Prognostic Relevance of Tumor-Infiltrating Immune Cells in Cervix Squamous Cell Carcinoma

There exists a variety of studies about tumor-infiltrating immune cells (TIICs) in cervical cancer, but their prognostic value in correlation with the histopathological subtype has never been investigated. Therefore, the aim of this study was to quantify TIICs in a panel of 238 sporadic cervical can...
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Autor*in:	Carl Mathis Wild [verfasserIn] Fabian Garrido [verfasserIn] Christian Dannecker [verfasserIn] Melitta B. Köpke [verfasserIn] Marie-Christine Chateau [verfasserIn] Florence Boissière-Michot [verfasserIn] Helene H. Heidegger [verfasserIn] Aurelia Vattai [verfasserIn] Mirjana Kessler [verfasserIn] Udo Jeschke [verfasserIn] Vincent Cavaillès [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	cervical cancer tumor-infiltrating immune cells (TIICs) cervix adenocarcinoma (CAC) cervix squamous cell carcinoma (CSCC) disease-free survival (DFS) overall survival (OS)

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 15(2023), 4952, p 4952
Übergeordnetes Werk:	volume:15 ; year:2023 ; number:4952, p 4952

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers15204952

Katalog-ID:	DOAJ093163657

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650		4	\|a cervical cancer
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allfields	10.3390/cancers15204952 doi (DE-627)DOAJ093163657 (DE-599)DOAJa6c1d06663b44af2b96529d13dd30923 DE-627 ger DE-627 rakwb eng RC254-282 Carl Mathis Wild verfasserin aut Prognostic Relevance of Tumor-Infiltrating Immune Cells in Cervix Squamous Cell Carcinoma 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier There exists a variety of studies about tumor-infiltrating immune cells (TIICs) in cervical cancer, but their prognostic value in correlation with the histopathological subtype has never been investigated. Therefore, the aim of this study was to quantify TIICs in a panel of 238 sporadic cervical cancers and investigate the correlation with cervical cancer subtype and patient survival. TIICs levels were significantly increased in the subgroup of CSCC (191 samples) in comparison to CAC (47 samples). In CSCC, TIICs’ infiltration showed a negative correlation with age, FIGO stage and with the histone protein modification H3K4me3. Moreover, in CAC, it was positively correlated with p16 and with the glucocorticoid receptor and inversely correlated with the MDM2 protein and with H3K4me3. Interestingly, immune infiltration was an independent positive prognosticator for disease-free survival (DFS) in patients with CSCC, those bearing tumors with the strongest TIICs infiltration showing the better DFS. Altogether, the present study provides a differentiated overview of the relations between TIIC levels and prognosis in patients with CSCC vs. patients with CAC. cervical cancer tumor-infiltrating immune cells (TIICs) cervix adenocarcinoma (CAC) cervix squamous cell carcinoma (CSCC) disease-free survival (DFS) overall survival (OS) Neoplasms. Tumors. Oncology. Including cancer and carcinogens Fabian Garrido verfasserin aut Christian Dannecker verfasserin aut Melitta B. Köpke verfasserin aut Marie-Christine Chateau verfasserin aut Florence Boissière-Michot verfasserin aut Helene H. Heidegger verfasserin aut Aurelia Vattai verfasserin aut Mirjana Kessler verfasserin aut Udo Jeschke verfasserin aut Vincent Cavaillès verfasserin aut In Cancers MDPI AG, 2010 15(2023), 4952, p 4952 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:4952, p 4952 https://doi.org/10.3390/cancers15204952 kostenfrei https://doaj.org/article/a6c1d06663b44af2b96529d13dd30923 kostenfrei https://www.mdpi.com/2072-6694/15/20/4952 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 4952, p 4952
spelling	10.3390/cancers15204952 doi (DE-627)DOAJ093163657 (DE-599)DOAJa6c1d06663b44af2b96529d13dd30923 DE-627 ger DE-627 rakwb eng RC254-282 Carl Mathis Wild verfasserin aut Prognostic Relevance of Tumor-Infiltrating Immune Cells in Cervix Squamous Cell Carcinoma 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier There exists a variety of studies about tumor-infiltrating immune cells (TIICs) in cervical cancer, but their prognostic value in correlation with the histopathological subtype has never been investigated. Therefore, the aim of this study was to quantify TIICs in a panel of 238 sporadic cervical cancers and investigate the correlation with cervical cancer subtype and patient survival. TIICs levels were significantly increased in the subgroup of CSCC (191 samples) in comparison to CAC (47 samples). In CSCC, TIICs’ infiltration showed a negative correlation with age, FIGO stage and with the histone protein modification H3K4me3. Moreover, in CAC, it was positively correlated with p16 and with the glucocorticoid receptor and inversely correlated with the MDM2 protein and with H3K4me3. Interestingly, immune infiltration was an independent positive prognosticator for disease-free survival (DFS) in patients with CSCC, those bearing tumors with the strongest TIICs infiltration showing the better DFS. Altogether, the present study provides a differentiated overview of the relations between TIIC levels and prognosis in patients with CSCC vs. patients with CAC. cervical cancer tumor-infiltrating immune cells (TIICs) cervix adenocarcinoma (CAC) cervix squamous cell carcinoma (CSCC) disease-free survival (DFS) overall survival (OS) Neoplasms. Tumors. Oncology. Including cancer and carcinogens Fabian Garrido verfasserin aut Christian Dannecker verfasserin aut Melitta B. Köpke verfasserin aut Marie-Christine Chateau verfasserin aut Florence Boissière-Michot verfasserin aut Helene H. Heidegger verfasserin aut Aurelia Vattai verfasserin aut Mirjana Kessler verfasserin aut Udo Jeschke verfasserin aut Vincent Cavaillès verfasserin aut In Cancers MDPI AG, 2010 15(2023), 4952, p 4952 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:4952, p 4952 https://doi.org/10.3390/cancers15204952 kostenfrei https://doaj.org/article/a6c1d06663b44af2b96529d13dd30923 kostenfrei https://www.mdpi.com/2072-6694/15/20/4952 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 4952, p 4952
allfields_unstemmed	10.3390/cancers15204952 doi (DE-627)DOAJ093163657 (DE-599)DOAJa6c1d06663b44af2b96529d13dd30923 DE-627 ger DE-627 rakwb eng RC254-282 Carl Mathis Wild verfasserin aut Prognostic Relevance of Tumor-Infiltrating Immune Cells in Cervix Squamous Cell Carcinoma 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier There exists a variety of studies about tumor-infiltrating immune cells (TIICs) in cervical cancer, but their prognostic value in correlation with the histopathological subtype has never been investigated. Therefore, the aim of this study was to quantify TIICs in a panel of 238 sporadic cervical cancers and investigate the correlation with cervical cancer subtype and patient survival. TIICs levels were significantly increased in the subgroup of CSCC (191 samples) in comparison to CAC (47 samples). In CSCC, TIICs’ infiltration showed a negative correlation with age, FIGO stage and with the histone protein modification H3K4me3. Moreover, in CAC, it was positively correlated with p16 and with the glucocorticoid receptor and inversely correlated with the MDM2 protein and with H3K4me3. Interestingly, immune infiltration was an independent positive prognosticator for disease-free survival (DFS) in patients with CSCC, those bearing tumors with the strongest TIICs infiltration showing the better DFS. Altogether, the present study provides a differentiated overview of the relations between TIIC levels and prognosis in patients with CSCC vs. patients with CAC. cervical cancer tumor-infiltrating immune cells (TIICs) cervix adenocarcinoma (CAC) cervix squamous cell carcinoma (CSCC) disease-free survival (DFS) overall survival (OS) Neoplasms. Tumors. Oncology. Including cancer and carcinogens Fabian Garrido verfasserin aut Christian Dannecker verfasserin aut Melitta B. Köpke verfasserin aut Marie-Christine Chateau verfasserin aut Florence Boissière-Michot verfasserin aut Helene H. Heidegger verfasserin aut Aurelia Vattai verfasserin aut Mirjana Kessler verfasserin aut Udo Jeschke verfasserin aut Vincent Cavaillès verfasserin aut In Cancers MDPI AG, 2010 15(2023), 4952, p 4952 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:4952, p 4952 https://doi.org/10.3390/cancers15204952 kostenfrei https://doaj.org/article/a6c1d06663b44af2b96529d13dd30923 kostenfrei https://www.mdpi.com/2072-6694/15/20/4952 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 4952, p 4952
allfieldsGer	10.3390/cancers15204952 doi (DE-627)DOAJ093163657 (DE-599)DOAJa6c1d06663b44af2b96529d13dd30923 DE-627 ger DE-627 rakwb eng RC254-282 Carl Mathis Wild verfasserin aut Prognostic Relevance of Tumor-Infiltrating Immune Cells in Cervix Squamous Cell Carcinoma 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier There exists a variety of studies about tumor-infiltrating immune cells (TIICs) in cervical cancer, but their prognostic value in correlation with the histopathological subtype has never been investigated. Therefore, the aim of this study was to quantify TIICs in a panel of 238 sporadic cervical cancers and investigate the correlation with cervical cancer subtype and patient survival. TIICs levels were significantly increased in the subgroup of CSCC (191 samples) in comparison to CAC (47 samples). In CSCC, TIICs’ infiltration showed a negative correlation with age, FIGO stage and with the histone protein modification H3K4me3. Moreover, in CAC, it was positively correlated with p16 and with the glucocorticoid receptor and inversely correlated with the MDM2 protein and with H3K4me3. Interestingly, immune infiltration was an independent positive prognosticator for disease-free survival (DFS) in patients with CSCC, those bearing tumors with the strongest TIICs infiltration showing the better DFS. Altogether, the present study provides a differentiated overview of the relations between TIIC levels and prognosis in patients with CSCC vs. patients with CAC. cervical cancer tumor-infiltrating immune cells (TIICs) cervix adenocarcinoma (CAC) cervix squamous cell carcinoma (CSCC) disease-free survival (DFS) overall survival (OS) Neoplasms. Tumors. Oncology. Including cancer and carcinogens Fabian Garrido verfasserin aut Christian Dannecker verfasserin aut Melitta B. Köpke verfasserin aut Marie-Christine Chateau verfasserin aut Florence Boissière-Michot verfasserin aut Helene H. Heidegger verfasserin aut Aurelia Vattai verfasserin aut Mirjana Kessler verfasserin aut Udo Jeschke verfasserin aut Vincent Cavaillès verfasserin aut In Cancers MDPI AG, 2010 15(2023), 4952, p 4952 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:4952, p 4952 https://doi.org/10.3390/cancers15204952 kostenfrei https://doaj.org/article/a6c1d06663b44af2b96529d13dd30923 kostenfrei https://www.mdpi.com/2072-6694/15/20/4952 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 4952, p 4952
allfieldsSound	10.3390/cancers15204952 doi (DE-627)DOAJ093163657 (DE-599)DOAJa6c1d06663b44af2b96529d13dd30923 DE-627 ger DE-627 rakwb eng RC254-282 Carl Mathis Wild verfasserin aut Prognostic Relevance of Tumor-Infiltrating Immune Cells in Cervix Squamous Cell Carcinoma 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier There exists a variety of studies about tumor-infiltrating immune cells (TIICs) in cervical cancer, but their prognostic value in correlation with the histopathological subtype has never been investigated. Therefore, the aim of this study was to quantify TIICs in a panel of 238 sporadic cervical cancers and investigate the correlation with cervical cancer subtype and patient survival. TIICs levels were significantly increased in the subgroup of CSCC (191 samples) in comparison to CAC (47 samples). In CSCC, TIICs’ infiltration showed a negative correlation with age, FIGO stage and with the histone protein modification H3K4me3. Moreover, in CAC, it was positively correlated with p16 and with the glucocorticoid receptor and inversely correlated with the MDM2 protein and with H3K4me3. Interestingly, immune infiltration was an independent positive prognosticator for disease-free survival (DFS) in patients with CSCC, those bearing tumors with the strongest TIICs infiltration showing the better DFS. Altogether, the present study provides a differentiated overview of the relations between TIIC levels and prognosis in patients with CSCC vs. patients with CAC. cervical cancer tumor-infiltrating immune cells (TIICs) cervix adenocarcinoma (CAC) cervix squamous cell carcinoma (CSCC) disease-free survival (DFS) overall survival (OS) Neoplasms. Tumors. Oncology. Including cancer and carcinogens Fabian Garrido verfasserin aut Christian Dannecker verfasserin aut Melitta B. Köpke verfasserin aut Marie-Christine Chateau verfasserin aut Florence Boissière-Michot verfasserin aut Helene H. Heidegger verfasserin aut Aurelia Vattai verfasserin aut Mirjana Kessler verfasserin aut Udo Jeschke verfasserin aut Vincent Cavaillès verfasserin aut In Cancers MDPI AG, 2010 15(2023), 4952, p 4952 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:4952, p 4952 https://doi.org/10.3390/cancers15204952 kostenfrei https://doaj.org/article/a6c1d06663b44af2b96529d13dd30923 kostenfrei https://www.mdpi.com/2072-6694/15/20/4952 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 4952, p 4952
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callnumber-first	R - Medicine
author	Carl Mathis Wild
spellingShingle	Carl Mathis Wild misc RC254-282 misc cervical cancer misc tumor-infiltrating immune cells (TIICs) misc cervix adenocarcinoma (CAC) misc cervix squamous cell carcinoma (CSCC) misc disease-free survival (DFS) misc overall survival (OS) misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Prognostic Relevance of Tumor-Infiltrating Immune Cells in Cervix Squamous Cell Carcinoma
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topic_title	RC254-282 Prognostic Relevance of Tumor-Infiltrating Immune Cells in Cervix Squamous Cell Carcinoma cervical cancer tumor-infiltrating immune cells (TIICs) cervix adenocarcinoma (CAC) cervix squamous cell carcinoma (CSCC) disease-free survival (DFS) overall survival (OS)
topic	misc RC254-282 misc cervical cancer misc tumor-infiltrating immune cells (TIICs) misc cervix adenocarcinoma (CAC) misc cervix squamous cell carcinoma (CSCC) misc disease-free survival (DFS) misc overall survival (OS) misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc cervical cancer misc tumor-infiltrating immune cells (TIICs) misc cervix adenocarcinoma (CAC) misc cervix squamous cell carcinoma (CSCC) misc disease-free survival (DFS) misc overall survival (OS) misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc cervical cancer misc tumor-infiltrating immune cells (TIICs) misc cervix adenocarcinoma (CAC) misc cervix squamous cell carcinoma (CSCC) misc disease-free survival (DFS) misc overall survival (OS) misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Prognostic Relevance of Tumor-Infiltrating Immune Cells in Cervix Squamous Cell Carcinoma
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title_full	Prognostic Relevance of Tumor-Infiltrating Immune Cells in Cervix Squamous Cell Carcinoma
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author_browse	Carl Mathis Wild Fabian Garrido Christian Dannecker Melitta B. Köpke Marie-Christine Chateau Florence Boissière-Michot Helene H. Heidegger Aurelia Vattai Mirjana Kessler Udo Jeschke Vincent Cavaillès
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title_sort	prognostic relevance of tumor-infiltrating immune cells in cervix squamous cell carcinoma
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title_auth	Prognostic Relevance of Tumor-Infiltrating Immune Cells in Cervix Squamous Cell Carcinoma
abstract	There exists a variety of studies about tumor-infiltrating immune cells (TIICs) in cervical cancer, but their prognostic value in correlation with the histopathological subtype has never been investigated. Therefore, the aim of this study was to quantify TIICs in a panel of 238 sporadic cervical cancers and investigate the correlation with cervical cancer subtype and patient survival. TIICs levels were significantly increased in the subgroup of CSCC (191 samples) in comparison to CAC (47 samples). In CSCC, TIICs’ infiltration showed a negative correlation with age, FIGO stage and with the histone protein modification H3K4me3. Moreover, in CAC, it was positively correlated with p16 and with the glucocorticoid receptor and inversely correlated with the MDM2 protein and with H3K4me3. Interestingly, immune infiltration was an independent positive prognosticator for disease-free survival (DFS) in patients with CSCC, those bearing tumors with the strongest TIICs infiltration showing the better DFS. Altogether, the present study provides a differentiated overview of the relations between TIIC levels and prognosis in patients with CSCC vs. patients with CAC.
abstractGer	There exists a variety of studies about tumor-infiltrating immune cells (TIICs) in cervical cancer, but their prognostic value in correlation with the histopathological subtype has never been investigated. Therefore, the aim of this study was to quantify TIICs in a panel of 238 sporadic cervical cancers and investigate the correlation with cervical cancer subtype and patient survival. TIICs levels were significantly increased in the subgroup of CSCC (191 samples) in comparison to CAC (47 samples). In CSCC, TIICs’ infiltration showed a negative correlation with age, FIGO stage and with the histone protein modification H3K4me3. Moreover, in CAC, it was positively correlated with p16 and with the glucocorticoid receptor and inversely correlated with the MDM2 protein and with H3K4me3. Interestingly, immune infiltration was an independent positive prognosticator for disease-free survival (DFS) in patients with CSCC, those bearing tumors with the strongest TIICs infiltration showing the better DFS. Altogether, the present study provides a differentiated overview of the relations between TIIC levels and prognosis in patients with CSCC vs. patients with CAC.
abstract_unstemmed	There exists a variety of studies about tumor-infiltrating immune cells (TIICs) in cervical cancer, but their prognostic value in correlation with the histopathological subtype has never been investigated. Therefore, the aim of this study was to quantify TIICs in a panel of 238 sporadic cervical cancers and investigate the correlation with cervical cancer subtype and patient survival. TIICs levels were significantly increased in the subgroup of CSCC (191 samples) in comparison to CAC (47 samples). In CSCC, TIICs’ infiltration showed a negative correlation with age, FIGO stage and with the histone protein modification H3K4me3. Moreover, in CAC, it was positively correlated with p16 and with the glucocorticoid receptor and inversely correlated with the MDM2 protein and with H3K4me3. Interestingly, immune infiltration was an independent positive prognosticator for disease-free survival (DFS) in patients with CSCC, those bearing tumors with the strongest TIICs infiltration showing the better DFS. Altogether, the present study provides a differentiated overview of the relations between TIIC levels and prognosis in patients with CSCC vs. patients with CAC.
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title_short	Prognostic Relevance of Tumor-Infiltrating Immune Cells in Cervix Squamous Cell Carcinoma
url	https://doi.org/10.3390/cancers15204952 https://doaj.org/article/a6c1d06663b44af2b96529d13dd30923 https://www.mdpi.com/2072-6694/15/20/4952 https://doaj.org/toc/2072-6694
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up_date	2024-07-03T15:39:39.008Z
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Therefore, the aim of this study was to quantify TIICs in a panel of 238 sporadic cervical cancers and investigate the correlation with cervical cancer subtype and patient survival. TIICs levels were significantly increased in the subgroup of CSCC (191 samples) in comparison to CAC (47 samples). In CSCC, TIICs’ infiltration showed a negative correlation with age, FIGO stage and with the histone protein modification H3K4me3. Moreover, in CAC, it was positively correlated with p16 and with the glucocorticoid receptor and inversely correlated with the MDM2 protein and with H3K4me3. Interestingly, immune infiltration was an independent positive prognosticator for disease-free survival (DFS) in patients with CSCC, those bearing tumors with the strongest TIICs infiltration showing the better DFS. 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Prognostic Relevance of Tumor-Infiltrating Immune Cells in Cervix Squamous Cell Carcinoma

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