A New Mechanism of Carbon Metabolism and Acetic Acid Balance Regulated by CcpA

Catabolite control protein A (CcpA) is a critical regulator in Gram-positive bacteria that orchestrates carbon metabolism by coordinating the utilization of different carbon sources. Although it has been widely proved that CcpA helps prioritize the utilization of glucose over other carbon sources, t...
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Autor*in:	Yupeng Zhang [verfasserIn] Fengxu Xiao [verfasserIn] Liang Zhang [verfasserIn] Zhongyang Ding [verfasserIn] Guiyang Shi [verfasserIn] Youran Li [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	glucose metabolic fluxes CcpA acetic acid metabolism

Übergeordnetes Werk:	In: Microorganisms - MDPI AG, 2013, 11(2023), 2303, p 2303
Übergeordnetes Werk:	volume:11 ; year:2023 ; number:2303, p 2303

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/microorganisms11092303

Katalog-ID:	DOAJ093348460

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520			\|a Catabolite control protein A (CcpA) is a critical regulator in Gram-positive bacteria that orchestrates carbon metabolism by coordinating the utilization of different carbon sources. Although it has been widely proved that CcpA helps prioritize the utilization of glucose over other carbon sources, this global regulator’s precise mechanism of action remains unclear. In this study, a mutant <i<Bacillus licheniformis</i< deleted for CcpA was constructed. Cell growth, carbon utilization, metabolites and the transcription of key enzymes of the mutant strain were compared with that of the wild-type one. It was found that CcpA is involved in the regulation of glucose concentration metabolism in Bacillus. At the same time, CcpA regulates glucose metabolism by inhibiting acetic acid synthesis and pentose phosphate pathway key gene <i<zwF</i<. The conversion rate of acetic acid is increased by about 3.5 times after <i<ccpA</i< is deleted. The present study provides a new mechanism of carbon metabolism and acetic acid balance regulated by CcpA. On the one hand, this work deepens the understanding of the regulatory function of CcpA and provides a new view on the regulation of glucose metabolism. On the other hand, it is helpful to the transformation of <i<B. licheniformis</i< chassis microorganisms.
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language	English
source	In Microorganisms 11(2023), 2303, p 2303 volume:11 year:2023 number:2303, p 2303
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topic_facet	glucose metabolic fluxes CcpA acetic acid metabolism <i<Bacillus licheniformis</i< Biology (General)
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authorswithroles_txt_mv	Yupeng Zhang @@aut@@ Fengxu Xiao @@aut@@ Liang Zhang @@aut@@ Zhongyang Ding @@aut@@ Guiyang Shi @@aut@@ Youran Li @@aut@@
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callnumber-first	Q - Science
author	Yupeng Zhang
spellingShingle	Yupeng Zhang misc QH301-705.5 misc glucose metabolic fluxes misc CcpA misc acetic acid metabolism misc <i<Bacillus licheniformis</i< misc Biology (General) A New Mechanism of Carbon Metabolism and Acetic Acid Balance Regulated by CcpA
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topic_title	QH301-705.5 A New Mechanism of Carbon Metabolism and Acetic Acid Balance Regulated by CcpA glucose metabolic fluxes CcpA acetic acid metabolism <i<Bacillus licheniformis</i<
topic	misc QH301-705.5 misc glucose metabolic fluxes misc CcpA misc acetic acid metabolism misc <i<Bacillus licheniformis</i< misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc glucose metabolic fluxes misc CcpA misc acetic acid metabolism misc <i<Bacillus licheniformis</i< misc Biology (General)
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title	A New Mechanism of Carbon Metabolism and Acetic Acid Balance Regulated by CcpA
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title_full	A New Mechanism of Carbon Metabolism and Acetic Acid Balance Regulated by CcpA
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title_sort	new mechanism of carbon metabolism and acetic acid balance regulated by ccpa
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title_auth	A New Mechanism of Carbon Metabolism and Acetic Acid Balance Regulated by CcpA
abstract	Catabolite control protein A (CcpA) is a critical regulator in Gram-positive bacteria that orchestrates carbon metabolism by coordinating the utilization of different carbon sources. Although it has been widely proved that CcpA helps prioritize the utilization of glucose over other carbon sources, this global regulator’s precise mechanism of action remains unclear. In this study, a mutant <i<Bacillus licheniformis</i< deleted for CcpA was constructed. Cell growth, carbon utilization, metabolites and the transcription of key enzymes of the mutant strain were compared with that of the wild-type one. It was found that CcpA is involved in the regulation of glucose concentration metabolism in Bacillus. At the same time, CcpA regulates glucose metabolism by inhibiting acetic acid synthesis and pentose phosphate pathway key gene <i<zwF</i<. The conversion rate of acetic acid is increased by about 3.5 times after <i<ccpA</i< is deleted. The present study provides a new mechanism of carbon metabolism and acetic acid balance regulated by CcpA. On the one hand, this work deepens the understanding of the regulatory function of CcpA and provides a new view on the regulation of glucose metabolism. On the other hand, it is helpful to the transformation of <i<B. licheniformis</i< chassis microorganisms.
abstractGer	Catabolite control protein A (CcpA) is a critical regulator in Gram-positive bacteria that orchestrates carbon metabolism by coordinating the utilization of different carbon sources. Although it has been widely proved that CcpA helps prioritize the utilization of glucose over other carbon sources, this global regulator’s precise mechanism of action remains unclear. In this study, a mutant <i<Bacillus licheniformis</i< deleted for CcpA was constructed. Cell growth, carbon utilization, metabolites and the transcription of key enzymes of the mutant strain were compared with that of the wild-type one. It was found that CcpA is involved in the regulation of glucose concentration metabolism in Bacillus. At the same time, CcpA regulates glucose metabolism by inhibiting acetic acid synthesis and pentose phosphate pathway key gene <i<zwF</i<. The conversion rate of acetic acid is increased by about 3.5 times after <i<ccpA</i< is deleted. The present study provides a new mechanism of carbon metabolism and acetic acid balance regulated by CcpA. On the one hand, this work deepens the understanding of the regulatory function of CcpA and provides a new view on the regulation of glucose metabolism. On the other hand, it is helpful to the transformation of <i<B. licheniformis</i< chassis microorganisms.
abstract_unstemmed	Catabolite control protein A (CcpA) is a critical regulator in Gram-positive bacteria that orchestrates carbon metabolism by coordinating the utilization of different carbon sources. Although it has been widely proved that CcpA helps prioritize the utilization of glucose over other carbon sources, this global regulator’s precise mechanism of action remains unclear. In this study, a mutant <i<Bacillus licheniformis</i< deleted for CcpA was constructed. Cell growth, carbon utilization, metabolites and the transcription of key enzymes of the mutant strain were compared with that of the wild-type one. It was found that CcpA is involved in the regulation of glucose concentration metabolism in Bacillus. At the same time, CcpA regulates glucose metabolism by inhibiting acetic acid synthesis and pentose phosphate pathway key gene <i<zwF</i<. The conversion rate of acetic acid is increased by about 3.5 times after <i<ccpA</i< is deleted. The present study provides a new mechanism of carbon metabolism and acetic acid balance regulated by CcpA. On the one hand, this work deepens the understanding of the regulatory function of CcpA and provides a new view on the regulation of glucose metabolism. On the other hand, it is helpful to the transformation of <i<B. licheniformis</i< chassis microorganisms.
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container_issue	2303, p 2303
title_short	A New Mechanism of Carbon Metabolism and Acetic Acid Balance Regulated by CcpA
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A New Mechanism of Carbon Metabolism and Acetic Acid Balance Regulated by CcpA

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