Protective Effects of Gnetin C from Melinjo Seed Extract against High-Fat Diet-Induced Hepatic Steatosis and Liver Fibrosis in NAFLD Mice Model

Nonalcoholic fatty liver disease (NAFLD), the most common form of chronic liver disease, can progress to hepatic steatosis, inflammation, and advanced fibrosis, increasing the risk of cirrhosis. Resveratrol, a natural polyphenol with antioxidant and anti-inflammatory properties, is beneficial in tre...
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Autor*in:	Tohfa Kabir [verfasserIn] Haruki Yoshiba [verfasserIn] Afifah Zahra Agista [verfasserIn] Halima Sultana [verfasserIn] Yusuke Ohsaki [verfasserIn] Chiu-Li Yeh [verfasserIn] Ryota Hirakawa [verfasserIn] Hiroko Tani [verfasserIn] Tomoki Ikuta [verfasserIn] Tomonori Nochi [verfasserIn] Suh-Ching Yang [verfasserIn] Hitoshi Shirakawa [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	NAFLD resveratrol gnetin C hepatic fibrosis hepatic steatosis

Übergeordnetes Werk:	In: Nutrients - MDPI AG, 2009, 15(2023), 3888, p 3888
Übergeordnetes Werk:	volume:15 ; year:2023 ; number:3888, p 3888

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/nu15183888

Katalog-ID:	DOAJ093331509

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520			\|a Nonalcoholic fatty liver disease (NAFLD), the most common form of chronic liver disease, can progress to hepatic steatosis, inflammation, and advanced fibrosis, increasing the risk of cirrhosis. Resveratrol, a natural polyphenol with antioxidant and anti-inflammatory properties, is beneficial in treating multiple metabolic diseases. Gnetin C, a resveratrol derivative obtained from Melinjo seed extract (MSE), shares similar health-promoting properties. We investigated the role of gnetin C in preventing NAFLD in a mouse model and compared it with resveratrol. Male C57BL/6J mice were fed a control diet (10% calories from fat), a high-fat choline-deficient (HFCD) diet (46% calories from fat) and HFCD diet supplemented with gnetin C (150 mg/kg BW·day<sup<−1</sup<) or resveratrol (150 mg/kg BW·day<sup<−1</sup<) for 12 weeks. Gnetin C supplementation reduced body and liver weight, and improved blood glucose levels and insulin sensitivity. Both gnetin C- and resveratrol reduced hepatic steatosis, with gnetin C also decreasing liver lipid content. Gnetin C and resveratrol ameliorated HFCD diet-induced hepatic fibrosis. The mRNA expression results, and western blot analyses showed that gnetin C and, to some extent, resveratrol downregulated fibrosis markers in the TGF-β1 signaling pathway, indicating a possible safeguarding mechanism against NAFLD. These results suggest that gnetin C supplementation may protect against lipid deposition and hepatic fibrosis.
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allfields	10.3390/nu15183888 doi (DE-627)DOAJ093331509 (DE-599)DOAJ45c3c0d6627345708f85e5c3615a97d8 DE-627 ger DE-627 rakwb eng TX341-641 Tohfa Kabir verfasserin aut Protective Effects of Gnetin C from Melinjo Seed Extract against High-Fat Diet-Induced Hepatic Steatosis and Liver Fibrosis in NAFLD Mice Model 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nonalcoholic fatty liver disease (NAFLD), the most common form of chronic liver disease, can progress to hepatic steatosis, inflammation, and advanced fibrosis, increasing the risk of cirrhosis. Resveratrol, a natural polyphenol with antioxidant and anti-inflammatory properties, is beneficial in treating multiple metabolic diseases. Gnetin C, a resveratrol derivative obtained from Melinjo seed extract (MSE), shares similar health-promoting properties. We investigated the role of gnetin C in preventing NAFLD in a mouse model and compared it with resveratrol. Male C57BL/6J mice were fed a control diet (10% calories from fat), a high-fat choline-deficient (HFCD) diet (46% calories from fat) and HFCD diet supplemented with gnetin C (150 mg/kg BW·day<sup<−1</sup<) or resveratrol (150 mg/kg BW·day<sup<−1</sup<) for 12 weeks. Gnetin C supplementation reduced body and liver weight, and improved blood glucose levels and insulin sensitivity. Both gnetin C- and resveratrol reduced hepatic steatosis, with gnetin C also decreasing liver lipid content. Gnetin C and resveratrol ameliorated HFCD diet-induced hepatic fibrosis. The mRNA expression results, and western blot analyses showed that gnetin C and, to some extent, resveratrol downregulated fibrosis markers in the TGF-β1 signaling pathway, indicating a possible safeguarding mechanism against NAFLD. These results suggest that gnetin C supplementation may protect against lipid deposition and hepatic fibrosis. NAFLD resveratrol gnetin C hepatic fibrosis hepatic steatosis Nutrition. Foods and food supply Haruki Yoshiba verfasserin aut Afifah Zahra Agista verfasserin aut Halima Sultana verfasserin aut Yusuke Ohsaki verfasserin aut Chiu-Li Yeh verfasserin aut Ryota Hirakawa verfasserin aut Hiroko Tani verfasserin aut Tomoki Ikuta verfasserin aut Tomonori Nochi verfasserin aut Suh-Ching Yang verfasserin aut Hitoshi Shirakawa verfasserin aut In Nutrients MDPI AG, 2009 15(2023), 3888, p 3888 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:15 year:2023 number:3888, p 3888 https://doi.org/10.3390/nu15183888 kostenfrei https://doaj.org/article/45c3c0d6627345708f85e5c3615a97d8 kostenfrei https://www.mdpi.com/2072-6643/15/18/3888 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 3888, p 3888
spelling	10.3390/nu15183888 doi (DE-627)DOAJ093331509 (DE-599)DOAJ45c3c0d6627345708f85e5c3615a97d8 DE-627 ger DE-627 rakwb eng TX341-641 Tohfa Kabir verfasserin aut Protective Effects of Gnetin C from Melinjo Seed Extract against High-Fat Diet-Induced Hepatic Steatosis and Liver Fibrosis in NAFLD Mice Model 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nonalcoholic fatty liver disease (NAFLD), the most common form of chronic liver disease, can progress to hepatic steatosis, inflammation, and advanced fibrosis, increasing the risk of cirrhosis. Resveratrol, a natural polyphenol with antioxidant and anti-inflammatory properties, is beneficial in treating multiple metabolic diseases. Gnetin C, a resveratrol derivative obtained from Melinjo seed extract (MSE), shares similar health-promoting properties. We investigated the role of gnetin C in preventing NAFLD in a mouse model and compared it with resveratrol. Male C57BL/6J mice were fed a control diet (10% calories from fat), a high-fat choline-deficient (HFCD) diet (46% calories from fat) and HFCD diet supplemented with gnetin C (150 mg/kg BW·day<sup<−1</sup<) or resveratrol (150 mg/kg BW·day<sup<−1</sup<) for 12 weeks. Gnetin C supplementation reduced body and liver weight, and improved blood glucose levels and insulin sensitivity. Both gnetin C- and resveratrol reduced hepatic steatosis, with gnetin C also decreasing liver lipid content. Gnetin C and resveratrol ameliorated HFCD diet-induced hepatic fibrosis. The mRNA expression results, and western blot analyses showed that gnetin C and, to some extent, resveratrol downregulated fibrosis markers in the TGF-β1 signaling pathway, indicating a possible safeguarding mechanism against NAFLD. These results suggest that gnetin C supplementation may protect against lipid deposition and hepatic fibrosis. NAFLD resveratrol gnetin C hepatic fibrosis hepatic steatosis Nutrition. Foods and food supply Haruki Yoshiba verfasserin aut Afifah Zahra Agista verfasserin aut Halima Sultana verfasserin aut Yusuke Ohsaki verfasserin aut Chiu-Li Yeh verfasserin aut Ryota Hirakawa verfasserin aut Hiroko Tani verfasserin aut Tomoki Ikuta verfasserin aut Tomonori Nochi verfasserin aut Suh-Ching Yang verfasserin aut Hitoshi Shirakawa verfasserin aut In Nutrients MDPI AG, 2009 15(2023), 3888, p 3888 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:15 year:2023 number:3888, p 3888 https://doi.org/10.3390/nu15183888 kostenfrei https://doaj.org/article/45c3c0d6627345708f85e5c3615a97d8 kostenfrei https://www.mdpi.com/2072-6643/15/18/3888 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 3888, p 3888
allfields_unstemmed	10.3390/nu15183888 doi (DE-627)DOAJ093331509 (DE-599)DOAJ45c3c0d6627345708f85e5c3615a97d8 DE-627 ger DE-627 rakwb eng TX341-641 Tohfa Kabir verfasserin aut Protective Effects of Gnetin C from Melinjo Seed Extract against High-Fat Diet-Induced Hepatic Steatosis and Liver Fibrosis in NAFLD Mice Model 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nonalcoholic fatty liver disease (NAFLD), the most common form of chronic liver disease, can progress to hepatic steatosis, inflammation, and advanced fibrosis, increasing the risk of cirrhosis. Resveratrol, a natural polyphenol with antioxidant and anti-inflammatory properties, is beneficial in treating multiple metabolic diseases. Gnetin C, a resveratrol derivative obtained from Melinjo seed extract (MSE), shares similar health-promoting properties. We investigated the role of gnetin C in preventing NAFLD in a mouse model and compared it with resveratrol. Male C57BL/6J mice were fed a control diet (10% calories from fat), a high-fat choline-deficient (HFCD) diet (46% calories from fat) and HFCD diet supplemented with gnetin C (150 mg/kg BW·day<sup<−1</sup<) or resveratrol (150 mg/kg BW·day<sup<−1</sup<) for 12 weeks. Gnetin C supplementation reduced body and liver weight, and improved blood glucose levels and insulin sensitivity. Both gnetin C- and resveratrol reduced hepatic steatosis, with gnetin C also decreasing liver lipid content. Gnetin C and resveratrol ameliorated HFCD diet-induced hepatic fibrosis. The mRNA expression results, and western blot analyses showed that gnetin C and, to some extent, resveratrol downregulated fibrosis markers in the TGF-β1 signaling pathway, indicating a possible safeguarding mechanism against NAFLD. These results suggest that gnetin C supplementation may protect against lipid deposition and hepatic fibrosis. NAFLD resveratrol gnetin C hepatic fibrosis hepatic steatosis Nutrition. Foods and food supply Haruki Yoshiba verfasserin aut Afifah Zahra Agista verfasserin aut Halima Sultana verfasserin aut Yusuke Ohsaki verfasserin aut Chiu-Li Yeh verfasserin aut Ryota Hirakawa verfasserin aut Hiroko Tani verfasserin aut Tomoki Ikuta verfasserin aut Tomonori Nochi verfasserin aut Suh-Ching Yang verfasserin aut Hitoshi Shirakawa verfasserin aut In Nutrients MDPI AG, 2009 15(2023), 3888, p 3888 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:15 year:2023 number:3888, p 3888 https://doi.org/10.3390/nu15183888 kostenfrei https://doaj.org/article/45c3c0d6627345708f85e5c3615a97d8 kostenfrei https://www.mdpi.com/2072-6643/15/18/3888 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 3888, p 3888
allfieldsGer	10.3390/nu15183888 doi (DE-627)DOAJ093331509 (DE-599)DOAJ45c3c0d6627345708f85e5c3615a97d8 DE-627 ger DE-627 rakwb eng TX341-641 Tohfa Kabir verfasserin aut Protective Effects of Gnetin C from Melinjo Seed Extract against High-Fat Diet-Induced Hepatic Steatosis and Liver Fibrosis in NAFLD Mice Model 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nonalcoholic fatty liver disease (NAFLD), the most common form of chronic liver disease, can progress to hepatic steatosis, inflammation, and advanced fibrosis, increasing the risk of cirrhosis. Resveratrol, a natural polyphenol with antioxidant and anti-inflammatory properties, is beneficial in treating multiple metabolic diseases. Gnetin C, a resveratrol derivative obtained from Melinjo seed extract (MSE), shares similar health-promoting properties. We investigated the role of gnetin C in preventing NAFLD in a mouse model and compared it with resveratrol. Male C57BL/6J mice were fed a control diet (10% calories from fat), a high-fat choline-deficient (HFCD) diet (46% calories from fat) and HFCD diet supplemented with gnetin C (150 mg/kg BW·day<sup<−1</sup<) or resveratrol (150 mg/kg BW·day<sup<−1</sup<) for 12 weeks. Gnetin C supplementation reduced body and liver weight, and improved blood glucose levels and insulin sensitivity. Both gnetin C- and resveratrol reduced hepatic steatosis, with gnetin C also decreasing liver lipid content. Gnetin C and resveratrol ameliorated HFCD diet-induced hepatic fibrosis. The mRNA expression results, and western blot analyses showed that gnetin C and, to some extent, resveratrol downregulated fibrosis markers in the TGF-β1 signaling pathway, indicating a possible safeguarding mechanism against NAFLD. These results suggest that gnetin C supplementation may protect against lipid deposition and hepatic fibrosis. NAFLD resveratrol gnetin C hepatic fibrosis hepatic steatosis Nutrition. Foods and food supply Haruki Yoshiba verfasserin aut Afifah Zahra Agista verfasserin aut Halima Sultana verfasserin aut Yusuke Ohsaki verfasserin aut Chiu-Li Yeh verfasserin aut Ryota Hirakawa verfasserin aut Hiroko Tani verfasserin aut Tomoki Ikuta verfasserin aut Tomonori Nochi verfasserin aut Suh-Ching Yang verfasserin aut Hitoshi Shirakawa verfasserin aut In Nutrients MDPI AG, 2009 15(2023), 3888, p 3888 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:15 year:2023 number:3888, p 3888 https://doi.org/10.3390/nu15183888 kostenfrei https://doaj.org/article/45c3c0d6627345708f85e5c3615a97d8 kostenfrei https://www.mdpi.com/2072-6643/15/18/3888 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 3888, p 3888
allfieldsSound	10.3390/nu15183888 doi (DE-627)DOAJ093331509 (DE-599)DOAJ45c3c0d6627345708f85e5c3615a97d8 DE-627 ger DE-627 rakwb eng TX341-641 Tohfa Kabir verfasserin aut Protective Effects of Gnetin C from Melinjo Seed Extract against High-Fat Diet-Induced Hepatic Steatosis and Liver Fibrosis in NAFLD Mice Model 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nonalcoholic fatty liver disease (NAFLD), the most common form of chronic liver disease, can progress to hepatic steatosis, inflammation, and advanced fibrosis, increasing the risk of cirrhosis. Resveratrol, a natural polyphenol with antioxidant and anti-inflammatory properties, is beneficial in treating multiple metabolic diseases. Gnetin C, a resveratrol derivative obtained from Melinjo seed extract (MSE), shares similar health-promoting properties. We investigated the role of gnetin C in preventing NAFLD in a mouse model and compared it with resveratrol. Male C57BL/6J mice were fed a control diet (10% calories from fat), a high-fat choline-deficient (HFCD) diet (46% calories from fat) and HFCD diet supplemented with gnetin C (150 mg/kg BW·day<sup<−1</sup<) or resveratrol (150 mg/kg BW·day<sup<−1</sup<) for 12 weeks. Gnetin C supplementation reduced body and liver weight, and improved blood glucose levels and insulin sensitivity. Both gnetin C- and resveratrol reduced hepatic steatosis, with gnetin C also decreasing liver lipid content. Gnetin C and resveratrol ameliorated HFCD diet-induced hepatic fibrosis. The mRNA expression results, and western blot analyses showed that gnetin C and, to some extent, resveratrol downregulated fibrosis markers in the TGF-β1 signaling pathway, indicating a possible safeguarding mechanism against NAFLD. These results suggest that gnetin C supplementation may protect against lipid deposition and hepatic fibrosis. NAFLD resveratrol gnetin C hepatic fibrosis hepatic steatosis Nutrition. Foods and food supply Haruki Yoshiba verfasserin aut Afifah Zahra Agista verfasserin aut Halima Sultana verfasserin aut Yusuke Ohsaki verfasserin aut Chiu-Li Yeh verfasserin aut Ryota Hirakawa verfasserin aut Hiroko Tani verfasserin aut Tomoki Ikuta verfasserin aut Tomonori Nochi verfasserin aut Suh-Ching Yang verfasserin aut Hitoshi Shirakawa verfasserin aut In Nutrients MDPI AG, 2009 15(2023), 3888, p 3888 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:15 year:2023 number:3888, p 3888 https://doi.org/10.3390/nu15183888 kostenfrei https://doaj.org/article/45c3c0d6627345708f85e5c3615a97d8 kostenfrei https://www.mdpi.com/2072-6643/15/18/3888 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 3888, p 3888
language	English
source	In Nutrients 15(2023), 3888, p 3888 volume:15 year:2023 number:3888, p 3888
sourceStr	In Nutrients 15(2023), 3888, p 3888 volume:15 year:2023 number:3888, p 3888
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topic_facet	NAFLD resveratrol gnetin C hepatic fibrosis hepatic steatosis Nutrition. Foods and food supply
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container_title	Nutrients
authorswithroles_txt_mv	Tohfa Kabir @@aut@@ Haruki Yoshiba @@aut@@ Afifah Zahra Agista @@aut@@ Halima Sultana @@aut@@ Yusuke Ohsaki @@aut@@ Chiu-Li Yeh @@aut@@ Ryota Hirakawa @@aut@@ Hiroko Tani @@aut@@ Tomoki Ikuta @@aut@@ Tomonori Nochi @@aut@@ Suh-Ching Yang @@aut@@ Hitoshi Shirakawa @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
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callnumber-first	T - Technology
author	Tohfa Kabir
spellingShingle	Tohfa Kabir misc TX341-641 misc NAFLD misc resveratrol misc gnetin C misc hepatic fibrosis misc hepatic steatosis misc Nutrition. Foods and food supply Protective Effects of Gnetin C from Melinjo Seed Extract against High-Fat Diet-Induced Hepatic Steatosis and Liver Fibrosis in NAFLD Mice Model
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issn	20726643
topic_title	TX341-641 Protective Effects of Gnetin C from Melinjo Seed Extract against High-Fat Diet-Induced Hepatic Steatosis and Liver Fibrosis in NAFLD Mice Model NAFLD resveratrol gnetin C hepatic fibrosis hepatic steatosis
topic	misc TX341-641 misc NAFLD misc resveratrol misc gnetin C misc hepatic fibrosis misc hepatic steatosis misc Nutrition. Foods and food supply
topic_unstemmed	misc TX341-641 misc NAFLD misc resveratrol misc gnetin C misc hepatic fibrosis misc hepatic steatosis misc Nutrition. Foods and food supply
topic_browse	misc TX341-641 misc NAFLD misc resveratrol misc gnetin C misc hepatic fibrosis misc hepatic steatosis misc Nutrition. Foods and food supply
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title	Protective Effects of Gnetin C from Melinjo Seed Extract against High-Fat Diet-Induced Hepatic Steatosis and Liver Fibrosis in NAFLD Mice Model
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title_full	Protective Effects of Gnetin C from Melinjo Seed Extract against High-Fat Diet-Induced Hepatic Steatosis and Liver Fibrosis in NAFLD Mice Model
author_sort	Tohfa Kabir
journal	Nutrients
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author_browse	Tohfa Kabir Haruki Yoshiba Afifah Zahra Agista Halima Sultana Yusuke Ohsaki Chiu-Li Yeh Ryota Hirakawa Hiroko Tani Tomoki Ikuta Tomonori Nochi Suh-Ching Yang Hitoshi Shirakawa
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doi_str_mv	10.3390/nu15183888
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title_sort	protective effects of gnetin c from melinjo seed extract against high-fat diet-induced hepatic steatosis and liver fibrosis in nafld mice model
callnumber	TX341-641
title_auth	Protective Effects of Gnetin C from Melinjo Seed Extract against High-Fat Diet-Induced Hepatic Steatosis and Liver Fibrosis in NAFLD Mice Model
abstract	Nonalcoholic fatty liver disease (NAFLD), the most common form of chronic liver disease, can progress to hepatic steatosis, inflammation, and advanced fibrosis, increasing the risk of cirrhosis. Resveratrol, a natural polyphenol with antioxidant and anti-inflammatory properties, is beneficial in treating multiple metabolic diseases. Gnetin C, a resveratrol derivative obtained from Melinjo seed extract (MSE), shares similar health-promoting properties. We investigated the role of gnetin C in preventing NAFLD in a mouse model and compared it with resveratrol. Male C57BL/6J mice were fed a control diet (10% calories from fat), a high-fat choline-deficient (HFCD) diet (46% calories from fat) and HFCD diet supplemented with gnetin C (150 mg/kg BW·day<sup<−1</sup<) or resveratrol (150 mg/kg BW·day<sup<−1</sup<) for 12 weeks. Gnetin C supplementation reduced body and liver weight, and improved blood glucose levels and insulin sensitivity. Both gnetin C- and resveratrol reduced hepatic steatosis, with gnetin C also decreasing liver lipid content. Gnetin C and resveratrol ameliorated HFCD diet-induced hepatic fibrosis. The mRNA expression results, and western blot analyses showed that gnetin C and, to some extent, resveratrol downregulated fibrosis markers in the TGF-β1 signaling pathway, indicating a possible safeguarding mechanism against NAFLD. These results suggest that gnetin C supplementation may protect against lipid deposition and hepatic fibrosis.
abstractGer	Nonalcoholic fatty liver disease (NAFLD), the most common form of chronic liver disease, can progress to hepatic steatosis, inflammation, and advanced fibrosis, increasing the risk of cirrhosis. Resveratrol, a natural polyphenol with antioxidant and anti-inflammatory properties, is beneficial in treating multiple metabolic diseases. Gnetin C, a resveratrol derivative obtained from Melinjo seed extract (MSE), shares similar health-promoting properties. We investigated the role of gnetin C in preventing NAFLD in a mouse model and compared it with resveratrol. Male C57BL/6J mice were fed a control diet (10% calories from fat), a high-fat choline-deficient (HFCD) diet (46% calories from fat) and HFCD diet supplemented with gnetin C (150 mg/kg BW·day<sup<−1</sup<) or resveratrol (150 mg/kg BW·day<sup<−1</sup<) for 12 weeks. Gnetin C supplementation reduced body and liver weight, and improved blood glucose levels and insulin sensitivity. Both gnetin C- and resveratrol reduced hepatic steatosis, with gnetin C also decreasing liver lipid content. Gnetin C and resveratrol ameliorated HFCD diet-induced hepatic fibrosis. The mRNA expression results, and western blot analyses showed that gnetin C and, to some extent, resveratrol downregulated fibrosis markers in the TGF-β1 signaling pathway, indicating a possible safeguarding mechanism against NAFLD. These results suggest that gnetin C supplementation may protect against lipid deposition and hepatic fibrosis.
abstract_unstemmed	Nonalcoholic fatty liver disease (NAFLD), the most common form of chronic liver disease, can progress to hepatic steatosis, inflammation, and advanced fibrosis, increasing the risk of cirrhosis. Resveratrol, a natural polyphenol with antioxidant and anti-inflammatory properties, is beneficial in treating multiple metabolic diseases. Gnetin C, a resveratrol derivative obtained from Melinjo seed extract (MSE), shares similar health-promoting properties. We investigated the role of gnetin C in preventing NAFLD in a mouse model and compared it with resveratrol. Male C57BL/6J mice were fed a control diet (10% calories from fat), a high-fat choline-deficient (HFCD) diet (46% calories from fat) and HFCD diet supplemented with gnetin C (150 mg/kg BW·day<sup<−1</sup<) or resveratrol (150 mg/kg BW·day<sup<−1</sup<) for 12 weeks. Gnetin C supplementation reduced body and liver weight, and improved blood glucose levels and insulin sensitivity. Both gnetin C- and resveratrol reduced hepatic steatosis, with gnetin C also decreasing liver lipid content. Gnetin C and resveratrol ameliorated HFCD diet-induced hepatic fibrosis. The mRNA expression results, and western blot analyses showed that gnetin C and, to some extent, resveratrol downregulated fibrosis markers in the TGF-β1 signaling pathway, indicating a possible safeguarding mechanism against NAFLD. These results suggest that gnetin C supplementation may protect against lipid deposition and hepatic fibrosis.
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container_issue	3888, p 3888
title_short	Protective Effects of Gnetin C from Melinjo Seed Extract against High-Fat Diet-Induced Hepatic Steatosis and Liver Fibrosis in NAFLD Mice Model
url	https://doi.org/10.3390/nu15183888 https://doaj.org/article/45c3c0d6627345708f85e5c3615a97d8 https://www.mdpi.com/2072-6643/15/18/3888 https://doaj.org/toc/2072-6643
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author2	Haruki Yoshiba Afifah Zahra Agista Halima Sultana Yusuke Ohsaki Chiu-Li Yeh Ryota Hirakawa Hiroko Tani Tomoki Ikuta Tomonori Nochi Suh-Ching Yang Hitoshi Shirakawa
author2Str	Haruki Yoshiba Afifah Zahra Agista Halima Sultana Yusuke Ohsaki Chiu-Li Yeh Ryota Hirakawa Hiroko Tani Tomoki Ikuta Tomonori Nochi Suh-Ching Yang Hitoshi Shirakawa
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doi_str	10.3390/nu15183888
callnumber-a	TX341-641
up_date	2024-07-03T16:41:12.052Z
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