From Poly(glycerol itaconate) Gels to Novel Nonwoven Materials for Biomedical Applications

Electrospinning is a process that has attracted significant interest in recent years. It provides the opportunity to produce nanofibers that mimic the extracellular matrix. As a result, it is possible to use the nonwovens as scaffolds characterized by high cellular adhesion. This work focused on the...
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Gespeichert in:

Autor*in:	Magdalena Miętus [verfasserIn] Krzysztof Kolankowski [verfasserIn] Tomasz Gołofit [verfasserIn] Piotr Denis [verfasserIn] Aleksandra Bandzerewicz [verfasserIn] Maciej Spychalski [verfasserIn] Marcin Mąkosa-Szczygieł [verfasserIn] Maciej Pilarek [verfasserIn] Kamil Wierzchowski [verfasserIn] Agnieszka Gadomska-Gajadhur [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	poly(glycerol itaconate) polylactide electrospinning tissue engineering hydrogels

Übergeordnetes Werk:	In: Gels - MDPI AG, 2015, 9(2023), 788, p 788
Übergeordnetes Werk:	volume:9 ; year:2023 ; number:788, p 788

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/gels9100788

Katalog-ID:	DOAJ093138288

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allfieldsSound	10.3390/gels9100788 doi (DE-627)DOAJ093138288 (DE-599)DOAJ33d36c30ca134f8f86ea25da589a2fc8 DE-627 ger DE-627 rakwb eng QD1-999 QD146-197 QD1-65 Magdalena Miętus verfasserin aut From Poly(glycerol itaconate) Gels to Novel Nonwoven Materials for Biomedical Applications 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Electrospinning is a process that has attracted significant interest in recent years. It provides the opportunity to produce nanofibers that mimic the extracellular matrix. As a result, it is possible to use the nonwovens as scaffolds characterized by high cellular adhesion. This work focused on the synthesis of poly(glycerol itaconate) (PGItc) and preparation of nonwovens based on PGItc gels and polylactide. PGItc gels were synthesized by a reaction between itaconic anhydride and glycerol. The use of a mixture of PGItc and PLA allowed us to obtain a material with different properties than with stand-alone polymers. In this study, we present the influence of the chosen ratios of polymers and the OH/COOH ratio in the synthesized PGItc on the properties of the obtained materials. The addition of PGItc results in hydrophilization of the nonwovens’ surface without disrupting the high porosity of the fibrous structure. Spectral and thermal analyzes are presented, along with SEM imagining. The preliminary cytotoxicity research showed that nonwovens were non-cytotoxic materials. It also helped to pre-determine the potential application of PGItc + PLA nonwovens as subcutaneous tissue fillers or drug delivery systems. poly(glycerol itaconate) polylactide electrospinning tissue engineering hydrogels Science Q Chemistry Inorganic chemistry General. Including alchemy Krzysztof Kolankowski verfasserin aut Tomasz Gołofit verfasserin aut Piotr Denis verfasserin aut Aleksandra Bandzerewicz verfasserin aut Maciej Spychalski verfasserin aut Marcin Mąkosa-Szczygieł verfasserin aut Maciej Pilarek verfasserin aut Kamil Wierzchowski verfasserin aut Agnieszka Gadomska-Gajadhur verfasserin aut In Gels MDPI AG, 2015 9(2023), 788, p 788 (DE-627)820684147 (DE-600)2813982-3 23102861 nnns volume:9 year:2023 number:788, p 788 https://doi.org/10.3390/gels9100788 kostenfrei https://doaj.org/article/33d36c30ca134f8f86ea25da589a2fc8 kostenfrei https://www.mdpi.com/2310-2861/9/10/788 kostenfrei https://doaj.org/toc/2310-2861 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2023 788, p 788
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callnumber-first	Q - Science
author	Magdalena Miętus
spellingShingle	Magdalena Miętus misc QD1-999 misc QD146-197 misc QD1-65 misc poly(glycerol itaconate) misc polylactide misc electrospinning misc tissue engineering misc hydrogels misc Science misc Q misc Chemistry misc Inorganic chemistry misc General. Including alchemy From Poly(glycerol itaconate) Gels to Novel Nonwoven Materials for Biomedical Applications
authorStr	Magdalena Miętus
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topic_title	QD1-999 QD146-197 QD1-65 From Poly(glycerol itaconate) Gels to Novel Nonwoven Materials for Biomedical Applications poly(glycerol itaconate) polylactide electrospinning tissue engineering hydrogels
topic	misc QD1-999 misc QD146-197 misc QD1-65 misc poly(glycerol itaconate) misc polylactide misc electrospinning misc tissue engineering misc hydrogels misc Science misc Q misc Chemistry misc Inorganic chemistry misc General. Including alchemy
topic_unstemmed	misc QD1-999 misc QD146-197 misc QD1-65 misc poly(glycerol itaconate) misc polylactide misc electrospinning misc tissue engineering misc hydrogels misc Science misc Q misc Chemistry misc Inorganic chemistry misc General. Including alchemy
topic_browse	misc QD1-999 misc QD146-197 misc QD1-65 misc poly(glycerol itaconate) misc polylactide misc electrospinning misc tissue engineering misc hydrogels misc Science misc Q misc Chemistry misc Inorganic chemistry misc General. Including alchemy
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title	From Poly(glycerol itaconate) Gels to Novel Nonwoven Materials for Biomedical Applications
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title_full	From Poly(glycerol itaconate) Gels to Novel Nonwoven Materials for Biomedical Applications
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author_browse	Magdalena Miętus Krzysztof Kolankowski Tomasz Gołofit Piotr Denis Aleksandra Bandzerewicz Maciej Spychalski Marcin Mąkosa-Szczygieł Maciej Pilarek Kamil Wierzchowski Agnieszka Gadomska-Gajadhur
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title_sort	from poly(glycerol itaconate) gels to novel nonwoven materials for biomedical applications
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title_auth	From Poly(glycerol itaconate) Gels to Novel Nonwoven Materials for Biomedical Applications
abstract	Electrospinning is a process that has attracted significant interest in recent years. It provides the opportunity to produce nanofibers that mimic the extracellular matrix. As a result, it is possible to use the nonwovens as scaffolds characterized by high cellular adhesion. This work focused on the synthesis of poly(glycerol itaconate) (PGItc) and preparation of nonwovens based on PGItc gels and polylactide. PGItc gels were synthesized by a reaction between itaconic anhydride and glycerol. The use of a mixture of PGItc and PLA allowed us to obtain a material with different properties than with stand-alone polymers. In this study, we present the influence of the chosen ratios of polymers and the OH/COOH ratio in the synthesized PGItc on the properties of the obtained materials. The addition of PGItc results in hydrophilization of the nonwovens’ surface without disrupting the high porosity of the fibrous structure. Spectral and thermal analyzes are presented, along with SEM imagining. The preliminary cytotoxicity research showed that nonwovens were non-cytotoxic materials. It also helped to pre-determine the potential application of PGItc + PLA nonwovens as subcutaneous tissue fillers or drug delivery systems.
abstractGer	Electrospinning is a process that has attracted significant interest in recent years. It provides the opportunity to produce nanofibers that mimic the extracellular matrix. As a result, it is possible to use the nonwovens as scaffolds characterized by high cellular adhesion. This work focused on the synthesis of poly(glycerol itaconate) (PGItc) and preparation of nonwovens based on PGItc gels and polylactide. PGItc gels were synthesized by a reaction between itaconic anhydride and glycerol. The use of a mixture of PGItc and PLA allowed us to obtain a material with different properties than with stand-alone polymers. In this study, we present the influence of the chosen ratios of polymers and the OH/COOH ratio in the synthesized PGItc on the properties of the obtained materials. The addition of PGItc results in hydrophilization of the nonwovens’ surface without disrupting the high porosity of the fibrous structure. Spectral and thermal analyzes are presented, along with SEM imagining. The preliminary cytotoxicity research showed that nonwovens were non-cytotoxic materials. It also helped to pre-determine the potential application of PGItc + PLA nonwovens as subcutaneous tissue fillers or drug delivery systems.
abstract_unstemmed	Electrospinning is a process that has attracted significant interest in recent years. It provides the opportunity to produce nanofibers that mimic the extracellular matrix. As a result, it is possible to use the nonwovens as scaffolds characterized by high cellular adhesion. This work focused on the synthesis of poly(glycerol itaconate) (PGItc) and preparation of nonwovens based on PGItc gels and polylactide. PGItc gels were synthesized by a reaction between itaconic anhydride and glycerol. The use of a mixture of PGItc and PLA allowed us to obtain a material with different properties than with stand-alone polymers. In this study, we present the influence of the chosen ratios of polymers and the OH/COOH ratio in the synthesized PGItc on the properties of the obtained materials. The addition of PGItc results in hydrophilization of the nonwovens’ surface without disrupting the high porosity of the fibrous structure. Spectral and thermal analyzes are presented, along with SEM imagining. The preliminary cytotoxicity research showed that nonwovens were non-cytotoxic materials. It also helped to pre-determine the potential application of PGItc + PLA nonwovens as subcutaneous tissue fillers or drug delivery systems.
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container_issue	788, p 788
title_short	From Poly(glycerol itaconate) Gels to Novel Nonwoven Materials for Biomedical Applications
url	https://doi.org/10.3390/gels9100788 https://doaj.org/article/33d36c30ca134f8f86ea25da589a2fc8 https://www.mdpi.com/2310-2861/9/10/788 https://doaj.org/toc/2310-2861
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author2	Krzysztof Kolankowski Tomasz Gołofit Piotr Denis Aleksandra Bandzerewicz Maciej Spychalski Marcin Mąkosa-Szczygieł Maciej Pilarek Kamil Wierzchowski Agnieszka Gadomska-Gajadhur
author2Str	Krzysztof Kolankowski Tomasz Gołofit Piotr Denis Aleksandra Bandzerewicz Maciej Spychalski Marcin Mąkosa-Szczygieł Maciej Pilarek Kamil Wierzchowski Agnieszka Gadomska-Gajadhur
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doi_str	10.3390/gels9100788
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up_date	2024-07-03T15:30:17.699Z
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From Poly(glycerol itaconate) Gels to Novel Nonwoven Materials for Biomedical Applications

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