Killer Cell Immunoglobulin-like Receptor Genotypes and Reproductive Outcomes in a Group of Infertile Women: A Romanian Study

A growing body of evidence suggests that endometrial immune disorders may be responsible for endometrial dysfunctions that can lead to gynecological and obstetrical pathology. The aim of this study was to explore the potential relationship between different killer cell immunoglobulin-like receptor (...
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Gespeichert in:

Autor*in:	Mihai Surcel [verfasserIn] Iulia Adina Neamtiu [verfasserIn] Daniel Muresan [verfasserIn] Iulian Goidescu [verfasserIn] Adelina Staicu [verfasserIn] Monica Mihaela Marta [verfasserIn] Georgiana Nemeti [verfasserIn] Radu Harsa [verfasserIn] Bogdan Doroftei [verfasserIn] Mihai Emil Capilna [verfasserIn] Gabriela Caracostea [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	endometrium disorder killer cell immunoglobulin-like receptor polymorphism infertility NK cells Romania

Übergeordnetes Werk:	In: Diagnostics - MDPI AG, 2012, 13(2023), 3048, p 3048
Übergeordnetes Werk:	volume:13 ; year:2023 ; number:3048, p 3048

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/diagnostics13193048

Katalog-ID:	DOAJ093237723

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allfields	10.3390/diagnostics13193048 doi (DE-627)DOAJ093237723 (DE-599)DOAJ220a56ffe2e840a8a93471ddf86934d8 DE-627 ger DE-627 rakwb eng R5-920 Mihai Surcel verfasserin aut Killer Cell Immunoglobulin-like Receptor Genotypes and Reproductive Outcomes in a Group of Infertile Women: A Romanian Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A growing body of evidence suggests that endometrial immune disorders may be responsible for endometrial dysfunctions that can lead to gynecological and obstetrical pathology. The aim of this study was to explore the potential relationship between different killer cell immunoglobulin-like receptor (KIR) genotypes and reproductive outcomes. We conducted a prospective cohort study that included 104 infertile patients undergoing an in vitro fertilization procedure. All participants underwent clinical and ultrasound examination, genetic evaluation (KIR genotyping), endometrial washing fluid sampling for cytokine determination, endometrial tissue sampling for histologic assessment and hysteroscopic evaluation. Our analysis showed statistically significant lower levels of uterine cytokines TNF-α (<i<p</i< = 0.001) and IL-1beta (<i<p</i< = 0.000) in the KIR AA genotype group as compared to KIR AB and BB among study participants with chronic endometritis. The study results suggest that the KIR AA genotype population subgroups may be more susceptible to developing endometrial disorders such as chronic endometritis. The changes in the behavior of NK cells seem to be subtle and expressed as an altered regulatory pattern. endometrium disorder killer cell immunoglobulin-like receptor polymorphism infertility NK cells Romania Medicine (General) Iulia Adina Neamtiu verfasserin aut Daniel Muresan verfasserin aut Iulian Goidescu verfasserin aut Adelina Staicu verfasserin aut Monica Mihaela Marta verfasserin aut Georgiana Nemeti verfasserin aut Radu Harsa verfasserin aut Bogdan Doroftei verfasserin aut Mihai Emil Capilna verfasserin aut Gabriela Caracostea verfasserin aut In Diagnostics MDPI AG, 2012 13(2023), 3048, p 3048 (DE-627)718627814 (DE-600)2662336-5 20754418 nnns volume:13 year:2023 number:3048, p 3048 https://doi.org/10.3390/diagnostics13193048 kostenfrei https://doaj.org/article/220a56ffe2e840a8a93471ddf86934d8 kostenfrei https://www.mdpi.com/2075-4418/13/19/3048 kostenfrei https://doaj.org/toc/2075-4418 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 3048, p 3048
spelling	10.3390/diagnostics13193048 doi (DE-627)DOAJ093237723 (DE-599)DOAJ220a56ffe2e840a8a93471ddf86934d8 DE-627 ger DE-627 rakwb eng R5-920 Mihai Surcel verfasserin aut Killer Cell Immunoglobulin-like Receptor Genotypes and Reproductive Outcomes in a Group of Infertile Women: A Romanian Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A growing body of evidence suggests that endometrial immune disorders may be responsible for endometrial dysfunctions that can lead to gynecological and obstetrical pathology. The aim of this study was to explore the potential relationship between different killer cell immunoglobulin-like receptor (KIR) genotypes and reproductive outcomes. We conducted a prospective cohort study that included 104 infertile patients undergoing an in vitro fertilization procedure. All participants underwent clinical and ultrasound examination, genetic evaluation (KIR genotyping), endometrial washing fluid sampling for cytokine determination, endometrial tissue sampling for histologic assessment and hysteroscopic evaluation. Our analysis showed statistically significant lower levels of uterine cytokines TNF-α (<i<p</i< = 0.001) and IL-1beta (<i<p</i< = 0.000) in the KIR AA genotype group as compared to KIR AB and BB among study participants with chronic endometritis. The study results suggest that the KIR AA genotype population subgroups may be more susceptible to developing endometrial disorders such as chronic endometritis. The changes in the behavior of NK cells seem to be subtle and expressed as an altered regulatory pattern. endometrium disorder killer cell immunoglobulin-like receptor polymorphism infertility NK cells Romania Medicine (General) Iulia Adina Neamtiu verfasserin aut Daniel Muresan verfasserin aut Iulian Goidescu verfasserin aut Adelina Staicu verfasserin aut Monica Mihaela Marta verfasserin aut Georgiana Nemeti verfasserin aut Radu Harsa verfasserin aut Bogdan Doroftei verfasserin aut Mihai Emil Capilna verfasserin aut Gabriela Caracostea verfasserin aut In Diagnostics MDPI AG, 2012 13(2023), 3048, p 3048 (DE-627)718627814 (DE-600)2662336-5 20754418 nnns volume:13 year:2023 number:3048, p 3048 https://doi.org/10.3390/diagnostics13193048 kostenfrei https://doaj.org/article/220a56ffe2e840a8a93471ddf86934d8 kostenfrei https://www.mdpi.com/2075-4418/13/19/3048 kostenfrei https://doaj.org/toc/2075-4418 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 3048, p 3048
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allfieldsGer	10.3390/diagnostics13193048 doi (DE-627)DOAJ093237723 (DE-599)DOAJ220a56ffe2e840a8a93471ddf86934d8 DE-627 ger DE-627 rakwb eng R5-920 Mihai Surcel verfasserin aut Killer Cell Immunoglobulin-like Receptor Genotypes and Reproductive Outcomes in a Group of Infertile Women: A Romanian Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A growing body of evidence suggests that endometrial immune disorders may be responsible for endometrial dysfunctions that can lead to gynecological and obstetrical pathology. The aim of this study was to explore the potential relationship between different killer cell immunoglobulin-like receptor (KIR) genotypes and reproductive outcomes. We conducted a prospective cohort study that included 104 infertile patients undergoing an in vitro fertilization procedure. All participants underwent clinical and ultrasound examination, genetic evaluation (KIR genotyping), endometrial washing fluid sampling for cytokine determination, endometrial tissue sampling for histologic assessment and hysteroscopic evaluation. Our analysis showed statistically significant lower levels of uterine cytokines TNF-α (<i<p</i< = 0.001) and IL-1beta (<i<p</i< = 0.000) in the KIR AA genotype group as compared to KIR AB and BB among study participants with chronic endometritis. The study results suggest that the KIR AA genotype population subgroups may be more susceptible to developing endometrial disorders such as chronic endometritis. The changes in the behavior of NK cells seem to be subtle and expressed as an altered regulatory pattern. endometrium disorder killer cell immunoglobulin-like receptor polymorphism infertility NK cells Romania Medicine (General) Iulia Adina Neamtiu verfasserin aut Daniel Muresan verfasserin aut Iulian Goidescu verfasserin aut Adelina Staicu verfasserin aut Monica Mihaela Marta verfasserin aut Georgiana Nemeti verfasserin aut Radu Harsa verfasserin aut Bogdan Doroftei verfasserin aut Mihai Emil Capilna verfasserin aut Gabriela Caracostea verfasserin aut In Diagnostics MDPI AG, 2012 13(2023), 3048, p 3048 (DE-627)718627814 (DE-600)2662336-5 20754418 nnns volume:13 year:2023 number:3048, p 3048 https://doi.org/10.3390/diagnostics13193048 kostenfrei https://doaj.org/article/220a56ffe2e840a8a93471ddf86934d8 kostenfrei https://www.mdpi.com/2075-4418/13/19/3048 kostenfrei https://doaj.org/toc/2075-4418 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 3048, p 3048
allfieldsSound	10.3390/diagnostics13193048 doi (DE-627)DOAJ093237723 (DE-599)DOAJ220a56ffe2e840a8a93471ddf86934d8 DE-627 ger DE-627 rakwb eng R5-920 Mihai Surcel verfasserin aut Killer Cell Immunoglobulin-like Receptor Genotypes and Reproductive Outcomes in a Group of Infertile Women: A Romanian Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A growing body of evidence suggests that endometrial immune disorders may be responsible for endometrial dysfunctions that can lead to gynecological and obstetrical pathology. The aim of this study was to explore the potential relationship between different killer cell immunoglobulin-like receptor (KIR) genotypes and reproductive outcomes. We conducted a prospective cohort study that included 104 infertile patients undergoing an in vitro fertilization procedure. All participants underwent clinical and ultrasound examination, genetic evaluation (KIR genotyping), endometrial washing fluid sampling for cytokine determination, endometrial tissue sampling for histologic assessment and hysteroscopic evaluation. Our analysis showed statistically significant lower levels of uterine cytokines TNF-α (<i<p</i< = 0.001) and IL-1beta (<i<p</i< = 0.000) in the KIR AA genotype group as compared to KIR AB and BB among study participants with chronic endometritis. The study results suggest that the KIR AA genotype population subgroups may be more susceptible to developing endometrial disorders such as chronic endometritis. The changes in the behavior of NK cells seem to be subtle and expressed as an altered regulatory pattern. endometrium disorder killer cell immunoglobulin-like receptor polymorphism infertility NK cells Romania Medicine (General) Iulia Adina Neamtiu verfasserin aut Daniel Muresan verfasserin aut Iulian Goidescu verfasserin aut Adelina Staicu verfasserin aut Monica Mihaela Marta verfasserin aut Georgiana Nemeti verfasserin aut Radu Harsa verfasserin aut Bogdan Doroftei verfasserin aut Mihai Emil Capilna verfasserin aut Gabriela Caracostea verfasserin aut In Diagnostics MDPI AG, 2012 13(2023), 3048, p 3048 (DE-627)718627814 (DE-600)2662336-5 20754418 nnns volume:13 year:2023 number:3048, p 3048 https://doi.org/10.3390/diagnostics13193048 kostenfrei https://doaj.org/article/220a56ffe2e840a8a93471ddf86934d8 kostenfrei https://www.mdpi.com/2075-4418/13/19/3048 kostenfrei https://doaj.org/toc/2075-4418 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 3048, p 3048
language	English
source	In Diagnostics 13(2023), 3048, p 3048 volume:13 year:2023 number:3048, p 3048
sourceStr	In Diagnostics 13(2023), 3048, p 3048 volume:13 year:2023 number:3048, p 3048
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topic_facet	endometrium disorder killer cell immunoglobulin-like receptor polymorphism infertility NK cells Romania Medicine (General)
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authorswithroles_txt_mv	Mihai Surcel @@aut@@ Iulia Adina Neamtiu @@aut@@ Daniel Muresan @@aut@@ Iulian Goidescu @@aut@@ Adelina Staicu @@aut@@ Monica Mihaela Marta @@aut@@ Georgiana Nemeti @@aut@@ Radu Harsa @@aut@@ Bogdan Doroftei @@aut@@ Mihai Emil Capilna @@aut@@ Gabriela Caracostea @@aut@@
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callnumber-first	R - Medicine
author	Mihai Surcel
spellingShingle	Mihai Surcel misc R5-920 misc endometrium disorder misc killer cell immunoglobulin-like receptor polymorphism misc infertility misc NK cells misc Romania misc Medicine (General) Killer Cell Immunoglobulin-like Receptor Genotypes and Reproductive Outcomes in a Group of Infertile Women: A Romanian Study
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topic_title	R5-920 Killer Cell Immunoglobulin-like Receptor Genotypes and Reproductive Outcomes in a Group of Infertile Women: A Romanian Study endometrium disorder killer cell immunoglobulin-like receptor polymorphism infertility NK cells Romania
topic	misc R5-920 misc endometrium disorder misc killer cell immunoglobulin-like receptor polymorphism misc infertility misc NK cells misc Romania misc Medicine (General)
topic_unstemmed	misc R5-920 misc endometrium disorder misc killer cell immunoglobulin-like receptor polymorphism misc infertility misc NK cells misc Romania misc Medicine (General)
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title	Killer Cell Immunoglobulin-like Receptor Genotypes and Reproductive Outcomes in a Group of Infertile Women: A Romanian Study
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title_full	Killer Cell Immunoglobulin-like Receptor Genotypes and Reproductive Outcomes in a Group of Infertile Women: A Romanian Study
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author_browse	Mihai Surcel Iulia Adina Neamtiu Daniel Muresan Iulian Goidescu Adelina Staicu Monica Mihaela Marta Georgiana Nemeti Radu Harsa Bogdan Doroftei Mihai Emil Capilna Gabriela Caracostea
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title_sort	killer cell immunoglobulin-like receptor genotypes and reproductive outcomes in a group of infertile women: a romanian study
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title_auth	Killer Cell Immunoglobulin-like Receptor Genotypes and Reproductive Outcomes in a Group of Infertile Women: A Romanian Study
abstract	A growing body of evidence suggests that endometrial immune disorders may be responsible for endometrial dysfunctions that can lead to gynecological and obstetrical pathology. The aim of this study was to explore the potential relationship between different killer cell immunoglobulin-like receptor (KIR) genotypes and reproductive outcomes. We conducted a prospective cohort study that included 104 infertile patients undergoing an in vitro fertilization procedure. All participants underwent clinical and ultrasound examination, genetic evaluation (KIR genotyping), endometrial washing fluid sampling for cytokine determination, endometrial tissue sampling for histologic assessment and hysteroscopic evaluation. Our analysis showed statistically significant lower levels of uterine cytokines TNF-α (<i<p</i< = 0.001) and IL-1beta (<i<p</i< = 0.000) in the KIR AA genotype group as compared to KIR AB and BB among study participants with chronic endometritis. The study results suggest that the KIR AA genotype population subgroups may be more susceptible to developing endometrial disorders such as chronic endometritis. The changes in the behavior of NK cells seem to be subtle and expressed as an altered regulatory pattern.
abstractGer	A growing body of evidence suggests that endometrial immune disorders may be responsible for endometrial dysfunctions that can lead to gynecological and obstetrical pathology. The aim of this study was to explore the potential relationship between different killer cell immunoglobulin-like receptor (KIR) genotypes and reproductive outcomes. We conducted a prospective cohort study that included 104 infertile patients undergoing an in vitro fertilization procedure. All participants underwent clinical and ultrasound examination, genetic evaluation (KIR genotyping), endometrial washing fluid sampling for cytokine determination, endometrial tissue sampling for histologic assessment and hysteroscopic evaluation. Our analysis showed statistically significant lower levels of uterine cytokines TNF-α (<i<p</i< = 0.001) and IL-1beta (<i<p</i< = 0.000) in the KIR AA genotype group as compared to KIR AB and BB among study participants with chronic endometritis. The study results suggest that the KIR AA genotype population subgroups may be more susceptible to developing endometrial disorders such as chronic endometritis. The changes in the behavior of NK cells seem to be subtle and expressed as an altered regulatory pattern.
abstract_unstemmed	A growing body of evidence suggests that endometrial immune disorders may be responsible for endometrial dysfunctions that can lead to gynecological and obstetrical pathology. The aim of this study was to explore the potential relationship between different killer cell immunoglobulin-like receptor (KIR) genotypes and reproductive outcomes. We conducted a prospective cohort study that included 104 infertile patients undergoing an in vitro fertilization procedure. All participants underwent clinical and ultrasound examination, genetic evaluation (KIR genotyping), endometrial washing fluid sampling for cytokine determination, endometrial tissue sampling for histologic assessment and hysteroscopic evaluation. Our analysis showed statistically significant lower levels of uterine cytokines TNF-α (<i<p</i< = 0.001) and IL-1beta (<i<p</i< = 0.000) in the KIR AA genotype group as compared to KIR AB and BB among study participants with chronic endometritis. The study results suggest that the KIR AA genotype population subgroups may be more susceptible to developing endometrial disorders such as chronic endometritis. The changes in the behavior of NK cells seem to be subtle and expressed as an altered regulatory pattern.
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title_short	Killer Cell Immunoglobulin-like Receptor Genotypes and Reproductive Outcomes in a Group of Infertile Women: A Romanian Study
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