Extracellular Signal-Regulated Kinases Play Essential but Contrasting Roles in Osteoclast Differentiation

Bone homeostasis is regulated by the balanced actions of osteoblasts that form the bone and osteoclasts (OCs) that resorb the bone. Bone-resorbing OCs are differentiated from hematopoietic monocyte/macrophage lineage cells, whereas osteoblasts are derived from mesenchymal progenitors. OC differentia...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Chaekyun Kim [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	bone osteoclast macrophage colony-stimulating factor (M-CSF) receptor activator of nuclear factor kappa-B ligand (RANKL) mitogen-activated protein kinases (MAPKs) extracellular signal-regulated kinases (ERKs)

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 24(2023), 15342, p 15342
Übergeordnetes Werk:	volume:24 ; year:2023 ; number:15342, p 15342

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms242015342

Katalog-ID:	DOAJ093131518

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allfields	10.3390/ijms242015342 doi (DE-627)DOAJ093131518 (DE-599)DOAJb6753d0bf94145ba899268c9d0d961bd DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Chaekyun Kim verfasserin aut Extracellular Signal-Regulated Kinases Play Essential but Contrasting Roles in Osteoclast Differentiation 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bone homeostasis is regulated by the balanced actions of osteoblasts that form the bone and osteoclasts (OCs) that resorb the bone. Bone-resorbing OCs are differentiated from hematopoietic monocyte/macrophage lineage cells, whereas osteoblasts are derived from mesenchymal progenitors. OC differentiation is induced by two key cytokines, macrophage colony-stimulating factor (M-CSF), a factor essential for the proliferation and survival of the OCs, and receptor activator of nuclear factor kappa-B ligand (RANKL), a factor for responsible for the differentiation of the OCs. Mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinases (ERKs), p38, and c-Jun N-terminal kinases, play an essential role in regulating the proliferation, differentiation, and function of OCs. ERKs have been known to play a critical role in the differentiation and activation of OCs. In most cases, ERKs positively regulate OC differentiation and function. However, several reports present conflicting conclusions. Interestingly, the inhibition of OC differentiation by ERK1/2 is observed only in OCs differentiated from RAW 264.7 cells. Therefore, in this review, we summarize the current understanding of the conflicting actions of ERK1/2 in OC differentiation. bone osteoclast macrophage colony-stimulating factor (M-CSF) receptor activator of nuclear factor kappa-B ligand (RANKL) mitogen-activated protein kinases (MAPKs) extracellular signal-regulated kinases (ERKs) Biology (General) Chemistry In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 15342, p 15342 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:15342, p 15342 https://doi.org/10.3390/ijms242015342 kostenfrei https://doaj.org/article/b6753d0bf94145ba899268c9d0d961bd kostenfrei https://www.mdpi.com/1422-0067/24/20/15342 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 15342, p 15342
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allfieldsSound	10.3390/ijms242015342 doi (DE-627)DOAJ093131518 (DE-599)DOAJb6753d0bf94145ba899268c9d0d961bd DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Chaekyun Kim verfasserin aut Extracellular Signal-Regulated Kinases Play Essential but Contrasting Roles in Osteoclast Differentiation 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bone homeostasis is regulated by the balanced actions of osteoblasts that form the bone and osteoclasts (OCs) that resorb the bone. Bone-resorbing OCs are differentiated from hematopoietic monocyte/macrophage lineage cells, whereas osteoblasts are derived from mesenchymal progenitors. OC differentiation is induced by two key cytokines, macrophage colony-stimulating factor (M-CSF), a factor essential for the proliferation and survival of the OCs, and receptor activator of nuclear factor kappa-B ligand (RANKL), a factor for responsible for the differentiation of the OCs. Mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinases (ERKs), p38, and c-Jun N-terminal kinases, play an essential role in regulating the proliferation, differentiation, and function of OCs. ERKs have been known to play a critical role in the differentiation and activation of OCs. In most cases, ERKs positively regulate OC differentiation and function. However, several reports present conflicting conclusions. Interestingly, the inhibition of OC differentiation by ERK1/2 is observed only in OCs differentiated from RAW 264.7 cells. Therefore, in this review, we summarize the current understanding of the conflicting actions of ERK1/2 in OC differentiation. bone osteoclast macrophage colony-stimulating factor (M-CSF) receptor activator of nuclear factor kappa-B ligand (RANKL) mitogen-activated protein kinases (MAPKs) extracellular signal-regulated kinases (ERKs) Biology (General) Chemistry In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 15342, p 15342 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:15342, p 15342 https://doi.org/10.3390/ijms242015342 kostenfrei https://doaj.org/article/b6753d0bf94145ba899268c9d0d961bd kostenfrei https://www.mdpi.com/1422-0067/24/20/15342 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 15342, p 15342
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callnumber-first	Q - Science
author	Chaekyun Kim
spellingShingle	Chaekyun Kim misc QH301-705.5 misc QD1-999 misc bone misc osteoclast misc macrophage colony-stimulating factor (M-CSF) misc receptor activator of nuclear factor kappa-B ligand (RANKL) misc mitogen-activated protein kinases (MAPKs) misc extracellular signal-regulated kinases (ERKs) misc Biology (General) misc Chemistry Extracellular Signal-Regulated Kinases Play Essential but Contrasting Roles in Osteoclast Differentiation
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topic_title	QH301-705.5 QD1-999 Extracellular Signal-Regulated Kinases Play Essential but Contrasting Roles in Osteoclast Differentiation bone osteoclast macrophage colony-stimulating factor (M-CSF) receptor activator of nuclear factor kappa-B ligand (RANKL) mitogen-activated protein kinases (MAPKs) extracellular signal-regulated kinases (ERKs)
topic	misc QH301-705.5 misc QD1-999 misc bone misc osteoclast misc macrophage colony-stimulating factor (M-CSF) misc receptor activator of nuclear factor kappa-B ligand (RANKL) misc mitogen-activated protein kinases (MAPKs) misc extracellular signal-regulated kinases (ERKs) misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc bone misc osteoclast misc macrophage colony-stimulating factor (M-CSF) misc receptor activator of nuclear factor kappa-B ligand (RANKL) misc mitogen-activated protein kinases (MAPKs) misc extracellular signal-regulated kinases (ERKs) misc Biology (General) misc Chemistry
topic_browse	misc QH301-705.5 misc QD1-999 misc bone misc osteoclast misc macrophage colony-stimulating factor (M-CSF) misc receptor activator of nuclear factor kappa-B ligand (RANKL) misc mitogen-activated protein kinases (MAPKs) misc extracellular signal-regulated kinases (ERKs) misc Biology (General) misc Chemistry
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title	Extracellular Signal-Regulated Kinases Play Essential but Contrasting Roles in Osteoclast Differentiation
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title_full	Extracellular Signal-Regulated Kinases Play Essential but Contrasting Roles in Osteoclast Differentiation
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title_sort	extracellular signal-regulated kinases play essential but contrasting roles in osteoclast differentiation
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title_auth	Extracellular Signal-Regulated Kinases Play Essential but Contrasting Roles in Osteoclast Differentiation
abstract	Bone homeostasis is regulated by the balanced actions of osteoblasts that form the bone and osteoclasts (OCs) that resorb the bone. Bone-resorbing OCs are differentiated from hematopoietic monocyte/macrophage lineage cells, whereas osteoblasts are derived from mesenchymal progenitors. OC differentiation is induced by two key cytokines, macrophage colony-stimulating factor (M-CSF), a factor essential for the proliferation and survival of the OCs, and receptor activator of nuclear factor kappa-B ligand (RANKL), a factor for responsible for the differentiation of the OCs. Mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinases (ERKs), p38, and c-Jun N-terminal kinases, play an essential role in regulating the proliferation, differentiation, and function of OCs. ERKs have been known to play a critical role in the differentiation and activation of OCs. In most cases, ERKs positively regulate OC differentiation and function. However, several reports present conflicting conclusions. Interestingly, the inhibition of OC differentiation by ERK1/2 is observed only in OCs differentiated from RAW 264.7 cells. Therefore, in this review, we summarize the current understanding of the conflicting actions of ERK1/2 in OC differentiation.
abstractGer	Bone homeostasis is regulated by the balanced actions of osteoblasts that form the bone and osteoclasts (OCs) that resorb the bone. Bone-resorbing OCs are differentiated from hematopoietic monocyte/macrophage lineage cells, whereas osteoblasts are derived from mesenchymal progenitors. OC differentiation is induced by two key cytokines, macrophage colony-stimulating factor (M-CSF), a factor essential for the proliferation and survival of the OCs, and receptor activator of nuclear factor kappa-B ligand (RANKL), a factor for responsible for the differentiation of the OCs. Mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinases (ERKs), p38, and c-Jun N-terminal kinases, play an essential role in regulating the proliferation, differentiation, and function of OCs. ERKs have been known to play a critical role in the differentiation and activation of OCs. In most cases, ERKs positively regulate OC differentiation and function. However, several reports present conflicting conclusions. Interestingly, the inhibition of OC differentiation by ERK1/2 is observed only in OCs differentiated from RAW 264.7 cells. Therefore, in this review, we summarize the current understanding of the conflicting actions of ERK1/2 in OC differentiation.
abstract_unstemmed	Bone homeostasis is regulated by the balanced actions of osteoblasts that form the bone and osteoclasts (OCs) that resorb the bone. Bone-resorbing OCs are differentiated from hematopoietic monocyte/macrophage lineage cells, whereas osteoblasts are derived from mesenchymal progenitors. OC differentiation is induced by two key cytokines, macrophage colony-stimulating factor (M-CSF), a factor essential for the proliferation and survival of the OCs, and receptor activator of nuclear factor kappa-B ligand (RANKL), a factor for responsible for the differentiation of the OCs. Mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinases (ERKs), p38, and c-Jun N-terminal kinases, play an essential role in regulating the proliferation, differentiation, and function of OCs. ERKs have been known to play a critical role in the differentiation and activation of OCs. In most cases, ERKs positively regulate OC differentiation and function. However, several reports present conflicting conclusions. Interestingly, the inhibition of OC differentiation by ERK1/2 is observed only in OCs differentiated from RAW 264.7 cells. Therefore, in this review, we summarize the current understanding of the conflicting actions of ERK1/2 in OC differentiation.
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title_short	Extracellular Signal-Regulated Kinases Play Essential but Contrasting Roles in Osteoclast Differentiation
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Extracellular Signal-Regulated Kinases Play Essential but Contrasting Roles in Osteoclast Differentiation

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