Hofbauer cell function in the term placenta associates with adult cardiovascular and depressive outcomes

Abstract Pathological placental inflammation increases the risk for several adult disorders, but these mediators are also expressed under homeostatic conditions, where their contribution to adult health outcomes is unknown. Here we define an inflammation-related expression signature, primarily expre...
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Autor*in:	Eamon Fitzgerald [verfasserIn] Mojun Shen [verfasserIn] Hannah Ee Juen Yong [verfasserIn] Zihan Wang [verfasserIn] Irina Pokhvisneva [verfasserIn] Sachin Patel [verfasserIn] Nicholas O’Toole [verfasserIn] Shiao-Yng Chan [verfasserIn] Yap Seng Chong [verfasserIn] Helen Chen [verfasserIn] Peter D. Gluckman [verfasserIn] Jerry Chan [verfasserIn] Patrick Kia Ming Lee [verfasserIn] Michael J. Meaney [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 14(2023), 1, Seite 11
Übergeordnetes Werk:	volume:14 ; year:2023 ; number:1 ; pages:11

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-023-42300-8

Katalog-ID:	DOAJ092890326

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allfields	10.1038/s41467-023-42300-8 doi (DE-627)DOAJ092890326 (DE-599)DOAJ562ebed74c8f4dc0a29125be9a4443f5 DE-627 ger DE-627 rakwb eng Eamon Fitzgerald verfasserin aut Hofbauer cell function in the term placenta associates with adult cardiovascular and depressive outcomes 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Pathological placental inflammation increases the risk for several adult disorders, but these mediators are also expressed under homeostatic conditions, where their contribution to adult health outcomes is unknown. Here we define an inflammation-related expression signature, primarily expressed in Hofbauer cells of the term placenta and use expression quantitative trait loci to create a polygenic score (PGS) predictive of its expression. Using this PGS in the UK Biobank we conduct a phenome-wide association study, followed by Mendelian randomization and identify protective, sex-dependent effects of the placental module on cardiovascular and depressive outcomes. Genes differentially regulated by intra-amniotic infection and preterm birth are over-represented within the module. We also identify aspirin as a putative modulator of this inflammation-related signature. Our data support a model where disruption of placental Hofbauer cell function, due to preterm birth or prenatal infection, contributes to the increased risk of depression and cardiovascular disease observed in these individuals. Science Q Mojun Shen verfasserin aut Hannah Ee Juen Yong verfasserin aut Zihan Wang verfasserin aut Irina Pokhvisneva verfasserin aut Sachin Patel verfasserin aut Nicholas O’Toole verfasserin aut Shiao-Yng Chan verfasserin aut Yap Seng Chong verfasserin aut Helen Chen verfasserin aut Peter D. Gluckman verfasserin aut Jerry Chan verfasserin aut Patrick Kia Ming Lee verfasserin aut Michael J. Meaney verfasserin aut In Nature Communications Nature Portfolio, 2016 14(2023), 1, Seite 11 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:14 year:2023 number:1 pages:11 https://doi.org/10.1038/s41467-023-42300-8 kostenfrei https://doaj.org/article/562ebed74c8f4dc0a29125be9a4443f5 kostenfrei https://doi.org/10.1038/s41467-023-42300-8 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1 11
spelling	10.1038/s41467-023-42300-8 doi (DE-627)DOAJ092890326 (DE-599)DOAJ562ebed74c8f4dc0a29125be9a4443f5 DE-627 ger DE-627 rakwb eng Eamon Fitzgerald verfasserin aut Hofbauer cell function in the term placenta associates with adult cardiovascular and depressive outcomes 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Pathological placental inflammation increases the risk for several adult disorders, but these mediators are also expressed under homeostatic conditions, where their contribution to adult health outcomes is unknown. Here we define an inflammation-related expression signature, primarily expressed in Hofbauer cells of the term placenta and use expression quantitative trait loci to create a polygenic score (PGS) predictive of its expression. Using this PGS in the UK Biobank we conduct a phenome-wide association study, followed by Mendelian randomization and identify protective, sex-dependent effects of the placental module on cardiovascular and depressive outcomes. Genes differentially regulated by intra-amniotic infection and preterm birth are over-represented within the module. We also identify aspirin as a putative modulator of this inflammation-related signature. Our data support a model where disruption of placental Hofbauer cell function, due to preterm birth or prenatal infection, contributes to the increased risk of depression and cardiovascular disease observed in these individuals. Science Q Mojun Shen verfasserin aut Hannah Ee Juen Yong verfasserin aut Zihan Wang verfasserin aut Irina Pokhvisneva verfasserin aut Sachin Patel verfasserin aut Nicholas O’Toole verfasserin aut Shiao-Yng Chan verfasserin aut Yap Seng Chong verfasserin aut Helen Chen verfasserin aut Peter D. Gluckman verfasserin aut Jerry Chan verfasserin aut Patrick Kia Ming Lee verfasserin aut Michael J. Meaney verfasserin aut In Nature Communications Nature Portfolio, 2016 14(2023), 1, Seite 11 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:14 year:2023 number:1 pages:11 https://doi.org/10.1038/s41467-023-42300-8 kostenfrei https://doaj.org/article/562ebed74c8f4dc0a29125be9a4443f5 kostenfrei https://doi.org/10.1038/s41467-023-42300-8 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1 11
allfields_unstemmed	10.1038/s41467-023-42300-8 doi (DE-627)DOAJ092890326 (DE-599)DOAJ562ebed74c8f4dc0a29125be9a4443f5 DE-627 ger DE-627 rakwb eng Eamon Fitzgerald verfasserin aut Hofbauer cell function in the term placenta associates with adult cardiovascular and depressive outcomes 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Pathological placental inflammation increases the risk for several adult disorders, but these mediators are also expressed under homeostatic conditions, where their contribution to adult health outcomes is unknown. Here we define an inflammation-related expression signature, primarily expressed in Hofbauer cells of the term placenta and use expression quantitative trait loci to create a polygenic score (PGS) predictive of its expression. Using this PGS in the UK Biobank we conduct a phenome-wide association study, followed by Mendelian randomization and identify protective, sex-dependent effects of the placental module on cardiovascular and depressive outcomes. Genes differentially regulated by intra-amniotic infection and preterm birth are over-represented within the module. We also identify aspirin as a putative modulator of this inflammation-related signature. Our data support a model where disruption of placental Hofbauer cell function, due to preterm birth or prenatal infection, contributes to the increased risk of depression and cardiovascular disease observed in these individuals. Science Q Mojun Shen verfasserin aut Hannah Ee Juen Yong verfasserin aut Zihan Wang verfasserin aut Irina Pokhvisneva verfasserin aut Sachin Patel verfasserin aut Nicholas O’Toole verfasserin aut Shiao-Yng Chan verfasserin aut Yap Seng Chong verfasserin aut Helen Chen verfasserin aut Peter D. Gluckman verfasserin aut Jerry Chan verfasserin aut Patrick Kia Ming Lee verfasserin aut Michael J. Meaney verfasserin aut In Nature Communications Nature Portfolio, 2016 14(2023), 1, Seite 11 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:14 year:2023 number:1 pages:11 https://doi.org/10.1038/s41467-023-42300-8 kostenfrei https://doaj.org/article/562ebed74c8f4dc0a29125be9a4443f5 kostenfrei https://doi.org/10.1038/s41467-023-42300-8 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1 11
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allfieldsSound	10.1038/s41467-023-42300-8 doi (DE-627)DOAJ092890326 (DE-599)DOAJ562ebed74c8f4dc0a29125be9a4443f5 DE-627 ger DE-627 rakwb eng Eamon Fitzgerald verfasserin aut Hofbauer cell function in the term placenta associates with adult cardiovascular and depressive outcomes 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Pathological placental inflammation increases the risk for several adult disorders, but these mediators are also expressed under homeostatic conditions, where their contribution to adult health outcomes is unknown. Here we define an inflammation-related expression signature, primarily expressed in Hofbauer cells of the term placenta and use expression quantitative trait loci to create a polygenic score (PGS) predictive of its expression. Using this PGS in the UK Biobank we conduct a phenome-wide association study, followed by Mendelian randomization and identify protective, sex-dependent effects of the placental module on cardiovascular and depressive outcomes. Genes differentially regulated by intra-amniotic infection and preterm birth are over-represented within the module. We also identify aspirin as a putative modulator of this inflammation-related signature. Our data support a model where disruption of placental Hofbauer cell function, due to preterm birth or prenatal infection, contributes to the increased risk of depression and cardiovascular disease observed in these individuals. Science Q Mojun Shen verfasserin aut Hannah Ee Juen Yong verfasserin aut Zihan Wang verfasserin aut Irina Pokhvisneva verfasserin aut Sachin Patel verfasserin aut Nicholas O’Toole verfasserin aut Shiao-Yng Chan verfasserin aut Yap Seng Chong verfasserin aut Helen Chen verfasserin aut Peter D. Gluckman verfasserin aut Jerry Chan verfasserin aut Patrick Kia Ming Lee verfasserin aut Michael J. Meaney verfasserin aut In Nature Communications Nature Portfolio, 2016 14(2023), 1, Seite 11 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:14 year:2023 number:1 pages:11 https://doi.org/10.1038/s41467-023-42300-8 kostenfrei https://doaj.org/article/562ebed74c8f4dc0a29125be9a4443f5 kostenfrei https://doi.org/10.1038/s41467-023-42300-8 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1 11
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author	Eamon Fitzgerald
spellingShingle	Eamon Fitzgerald misc Science misc Q Hofbauer cell function in the term placenta associates with adult cardiovascular and depressive outcomes
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topic_title	Hofbauer cell function in the term placenta associates with adult cardiovascular and depressive outcomes
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title	Hofbauer cell function in the term placenta associates with adult cardiovascular and depressive outcomes
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title_full	Hofbauer cell function in the term placenta associates with adult cardiovascular and depressive outcomes
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author_browse	Eamon Fitzgerald Mojun Shen Hannah Ee Juen Yong Zihan Wang Irina Pokhvisneva Sachin Patel Nicholas O’Toole Shiao-Yng Chan Yap Seng Chong Helen Chen Peter D. Gluckman Jerry Chan Patrick Kia Ming Lee Michael J. Meaney
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title_sort	hofbauer cell function in the term placenta associates with adult cardiovascular and depressive outcomes
title_auth	Hofbauer cell function in the term placenta associates with adult cardiovascular and depressive outcomes
abstract	Abstract Pathological placental inflammation increases the risk for several adult disorders, but these mediators are also expressed under homeostatic conditions, where their contribution to adult health outcomes is unknown. Here we define an inflammation-related expression signature, primarily expressed in Hofbauer cells of the term placenta and use expression quantitative trait loci to create a polygenic score (PGS) predictive of its expression. Using this PGS in the UK Biobank we conduct a phenome-wide association study, followed by Mendelian randomization and identify protective, sex-dependent effects of the placental module on cardiovascular and depressive outcomes. Genes differentially regulated by intra-amniotic infection and preterm birth are over-represented within the module. We also identify aspirin as a putative modulator of this inflammation-related signature. Our data support a model where disruption of placental Hofbauer cell function, due to preterm birth or prenatal infection, contributes to the increased risk of depression and cardiovascular disease observed in these individuals.
abstractGer	Abstract Pathological placental inflammation increases the risk for several adult disorders, but these mediators are also expressed under homeostatic conditions, where their contribution to adult health outcomes is unknown. Here we define an inflammation-related expression signature, primarily expressed in Hofbauer cells of the term placenta and use expression quantitative trait loci to create a polygenic score (PGS) predictive of its expression. Using this PGS in the UK Biobank we conduct a phenome-wide association study, followed by Mendelian randomization and identify protective, sex-dependent effects of the placental module on cardiovascular and depressive outcomes. Genes differentially regulated by intra-amniotic infection and preterm birth are over-represented within the module. We also identify aspirin as a putative modulator of this inflammation-related signature. Our data support a model where disruption of placental Hofbauer cell function, due to preterm birth or prenatal infection, contributes to the increased risk of depression and cardiovascular disease observed in these individuals.
abstract_unstemmed	Abstract Pathological placental inflammation increases the risk for several adult disorders, but these mediators are also expressed under homeostatic conditions, where their contribution to adult health outcomes is unknown. Here we define an inflammation-related expression signature, primarily expressed in Hofbauer cells of the term placenta and use expression quantitative trait loci to create a polygenic score (PGS) predictive of its expression. Using this PGS in the UK Biobank we conduct a phenome-wide association study, followed by Mendelian randomization and identify protective, sex-dependent effects of the placental module on cardiovascular and depressive outcomes. Genes differentially regulated by intra-amniotic infection and preterm birth are over-represented within the module. We also identify aspirin as a putative modulator of this inflammation-related signature. Our data support a model where disruption of placental Hofbauer cell function, due to preterm birth or prenatal infection, contributes to the increased risk of depression and cardiovascular disease observed in these individuals.
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title_short	Hofbauer cell function in the term placenta associates with adult cardiovascular and depressive outcomes
url	https://doi.org/10.1038/s41467-023-42300-8 https://doaj.org/article/562ebed74c8f4dc0a29125be9a4443f5 https://doaj.org/toc/2041-1723
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author2	Mojun Shen Hannah Ee Juen Yong Zihan Wang Irina Pokhvisneva Sachin Patel Nicholas O’Toole Shiao-Yng Chan Yap Seng Chong Helen Chen Peter D. Gluckman Jerry Chan Patrick Kia Ming Lee Michael J. Meaney
author2Str	Mojun Shen Hannah Ee Juen Yong Zihan Wang Irina Pokhvisneva Sachin Patel Nicholas O’Toole Shiao-Yng Chan Yap Seng Chong Helen Chen Peter D. Gluckman Jerry Chan Patrick Kia Ming Lee Michael J. Meaney
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Hofbauer cell function in the term placenta associates with adult cardiovascular and depressive outcomes

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