Local Treatment Efficacy for Single-Area Squamous Cell Carcinoma of the Unknown Primary Site

The prognosis for cancer of unknown primary site (CUP) is poor, and squamous cell carcinoma of the unknown primary site (SCCUP) is a rare histological type. CUP is often treated with aggressive multimodal treatments, while the treatment of single-area localized CUP remains controversial. We retrospe...
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Autor*in:	Tomoko Kurita [verfasserIn] Mayu Yunokawa [verfasserIn] Yuji Tanaka [verfasserIn] Kota Okamoto [verfasserIn] Motoko Kanno [verfasserIn] Atsushi Fusegi [verfasserIn] Makiko Omi [verfasserIn] Sachiho Netsu [verfasserIn] Hidetaka Nomura [verfasserIn] Akiko Tonooka [verfasserIn] Hiroyuki Kanao [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	squamous cell carcinoma cancer of unknown primary site SCCUP local treatment prognosis

Übergeordnetes Werk:	In: Current Oncology - MDPI AG, 2021, 30(2023), 674, Seite 9327-9334
Übergeordnetes Werk:	volume:30 ; year:2023 ; number:674 ; pages:9327-9334

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/curroncol30100674

Katalog-ID:	DOAJ093154933

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520			\|a The prognosis for cancer of unknown primary site (CUP) is poor, and squamous cell carcinoma of the unknown primary site (SCCUP) is a rare histological type. CUP is often treated with aggressive multimodal treatments, while the treatment of single-area localized CUP remains controversial. We retrospectively reviewed the medical records of patients with CUP. SCCUP in women was classified according to several definitions. Based on the histologic type and site, they were classified into favorable and unfavorable subsets. We further divided SCCUP into two types (single and multiple areas) and reviewed treatment and efficacy. Among the 227 female CUP patients, 36 (15%) had SCCUP. The median age was 59.9 years (range, 31–90 years). Most patients (61.1%) had a good performance status. Of the SCCUP patients, 22 had cancer in a single area, and 14 in multiple areas. Single-area SCCUP was further divided into favorable (16 cases) and unfavorable subsets (6 cases). In the favorable subset, local treatment was predominant, and almost all cases had a good prognosis. Even in the unfavorable subset, local therapy was combined with systemic chemotherapy in only two cases, and four cases showed no recurrences. Local treatment may be effective for single-area SCCUP, even in the unfavorable subset.
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allfields	10.3390/curroncol30100674 doi (DE-627)DOAJ093154933 (DE-599)DOAJ66b18c0745504f79a9c334bd7abc5af4 DE-627 ger DE-627 rakwb eng RC254-282 Tomoko Kurita verfasserin aut Local Treatment Efficacy for Single-Area Squamous Cell Carcinoma of the Unknown Primary Site 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The prognosis for cancer of unknown primary site (CUP) is poor, and squamous cell carcinoma of the unknown primary site (SCCUP) is a rare histological type. CUP is often treated with aggressive multimodal treatments, while the treatment of single-area localized CUP remains controversial. We retrospectively reviewed the medical records of patients with CUP. SCCUP in women was classified according to several definitions. Based on the histologic type and site, they were classified into favorable and unfavorable subsets. We further divided SCCUP into two types (single and multiple areas) and reviewed treatment and efficacy. Among the 227 female CUP patients, 36 (15%) had SCCUP. The median age was 59.9 years (range, 31–90 years). Most patients (61.1%) had a good performance status. Of the SCCUP patients, 22 had cancer in a single area, and 14 in multiple areas. Single-area SCCUP was further divided into favorable (16 cases) and unfavorable subsets (6 cases). In the favorable subset, local treatment was predominant, and almost all cases had a good prognosis. Even in the unfavorable subset, local therapy was combined with systemic chemotherapy in only two cases, and four cases showed no recurrences. Local treatment may be effective for single-area SCCUP, even in the unfavorable subset. squamous cell carcinoma cancer of unknown primary site SCCUP local treatment prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens Mayu Yunokawa verfasserin aut Yuji Tanaka verfasserin aut Kota Okamoto verfasserin aut Motoko Kanno verfasserin aut Atsushi Fusegi verfasserin aut Makiko Omi verfasserin aut Sachiho Netsu verfasserin aut Hidetaka Nomura verfasserin aut Akiko Tonooka verfasserin aut Hiroyuki Kanao verfasserin aut In Current Oncology MDPI AG, 2021 30(2023), 674, Seite 9327-9334 (DE-627)524623112 (DE-600)2270777-3 17187729 nnns volume:30 year:2023 number:674 pages:9327-9334 https://doi.org/10.3390/curroncol30100674 kostenfrei https://doaj.org/article/66b18c0745504f79a9c334bd7abc5af4 kostenfrei https://www.mdpi.com/1718-7729/30/10/674 kostenfrei https://doaj.org/toc/1198-0052 Journal toc kostenfrei https://doaj.org/toc/1718-7729 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 30 2023 674 9327-9334
spelling	10.3390/curroncol30100674 doi (DE-627)DOAJ093154933 (DE-599)DOAJ66b18c0745504f79a9c334bd7abc5af4 DE-627 ger DE-627 rakwb eng RC254-282 Tomoko Kurita verfasserin aut Local Treatment Efficacy for Single-Area Squamous Cell Carcinoma of the Unknown Primary Site 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The prognosis for cancer of unknown primary site (CUP) is poor, and squamous cell carcinoma of the unknown primary site (SCCUP) is a rare histological type. CUP is often treated with aggressive multimodal treatments, while the treatment of single-area localized CUP remains controversial. We retrospectively reviewed the medical records of patients with CUP. SCCUP in women was classified according to several definitions. Based on the histologic type and site, they were classified into favorable and unfavorable subsets. We further divided SCCUP into two types (single and multiple areas) and reviewed treatment and efficacy. Among the 227 female CUP patients, 36 (15%) had SCCUP. The median age was 59.9 years (range, 31–90 years). Most patients (61.1%) had a good performance status. Of the SCCUP patients, 22 had cancer in a single area, and 14 in multiple areas. Single-area SCCUP was further divided into favorable (16 cases) and unfavorable subsets (6 cases). In the favorable subset, local treatment was predominant, and almost all cases had a good prognosis. Even in the unfavorable subset, local therapy was combined with systemic chemotherapy in only two cases, and four cases showed no recurrences. Local treatment may be effective for single-area SCCUP, even in the unfavorable subset. squamous cell carcinoma cancer of unknown primary site SCCUP local treatment prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens Mayu Yunokawa verfasserin aut Yuji Tanaka verfasserin aut Kota Okamoto verfasserin aut Motoko Kanno verfasserin aut Atsushi Fusegi verfasserin aut Makiko Omi verfasserin aut Sachiho Netsu verfasserin aut Hidetaka Nomura verfasserin aut Akiko Tonooka verfasserin aut Hiroyuki Kanao verfasserin aut In Current Oncology MDPI AG, 2021 30(2023), 674, Seite 9327-9334 (DE-627)524623112 (DE-600)2270777-3 17187729 nnns volume:30 year:2023 number:674 pages:9327-9334 https://doi.org/10.3390/curroncol30100674 kostenfrei https://doaj.org/article/66b18c0745504f79a9c334bd7abc5af4 kostenfrei https://www.mdpi.com/1718-7729/30/10/674 kostenfrei https://doaj.org/toc/1198-0052 Journal toc kostenfrei https://doaj.org/toc/1718-7729 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 30 2023 674 9327-9334
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allfieldsGer	10.3390/curroncol30100674 doi (DE-627)DOAJ093154933 (DE-599)DOAJ66b18c0745504f79a9c334bd7abc5af4 DE-627 ger DE-627 rakwb eng RC254-282 Tomoko Kurita verfasserin aut Local Treatment Efficacy for Single-Area Squamous Cell Carcinoma of the Unknown Primary Site 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The prognosis for cancer of unknown primary site (CUP) is poor, and squamous cell carcinoma of the unknown primary site (SCCUP) is a rare histological type. CUP is often treated with aggressive multimodal treatments, while the treatment of single-area localized CUP remains controversial. We retrospectively reviewed the medical records of patients with CUP. SCCUP in women was classified according to several definitions. Based on the histologic type and site, they were classified into favorable and unfavorable subsets. We further divided SCCUP into two types (single and multiple areas) and reviewed treatment and efficacy. Among the 227 female CUP patients, 36 (15%) had SCCUP. The median age was 59.9 years (range, 31–90 years). Most patients (61.1%) had a good performance status. Of the SCCUP patients, 22 had cancer in a single area, and 14 in multiple areas. Single-area SCCUP was further divided into favorable (16 cases) and unfavorable subsets (6 cases). In the favorable subset, local treatment was predominant, and almost all cases had a good prognosis. Even in the unfavorable subset, local therapy was combined with systemic chemotherapy in only two cases, and four cases showed no recurrences. Local treatment may be effective for single-area SCCUP, even in the unfavorable subset. squamous cell carcinoma cancer of unknown primary site SCCUP local treatment prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens Mayu Yunokawa verfasserin aut Yuji Tanaka verfasserin aut Kota Okamoto verfasserin aut Motoko Kanno verfasserin aut Atsushi Fusegi verfasserin aut Makiko Omi verfasserin aut Sachiho Netsu verfasserin aut Hidetaka Nomura verfasserin aut Akiko Tonooka verfasserin aut Hiroyuki Kanao verfasserin aut In Current Oncology MDPI AG, 2021 30(2023), 674, Seite 9327-9334 (DE-627)524623112 (DE-600)2270777-3 17187729 nnns volume:30 year:2023 number:674 pages:9327-9334 https://doi.org/10.3390/curroncol30100674 kostenfrei https://doaj.org/article/66b18c0745504f79a9c334bd7abc5af4 kostenfrei https://www.mdpi.com/1718-7729/30/10/674 kostenfrei https://doaj.org/toc/1198-0052 Journal toc kostenfrei https://doaj.org/toc/1718-7729 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 30 2023 674 9327-9334
allfieldsSound	10.3390/curroncol30100674 doi (DE-627)DOAJ093154933 (DE-599)DOAJ66b18c0745504f79a9c334bd7abc5af4 DE-627 ger DE-627 rakwb eng RC254-282 Tomoko Kurita verfasserin aut Local Treatment Efficacy for Single-Area Squamous Cell Carcinoma of the Unknown Primary Site 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The prognosis for cancer of unknown primary site (CUP) is poor, and squamous cell carcinoma of the unknown primary site (SCCUP) is a rare histological type. CUP is often treated with aggressive multimodal treatments, while the treatment of single-area localized CUP remains controversial. We retrospectively reviewed the medical records of patients with CUP. SCCUP in women was classified according to several definitions. Based on the histologic type and site, they were classified into favorable and unfavorable subsets. We further divided SCCUP into two types (single and multiple areas) and reviewed treatment and efficacy. Among the 227 female CUP patients, 36 (15%) had SCCUP. The median age was 59.9 years (range, 31–90 years). Most patients (61.1%) had a good performance status. Of the SCCUP patients, 22 had cancer in a single area, and 14 in multiple areas. Single-area SCCUP was further divided into favorable (16 cases) and unfavorable subsets (6 cases). In the favorable subset, local treatment was predominant, and almost all cases had a good prognosis. Even in the unfavorable subset, local therapy was combined with systemic chemotherapy in only two cases, and four cases showed no recurrences. Local treatment may be effective for single-area SCCUP, even in the unfavorable subset. squamous cell carcinoma cancer of unknown primary site SCCUP local treatment prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens Mayu Yunokawa verfasserin aut Yuji Tanaka verfasserin aut Kota Okamoto verfasserin aut Motoko Kanno verfasserin aut Atsushi Fusegi verfasserin aut Makiko Omi verfasserin aut Sachiho Netsu verfasserin aut Hidetaka Nomura verfasserin aut Akiko Tonooka verfasserin aut Hiroyuki Kanao verfasserin aut In Current Oncology MDPI AG, 2021 30(2023), 674, Seite 9327-9334 (DE-627)524623112 (DE-600)2270777-3 17187729 nnns volume:30 year:2023 number:674 pages:9327-9334 https://doi.org/10.3390/curroncol30100674 kostenfrei https://doaj.org/article/66b18c0745504f79a9c334bd7abc5af4 kostenfrei https://www.mdpi.com/1718-7729/30/10/674 kostenfrei https://doaj.org/toc/1198-0052 Journal toc kostenfrei https://doaj.org/toc/1718-7729 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 30 2023 674 9327-9334
language	English
source	In Current Oncology 30(2023), 674, Seite 9327-9334 volume:30 year:2023 number:674 pages:9327-9334
sourceStr	In Current Oncology 30(2023), 674, Seite 9327-9334 volume:30 year:2023 number:674 pages:9327-9334
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topic_facet	squamous cell carcinoma cancer of unknown primary site SCCUP local treatment prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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callnumber-first	R - Medicine
author	Tomoko Kurita
spellingShingle	Tomoko Kurita misc RC254-282 misc squamous cell carcinoma misc cancer of unknown primary site misc SCCUP misc local treatment misc prognosis misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Local Treatment Efficacy for Single-Area Squamous Cell Carcinoma of the Unknown Primary Site
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topic_title	RC254-282 Local Treatment Efficacy for Single-Area Squamous Cell Carcinoma of the Unknown Primary Site squamous cell carcinoma cancer of unknown primary site SCCUP local treatment prognosis
topic	misc RC254-282 misc squamous cell carcinoma misc cancer of unknown primary site misc SCCUP misc local treatment misc prognosis misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Local Treatment Efficacy for Single-Area Squamous Cell Carcinoma of the Unknown Primary Site
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title_sort	local treatment efficacy for single-area squamous cell carcinoma of the unknown primary site
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title_auth	Local Treatment Efficacy for Single-Area Squamous Cell Carcinoma of the Unknown Primary Site
abstract	The prognosis for cancer of unknown primary site (CUP) is poor, and squamous cell carcinoma of the unknown primary site (SCCUP) is a rare histological type. CUP is often treated with aggressive multimodal treatments, while the treatment of single-area localized CUP remains controversial. We retrospectively reviewed the medical records of patients with CUP. SCCUP in women was classified according to several definitions. Based on the histologic type and site, they were classified into favorable and unfavorable subsets. We further divided SCCUP into two types (single and multiple areas) and reviewed treatment and efficacy. Among the 227 female CUP patients, 36 (15%) had SCCUP. The median age was 59.9 years (range, 31–90 years). Most patients (61.1%) had a good performance status. Of the SCCUP patients, 22 had cancer in a single area, and 14 in multiple areas. Single-area SCCUP was further divided into favorable (16 cases) and unfavorable subsets (6 cases). In the favorable subset, local treatment was predominant, and almost all cases had a good prognosis. Even in the unfavorable subset, local therapy was combined with systemic chemotherapy in only two cases, and four cases showed no recurrences. Local treatment may be effective for single-area SCCUP, even in the unfavorable subset.
abstractGer	The prognosis for cancer of unknown primary site (CUP) is poor, and squamous cell carcinoma of the unknown primary site (SCCUP) is a rare histological type. CUP is often treated with aggressive multimodal treatments, while the treatment of single-area localized CUP remains controversial. We retrospectively reviewed the medical records of patients with CUP. SCCUP in women was classified according to several definitions. Based on the histologic type and site, they were classified into favorable and unfavorable subsets. We further divided SCCUP into two types (single and multiple areas) and reviewed treatment and efficacy. Among the 227 female CUP patients, 36 (15%) had SCCUP. The median age was 59.9 years (range, 31–90 years). Most patients (61.1%) had a good performance status. Of the SCCUP patients, 22 had cancer in a single area, and 14 in multiple areas. Single-area SCCUP was further divided into favorable (16 cases) and unfavorable subsets (6 cases). In the favorable subset, local treatment was predominant, and almost all cases had a good prognosis. Even in the unfavorable subset, local therapy was combined with systemic chemotherapy in only two cases, and four cases showed no recurrences. Local treatment may be effective for single-area SCCUP, even in the unfavorable subset.
abstract_unstemmed	The prognosis for cancer of unknown primary site (CUP) is poor, and squamous cell carcinoma of the unknown primary site (SCCUP) is a rare histological type. CUP is often treated with aggressive multimodal treatments, while the treatment of single-area localized CUP remains controversial. We retrospectively reviewed the medical records of patients with CUP. SCCUP in women was classified according to several definitions. Based on the histologic type and site, they were classified into favorable and unfavorable subsets. We further divided SCCUP into two types (single and multiple areas) and reviewed treatment and efficacy. Among the 227 female CUP patients, 36 (15%) had SCCUP. The median age was 59.9 years (range, 31–90 years). Most patients (61.1%) had a good performance status. Of the SCCUP patients, 22 had cancer in a single area, and 14 in multiple areas. Single-area SCCUP was further divided into favorable (16 cases) and unfavorable subsets (6 cases). In the favorable subset, local treatment was predominant, and almost all cases had a good prognosis. Even in the unfavorable subset, local therapy was combined with systemic chemotherapy in only two cases, and four cases showed no recurrences. Local treatment may be effective for single-area SCCUP, even in the unfavorable subset.
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title_short	Local Treatment Efficacy for Single-Area Squamous Cell Carcinoma of the Unknown Primary Site
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Local Treatment Efficacy for Single-Area Squamous Cell Carcinoma of the Unknown Primary Site

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