Protein Plasma Levels of the IGF Signalling System Are Altered in Major Depressive Disorder

The Insulin-like growth factor 2 (IGF-2) has been recently proven to alleviate depressive-like behaviors in both rats and mice models. However, its potential role as a peripheral biomarker has not been evaluated in depression. To do this, we measured plasma IGF-2 and other members of the IGF family...
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Autor*in:	Carlos Fernández-Pereira [verfasserIn] Maria Aránzazu Penedo [verfasserIn] Tania Rivera-Baltanás [verfasserIn] Tania Pérez-Márquez [verfasserIn] Marta Alves-Villar [verfasserIn] Rafael Fernández-Martínez [verfasserIn] César Veiga [verfasserIn] Ángel Salgado-Barreira [verfasserIn] José María Prieto-González [verfasserIn] Saida Ortolano [verfasserIn] José Manuel Olivares [verfasserIn] Roberto Carlos Agís-Balboa [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Insulin-like growth factor 2 (IGF-2) Insulin-like growth factor binding protein 1 (IGFBP-1) Insulin-like growth factor binding protein 3 (IGFBP-3) Insulin-like growth factor binding protein 5 (IGFBP-5) Insulin-like growth factor binding protein 7 (IGFBP-7) depression

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 24(2023), 15254, p 15254
Übergeordnetes Werk:	volume:24 ; year:2023 ; number:15254, p 15254

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms242015254

Katalog-ID:	DOAJ093132433

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allfields	10.3390/ijms242015254 doi (DE-627)DOAJ093132433 (DE-599)DOAJdfc1d3a1f98a4937baf3bdaa86785197 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Carlos Fernández-Pereira verfasserin aut Protein Plasma Levels of the IGF Signalling System Are Altered in Major Depressive Disorder 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Insulin-like growth factor 2 (IGF-2) has been recently proven to alleviate depressive-like behaviors in both rats and mice models. However, its potential role as a peripheral biomarker has not been evaluated in depression. To do this, we measured plasma IGF-2 and other members of the IGF family such as Binding Proteins (IGFBP-1, IGFBP-3, IGFBP-5 and IGFBP-7) in a depressed group of patients (n = 51) and in a healthy control group (n = 48). In some of these patients (n = 15), we measured these proteins after a period (19 ± 6 days) of treatment with antidepressants. The Hamilton Depressive Rating Scale (HDRS) and the Self-Assessment Anhedonia Scale (SAAS) were used to measure depression severity and anhedonia, respectively. The general cognition state was assessed by the Mini-Mental State Examination (MMSE) test and memory with the Free and Cued Selective Reminding Test (FCSRT). The levels of both IGF-2 and IGFBP-7 were found to be significantly increased in the depressed group; however, only IGF-2 remained significantly elevated after correction by age and sex. On the other hand, the levels of IGF-2, IGFBP-3 and IGFBP-5 were significantly decreased after treatment, whereas only IGFBP-7 was significantly increased. Therefore, peripheral changes in the IGF family and their response to antidepressants might represent alterations at the brain level in depression. Insulin-like growth factor 2 (IGF-2) Insulin-like growth factor binding protein 1 (IGFBP-1) Insulin-like growth factor binding protein 3 (IGFBP-3) Insulin-like growth factor binding protein 5 (IGFBP-5) Insulin-like growth factor binding protein 7 (IGFBP-7) depression Biology (General) Chemistry Maria Aránzazu Penedo verfasserin aut Tania Rivera-Baltanás verfasserin aut Tania Pérez-Márquez verfasserin aut Marta Alves-Villar verfasserin aut Rafael Fernández-Martínez verfasserin aut César Veiga verfasserin aut Ángel Salgado-Barreira verfasserin aut José María Prieto-González verfasserin aut Saida Ortolano verfasserin aut José Manuel Olivares verfasserin aut Roberto Carlos Agís-Balboa verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 15254, p 15254 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:15254, p 15254 https://doi.org/10.3390/ijms242015254 kostenfrei https://doaj.org/article/dfc1d3a1f98a4937baf3bdaa86785197 kostenfrei https://www.mdpi.com/1422-0067/24/20/15254 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 15254, p 15254
spelling	10.3390/ijms242015254 doi (DE-627)DOAJ093132433 (DE-599)DOAJdfc1d3a1f98a4937baf3bdaa86785197 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Carlos Fernández-Pereira verfasserin aut Protein Plasma Levels of the IGF Signalling System Are Altered in Major Depressive Disorder 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Insulin-like growth factor 2 (IGF-2) has been recently proven to alleviate depressive-like behaviors in both rats and mice models. However, its potential role as a peripheral biomarker has not been evaluated in depression. To do this, we measured plasma IGF-2 and other members of the IGF family such as Binding Proteins (IGFBP-1, IGFBP-3, IGFBP-5 and IGFBP-7) in a depressed group of patients (n = 51) and in a healthy control group (n = 48). In some of these patients (n = 15), we measured these proteins after a period (19 ± 6 days) of treatment with antidepressants. The Hamilton Depressive Rating Scale (HDRS) and the Self-Assessment Anhedonia Scale (SAAS) were used to measure depression severity and anhedonia, respectively. The general cognition state was assessed by the Mini-Mental State Examination (MMSE) test and memory with the Free and Cued Selective Reminding Test (FCSRT). The levels of both IGF-2 and IGFBP-7 were found to be significantly increased in the depressed group; however, only IGF-2 remained significantly elevated after correction by age and sex. On the other hand, the levels of IGF-2, IGFBP-3 and IGFBP-5 were significantly decreased after treatment, whereas only IGFBP-7 was significantly increased. Therefore, peripheral changes in the IGF family and their response to antidepressants might represent alterations at the brain level in depression. Insulin-like growth factor 2 (IGF-2) Insulin-like growth factor binding protein 1 (IGFBP-1) Insulin-like growth factor binding protein 3 (IGFBP-3) Insulin-like growth factor binding protein 5 (IGFBP-5) Insulin-like growth factor binding protein 7 (IGFBP-7) depression Biology (General) Chemistry Maria Aránzazu Penedo verfasserin aut Tania Rivera-Baltanás verfasserin aut Tania Pérez-Márquez verfasserin aut Marta Alves-Villar verfasserin aut Rafael Fernández-Martínez verfasserin aut César Veiga verfasserin aut Ángel Salgado-Barreira verfasserin aut José María Prieto-González verfasserin aut Saida Ortolano verfasserin aut José Manuel Olivares verfasserin aut Roberto Carlos Agís-Balboa verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 15254, p 15254 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:15254, p 15254 https://doi.org/10.3390/ijms242015254 kostenfrei https://doaj.org/article/dfc1d3a1f98a4937baf3bdaa86785197 kostenfrei https://www.mdpi.com/1422-0067/24/20/15254 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 15254, p 15254
allfields_unstemmed	10.3390/ijms242015254 doi (DE-627)DOAJ093132433 (DE-599)DOAJdfc1d3a1f98a4937baf3bdaa86785197 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Carlos Fernández-Pereira verfasserin aut Protein Plasma Levels of the IGF Signalling System Are Altered in Major Depressive Disorder 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Insulin-like growth factor 2 (IGF-2) has been recently proven to alleviate depressive-like behaviors in both rats and mice models. However, its potential role as a peripheral biomarker has not been evaluated in depression. To do this, we measured plasma IGF-2 and other members of the IGF family such as Binding Proteins (IGFBP-1, IGFBP-3, IGFBP-5 and IGFBP-7) in a depressed group of patients (n = 51) and in a healthy control group (n = 48). In some of these patients (n = 15), we measured these proteins after a period (19 ± 6 days) of treatment with antidepressants. The Hamilton Depressive Rating Scale (HDRS) and the Self-Assessment Anhedonia Scale (SAAS) were used to measure depression severity and anhedonia, respectively. The general cognition state was assessed by the Mini-Mental State Examination (MMSE) test and memory with the Free and Cued Selective Reminding Test (FCSRT). The levels of both IGF-2 and IGFBP-7 were found to be significantly increased in the depressed group; however, only IGF-2 remained significantly elevated after correction by age and sex. On the other hand, the levels of IGF-2, IGFBP-3 and IGFBP-5 were significantly decreased after treatment, whereas only IGFBP-7 was significantly increased. Therefore, peripheral changes in the IGF family and their response to antidepressants might represent alterations at the brain level in depression. Insulin-like growth factor 2 (IGF-2) Insulin-like growth factor binding protein 1 (IGFBP-1) Insulin-like growth factor binding protein 3 (IGFBP-3) Insulin-like growth factor binding protein 5 (IGFBP-5) Insulin-like growth factor binding protein 7 (IGFBP-7) depression Biology (General) Chemistry Maria Aránzazu Penedo verfasserin aut Tania Rivera-Baltanás verfasserin aut Tania Pérez-Márquez verfasserin aut Marta Alves-Villar verfasserin aut Rafael Fernández-Martínez verfasserin aut César Veiga verfasserin aut Ángel Salgado-Barreira verfasserin aut José María Prieto-González verfasserin aut Saida Ortolano verfasserin aut José Manuel Olivares verfasserin aut Roberto Carlos Agís-Balboa verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 15254, p 15254 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:15254, p 15254 https://doi.org/10.3390/ijms242015254 kostenfrei https://doaj.org/article/dfc1d3a1f98a4937baf3bdaa86785197 kostenfrei https://www.mdpi.com/1422-0067/24/20/15254 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 15254, p 15254
allfieldsGer	10.3390/ijms242015254 doi (DE-627)DOAJ093132433 (DE-599)DOAJdfc1d3a1f98a4937baf3bdaa86785197 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Carlos Fernández-Pereira verfasserin aut Protein Plasma Levels of the IGF Signalling System Are Altered in Major Depressive Disorder 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Insulin-like growth factor 2 (IGF-2) has been recently proven to alleviate depressive-like behaviors in both rats and mice models. However, its potential role as a peripheral biomarker has not been evaluated in depression. To do this, we measured plasma IGF-2 and other members of the IGF family such as Binding Proteins (IGFBP-1, IGFBP-3, IGFBP-5 and IGFBP-7) in a depressed group of patients (n = 51) and in a healthy control group (n = 48). In some of these patients (n = 15), we measured these proteins after a period (19 ± 6 days) of treatment with antidepressants. The Hamilton Depressive Rating Scale (HDRS) and the Self-Assessment Anhedonia Scale (SAAS) were used to measure depression severity and anhedonia, respectively. The general cognition state was assessed by the Mini-Mental State Examination (MMSE) test and memory with the Free and Cued Selective Reminding Test (FCSRT). The levels of both IGF-2 and IGFBP-7 were found to be significantly increased in the depressed group; however, only IGF-2 remained significantly elevated after correction by age and sex. On the other hand, the levels of IGF-2, IGFBP-3 and IGFBP-5 were significantly decreased after treatment, whereas only IGFBP-7 was significantly increased. Therefore, peripheral changes in the IGF family and their response to antidepressants might represent alterations at the brain level in depression. Insulin-like growth factor 2 (IGF-2) Insulin-like growth factor binding protein 1 (IGFBP-1) Insulin-like growth factor binding protein 3 (IGFBP-3) Insulin-like growth factor binding protein 5 (IGFBP-5) Insulin-like growth factor binding protein 7 (IGFBP-7) depression Biology (General) Chemistry Maria Aránzazu Penedo verfasserin aut Tania Rivera-Baltanás verfasserin aut Tania Pérez-Márquez verfasserin aut Marta Alves-Villar verfasserin aut Rafael Fernández-Martínez verfasserin aut César Veiga verfasserin aut Ángel Salgado-Barreira verfasserin aut José María Prieto-González verfasserin aut Saida Ortolano verfasserin aut José Manuel Olivares verfasserin aut Roberto Carlos Agís-Balboa verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 15254, p 15254 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:15254, p 15254 https://doi.org/10.3390/ijms242015254 kostenfrei https://doaj.org/article/dfc1d3a1f98a4937baf3bdaa86785197 kostenfrei https://www.mdpi.com/1422-0067/24/20/15254 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 15254, p 15254
allfieldsSound	10.3390/ijms242015254 doi (DE-627)DOAJ093132433 (DE-599)DOAJdfc1d3a1f98a4937baf3bdaa86785197 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Carlos Fernández-Pereira verfasserin aut Protein Plasma Levels of the IGF Signalling System Are Altered in Major Depressive Disorder 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Insulin-like growth factor 2 (IGF-2) has been recently proven to alleviate depressive-like behaviors in both rats and mice models. However, its potential role as a peripheral biomarker has not been evaluated in depression. To do this, we measured plasma IGF-2 and other members of the IGF family such as Binding Proteins (IGFBP-1, IGFBP-3, IGFBP-5 and IGFBP-7) in a depressed group of patients (n = 51) and in a healthy control group (n = 48). In some of these patients (n = 15), we measured these proteins after a period (19 ± 6 days) of treatment with antidepressants. The Hamilton Depressive Rating Scale (HDRS) and the Self-Assessment Anhedonia Scale (SAAS) were used to measure depression severity and anhedonia, respectively. The general cognition state was assessed by the Mini-Mental State Examination (MMSE) test and memory with the Free and Cued Selective Reminding Test (FCSRT). The levels of both IGF-2 and IGFBP-7 were found to be significantly increased in the depressed group; however, only IGF-2 remained significantly elevated after correction by age and sex. On the other hand, the levels of IGF-2, IGFBP-3 and IGFBP-5 were significantly decreased after treatment, whereas only IGFBP-7 was significantly increased. Therefore, peripheral changes in the IGF family and their response to antidepressants might represent alterations at the brain level in depression. Insulin-like growth factor 2 (IGF-2) Insulin-like growth factor binding protein 1 (IGFBP-1) Insulin-like growth factor binding protein 3 (IGFBP-3) Insulin-like growth factor binding protein 5 (IGFBP-5) Insulin-like growth factor binding protein 7 (IGFBP-7) depression Biology (General) Chemistry Maria Aránzazu Penedo verfasserin aut Tania Rivera-Baltanás verfasserin aut Tania Pérez-Márquez verfasserin aut Marta Alves-Villar verfasserin aut Rafael Fernández-Martínez verfasserin aut César Veiga verfasserin aut Ángel Salgado-Barreira verfasserin aut José María Prieto-González verfasserin aut Saida Ortolano verfasserin aut José Manuel Olivares verfasserin aut Roberto Carlos Agís-Balboa verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 15254, p 15254 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:15254, p 15254 https://doi.org/10.3390/ijms242015254 kostenfrei https://doaj.org/article/dfc1d3a1f98a4937baf3bdaa86785197 kostenfrei https://www.mdpi.com/1422-0067/24/20/15254 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 15254, p 15254
language	English
source	In International Journal of Molecular Sciences 24(2023), 15254, p 15254 volume:24 year:2023 number:15254, p 15254
sourceStr	In International Journal of Molecular Sciences 24(2023), 15254, p 15254 volume:24 year:2023 number:15254, p 15254
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Insulin-like growth factor 2 (IGF-2) Insulin-like growth factor binding protein 1 (IGFBP-1) Insulin-like growth factor binding protein 3 (IGFBP-3) Insulin-like growth factor binding protein 5 (IGFBP-5) Insulin-like growth factor binding protein 7 (IGFBP-7) depression Biology (General) Chemistry
isfreeaccess_bool	true
container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Carlos Fernández-Pereira @@aut@@ Maria Aránzazu Penedo @@aut@@ Tania Rivera-Baltanás @@aut@@ Tania Pérez-Márquez @@aut@@ Marta Alves-Villar @@aut@@ Rafael Fernández-Martínez @@aut@@ César Veiga @@aut@@ Ángel Salgado-Barreira @@aut@@ José María Prieto-González @@aut@@ Saida Ortolano @@aut@@ José Manuel Olivares @@aut@@ Roberto Carlos Agís-Balboa @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	316340715
id	DOAJ093132433
language_de	englisch
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callnumber-first	Q - Science
author	Carlos Fernández-Pereira
spellingShingle	Carlos Fernández-Pereira misc QH301-705.5 misc QD1-999 misc Insulin-like growth factor 2 (IGF-2) misc Insulin-like growth factor binding protein 1 (IGFBP-1) misc Insulin-like growth factor binding protein 3 (IGFBP-3) misc Insulin-like growth factor binding protein 5 (IGFBP-5) misc Insulin-like growth factor binding protein 7 (IGFBP-7) misc depression misc Biology (General) misc Chemistry Protein Plasma Levels of the IGF Signalling System Are Altered in Major Depressive Disorder
authorStr	Carlos Fernández-Pereira
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topic_title	QH301-705.5 QD1-999 Protein Plasma Levels of the IGF Signalling System Are Altered in Major Depressive Disorder Insulin-like growth factor 2 (IGF-2) Insulin-like growth factor binding protein 1 (IGFBP-1) Insulin-like growth factor binding protein 3 (IGFBP-3) Insulin-like growth factor binding protein 5 (IGFBP-5) Insulin-like growth factor binding protein 7 (IGFBP-7) depression
topic	misc QH301-705.5 misc QD1-999 misc Insulin-like growth factor 2 (IGF-2) misc Insulin-like growth factor binding protein 1 (IGFBP-1) misc Insulin-like growth factor binding protein 3 (IGFBP-3) misc Insulin-like growth factor binding protein 5 (IGFBP-5) misc Insulin-like growth factor binding protein 7 (IGFBP-7) misc depression misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc Insulin-like growth factor 2 (IGF-2) misc Insulin-like growth factor binding protein 1 (IGFBP-1) misc Insulin-like growth factor binding protein 3 (IGFBP-3) misc Insulin-like growth factor binding protein 5 (IGFBP-5) misc Insulin-like growth factor binding protein 7 (IGFBP-7) misc depression misc Biology (General) misc Chemistry
topic_browse	misc QH301-705.5 misc QD1-999 misc Insulin-like growth factor 2 (IGF-2) misc Insulin-like growth factor binding protein 1 (IGFBP-1) misc Insulin-like growth factor binding protein 3 (IGFBP-3) misc Insulin-like growth factor binding protein 5 (IGFBP-5) misc Insulin-like growth factor binding protein 7 (IGFBP-7) misc depression misc Biology (General) misc Chemistry
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title	Protein Plasma Levels of the IGF Signalling System Are Altered in Major Depressive Disorder
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title_full	Protein Plasma Levels of the IGF Signalling System Are Altered in Major Depressive Disorder
author_sort	Carlos Fernández-Pereira
journal	International Journal of Molecular Sciences
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author_browse	Carlos Fernández-Pereira Maria Aránzazu Penedo Tania Rivera-Baltanás Tania Pérez-Márquez Marta Alves-Villar Rafael Fernández-Martínez César Veiga Ángel Salgado-Barreira José María Prieto-González Saida Ortolano José Manuel Olivares Roberto Carlos Agís-Balboa
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author-letter	Carlos Fernández-Pereira
doi_str_mv	10.3390/ijms242015254
author2-role	verfasserin
title_sort	protein plasma levels of the igf signalling system are altered in major depressive disorder
callnumber	QH301-705.5
title_auth	Protein Plasma Levels of the IGF Signalling System Are Altered in Major Depressive Disorder
abstract	The Insulin-like growth factor 2 (IGF-2) has been recently proven to alleviate depressive-like behaviors in both rats and mice models. However, its potential role as a peripheral biomarker has not been evaluated in depression. To do this, we measured plasma IGF-2 and other members of the IGF family such as Binding Proteins (IGFBP-1, IGFBP-3, IGFBP-5 and IGFBP-7) in a depressed group of patients (n = 51) and in a healthy control group (n = 48). In some of these patients (n = 15), we measured these proteins after a period (19 ± 6 days) of treatment with antidepressants. The Hamilton Depressive Rating Scale (HDRS) and the Self-Assessment Anhedonia Scale (SAAS) were used to measure depression severity and anhedonia, respectively. The general cognition state was assessed by the Mini-Mental State Examination (MMSE) test and memory with the Free and Cued Selective Reminding Test (FCSRT). The levels of both IGF-2 and IGFBP-7 were found to be significantly increased in the depressed group; however, only IGF-2 remained significantly elevated after correction by age and sex. On the other hand, the levels of IGF-2, IGFBP-3 and IGFBP-5 were significantly decreased after treatment, whereas only IGFBP-7 was significantly increased. Therefore, peripheral changes in the IGF family and their response to antidepressants might represent alterations at the brain level in depression.
abstractGer	The Insulin-like growth factor 2 (IGF-2) has been recently proven to alleviate depressive-like behaviors in both rats and mice models. However, its potential role as a peripheral biomarker has not been evaluated in depression. To do this, we measured plasma IGF-2 and other members of the IGF family such as Binding Proteins (IGFBP-1, IGFBP-3, IGFBP-5 and IGFBP-7) in a depressed group of patients (n = 51) and in a healthy control group (n = 48). In some of these patients (n = 15), we measured these proteins after a period (19 ± 6 days) of treatment with antidepressants. The Hamilton Depressive Rating Scale (HDRS) and the Self-Assessment Anhedonia Scale (SAAS) were used to measure depression severity and anhedonia, respectively. The general cognition state was assessed by the Mini-Mental State Examination (MMSE) test and memory with the Free and Cued Selective Reminding Test (FCSRT). The levels of both IGF-2 and IGFBP-7 were found to be significantly increased in the depressed group; however, only IGF-2 remained significantly elevated after correction by age and sex. On the other hand, the levels of IGF-2, IGFBP-3 and IGFBP-5 were significantly decreased after treatment, whereas only IGFBP-7 was significantly increased. Therefore, peripheral changes in the IGF family and their response to antidepressants might represent alterations at the brain level in depression.
abstract_unstemmed	The Insulin-like growth factor 2 (IGF-2) has been recently proven to alleviate depressive-like behaviors in both rats and mice models. However, its potential role as a peripheral biomarker has not been evaluated in depression. To do this, we measured plasma IGF-2 and other members of the IGF family such as Binding Proteins (IGFBP-1, IGFBP-3, IGFBP-5 and IGFBP-7) in a depressed group of patients (n = 51) and in a healthy control group (n = 48). In some of these patients (n = 15), we measured these proteins after a period (19 ± 6 days) of treatment with antidepressants. The Hamilton Depressive Rating Scale (HDRS) and the Self-Assessment Anhedonia Scale (SAAS) were used to measure depression severity and anhedonia, respectively. The general cognition state was assessed by the Mini-Mental State Examination (MMSE) test and memory with the Free and Cued Selective Reminding Test (FCSRT). The levels of both IGF-2 and IGFBP-7 were found to be significantly increased in the depressed group; however, only IGF-2 remained significantly elevated after correction by age and sex. On the other hand, the levels of IGF-2, IGFBP-3 and IGFBP-5 were significantly decreased after treatment, whereas only IGFBP-7 was significantly increased. Therefore, peripheral changes in the IGF family and their response to antidepressants might represent alterations at the brain level in depression.
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title_short	Protein Plasma Levels of the IGF Signalling System Are Altered in Major Depressive Disorder
url	https://doi.org/10.3390/ijms242015254 https://doaj.org/article/dfc1d3a1f98a4937baf3bdaa86785197 https://www.mdpi.com/1422-0067/24/20/15254 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067
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author2Str	Maria Aránzazu Penedo Tania Rivera-Baltanás Tania Pérez-Márquez Marta Alves-Villar Rafael Fernández-Martínez César Veiga Ángel Salgado-Barreira José María Prieto-González Saida Ortolano José Manuel Olivares Roberto Carlos Agís-Balboa
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Protein Plasma Levels of the IGF Signalling System Are Altered in Major Depressive Disorder

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