Role of SIRT1 in Chemoresistant Leukemia

Leukemias of the AML, CML, and CLL types are the most common blood cancers worldwide, making them a major global public health problem. Furthermore, less than 24% of patients treated with conventional chemotherapy (low-risk patients) and 10–15% of patients ineligible for conventional chemotherapy (h...
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Autor*in:	Guadalupe Rosario Fajardo-Orduña [verfasserIn] Edgar Ledesma-Martínez [verfasserIn] Itzen Aguiñiga-Sanchez [verfasserIn] Benny Weiss-Steider [verfasserIn] Edelmiro Santiago-Osorio [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	sirtuins AML CML aberrant epigenetic

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 24(2023), 14470, p 14470
Übergeordnetes Werk:	volume:24 ; year:2023 ; number:14470, p 14470

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms241914470

Katalog-ID:	DOAJ093228430

Internformat


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allfields	10.3390/ijms241914470 doi (DE-627)DOAJ093228430 (DE-599)DOAJc4e290e4ad4844aca89bc4964f675422 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Guadalupe Rosario Fajardo-Orduña verfasserin aut Role of SIRT1 in Chemoresistant Leukemia 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Leukemias of the AML, CML, and CLL types are the most common blood cancers worldwide, making them a major global public health problem. Furthermore, less than 24% of patients treated with conventional chemotherapy (low-risk patients) and 10–15% of patients ineligible for conventional chemotherapy (high-risk patients) survive five years. The low levels of survival are mainly due to toxicity and resistance to chemotherapy or other medication, the latter leading to relapse of the disease, which is the main obstacle to the treatment of leukemia. Drug resistance may include different molecular mechanisms, among which epigenetic regulators are involved. Silent information regulator 2 homolog 1 (SIRT1) is an epigenetic factor belonging to the sirtuin (SIRT) family known to regulate aspects of chromatin biology, genome stability, and metabolism, both in homeostasis processes and in different diseases, including cancer. The regulatory functions of SIRT1 in different biological processes and molecular pathways are dependent on the type and stage of the neoplasia; thus, it may act as both an oncogenic and tumor suppressor factor and may also participate in drug resistance. In this review, we explore the role of SIRT1 in drug-resistant leukemia and its potential as a therapeutic target. sirtuins AML CML aberrant epigenetic Biology (General) Chemistry Edgar Ledesma-Martínez verfasserin aut Itzen Aguiñiga-Sanchez verfasserin aut Benny Weiss-Steider verfasserin aut Edelmiro Santiago-Osorio verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 14470, p 14470 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:14470, p 14470 https://doi.org/10.3390/ijms241914470 kostenfrei https://doaj.org/article/c4e290e4ad4844aca89bc4964f675422 kostenfrei https://www.mdpi.com/1422-0067/24/19/14470 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 14470, p 14470
spelling	10.3390/ijms241914470 doi (DE-627)DOAJ093228430 (DE-599)DOAJc4e290e4ad4844aca89bc4964f675422 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Guadalupe Rosario Fajardo-Orduña verfasserin aut Role of SIRT1 in Chemoresistant Leukemia 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Leukemias of the AML, CML, and CLL types are the most common blood cancers worldwide, making them a major global public health problem. Furthermore, less than 24% of patients treated with conventional chemotherapy (low-risk patients) and 10–15% of patients ineligible for conventional chemotherapy (high-risk patients) survive five years. The low levels of survival are mainly due to toxicity and resistance to chemotherapy or other medication, the latter leading to relapse of the disease, which is the main obstacle to the treatment of leukemia. Drug resistance may include different molecular mechanisms, among which epigenetic regulators are involved. Silent information regulator 2 homolog 1 (SIRT1) is an epigenetic factor belonging to the sirtuin (SIRT) family known to regulate aspects of chromatin biology, genome stability, and metabolism, both in homeostasis processes and in different diseases, including cancer. The regulatory functions of SIRT1 in different biological processes and molecular pathways are dependent on the type and stage of the neoplasia; thus, it may act as both an oncogenic and tumor suppressor factor and may also participate in drug resistance. In this review, we explore the role of SIRT1 in drug-resistant leukemia and its potential as a therapeutic target. sirtuins AML CML aberrant epigenetic Biology (General) Chemistry Edgar Ledesma-Martínez verfasserin aut Itzen Aguiñiga-Sanchez verfasserin aut Benny Weiss-Steider verfasserin aut Edelmiro Santiago-Osorio verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 14470, p 14470 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:14470, p 14470 https://doi.org/10.3390/ijms241914470 kostenfrei https://doaj.org/article/c4e290e4ad4844aca89bc4964f675422 kostenfrei https://www.mdpi.com/1422-0067/24/19/14470 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 14470, p 14470
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allfieldsGer	10.3390/ijms241914470 doi (DE-627)DOAJ093228430 (DE-599)DOAJc4e290e4ad4844aca89bc4964f675422 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Guadalupe Rosario Fajardo-Orduña verfasserin aut Role of SIRT1 in Chemoresistant Leukemia 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Leukemias of the AML, CML, and CLL types are the most common blood cancers worldwide, making them a major global public health problem. Furthermore, less than 24% of patients treated with conventional chemotherapy (low-risk patients) and 10–15% of patients ineligible for conventional chemotherapy (high-risk patients) survive five years. The low levels of survival are mainly due to toxicity and resistance to chemotherapy or other medication, the latter leading to relapse of the disease, which is the main obstacle to the treatment of leukemia. Drug resistance may include different molecular mechanisms, among which epigenetic regulators are involved. Silent information regulator 2 homolog 1 (SIRT1) is an epigenetic factor belonging to the sirtuin (SIRT) family known to regulate aspects of chromatin biology, genome stability, and metabolism, both in homeostasis processes and in different diseases, including cancer. The regulatory functions of SIRT1 in different biological processes and molecular pathways are dependent on the type and stage of the neoplasia; thus, it may act as both an oncogenic and tumor suppressor factor and may also participate in drug resistance. In this review, we explore the role of SIRT1 in drug-resistant leukemia and its potential as a therapeutic target. sirtuins AML CML aberrant epigenetic Biology (General) Chemistry Edgar Ledesma-Martínez verfasserin aut Itzen Aguiñiga-Sanchez verfasserin aut Benny Weiss-Steider verfasserin aut Edelmiro Santiago-Osorio verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 14470, p 14470 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:14470, p 14470 https://doi.org/10.3390/ijms241914470 kostenfrei https://doaj.org/article/c4e290e4ad4844aca89bc4964f675422 kostenfrei https://www.mdpi.com/1422-0067/24/19/14470 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 14470, p 14470
allfieldsSound	10.3390/ijms241914470 doi (DE-627)DOAJ093228430 (DE-599)DOAJc4e290e4ad4844aca89bc4964f675422 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Guadalupe Rosario Fajardo-Orduña verfasserin aut Role of SIRT1 in Chemoresistant Leukemia 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Leukemias of the AML, CML, and CLL types are the most common blood cancers worldwide, making them a major global public health problem. Furthermore, less than 24% of patients treated with conventional chemotherapy (low-risk patients) and 10–15% of patients ineligible for conventional chemotherapy (high-risk patients) survive five years. The low levels of survival are mainly due to toxicity and resistance to chemotherapy or other medication, the latter leading to relapse of the disease, which is the main obstacle to the treatment of leukemia. Drug resistance may include different molecular mechanisms, among which epigenetic regulators are involved. Silent information regulator 2 homolog 1 (SIRT1) is an epigenetic factor belonging to the sirtuin (SIRT) family known to regulate aspects of chromatin biology, genome stability, and metabolism, both in homeostasis processes and in different diseases, including cancer. The regulatory functions of SIRT1 in different biological processes and molecular pathways are dependent on the type and stage of the neoplasia; thus, it may act as both an oncogenic and tumor suppressor factor and may also participate in drug resistance. In this review, we explore the role of SIRT1 in drug-resistant leukemia and its potential as a therapeutic target. sirtuins AML CML aberrant epigenetic Biology (General) Chemistry Edgar Ledesma-Martínez verfasserin aut Itzen Aguiñiga-Sanchez verfasserin aut Benny Weiss-Steider verfasserin aut Edelmiro Santiago-Osorio verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 14470, p 14470 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:14470, p 14470 https://doi.org/10.3390/ijms241914470 kostenfrei https://doaj.org/article/c4e290e4ad4844aca89bc4964f675422 kostenfrei https://www.mdpi.com/1422-0067/24/19/14470 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 14470, p 14470
language	English
source	In International Journal of Molecular Sciences 24(2023), 14470, p 14470 volume:24 year:2023 number:14470, p 14470
sourceStr	In International Journal of Molecular Sciences 24(2023), 14470, p 14470 volume:24 year:2023 number:14470, p 14470
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topic_facet	sirtuins AML CML aberrant epigenetic Biology (General) Chemistry
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container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Guadalupe Rosario Fajardo-Orduña @@aut@@ Edgar Ledesma-Martínez @@aut@@ Itzen Aguiñiga-Sanchez @@aut@@ Benny Weiss-Steider @@aut@@ Edelmiro Santiago-Osorio @@aut@@
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callnumber-first	Q - Science
author	Guadalupe Rosario Fajardo-Orduña
spellingShingle	Guadalupe Rosario Fajardo-Orduña misc QH301-705.5 misc QD1-999 misc sirtuins misc AML misc CML misc aberrant epigenetic misc Biology (General) misc Chemistry Role of SIRT1 in Chemoresistant Leukemia
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title	Role of SIRT1 in Chemoresistant Leukemia
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title_full	Role of SIRT1 in Chemoresistant Leukemia
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title_sort	role of sirt1 in chemoresistant leukemia
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title_auth	Role of SIRT1 in Chemoresistant Leukemia
abstract	Leukemias of the AML, CML, and CLL types are the most common blood cancers worldwide, making them a major global public health problem. Furthermore, less than 24% of patients treated with conventional chemotherapy (low-risk patients) and 10–15% of patients ineligible for conventional chemotherapy (high-risk patients) survive five years. The low levels of survival are mainly due to toxicity and resistance to chemotherapy or other medication, the latter leading to relapse of the disease, which is the main obstacle to the treatment of leukemia. Drug resistance may include different molecular mechanisms, among which epigenetic regulators are involved. Silent information regulator 2 homolog 1 (SIRT1) is an epigenetic factor belonging to the sirtuin (SIRT) family known to regulate aspects of chromatin biology, genome stability, and metabolism, both in homeostasis processes and in different diseases, including cancer. The regulatory functions of SIRT1 in different biological processes and molecular pathways are dependent on the type and stage of the neoplasia; thus, it may act as both an oncogenic and tumor suppressor factor and may also participate in drug resistance. In this review, we explore the role of SIRT1 in drug-resistant leukemia and its potential as a therapeutic target.
abstractGer	Leukemias of the AML, CML, and CLL types are the most common blood cancers worldwide, making them a major global public health problem. Furthermore, less than 24% of patients treated with conventional chemotherapy (low-risk patients) and 10–15% of patients ineligible for conventional chemotherapy (high-risk patients) survive five years. The low levels of survival are mainly due to toxicity and resistance to chemotherapy or other medication, the latter leading to relapse of the disease, which is the main obstacle to the treatment of leukemia. Drug resistance may include different molecular mechanisms, among which epigenetic regulators are involved. Silent information regulator 2 homolog 1 (SIRT1) is an epigenetic factor belonging to the sirtuin (SIRT) family known to regulate aspects of chromatin biology, genome stability, and metabolism, both in homeostasis processes and in different diseases, including cancer. The regulatory functions of SIRT1 in different biological processes and molecular pathways are dependent on the type and stage of the neoplasia; thus, it may act as both an oncogenic and tumor suppressor factor and may also participate in drug resistance. In this review, we explore the role of SIRT1 in drug-resistant leukemia and its potential as a therapeutic target.
abstract_unstemmed	Leukemias of the AML, CML, and CLL types are the most common blood cancers worldwide, making them a major global public health problem. Furthermore, less than 24% of patients treated with conventional chemotherapy (low-risk patients) and 10–15% of patients ineligible for conventional chemotherapy (high-risk patients) survive five years. The low levels of survival are mainly due to toxicity and resistance to chemotherapy or other medication, the latter leading to relapse of the disease, which is the main obstacle to the treatment of leukemia. Drug resistance may include different molecular mechanisms, among which epigenetic regulators are involved. Silent information regulator 2 homolog 1 (SIRT1) is an epigenetic factor belonging to the sirtuin (SIRT) family known to regulate aspects of chromatin biology, genome stability, and metabolism, both in homeostasis processes and in different diseases, including cancer. The regulatory functions of SIRT1 in different biological processes and molecular pathways are dependent on the type and stage of the neoplasia; thus, it may act as both an oncogenic and tumor suppressor factor and may also participate in drug resistance. In this review, we explore the role of SIRT1 in drug-resistant leukemia and its potential as a therapeutic target.
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title_short	Role of SIRT1 in Chemoresistant Leukemia
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up_date	2024-07-03T16:02:51.810Z
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Role of SIRT1 in Chemoresistant Leukemia

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