Antibacterial and Disinfecting Effects of Standardised Tea Extracts on More than 100 Clinical Isolates of Methicillin-Resistant <i<Staphylococcus aureus</i<

Methicillin-resistant <i<Staphylococcus aureus</i< (MRSA) infections are still a major problem in hospitals. The excellent safety profile, accessibility and anti-infective activity of tea extracts make them promising agents for the treatment of infected wounds. To investigate the possibi...
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Autor*in:	Ruth Feilcke [verfasserIn] Volker Bär [verfasserIn] Constanze Wendt [verfasserIn] Peter Imming [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	multi-resistance tea extracts time–kill plot

Übergeordnetes Werk:	In: Plants - MDPI AG, 2013, 12(2023), 3440, p 3440
Übergeordnetes Werk:	volume:12 ; year:2023 ; number:3440, p 3440

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/plants12193440

Katalog-ID:	DOAJ093208715

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authorswithroles_txt_mv	Ruth Feilcke @@aut@@ Volker Bär @@aut@@ Constanze Wendt @@aut@@ Peter Imming @@aut@@
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callnumber-first	Q - Science
author	Ruth Feilcke
spellingShingle	Ruth Feilcke misc QK1-989 misc multi-resistance misc <i<Staphylococcus</i< misc tea extracts misc <i<Camellia sinensis</i< misc time–kill plot misc Botany Antibacterial and Disinfecting Effects of Standardised Tea Extracts on More than 100 Clinical Isolates of Methicillin-Resistant <i<Staphylococcus aureus</i<
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topic_title	QK1-989 Antibacterial and Disinfecting Effects of Standardised Tea Extracts on More than 100 Clinical Isolates of Methicillin-Resistant <i<Staphylococcus aureus</i< multi-resistance <i<Staphylococcus</i< tea extracts <i<Camellia sinensis</i< time–kill plot
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title	Antibacterial and Disinfecting Effects of Standardised Tea Extracts on More than 100 Clinical Isolates of Methicillin-Resistant <i<Staphylococcus aureus</i<
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title_full	Antibacterial and Disinfecting Effects of Standardised Tea Extracts on More than 100 Clinical Isolates of Methicillin-Resistant <i<Staphylococcus aureus</i<
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title_sort	antibacterial and disinfecting effects of standardised tea extracts on more than 100 clinical isolates of methicillin-resistant <i<staphylococcus aureus</i<
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title_auth	Antibacterial and Disinfecting Effects of Standardised Tea Extracts on More than 100 Clinical Isolates of Methicillin-Resistant <i<Staphylococcus aureus</i<
abstract	Methicillin-resistant <i<Staphylococcus aureus</i< (MRSA) infections are still a major problem in hospitals. The excellent safety profile, accessibility and anti-infective activity of tea extracts make them promising agents for the treatment of infected wounds. To investigate the possibility of sterilising MRSA-infected surfaces, including skin with tea extracts, we determined the MICs for different extracts from green and black tea (<i<Camellia sinensis</i<), including epigallocatechin gallate (EGCG), on a large number of clinical isolates of MRSA, selected to represent a high genetic diversity. The extracts were prepared to achieve the maximal extraction of EGCG from tea and were used as stable lyophilisate with a defined EGCG content. All extracts showed a complete inhibition of cell growth at a concentration of approx. 80 µg/mL of EGCG after a contact time of 24 h. Time–kill plots were recorded for the extract with the highest amount of EGCG. The reduction factor (RF) was 5 after a contact time of 240 min. EGCG and tea extracts showed an RF of 2 in methicillin-sensitive <i<S. aureus.</i< Extracts from green and black tea showed lower MICs than an aqueous solution with the same concentration of pure EGCG. To the best of our knowledge, we are the first to show a reduction of 99.999% of clinically isolated MRSA by green tea extract within 4 h.
abstractGer	Methicillin-resistant <i<Staphylococcus aureus</i< (MRSA) infections are still a major problem in hospitals. The excellent safety profile, accessibility and anti-infective activity of tea extracts make them promising agents for the treatment of infected wounds. To investigate the possibility of sterilising MRSA-infected surfaces, including skin with tea extracts, we determined the MICs for different extracts from green and black tea (<i<Camellia sinensis</i<), including epigallocatechin gallate (EGCG), on a large number of clinical isolates of MRSA, selected to represent a high genetic diversity. The extracts were prepared to achieve the maximal extraction of EGCG from tea and were used as stable lyophilisate with a defined EGCG content. All extracts showed a complete inhibition of cell growth at a concentration of approx. 80 µg/mL of EGCG after a contact time of 24 h. Time–kill plots were recorded for the extract with the highest amount of EGCG. The reduction factor (RF) was 5 after a contact time of 240 min. EGCG and tea extracts showed an RF of 2 in methicillin-sensitive <i<S. aureus.</i< Extracts from green and black tea showed lower MICs than an aqueous solution with the same concentration of pure EGCG. To the best of our knowledge, we are the first to show a reduction of 99.999% of clinically isolated MRSA by green tea extract within 4 h.
abstract_unstemmed	Methicillin-resistant <i<Staphylococcus aureus</i< (MRSA) infections are still a major problem in hospitals. The excellent safety profile, accessibility and anti-infective activity of tea extracts make them promising agents for the treatment of infected wounds. To investigate the possibility of sterilising MRSA-infected surfaces, including skin with tea extracts, we determined the MICs for different extracts from green and black tea (<i<Camellia sinensis</i<), including epigallocatechin gallate (EGCG), on a large number of clinical isolates of MRSA, selected to represent a high genetic diversity. The extracts were prepared to achieve the maximal extraction of EGCG from tea and were used as stable lyophilisate with a defined EGCG content. All extracts showed a complete inhibition of cell growth at a concentration of approx. 80 µg/mL of EGCG after a contact time of 24 h. Time–kill plots were recorded for the extract with the highest amount of EGCG. The reduction factor (RF) was 5 after a contact time of 240 min. EGCG and tea extracts showed an RF of 2 in methicillin-sensitive <i<S. aureus.</i< Extracts from green and black tea showed lower MICs than an aqueous solution with the same concentration of pure EGCG. To the best of our knowledge, we are the first to show a reduction of 99.999% of clinically isolated MRSA by green tea extract within 4 h.
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title_short	Antibacterial and Disinfecting Effects of Standardised Tea Extracts on More than 100 Clinical Isolates of Methicillin-Resistant <i<Staphylococcus aureus</i<
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Antibacterial and Disinfecting Effects of Standardised Tea Extracts on More than 100 Clinical Isolates of Methicillin-Resistant <i<Staphylococcus aureus</i<

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