The Site of Origin of Medulloblastoma: Surgical Observations Correlated to Molecular Groups

Developmental gene expression data from medulloblastoma (MB) suggest that WNT-MB originates from the region of the embryonic lower rhombic lip (LRL), whereas SHH-MB and non-WNT/non-SHH MB arise from cerebellar precursor matrix regions. This study aimed to analyze detailed intraoperative data with re...
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Gespeichert in:

Autor*in:	Olga Ciobanu-Caraus [verfasserIn] Thomas Czech [verfasserIn] Andreas Peyrl [verfasserIn] Christine Haberler [verfasserIn] Gregor Kasprian [verfasserIn] Julia Furtner [verfasserIn] Marcel Kool [verfasserIn] Martin Sill [verfasserIn] Josa M. Frischer [verfasserIn] Anna Cho [verfasserIn] Irene Slavc [verfasserIn] Karl Rössler [verfasserIn] Johannes Gojo [verfasserIn] Christian Dorfer [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	MB origin molecular group neurosurgery

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 15(2023), 4877, p 4877
Übergeordnetes Werk:	volume:15 ; year:2023 ; number:4877, p 4877

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers15194877

Katalog-ID:	DOAJ09323919X

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520			\|a Developmental gene expression data from medulloblastoma (MB) suggest that WNT-MB originates from the region of the embryonic lower rhombic lip (LRL), whereas SHH-MB and non-WNT/non-SHH MB arise from cerebellar precursor matrix regions. This study aimed to analyze detailed intraoperative data with regard to the site of origin (STO) and compare these findings with the hypothesized regions of origin associated with the molecular group. A review of the institutional database identified 58 out of 72 pediatric patients who were operated for an MB at our department between 1996 and 2020 that had a detailed operative report and a surgical video as well as clinical and genetic classification data available for analysis. The STO was assessed based on intraoperative findings. Using the intraoperatively defined STO, “correct” prediction of molecular groups was feasible in 20% of WNT-MB, 60% of SHH-MB and 71% of non-WNT/non-SHH MB. The positive predictive values of the neurosurgical inspection to detect the molecular group were 0.21 (95% CI 0.08–0.48) for WNT-MB, 0.86 (95% CI 0.49–0.97) for SHH-MB and 0.73 (95% CI 0.57–0.85) for non-WNT/non-SHH MB. The present study demonstrated a limited predictive value of the intraoperatively observed STO for the prediction of the molecular group of MB.
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allfieldsSound	10.3390/cancers15194877 doi (DE-627)DOAJ09323919X (DE-599)DOAJ8e683815539744f2b134cdcde62b38ec DE-627 ger DE-627 rakwb eng RC254-282 Olga Ciobanu-Caraus verfasserin aut The Site of Origin of Medulloblastoma: Surgical Observations Correlated to Molecular Groups 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Developmental gene expression data from medulloblastoma (MB) suggest that WNT-MB originates from the region of the embryonic lower rhombic lip (LRL), whereas SHH-MB and non-WNT/non-SHH MB arise from cerebellar precursor matrix regions. This study aimed to analyze detailed intraoperative data with regard to the site of origin (STO) and compare these findings with the hypothesized regions of origin associated with the molecular group. A review of the institutional database identified 58 out of 72 pediatric patients who were operated for an MB at our department between 1996 and 2020 that had a detailed operative report and a surgical video as well as clinical and genetic classification data available for analysis. The STO was assessed based on intraoperative findings. Using the intraoperatively defined STO, “correct” prediction of molecular groups was feasible in 20% of WNT-MB, 60% of SHH-MB and 71% of non-WNT/non-SHH MB. The positive predictive values of the neurosurgical inspection to detect the molecular group were 0.21 (95% CI 0.08–0.48) for WNT-MB, 0.86 (95% CI 0.49–0.97) for SHH-MB and 0.73 (95% CI 0.57–0.85) for non-WNT/non-SHH MB. The present study demonstrated a limited predictive value of the intraoperatively observed STO for the prediction of the molecular group of MB. MB origin molecular group neurosurgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens Thomas Czech verfasserin aut Andreas Peyrl verfasserin aut Christine Haberler verfasserin aut Gregor Kasprian verfasserin aut Julia Furtner verfasserin aut Marcel Kool verfasserin aut Martin Sill verfasserin aut Josa M. Frischer verfasserin aut Anna Cho verfasserin aut Irene Slavc verfasserin aut Karl Rössler verfasserin aut Johannes Gojo verfasserin aut Christian Dorfer verfasserin aut In Cancers MDPI AG, 2010 15(2023), 4877, p 4877 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:4877, p 4877 https://doi.org/10.3390/cancers15194877 kostenfrei https://doaj.org/article/8e683815539744f2b134cdcde62b38ec kostenfrei https://www.mdpi.com/2072-6694/15/19/4877 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 4877, p 4877
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author	Olga Ciobanu-Caraus
spellingShingle	Olga Ciobanu-Caraus misc RC254-282 misc MB misc origin misc molecular group misc neurosurgery misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens The Site of Origin of Medulloblastoma: Surgical Observations Correlated to Molecular Groups
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topic_title	RC254-282 The Site of Origin of Medulloblastoma: Surgical Observations Correlated to Molecular Groups MB origin molecular group neurosurgery
topic	misc RC254-282 misc MB misc origin misc molecular group misc neurosurgery misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	The Site of Origin of Medulloblastoma: Surgical Observations Correlated to Molecular Groups
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title_sort	site of origin of medulloblastoma: surgical observations correlated to molecular groups
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title_auth	The Site of Origin of Medulloblastoma: Surgical Observations Correlated to Molecular Groups
abstract	Developmental gene expression data from medulloblastoma (MB) suggest that WNT-MB originates from the region of the embryonic lower rhombic lip (LRL), whereas SHH-MB and non-WNT/non-SHH MB arise from cerebellar precursor matrix regions. This study aimed to analyze detailed intraoperative data with regard to the site of origin (STO) and compare these findings with the hypothesized regions of origin associated with the molecular group. A review of the institutional database identified 58 out of 72 pediatric patients who were operated for an MB at our department between 1996 and 2020 that had a detailed operative report and a surgical video as well as clinical and genetic classification data available for analysis. The STO was assessed based on intraoperative findings. Using the intraoperatively defined STO, “correct” prediction of molecular groups was feasible in 20% of WNT-MB, 60% of SHH-MB and 71% of non-WNT/non-SHH MB. The positive predictive values of the neurosurgical inspection to detect the molecular group were 0.21 (95% CI 0.08–0.48) for WNT-MB, 0.86 (95% CI 0.49–0.97) for SHH-MB and 0.73 (95% CI 0.57–0.85) for non-WNT/non-SHH MB. The present study demonstrated a limited predictive value of the intraoperatively observed STO for the prediction of the molecular group of MB.
abstractGer	Developmental gene expression data from medulloblastoma (MB) suggest that WNT-MB originates from the region of the embryonic lower rhombic lip (LRL), whereas SHH-MB and non-WNT/non-SHH MB arise from cerebellar precursor matrix regions. This study aimed to analyze detailed intraoperative data with regard to the site of origin (STO) and compare these findings with the hypothesized regions of origin associated with the molecular group. A review of the institutional database identified 58 out of 72 pediatric patients who were operated for an MB at our department between 1996 and 2020 that had a detailed operative report and a surgical video as well as clinical and genetic classification data available for analysis. The STO was assessed based on intraoperative findings. Using the intraoperatively defined STO, “correct” prediction of molecular groups was feasible in 20% of WNT-MB, 60% of SHH-MB and 71% of non-WNT/non-SHH MB. The positive predictive values of the neurosurgical inspection to detect the molecular group were 0.21 (95% CI 0.08–0.48) for WNT-MB, 0.86 (95% CI 0.49–0.97) for SHH-MB and 0.73 (95% CI 0.57–0.85) for non-WNT/non-SHH MB. The present study demonstrated a limited predictive value of the intraoperatively observed STO for the prediction of the molecular group of MB.
abstract_unstemmed	Developmental gene expression data from medulloblastoma (MB) suggest that WNT-MB originates from the region of the embryonic lower rhombic lip (LRL), whereas SHH-MB and non-WNT/non-SHH MB arise from cerebellar precursor matrix regions. This study aimed to analyze detailed intraoperative data with regard to the site of origin (STO) and compare these findings with the hypothesized regions of origin associated with the molecular group. A review of the institutional database identified 58 out of 72 pediatric patients who were operated for an MB at our department between 1996 and 2020 that had a detailed operative report and a surgical video as well as clinical and genetic classification data available for analysis. The STO was assessed based on intraoperative findings. Using the intraoperatively defined STO, “correct” prediction of molecular groups was feasible in 20% of WNT-MB, 60% of SHH-MB and 71% of non-WNT/non-SHH MB. The positive predictive values of the neurosurgical inspection to detect the molecular group were 0.21 (95% CI 0.08–0.48) for WNT-MB, 0.86 (95% CI 0.49–0.97) for SHH-MB and 0.73 (95% CI 0.57–0.85) for non-WNT/non-SHH MB. The present study demonstrated a limited predictive value of the intraoperatively observed STO for the prediction of the molecular group of MB.
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The Site of Origin of Medulloblastoma: Surgical Observations Correlated to Molecular Groups

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