Mitochondrial-Derived Vesicles: The Good, the Bad, and the Ugly

Mitophagy is crucial for maintaining mitochondrial quality. However, its assessment in vivo is challenging. The endosomal–lysosomal system is a more accessible pathway through which subtypes of extracellular vesicles (EVs), which also contain mitochondrial constituents, are released for disposal. Th...
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Gespeichert in:

Autor*in:	Anna Picca [verfasserIn] Flora Guerra [verfasserIn] Riccardo Calvani [verfasserIn] Hélio José Coelho-Júnior [verfasserIn] Francesco Landi [verfasserIn] Cecilia Bucci [verfasserIn] Emanuele Marzetti [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	damage-associated molecular patterns (DAMPs) endosomal–lysosomal system exosomes extracellular vesicles inflammation mitochondrial quality control

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 24(2023), 13835, p 13835
Übergeordnetes Werk:	volume:24 ; year:2023 ; number:13835, p 13835

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms241813835

Katalog-ID:	DOAJ093390793

Internformat


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520			\|a Mitophagy is crucial for maintaining mitochondrial quality. However, its assessment in vivo is challenging. The endosomal–lysosomal system is a more accessible pathway through which subtypes of extracellular vesicles (EVs), which also contain mitochondrial constituents, are released for disposal. The inclusion of mitochondrial components into EVs occurs in the setting of mild mitochondrial damage and during impairment of lysosomal function. By releasing mitochondrial-derived vesicles (MDVs), cells limit the unload of mitochondrial damage-associated molecular patterns with proinflammatory activity. Both positive and negative effects of EVs on recipient cells have been described. Whether this is due to the production of EVs other than those containing mitochondria, such as MDVs, holding specific biological functions is currently unknown. Evidence on the existence of different MDV subtypes has been produced. However, their characterization is not always pursued, which would be relevant to exploring the dynamics of mitochondrial quality control in health and disease. Furthermore, MDV classification may be instrumental in understanding their biological roles and promoting their implementation as biomarkers in clinical studies.
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allfields	10.3390/ijms241813835 doi (DE-627)DOAJ093390793 (DE-599)DOAJ1400f16eef904a2db9b2ff3322bc2831 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Anna Picca verfasserin aut Mitochondrial-Derived Vesicles: The Good, the Bad, and the Ugly 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Mitophagy is crucial for maintaining mitochondrial quality. However, its assessment in vivo is challenging. The endosomal–lysosomal system is a more accessible pathway through which subtypes of extracellular vesicles (EVs), which also contain mitochondrial constituents, are released for disposal. The inclusion of mitochondrial components into EVs occurs in the setting of mild mitochondrial damage and during impairment of lysosomal function. By releasing mitochondrial-derived vesicles (MDVs), cells limit the unload of mitochondrial damage-associated molecular patterns with proinflammatory activity. Both positive and negative effects of EVs on recipient cells have been described. Whether this is due to the production of EVs other than those containing mitochondria, such as MDVs, holding specific biological functions is currently unknown. Evidence on the existence of different MDV subtypes has been produced. However, their characterization is not always pursued, which would be relevant to exploring the dynamics of mitochondrial quality control in health and disease. Furthermore, MDV classification may be instrumental in understanding their biological roles and promoting their implementation as biomarkers in clinical studies. damage-associated molecular patterns (DAMPs) endosomal–lysosomal system exosomes extracellular vesicles inflammation mitochondrial quality control Biology (General) Chemistry Flora Guerra verfasserin aut Riccardo Calvani verfasserin aut Hélio José Coelho-Júnior verfasserin aut Francesco Landi verfasserin aut Cecilia Bucci verfasserin aut Emanuele Marzetti verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 13835, p 13835 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:13835, p 13835 https://doi.org/10.3390/ijms241813835 kostenfrei https://doaj.org/article/1400f16eef904a2db9b2ff3322bc2831 kostenfrei https://www.mdpi.com/1422-0067/24/18/13835 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 13835, p 13835
spelling	10.3390/ijms241813835 doi (DE-627)DOAJ093390793 (DE-599)DOAJ1400f16eef904a2db9b2ff3322bc2831 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Anna Picca verfasserin aut Mitochondrial-Derived Vesicles: The Good, the Bad, and the Ugly 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Mitophagy is crucial for maintaining mitochondrial quality. However, its assessment in vivo is challenging. The endosomal–lysosomal system is a more accessible pathway through which subtypes of extracellular vesicles (EVs), which also contain mitochondrial constituents, are released for disposal. The inclusion of mitochondrial components into EVs occurs in the setting of mild mitochondrial damage and during impairment of lysosomal function. By releasing mitochondrial-derived vesicles (MDVs), cells limit the unload of mitochondrial damage-associated molecular patterns with proinflammatory activity. Both positive and negative effects of EVs on recipient cells have been described. Whether this is due to the production of EVs other than those containing mitochondria, such as MDVs, holding specific biological functions is currently unknown. Evidence on the existence of different MDV subtypes has been produced. However, their characterization is not always pursued, which would be relevant to exploring the dynamics of mitochondrial quality control in health and disease. Furthermore, MDV classification may be instrumental in understanding their biological roles and promoting their implementation as biomarkers in clinical studies. damage-associated molecular patterns (DAMPs) endosomal–lysosomal system exosomes extracellular vesicles inflammation mitochondrial quality control Biology (General) Chemistry Flora Guerra verfasserin aut Riccardo Calvani verfasserin aut Hélio José Coelho-Júnior verfasserin aut Francesco Landi verfasserin aut Cecilia Bucci verfasserin aut Emanuele Marzetti verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 13835, p 13835 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:13835, p 13835 https://doi.org/10.3390/ijms241813835 kostenfrei https://doaj.org/article/1400f16eef904a2db9b2ff3322bc2831 kostenfrei https://www.mdpi.com/1422-0067/24/18/13835 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 13835, p 13835
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allfieldsGer	10.3390/ijms241813835 doi (DE-627)DOAJ093390793 (DE-599)DOAJ1400f16eef904a2db9b2ff3322bc2831 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Anna Picca verfasserin aut Mitochondrial-Derived Vesicles: The Good, the Bad, and the Ugly 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Mitophagy is crucial for maintaining mitochondrial quality. However, its assessment in vivo is challenging. The endosomal–lysosomal system is a more accessible pathway through which subtypes of extracellular vesicles (EVs), which also contain mitochondrial constituents, are released for disposal. The inclusion of mitochondrial components into EVs occurs in the setting of mild mitochondrial damage and during impairment of lysosomal function. By releasing mitochondrial-derived vesicles (MDVs), cells limit the unload of mitochondrial damage-associated molecular patterns with proinflammatory activity. Both positive and negative effects of EVs on recipient cells have been described. Whether this is due to the production of EVs other than those containing mitochondria, such as MDVs, holding specific biological functions is currently unknown. Evidence on the existence of different MDV subtypes has been produced. However, their characterization is not always pursued, which would be relevant to exploring the dynamics of mitochondrial quality control in health and disease. Furthermore, MDV classification may be instrumental in understanding their biological roles and promoting their implementation as biomarkers in clinical studies. damage-associated molecular patterns (DAMPs) endosomal–lysosomal system exosomes extracellular vesicles inflammation mitochondrial quality control Biology (General) Chemistry Flora Guerra verfasserin aut Riccardo Calvani verfasserin aut Hélio José Coelho-Júnior verfasserin aut Francesco Landi verfasserin aut Cecilia Bucci verfasserin aut Emanuele Marzetti verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 13835, p 13835 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:13835, p 13835 https://doi.org/10.3390/ijms241813835 kostenfrei https://doaj.org/article/1400f16eef904a2db9b2ff3322bc2831 kostenfrei https://www.mdpi.com/1422-0067/24/18/13835 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 13835, p 13835
allfieldsSound	10.3390/ijms241813835 doi (DE-627)DOAJ093390793 (DE-599)DOAJ1400f16eef904a2db9b2ff3322bc2831 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Anna Picca verfasserin aut Mitochondrial-Derived Vesicles: The Good, the Bad, and the Ugly 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Mitophagy is crucial for maintaining mitochondrial quality. However, its assessment in vivo is challenging. The endosomal–lysosomal system is a more accessible pathway through which subtypes of extracellular vesicles (EVs), which also contain mitochondrial constituents, are released for disposal. The inclusion of mitochondrial components into EVs occurs in the setting of mild mitochondrial damage and during impairment of lysosomal function. By releasing mitochondrial-derived vesicles (MDVs), cells limit the unload of mitochondrial damage-associated molecular patterns with proinflammatory activity. Both positive and negative effects of EVs on recipient cells have been described. Whether this is due to the production of EVs other than those containing mitochondria, such as MDVs, holding specific biological functions is currently unknown. Evidence on the existence of different MDV subtypes has been produced. However, their characterization is not always pursued, which would be relevant to exploring the dynamics of mitochondrial quality control in health and disease. Furthermore, MDV classification may be instrumental in understanding their biological roles and promoting their implementation as biomarkers in clinical studies. damage-associated molecular patterns (DAMPs) endosomal–lysosomal system exosomes extracellular vesicles inflammation mitochondrial quality control Biology (General) Chemistry Flora Guerra verfasserin aut Riccardo Calvani verfasserin aut Hélio José Coelho-Júnior verfasserin aut Francesco Landi verfasserin aut Cecilia Bucci verfasserin aut Emanuele Marzetti verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 13835, p 13835 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:13835, p 13835 https://doi.org/10.3390/ijms241813835 kostenfrei https://doaj.org/article/1400f16eef904a2db9b2ff3322bc2831 kostenfrei https://www.mdpi.com/1422-0067/24/18/13835 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 13835, p 13835
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callnumber-first	Q - Science
author	Anna Picca
spellingShingle	Anna Picca misc QH301-705.5 misc QD1-999 misc damage-associated molecular patterns (DAMPs) misc endosomal–lysosomal system misc exosomes misc extracellular vesicles misc inflammation misc mitochondrial quality control misc Biology (General) misc Chemistry Mitochondrial-Derived Vesicles: The Good, the Bad, and the Ugly
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topic_title	QH301-705.5 QD1-999 Mitochondrial-Derived Vesicles: The Good, the Bad, and the Ugly damage-associated molecular patterns (DAMPs) endosomal–lysosomal system exosomes extracellular vesicles inflammation mitochondrial quality control
topic	misc QH301-705.5 misc QD1-999 misc damage-associated molecular patterns (DAMPs) misc endosomal–lysosomal system misc exosomes misc extracellular vesicles misc inflammation misc mitochondrial quality control misc Biology (General) misc Chemistry
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title_sort	mitochondrial-derived vesicles: the good, the bad, and the ugly
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title_auth	Mitochondrial-Derived Vesicles: The Good, the Bad, and the Ugly
abstract	Mitophagy is crucial for maintaining mitochondrial quality. However, its assessment in vivo is challenging. The endosomal–lysosomal system is a more accessible pathway through which subtypes of extracellular vesicles (EVs), which also contain mitochondrial constituents, are released for disposal. The inclusion of mitochondrial components into EVs occurs in the setting of mild mitochondrial damage and during impairment of lysosomal function. By releasing mitochondrial-derived vesicles (MDVs), cells limit the unload of mitochondrial damage-associated molecular patterns with proinflammatory activity. Both positive and negative effects of EVs on recipient cells have been described. Whether this is due to the production of EVs other than those containing mitochondria, such as MDVs, holding specific biological functions is currently unknown. Evidence on the existence of different MDV subtypes has been produced. However, their characterization is not always pursued, which would be relevant to exploring the dynamics of mitochondrial quality control in health and disease. Furthermore, MDV classification may be instrumental in understanding their biological roles and promoting their implementation as biomarkers in clinical studies.
abstractGer	Mitophagy is crucial for maintaining mitochondrial quality. However, its assessment in vivo is challenging. The endosomal–lysosomal system is a more accessible pathway through which subtypes of extracellular vesicles (EVs), which also contain mitochondrial constituents, are released for disposal. The inclusion of mitochondrial components into EVs occurs in the setting of mild mitochondrial damage and during impairment of lysosomal function. By releasing mitochondrial-derived vesicles (MDVs), cells limit the unload of mitochondrial damage-associated molecular patterns with proinflammatory activity. Both positive and negative effects of EVs on recipient cells have been described. Whether this is due to the production of EVs other than those containing mitochondria, such as MDVs, holding specific biological functions is currently unknown. Evidence on the existence of different MDV subtypes has been produced. However, their characterization is not always pursued, which would be relevant to exploring the dynamics of mitochondrial quality control in health and disease. Furthermore, MDV classification may be instrumental in understanding their biological roles and promoting their implementation as biomarkers in clinical studies.
abstract_unstemmed	Mitophagy is crucial for maintaining mitochondrial quality. However, its assessment in vivo is challenging. The endosomal–lysosomal system is a more accessible pathway through which subtypes of extracellular vesicles (EVs), which also contain mitochondrial constituents, are released for disposal. The inclusion of mitochondrial components into EVs occurs in the setting of mild mitochondrial damage and during impairment of lysosomal function. By releasing mitochondrial-derived vesicles (MDVs), cells limit the unload of mitochondrial damage-associated molecular patterns with proinflammatory activity. Both positive and negative effects of EVs on recipient cells have been described. Whether this is due to the production of EVs other than those containing mitochondria, such as MDVs, holding specific biological functions is currently unknown. Evidence on the existence of different MDV subtypes has been produced. However, their characterization is not always pursued, which would be relevant to exploring the dynamics of mitochondrial quality control in health and disease. Furthermore, MDV classification may be instrumental in understanding their biological roles and promoting their implementation as biomarkers in clinical studies.
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title_short	Mitochondrial-Derived Vesicles: The Good, the Bad, and the Ugly
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