @@aut@@ Jing Zhang @@aut@@ Honggang Gao @@aut@@ Wei Qin @@aut@@
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callnumber-first	R - Medicine
author	Minghui Wang
spellingShingle	Minghui Wang misc RM1-950 misc myocardial fibrosis misc Chinese herbal medicine misc ncRNAs misc miRNAs misc lncRNAs misc circRNAs misc Therapeutics. Pharmacology Non-coding RNAs: targets for Chinese herbal medicine in treating myocardial fibrosis
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topic_title	RM1-950 Non-coding RNAs: targets for Chinese herbal medicine in treating myocardial fibrosis myocardial fibrosis Chinese herbal medicine ncRNAs miRNAs lncRNAs circRNAs
topic	misc RM1-950 misc myocardial fibrosis misc Chinese herbal medicine misc ncRNAs misc miRNAs misc lncRNAs misc circRNAs misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc myocardial fibrosis misc Chinese herbal medicine misc ncRNAs misc miRNAs misc lncRNAs misc circRNAs misc Therapeutics. Pharmacology
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title	Non-coding RNAs: targets for Chinese herbal medicine in treating myocardial fibrosis
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title_full	Non-coding RNAs: targets for Chinese herbal medicine in treating myocardial fibrosis
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title_sort	non-coding rnas: targets for chinese herbal medicine in treating myocardial fibrosis
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title_auth	Non-coding RNAs: targets for Chinese herbal medicine in treating myocardial fibrosis
abstract	Cardiovascular diseases have become the leading cause of death in urban and rural areas. Myocardial fibrosis is a common pathological manifestation at the adaptive and repair stage of cardiovascular diseases, easily predisposing to cardiac death. Non-coding RNAs (ncRNAs), RNA molecules with no coding potential, can regulate gene expression in the occurrence and development of myocardial fibrosis. Recent studies have suggested that Chinese herbal medicine can relieve myocardial fibrosis through targeting various ncRNAs, mainly including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). Thus, ncRNAs are novel drug targets for Chinese herbal medicine. Herein, we summarized the current understanding of ncRNAs in the pathogenesis of myocardial fibrosis, and highlighted the contribution of ncRNAs to the therapeutic effect of Chinese herbal medicine on myocardial fibrosis. Further, we discussed the future directions regarding the potential applications of ncRNA-based drug screening platform to screen drugs for myocardial fibrosis.
abstractGer	Cardiovascular diseases have become the leading cause of death in urban and rural areas. Myocardial fibrosis is a common pathological manifestation at the adaptive and repair stage of cardiovascular diseases, easily predisposing to cardiac death. Non-coding RNAs (ncRNAs), RNA molecules with no coding potential, can regulate gene expression in the occurrence and development of myocardial fibrosis. Recent studies have suggested that Chinese herbal medicine can relieve myocardial fibrosis through targeting various ncRNAs, mainly including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). Thus, ncRNAs are novel drug targets for Chinese herbal medicine. Herein, we summarized the current understanding of ncRNAs in the pathogenesis of myocardial fibrosis, and highlighted the contribution of ncRNAs to the therapeutic effect of Chinese herbal medicine on myocardial fibrosis. Further, we discussed the future directions regarding the potential applications of ncRNA-based drug screening platform to screen drugs for myocardial fibrosis.
abstract_unstemmed	Cardiovascular diseases have become the leading cause of death in urban and rural areas. Myocardial fibrosis is a common pathological manifestation at the adaptive and repair stage of cardiovascular diseases, easily predisposing to cardiac death. Non-coding RNAs (ncRNAs), RNA molecules with no coding potential, can regulate gene expression in the occurrence and development of myocardial fibrosis. Recent studies have suggested that Chinese herbal medicine can relieve myocardial fibrosis through targeting various ncRNAs, mainly including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). Thus, ncRNAs are novel drug targets for Chinese herbal medicine. Herein, we summarized the current understanding of ncRNAs in the pathogenesis of myocardial fibrosis, and highlighted the contribution of ncRNAs to the therapeutic effect of Chinese herbal medicine on myocardial fibrosis. Further, we discussed the future directions regarding the potential applications of ncRNA-based drug screening platform to screen drugs for myocardial fibrosis.
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title_short	Non-coding RNAs: targets for Chinese herbal medicine in treating myocardial fibrosis
url	https://doi.org/10.3389/fphar.2024.1337623 https://doaj.org/article/fdeccf97d066488bbf987e41f7b4336b https://www.frontiersin.org/articles/10.3389/fphar.2024.1337623/full https://doaj.org/toc/1663-9812
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up_date	2024-07-03T13:46:47.521Z
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