Polyacrylate–Cholesterol Amphiphilic Derivative: Formulation Development and Scale-up for Health Care Applications

The novel amphiphilic polyacrylate grafted with cholesterol moieties, PAAbCH, previously synthesized, was deeply characterized and investigated in the lab and on a pre-industrial scale. Solid-state NMR analysis confirmed the polymer structure, and several water-based pharmaceutical and cosmetic prod...
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Autor*in:	Marco Viola [verfasserIn] Claudia Migliorini [verfasserIn] Fabio Ziarelli [verfasserIn] Stéphane Viel [verfasserIn] Claudia Cencetti [verfasserIn] Daniel Di Risola [verfasserIn] Luciana Mosca [verfasserIn] Laura Masuelli [verfasserIn] Pietro Matricardi [verfasserIn] Chiara Di Meo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	polyacrylate cholesterol amphiphilic topical formulations emulsifier solid-state NMR

Übergeordnetes Werk:	In: Journal of Functional Biomaterials - MDPI AG, 2011, 14(2023), 482, p 482
Übergeordnetes Werk:	volume:14 ; year:2023 ; number:482, p 482

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jfb14090482

Katalog-ID:	DOAJ093376995

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allfields	10.3390/jfb14090482 doi (DE-627)DOAJ093376995 (DE-599)DOAJ1710e8d4cd144f618d42fed00d778565 DE-627 ger DE-627 rakwb eng TP248.13-248.65 R5-920 Marco Viola verfasserin aut Polyacrylate–Cholesterol Amphiphilic Derivative: Formulation Development and Scale-up for Health Care Applications 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The novel amphiphilic polyacrylate grafted with cholesterol moieties, PAAbCH, previously synthesized, was deeply characterized and investigated in the lab and on a pre-industrial scale. Solid-state NMR analysis confirmed the polymer structure, and several water-based pharmaceutical and cosmetic products were developed. In particular, stable oil/water emulsions with vegetable oils, squalene, and ceramides were prepared, as well as hydrophilic medicated films loaded with diclofenac, providing a prolonged drug release. PAAbCH also formed polyelectrolyte hydrogel complexes with chitosan, both at the macro- and nano-scale. The results demonstrate that this polymer has promising potential as an innovative excipient, acting as a solubility enhancer, viscosity enhancer, and emulsifying agent with an easy scale-up transfer process. polyacrylate cholesterol amphiphilic topical formulations emulsifier solid-state NMR Biotechnology Medicine (General) Claudia Migliorini verfasserin aut Fabio Ziarelli verfasserin aut Stéphane Viel verfasserin aut Claudia Cencetti verfasserin aut Daniel Di Risola verfasserin aut Luciana Mosca verfasserin aut Laura Masuelli verfasserin aut Pietro Matricardi verfasserin aut Chiara Di Meo verfasserin aut In Journal of Functional Biomaterials MDPI AG, 2011 14(2023), 482, p 482 (DE-627)68456775X (DE-600)2648525-4 20794983 nnns volume:14 year:2023 number:482, p 482 https://doi.org/10.3390/jfb14090482 kostenfrei https://doaj.org/article/1710e8d4cd144f618d42fed00d778565 kostenfrei https://www.mdpi.com/2079-4983/14/9/482 kostenfrei https://doaj.org/toc/2079-4983 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 482, p 482
spelling	10.3390/jfb14090482 doi (DE-627)DOAJ093376995 (DE-599)DOAJ1710e8d4cd144f618d42fed00d778565 DE-627 ger DE-627 rakwb eng TP248.13-248.65 R5-920 Marco Viola verfasserin aut Polyacrylate–Cholesterol Amphiphilic Derivative: Formulation Development and Scale-up for Health Care Applications 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The novel amphiphilic polyacrylate grafted with cholesterol moieties, PAAbCH, previously synthesized, was deeply characterized and investigated in the lab and on a pre-industrial scale. Solid-state NMR analysis confirmed the polymer structure, and several water-based pharmaceutical and cosmetic products were developed. In particular, stable oil/water emulsions with vegetable oils, squalene, and ceramides were prepared, as well as hydrophilic medicated films loaded with diclofenac, providing a prolonged drug release. PAAbCH also formed polyelectrolyte hydrogel complexes with chitosan, both at the macro- and nano-scale. The results demonstrate that this polymer has promising potential as an innovative excipient, acting as a solubility enhancer, viscosity enhancer, and emulsifying agent with an easy scale-up transfer process. polyacrylate cholesterol amphiphilic topical formulations emulsifier solid-state NMR Biotechnology Medicine (General) Claudia Migliorini verfasserin aut Fabio Ziarelli verfasserin aut Stéphane Viel verfasserin aut Claudia Cencetti verfasserin aut Daniel Di Risola verfasserin aut Luciana Mosca verfasserin aut Laura Masuelli verfasserin aut Pietro Matricardi verfasserin aut Chiara Di Meo verfasserin aut In Journal of Functional Biomaterials MDPI AG, 2011 14(2023), 482, p 482 (DE-627)68456775X (DE-600)2648525-4 20794983 nnns volume:14 year:2023 number:482, p 482 https://doi.org/10.3390/jfb14090482 kostenfrei https://doaj.org/article/1710e8d4cd144f618d42fed00d778565 kostenfrei https://www.mdpi.com/2079-4983/14/9/482 kostenfrei https://doaj.org/toc/2079-4983 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 482, p 482
allfields_unstemmed	10.3390/jfb14090482 doi (DE-627)DOAJ093376995 (DE-599)DOAJ1710e8d4cd144f618d42fed00d778565 DE-627 ger DE-627 rakwb eng TP248.13-248.65 R5-920 Marco Viola verfasserin aut Polyacrylate–Cholesterol Amphiphilic Derivative: Formulation Development and Scale-up for Health Care Applications 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The novel amphiphilic polyacrylate grafted with cholesterol moieties, PAAbCH, previously synthesized, was deeply characterized and investigated in the lab and on a pre-industrial scale. Solid-state NMR analysis confirmed the polymer structure, and several water-based pharmaceutical and cosmetic products were developed. In particular, stable oil/water emulsions with vegetable oils, squalene, and ceramides were prepared, as well as hydrophilic medicated films loaded with diclofenac, providing a prolonged drug release. PAAbCH also formed polyelectrolyte hydrogel complexes with chitosan, both at the macro- and nano-scale. The results demonstrate that this polymer has promising potential as an innovative excipient, acting as a solubility enhancer, viscosity enhancer, and emulsifying agent with an easy scale-up transfer process. polyacrylate cholesterol amphiphilic topical formulations emulsifier solid-state NMR Biotechnology Medicine (General) Claudia Migliorini verfasserin aut Fabio Ziarelli verfasserin aut Stéphane Viel verfasserin aut Claudia Cencetti verfasserin aut Daniel Di Risola verfasserin aut Luciana Mosca verfasserin aut Laura Masuelli verfasserin aut Pietro Matricardi verfasserin aut Chiara Di Meo verfasserin aut In Journal of Functional Biomaterials MDPI AG, 2011 14(2023), 482, p 482 (DE-627)68456775X (DE-600)2648525-4 20794983 nnns volume:14 year:2023 number:482, p 482 https://doi.org/10.3390/jfb14090482 kostenfrei https://doaj.org/article/1710e8d4cd144f618d42fed00d778565 kostenfrei https://www.mdpi.com/2079-4983/14/9/482 kostenfrei https://doaj.org/toc/2079-4983 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 482, p 482
allfieldsGer	10.3390/jfb14090482 doi (DE-627)DOAJ093376995 (DE-599)DOAJ1710e8d4cd144f618d42fed00d778565 DE-627 ger DE-627 rakwb eng TP248.13-248.65 R5-920 Marco Viola verfasserin aut Polyacrylate–Cholesterol Amphiphilic Derivative: Formulation Development and Scale-up for Health Care Applications 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The novel amphiphilic polyacrylate grafted with cholesterol moieties, PAAbCH, previously synthesized, was deeply characterized and investigated in the lab and on a pre-industrial scale. Solid-state NMR analysis confirmed the polymer structure, and several water-based pharmaceutical and cosmetic products were developed. In particular, stable oil/water emulsions with vegetable oils, squalene, and ceramides were prepared, as well as hydrophilic medicated films loaded with diclofenac, providing a prolonged drug release. PAAbCH also formed polyelectrolyte hydrogel complexes with chitosan, both at the macro- and nano-scale. The results demonstrate that this polymer has promising potential as an innovative excipient, acting as a solubility enhancer, viscosity enhancer, and emulsifying agent with an easy scale-up transfer process. polyacrylate cholesterol amphiphilic topical formulations emulsifier solid-state NMR Biotechnology Medicine (General) Claudia Migliorini verfasserin aut Fabio Ziarelli verfasserin aut Stéphane Viel verfasserin aut Claudia Cencetti verfasserin aut Daniel Di Risola verfasserin aut Luciana Mosca verfasserin aut Laura Masuelli verfasserin aut Pietro Matricardi verfasserin aut Chiara Di Meo verfasserin aut In Journal of Functional Biomaterials MDPI AG, 2011 14(2023), 482, p 482 (DE-627)68456775X (DE-600)2648525-4 20794983 nnns volume:14 year:2023 number:482, p 482 https://doi.org/10.3390/jfb14090482 kostenfrei https://doaj.org/article/1710e8d4cd144f618d42fed00d778565 kostenfrei https://www.mdpi.com/2079-4983/14/9/482 kostenfrei https://doaj.org/toc/2079-4983 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 482, p 482
allfieldsSound	10.3390/jfb14090482 doi (DE-627)DOAJ093376995 (DE-599)DOAJ1710e8d4cd144f618d42fed00d778565 DE-627 ger DE-627 rakwb eng TP248.13-248.65 R5-920 Marco Viola verfasserin aut Polyacrylate–Cholesterol Amphiphilic Derivative: Formulation Development and Scale-up for Health Care Applications 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The novel amphiphilic polyacrylate grafted with cholesterol moieties, PAAbCH, previously synthesized, was deeply characterized and investigated in the lab and on a pre-industrial scale. Solid-state NMR analysis confirmed the polymer structure, and several water-based pharmaceutical and cosmetic products were developed. In particular, stable oil/water emulsions with vegetable oils, squalene, and ceramides were prepared, as well as hydrophilic medicated films loaded with diclofenac, providing a prolonged drug release. PAAbCH also formed polyelectrolyte hydrogel complexes with chitosan, both at the macro- and nano-scale. The results demonstrate that this polymer has promising potential as an innovative excipient, acting as a solubility enhancer, viscosity enhancer, and emulsifying agent with an easy scale-up transfer process. polyacrylate cholesterol amphiphilic topical formulations emulsifier solid-state NMR Biotechnology Medicine (General) Claudia Migliorini verfasserin aut Fabio Ziarelli verfasserin aut Stéphane Viel verfasserin aut Claudia Cencetti verfasserin aut Daniel Di Risola verfasserin aut Luciana Mosca verfasserin aut Laura Masuelli verfasserin aut Pietro Matricardi verfasserin aut Chiara Di Meo verfasserin aut In Journal of Functional Biomaterials MDPI AG, 2011 14(2023), 482, p 482 (DE-627)68456775X (DE-600)2648525-4 20794983 nnns volume:14 year:2023 number:482, p 482 https://doi.org/10.3390/jfb14090482 kostenfrei https://doaj.org/article/1710e8d4cd144f618d42fed00d778565 kostenfrei https://www.mdpi.com/2079-4983/14/9/482 kostenfrei https://doaj.org/toc/2079-4983 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 482, p 482
language	English
source	In Journal of Functional Biomaterials 14(2023), 482, p 482 volume:14 year:2023 number:482, p 482
sourceStr	In Journal of Functional Biomaterials 14(2023), 482, p 482 volume:14 year:2023 number:482, p 482
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topic_facet	polyacrylate cholesterol amphiphilic topical formulations emulsifier solid-state NMR Biotechnology Medicine (General)
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authorswithroles_txt_mv	Marco Viola @@aut@@ Claudia Migliorini @@aut@@ Fabio Ziarelli @@aut@@ Stéphane Viel @@aut@@ Claudia Cencetti @@aut@@ Daniel Di Risola @@aut@@ Luciana Mosca @@aut@@ Laura Masuelli @@aut@@ Pietro Matricardi @@aut@@ Chiara Di Meo @@aut@@
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callnumber-first	T - Technology
author	Marco Viola
spellingShingle	Marco Viola misc TP248.13-248.65 misc R5-920 misc polyacrylate misc cholesterol misc amphiphilic misc topical formulations misc emulsifier misc solid-state NMR misc Biotechnology misc Medicine (General) Polyacrylate–Cholesterol Amphiphilic Derivative: Formulation Development and Scale-up for Health Care Applications
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topic_title	TP248.13-248.65 R5-920 Polyacrylate–Cholesterol Amphiphilic Derivative: Formulation Development and Scale-up for Health Care Applications polyacrylate cholesterol amphiphilic topical formulations emulsifier solid-state NMR
topic	misc TP248.13-248.65 misc R5-920 misc polyacrylate misc cholesterol misc amphiphilic misc topical formulations misc emulsifier misc solid-state NMR misc Biotechnology misc Medicine (General)
topic_unstemmed	misc TP248.13-248.65 misc R5-920 misc polyacrylate misc cholesterol misc amphiphilic misc topical formulations misc emulsifier misc solid-state NMR misc Biotechnology misc Medicine (General)
topic_browse	misc TP248.13-248.65 misc R5-920 misc polyacrylate misc cholesterol misc amphiphilic misc topical formulations misc emulsifier misc solid-state NMR misc Biotechnology misc Medicine (General)
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title	Polyacrylate–Cholesterol Amphiphilic Derivative: Formulation Development and Scale-up for Health Care Applications
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title_full	Polyacrylate–Cholesterol Amphiphilic Derivative: Formulation Development and Scale-up for Health Care Applications
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author_browse	Marco Viola Claudia Migliorini Fabio Ziarelli Stéphane Viel Claudia Cencetti Daniel Di Risola Luciana Mosca Laura Masuelli Pietro Matricardi Chiara Di Meo
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title_sort	polyacrylate–cholesterol amphiphilic derivative: formulation development and scale-up for health care applications
callnumber	TP248.13-248.65
title_auth	Polyacrylate–Cholesterol Amphiphilic Derivative: Formulation Development and Scale-up for Health Care Applications
abstract	The novel amphiphilic polyacrylate grafted with cholesterol moieties, PAAbCH, previously synthesized, was deeply characterized and investigated in the lab and on a pre-industrial scale. Solid-state NMR analysis confirmed the polymer structure, and several water-based pharmaceutical and cosmetic products were developed. In particular, stable oil/water emulsions with vegetable oils, squalene, and ceramides were prepared, as well as hydrophilic medicated films loaded with diclofenac, providing a prolonged drug release. PAAbCH also formed polyelectrolyte hydrogel complexes with chitosan, both at the macro- and nano-scale. The results demonstrate that this polymer has promising potential as an innovative excipient, acting as a solubility enhancer, viscosity enhancer, and emulsifying agent with an easy scale-up transfer process.
abstractGer	The novel amphiphilic polyacrylate grafted with cholesterol moieties, PAAbCH, previously synthesized, was deeply characterized and investigated in the lab and on a pre-industrial scale. Solid-state NMR analysis confirmed the polymer structure, and several water-based pharmaceutical and cosmetic products were developed. In particular, stable oil/water emulsions with vegetable oils, squalene, and ceramides were prepared, as well as hydrophilic medicated films loaded with diclofenac, providing a prolonged drug release. PAAbCH also formed polyelectrolyte hydrogel complexes with chitosan, both at the macro- and nano-scale. The results demonstrate that this polymer has promising potential as an innovative excipient, acting as a solubility enhancer, viscosity enhancer, and emulsifying agent with an easy scale-up transfer process.
abstract_unstemmed	The novel amphiphilic polyacrylate grafted with cholesterol moieties, PAAbCH, previously synthesized, was deeply characterized and investigated in the lab and on a pre-industrial scale. Solid-state NMR analysis confirmed the polymer structure, and several water-based pharmaceutical and cosmetic products were developed. In particular, stable oil/water emulsions with vegetable oils, squalene, and ceramides were prepared, as well as hydrophilic medicated films loaded with diclofenac, providing a prolonged drug release. PAAbCH also formed polyelectrolyte hydrogel complexes with chitosan, both at the macro- and nano-scale. The results demonstrate that this polymer has promising potential as an innovative excipient, acting as a solubility enhancer, viscosity enhancer, and emulsifying agent with an easy scale-up transfer process.
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container_issue	482, p 482
title_short	Polyacrylate–Cholesterol Amphiphilic Derivative: Formulation Development and Scale-up for Health Care Applications
url	https://doi.org/10.3390/jfb14090482 https://doaj.org/article/1710e8d4cd144f618d42fed00d778565 https://www.mdpi.com/2079-4983/14/9/482 https://doaj.org/toc/2079-4983
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up_date	2024-07-03T16:57:10.995Z
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