High Prevalence of Capsular Type I and Resistance to Multiple Antibiotics Among Streptococcus agalactiae Isolated from Pregnant Women

Background and purpose: Emergence of multidrug resistance (MDR) among Streptococcus agalactiae isolated from pregnant women and the presence of polysaccharide capsules in these strains play a significant role in pathogenicity. Therefore, the aim of this study was to investigate the prevalence of ant...
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Autor*in:	Mona Zakerifar [verfasserIn] Hamid Reza Goli [verfasserIn] Hami Kaboosi [verfasserIn] Zahra Rahmani [verfasserIn] Fatemeh Peyravii Ghadikolaii [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch ; Persisch

Erschienen:	2023

Schlagwörter:	streptococcus agalactiae multidrug resistance capsular type pregnant women

Übergeordnetes Werk:	In: Journal of Mazandaran University of Medical Sciences - Mazandaran University of Medical Sciences, 2018, 33(2023), 226, Seite 74-87
Übergeordnetes Werk:	volume:33 ; year:2023 ; number:226 ; pages:74-87

Links:	Link aufrufen Link aufrufen Journal toc Journal toc

Katalog-ID:	DOAJ092937160

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520			\|a Background and purpose: Emergence of multidrug resistance (MDR) among Streptococcus agalactiae isolated from pregnant women and the presence of polysaccharide capsules in these strains play a significant role in pathogenicity. Therefore, the aim of this study was to investigate the prevalence of antibiotic resistance, multidrug resistance, and Ia and Ib capsular types in these strains. Materials and methods: Vaginal samples were transferred to Todd-Hewitt Broth medium. After 24 hours, they were inoculated on the blood agar medium, and then the bacteria were identified using standard methods. The antibiotic resistance pattern of the isolates was determined by the disk agar diffusion method. Then, the bacterial DNA was extracted and the capsular genes were identified using PCR method. Results: The prevalence of colonization in pregnant women was 23.25%. Tetracycline with 94.33% resistance rate was the least effective drug, while 78.3%, 81.13% and 83.01% of the isolates were non-susceptible to ofloxacin, erythromycin and quinupristin-dalfopristin, respectively. Also, 78.3% of the isolates were sensitive to penicillin. Meanwhile, 94 (88.7%) isolates were MDR, while 20 (18.86%) isolates and 32 (30.18%) isolates had the Ia and Ib capsular types, respectively. Conclusion: Penicillin is a suitable drug for prophylaxis in high-risk pregnant women in this region. The high prevalence of MDR strains indicates the lack of proper management of antibiotics. In addition, the high prevalence of capsular types Ib and Ia, especially in MDR strains, shows the importance of these serotypes for designing capsular vaccines.
650		4	\|a streptococcus agalactiae
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700	0		\|a Fatemeh Peyravii Ghadikolaii \|e verfasserin \|4 aut
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912			\|a GBV_ILN_2055
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912			\|a GBV_ILN_4037
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allfields	(DE-627)DOAJ092937160 (DE-599)DOAJ93e70cefea6f48bc92fed2f136e7d977 DE-627 ger DE-627 rakwb eng per R5-920 Mona Zakerifar verfasserin aut High Prevalence of Capsular Type I and Resistance to Multiple Antibiotics Among Streptococcus agalactiae Isolated from Pregnant Women 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and purpose: Emergence of multidrug resistance (MDR) among Streptococcus agalactiae isolated from pregnant women and the presence of polysaccharide capsules in these strains play a significant role in pathogenicity. Therefore, the aim of this study was to investigate the prevalence of antibiotic resistance, multidrug resistance, and Ia and Ib capsular types in these strains. Materials and methods: Vaginal samples were transferred to Todd-Hewitt Broth medium. After 24 hours, they were inoculated on the blood agar medium, and then the bacteria were identified using standard methods. The antibiotic resistance pattern of the isolates was determined by the disk agar diffusion method. Then, the bacterial DNA was extracted and the capsular genes were identified using PCR method. Results: The prevalence of colonization in pregnant women was 23.25%. Tetracycline with 94.33% resistance rate was the least effective drug, while 78.3%, 81.13% and 83.01% of the isolates were non-susceptible to ofloxacin, erythromycin and quinupristin-dalfopristin, respectively. Also, 78.3% of the isolates were sensitive to penicillin. Meanwhile, 94 (88.7%) isolates were MDR, while 20 (18.86%) isolates and 32 (30.18%) isolates had the Ia and Ib capsular types, respectively. Conclusion: Penicillin is a suitable drug for prophylaxis in high-risk pregnant women in this region. The high prevalence of MDR strains indicates the lack of proper management of antibiotics. In addition, the high prevalence of capsular types Ib and Ia, especially in MDR strains, shows the importance of these serotypes for designing capsular vaccines. streptococcus agalactiae multidrug resistance capsular type pregnant women Medicine R Medicine (General) Hamid Reza Goli verfasserin aut Hami Kaboosi verfasserin aut Zahra Rahmani verfasserin aut Fatemeh Peyravii Ghadikolaii verfasserin aut In Journal of Mazandaran University of Medical Sciences Mazandaran University of Medical Sciences, 2018 33(2023), 226, Seite 74-87 (DE-627)59095623X (DE-600)2476989-7 17359279 nnns volume:33 year:2023 number:226 pages:74-87 https://doaj.org/article/93e70cefea6f48bc92fed2f136e7d977 kostenfrei http://jmums.mazums.ac.ir/article-1-19665-en.pdf kostenfrei https://doaj.org/toc/1735-9260 Journal toc kostenfrei https://doaj.org/toc/1735-9279 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 33 2023 226 74-87
spelling	(DE-627)DOAJ092937160 (DE-599)DOAJ93e70cefea6f48bc92fed2f136e7d977 DE-627 ger DE-627 rakwb eng per R5-920 Mona Zakerifar verfasserin aut High Prevalence of Capsular Type I and Resistance to Multiple Antibiotics Among Streptococcus agalactiae Isolated from Pregnant Women 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and purpose: Emergence of multidrug resistance (MDR) among Streptococcus agalactiae isolated from pregnant women and the presence of polysaccharide capsules in these strains play a significant role in pathogenicity. Therefore, the aim of this study was to investigate the prevalence of antibiotic resistance, multidrug resistance, and Ia and Ib capsular types in these strains. Materials and methods: Vaginal samples were transferred to Todd-Hewitt Broth medium. After 24 hours, they were inoculated on the blood agar medium, and then the bacteria were identified using standard methods. The antibiotic resistance pattern of the isolates was determined by the disk agar diffusion method. Then, the bacterial DNA was extracted and the capsular genes were identified using PCR method. Results: The prevalence of colonization in pregnant women was 23.25%. Tetracycline with 94.33% resistance rate was the least effective drug, while 78.3%, 81.13% and 83.01% of the isolates were non-susceptible to ofloxacin, erythromycin and quinupristin-dalfopristin, respectively. Also, 78.3% of the isolates were sensitive to penicillin. Meanwhile, 94 (88.7%) isolates were MDR, while 20 (18.86%) isolates and 32 (30.18%) isolates had the Ia and Ib capsular types, respectively. Conclusion: Penicillin is a suitable drug for prophylaxis in high-risk pregnant women in this region. The high prevalence of MDR strains indicates the lack of proper management of antibiotics. In addition, the high prevalence of capsular types Ib and Ia, especially in MDR strains, shows the importance of these serotypes for designing capsular vaccines. streptococcus agalactiae multidrug resistance capsular type pregnant women Medicine R Medicine (General) Hamid Reza Goli verfasserin aut Hami Kaboosi verfasserin aut Zahra Rahmani verfasserin aut Fatemeh Peyravii Ghadikolaii verfasserin aut In Journal of Mazandaran University of Medical Sciences Mazandaran University of Medical Sciences, 2018 33(2023), 226, Seite 74-87 (DE-627)59095623X (DE-600)2476989-7 17359279 nnns volume:33 year:2023 number:226 pages:74-87 https://doaj.org/article/93e70cefea6f48bc92fed2f136e7d977 kostenfrei http://jmums.mazums.ac.ir/article-1-19665-en.pdf kostenfrei https://doaj.org/toc/1735-9260 Journal toc kostenfrei https://doaj.org/toc/1735-9279 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 33 2023 226 74-87
allfields_unstemmed	(DE-627)DOAJ092937160 (DE-599)DOAJ93e70cefea6f48bc92fed2f136e7d977 DE-627 ger DE-627 rakwb eng per R5-920 Mona Zakerifar verfasserin aut High Prevalence of Capsular Type I and Resistance to Multiple Antibiotics Among Streptococcus agalactiae Isolated from Pregnant Women 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and purpose: Emergence of multidrug resistance (MDR) among Streptococcus agalactiae isolated from pregnant women and the presence of polysaccharide capsules in these strains play a significant role in pathogenicity. Therefore, the aim of this study was to investigate the prevalence of antibiotic resistance, multidrug resistance, and Ia and Ib capsular types in these strains. Materials and methods: Vaginal samples were transferred to Todd-Hewitt Broth medium. After 24 hours, they were inoculated on the blood agar medium, and then the bacteria were identified using standard methods. The antibiotic resistance pattern of the isolates was determined by the disk agar diffusion method. Then, the bacterial DNA was extracted and the capsular genes were identified using PCR method. Results: The prevalence of colonization in pregnant women was 23.25%. Tetracycline with 94.33% resistance rate was the least effective drug, while 78.3%, 81.13% and 83.01% of the isolates were non-susceptible to ofloxacin, erythromycin and quinupristin-dalfopristin, respectively. Also, 78.3% of the isolates were sensitive to penicillin. Meanwhile, 94 (88.7%) isolates were MDR, while 20 (18.86%) isolates and 32 (30.18%) isolates had the Ia and Ib capsular types, respectively. Conclusion: Penicillin is a suitable drug for prophylaxis in high-risk pregnant women in this region. The high prevalence of MDR strains indicates the lack of proper management of antibiotics. In addition, the high prevalence of capsular types Ib and Ia, especially in MDR strains, shows the importance of these serotypes for designing capsular vaccines. streptococcus agalactiae multidrug resistance capsular type pregnant women Medicine R Medicine (General) Hamid Reza Goli verfasserin aut Hami Kaboosi verfasserin aut Zahra Rahmani verfasserin aut Fatemeh Peyravii Ghadikolaii verfasserin aut In Journal of Mazandaran University of Medical Sciences Mazandaran University of Medical Sciences, 2018 33(2023), 226, Seite 74-87 (DE-627)59095623X (DE-600)2476989-7 17359279 nnns volume:33 year:2023 number:226 pages:74-87 https://doaj.org/article/93e70cefea6f48bc92fed2f136e7d977 kostenfrei http://jmums.mazums.ac.ir/article-1-19665-en.pdf kostenfrei https://doaj.org/toc/1735-9260 Journal toc kostenfrei https://doaj.org/toc/1735-9279 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 33 2023 226 74-87
allfieldsGer	(DE-627)DOAJ092937160 (DE-599)DOAJ93e70cefea6f48bc92fed2f136e7d977 DE-627 ger DE-627 rakwb eng per R5-920 Mona Zakerifar verfasserin aut High Prevalence of Capsular Type I and Resistance to Multiple Antibiotics Among Streptococcus agalactiae Isolated from Pregnant Women 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and purpose: Emergence of multidrug resistance (MDR) among Streptococcus agalactiae isolated from pregnant women and the presence of polysaccharide capsules in these strains play a significant role in pathogenicity. Therefore, the aim of this study was to investigate the prevalence of antibiotic resistance, multidrug resistance, and Ia and Ib capsular types in these strains. Materials and methods: Vaginal samples were transferred to Todd-Hewitt Broth medium. After 24 hours, they were inoculated on the blood agar medium, and then the bacteria were identified using standard methods. The antibiotic resistance pattern of the isolates was determined by the disk agar diffusion method. Then, the bacterial DNA was extracted and the capsular genes were identified using PCR method. Results: The prevalence of colonization in pregnant women was 23.25%. Tetracycline with 94.33% resistance rate was the least effective drug, while 78.3%, 81.13% and 83.01% of the isolates were non-susceptible to ofloxacin, erythromycin and quinupristin-dalfopristin, respectively. Also, 78.3% of the isolates were sensitive to penicillin. Meanwhile, 94 (88.7%) isolates were MDR, while 20 (18.86%) isolates and 32 (30.18%) isolates had the Ia and Ib capsular types, respectively. Conclusion: Penicillin is a suitable drug for prophylaxis in high-risk pregnant women in this region. The high prevalence of MDR strains indicates the lack of proper management of antibiotics. In addition, the high prevalence of capsular types Ib and Ia, especially in MDR strains, shows the importance of these serotypes for designing capsular vaccines. streptococcus agalactiae multidrug resistance capsular type pregnant women Medicine R Medicine (General) Hamid Reza Goli verfasserin aut Hami Kaboosi verfasserin aut Zahra Rahmani verfasserin aut Fatemeh Peyravii Ghadikolaii verfasserin aut In Journal of Mazandaran University of Medical Sciences Mazandaran University of Medical Sciences, 2018 33(2023), 226, Seite 74-87 (DE-627)59095623X (DE-600)2476989-7 17359279 nnns volume:33 year:2023 number:226 pages:74-87 https://doaj.org/article/93e70cefea6f48bc92fed2f136e7d977 kostenfrei http://jmums.mazums.ac.ir/article-1-19665-en.pdf kostenfrei https://doaj.org/toc/1735-9260 Journal toc kostenfrei https://doaj.org/toc/1735-9279 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 33 2023 226 74-87
allfieldsSound	(DE-627)DOAJ092937160 (DE-599)DOAJ93e70cefea6f48bc92fed2f136e7d977 DE-627 ger DE-627 rakwb eng per R5-920 Mona Zakerifar verfasserin aut High Prevalence of Capsular Type I and Resistance to Multiple Antibiotics Among Streptococcus agalactiae Isolated from Pregnant Women 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and purpose: Emergence of multidrug resistance (MDR) among Streptococcus agalactiae isolated from pregnant women and the presence of polysaccharide capsules in these strains play a significant role in pathogenicity. Therefore, the aim of this study was to investigate the prevalence of antibiotic resistance, multidrug resistance, and Ia and Ib capsular types in these strains. Materials and methods: Vaginal samples were transferred to Todd-Hewitt Broth medium. After 24 hours, they were inoculated on the blood agar medium, and then the bacteria were identified using standard methods. The antibiotic resistance pattern of the isolates was determined by the disk agar diffusion method. Then, the bacterial DNA was extracted and the capsular genes were identified using PCR method. Results: The prevalence of colonization in pregnant women was 23.25%. Tetracycline with 94.33% resistance rate was the least effective drug, while 78.3%, 81.13% and 83.01% of the isolates were non-susceptible to ofloxacin, erythromycin and quinupristin-dalfopristin, respectively. Also, 78.3% of the isolates were sensitive to penicillin. Meanwhile, 94 (88.7%) isolates were MDR, while 20 (18.86%) isolates and 32 (30.18%) isolates had the Ia and Ib capsular types, respectively. Conclusion: Penicillin is a suitable drug for prophylaxis in high-risk pregnant women in this region. The high prevalence of MDR strains indicates the lack of proper management of antibiotics. In addition, the high prevalence of capsular types Ib and Ia, especially in MDR strains, shows the importance of these serotypes for designing capsular vaccines. streptococcus agalactiae multidrug resistance capsular type pregnant women Medicine R Medicine (General) Hamid Reza Goli verfasserin aut Hami Kaboosi verfasserin aut Zahra Rahmani verfasserin aut Fatemeh Peyravii Ghadikolaii verfasserin aut In Journal of Mazandaran University of Medical Sciences Mazandaran University of Medical Sciences, 2018 33(2023), 226, Seite 74-87 (DE-627)59095623X (DE-600)2476989-7 17359279 nnns volume:33 year:2023 number:226 pages:74-87 https://doaj.org/article/93e70cefea6f48bc92fed2f136e7d977 kostenfrei http://jmums.mazums.ac.ir/article-1-19665-en.pdf kostenfrei https://doaj.org/toc/1735-9260 Journal toc kostenfrei https://doaj.org/toc/1735-9279 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 33 2023 226 74-87
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callnumber-first	R - Medicine
author	Mona Zakerifar
spellingShingle	Mona Zakerifar misc R5-920 misc streptococcus agalactiae misc multidrug resistance misc capsular type misc pregnant women misc Medicine misc R misc Medicine (General) High Prevalence of Capsular Type I and Resistance to Multiple Antibiotics Among Streptococcus agalactiae Isolated from Pregnant Women
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topic_title	R5-920 High Prevalence of Capsular Type I and Resistance to Multiple Antibiotics Among Streptococcus agalactiae Isolated from Pregnant Women streptococcus agalactiae multidrug resistance capsular type pregnant women
topic	misc R5-920 misc streptococcus agalactiae misc multidrug resistance misc capsular type misc pregnant women misc Medicine misc R misc Medicine (General)
topic_unstemmed	misc R5-920 misc streptococcus agalactiae misc multidrug resistance misc capsular type misc pregnant women misc Medicine misc R misc Medicine (General)
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title	High Prevalence of Capsular Type I and Resistance to Multiple Antibiotics Among Streptococcus agalactiae Isolated from Pregnant Women
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title_full	High Prevalence of Capsular Type I and Resistance to Multiple Antibiotics Among Streptococcus agalactiae Isolated from Pregnant Women
author_sort	Mona Zakerifar
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author_browse	Mona Zakerifar Hamid Reza Goli Hami Kaboosi Zahra Rahmani Fatemeh Peyravii Ghadikolaii
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title_sort	high prevalence of capsular type i and resistance to multiple antibiotics among streptococcus agalactiae isolated from pregnant women
callnumber	R5-920
title_auth	High Prevalence of Capsular Type I and Resistance to Multiple Antibiotics Among Streptococcus agalactiae Isolated from Pregnant Women
abstract	Background and purpose: Emergence of multidrug resistance (MDR) among Streptococcus agalactiae isolated from pregnant women and the presence of polysaccharide capsules in these strains play a significant role in pathogenicity. Therefore, the aim of this study was to investigate the prevalence of antibiotic resistance, multidrug resistance, and Ia and Ib capsular types in these strains. Materials and methods: Vaginal samples were transferred to Todd-Hewitt Broth medium. After 24 hours, they were inoculated on the blood agar medium, and then the bacteria were identified using standard methods. The antibiotic resistance pattern of the isolates was determined by the disk agar diffusion method. Then, the bacterial DNA was extracted and the capsular genes were identified using PCR method. Results: The prevalence of colonization in pregnant women was 23.25%. Tetracycline with 94.33% resistance rate was the least effective drug, while 78.3%, 81.13% and 83.01% of the isolates were non-susceptible to ofloxacin, erythromycin and quinupristin-dalfopristin, respectively. Also, 78.3% of the isolates were sensitive to penicillin. Meanwhile, 94 (88.7%) isolates were MDR, while 20 (18.86%) isolates and 32 (30.18%) isolates had the Ia and Ib capsular types, respectively. Conclusion: Penicillin is a suitable drug for prophylaxis in high-risk pregnant women in this region. The high prevalence of MDR strains indicates the lack of proper management of antibiotics. In addition, the high prevalence of capsular types Ib and Ia, especially in MDR strains, shows the importance of these serotypes for designing capsular vaccines.
abstractGer	Background and purpose: Emergence of multidrug resistance (MDR) among Streptococcus agalactiae isolated from pregnant women and the presence of polysaccharide capsules in these strains play a significant role in pathogenicity. Therefore, the aim of this study was to investigate the prevalence of antibiotic resistance, multidrug resistance, and Ia and Ib capsular types in these strains. Materials and methods: Vaginal samples were transferred to Todd-Hewitt Broth medium. After 24 hours, they were inoculated on the blood agar medium, and then the bacteria were identified using standard methods. The antibiotic resistance pattern of the isolates was determined by the disk agar diffusion method. Then, the bacterial DNA was extracted and the capsular genes were identified using PCR method. Results: The prevalence of colonization in pregnant women was 23.25%. Tetracycline with 94.33% resistance rate was the least effective drug, while 78.3%, 81.13% and 83.01% of the isolates were non-susceptible to ofloxacin, erythromycin and quinupristin-dalfopristin, respectively. Also, 78.3% of the isolates were sensitive to penicillin. Meanwhile, 94 (88.7%) isolates were MDR, while 20 (18.86%) isolates and 32 (30.18%) isolates had the Ia and Ib capsular types, respectively. Conclusion: Penicillin is a suitable drug for prophylaxis in high-risk pregnant women in this region. The high prevalence of MDR strains indicates the lack of proper management of antibiotics. In addition, the high prevalence of capsular types Ib and Ia, especially in MDR strains, shows the importance of these serotypes for designing capsular vaccines.
abstract_unstemmed	Background and purpose: Emergence of multidrug resistance (MDR) among Streptococcus agalactiae isolated from pregnant women and the presence of polysaccharide capsules in these strains play a significant role in pathogenicity. Therefore, the aim of this study was to investigate the prevalence of antibiotic resistance, multidrug resistance, and Ia and Ib capsular types in these strains. Materials and methods: Vaginal samples were transferred to Todd-Hewitt Broth medium. After 24 hours, they were inoculated on the blood agar medium, and then the bacteria were identified using standard methods. The antibiotic resistance pattern of the isolates was determined by the disk agar diffusion method. Then, the bacterial DNA was extracted and the capsular genes were identified using PCR method. Results: The prevalence of colonization in pregnant women was 23.25%. Tetracycline with 94.33% resistance rate was the least effective drug, while 78.3%, 81.13% and 83.01% of the isolates were non-susceptible to ofloxacin, erythromycin and quinupristin-dalfopristin, respectively. Also, 78.3% of the isolates were sensitive to penicillin. Meanwhile, 94 (88.7%) isolates were MDR, while 20 (18.86%) isolates and 32 (30.18%) isolates had the Ia and Ib capsular types, respectively. Conclusion: Penicillin is a suitable drug for prophylaxis in high-risk pregnant women in this region. The high prevalence of MDR strains indicates the lack of proper management of antibiotics. In addition, the high prevalence of capsular types Ib and Ia, especially in MDR strains, shows the importance of these serotypes for designing capsular vaccines.
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title_short	High Prevalence of Capsular Type I and Resistance to Multiple Antibiotics Among Streptococcus agalactiae Isolated from Pregnant Women
url	https://doaj.org/article/93e70cefea6f48bc92fed2f136e7d977 http://jmums.mazums.ac.ir/article-1-19665-en.pdf https://doaj.org/toc/1735-9260 https://doaj.org/toc/1735-9279
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Meanwhile, 94 (88.7%) isolates were MDR, while 20 (18.86%) isolates and 32 (30.18%) isolates had the Ia and Ib capsular types, respectively. Conclusion: Penicillin is a suitable drug for prophylaxis in high-risk pregnant women in this region. The high prevalence of MDR strains indicates the lack of proper management of antibiotics. 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High Prevalence of Capsular Type I and Resistance to Multiple Antibiotics Among Streptococcus agalactiae Isolated from Pregnant Women

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