The Role of NAD<sup<+</sup< in Metabolic Regulation of Adipose Tissue: Implications for Obesity-Induced Insulin Resistance

Obesity-induced insulin resistance is among the key factors in the development of type 2 diabetes, atherogenic dyslipidemia and cardiovascular disease. Adipose tissue plays a key role in the regulation of whole-body metabolism and insulin sensitivity. In obesity, adipose tissue becomes inflamed and...
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Autor*in:	Tatjana Ruskovska [verfasserIn] David A. Bernlohr [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	sirtuin PARP CD38 nicotinamide nicotinamide riboside nicotinamide mononucleotide

Übergeordnetes Werk:	In: Biomedicines - MDPI AG, 2014, 11(2023), 2560, p 2560
Übergeordnetes Werk:	volume:11 ; year:2023 ; number:2560, p 2560

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/biomedicines11092560

Katalog-ID:	DOAJ093448910

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520			\|a Obesity-induced insulin resistance is among the key factors in the development of type 2 diabetes, atherogenic dyslipidemia and cardiovascular disease. Adipose tissue plays a key role in the regulation of whole-body metabolism and insulin sensitivity. In obesity, adipose tissue becomes inflamed and dysfunctional, exhibiting a modified biochemical signature and adipokine secretion pattern that promotes insulin resistance in peripheral tissues. An important hallmark of dysfunctional obese adipose tissue is impaired NAD<sup<+</sup</sirtuin signaling. In this chapter, we summarize the evidence for impairment of the NAD<sup<+</sup</sirtuin pathway in obesity, not only in white adipose tissue but also in brown adipose tissue and during the process of beiging, together with correlative evidence from human studies. We also describe the role of PARPs and CD38 as important NAD<sup<+</sup< consumers and discuss findings from experimental studies that investigated potential NAD<sup<+</sup< boosting strategies and their efficacy in restoring impaired NAD<sup<+</sup< metabolism in dysfunctional obese adipose tissue. In sum, these studies suggest a critical role of NAD<sup<+</sup< metabolism in adipose biology and provide a basis for the potential development of strategies to restore metabolic health in obesity.
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spelling	10.3390/biomedicines11092560 doi (DE-627)DOAJ093448910 (DE-599)DOAJ8ce7704be96f432baf856bca1e0ff696 DE-627 ger DE-627 rakwb eng QH301-705.5 Tatjana Ruskovska verfasserin aut The Role of NAD<sup<+</sup< in Metabolic Regulation of Adipose Tissue: Implications for Obesity-Induced Insulin Resistance 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Obesity-induced insulin resistance is among the key factors in the development of type 2 diabetes, atherogenic dyslipidemia and cardiovascular disease. Adipose tissue plays a key role in the regulation of whole-body metabolism and insulin sensitivity. In obesity, adipose tissue becomes inflamed and dysfunctional, exhibiting a modified biochemical signature and adipokine secretion pattern that promotes insulin resistance in peripheral tissues. An important hallmark of dysfunctional obese adipose tissue is impaired NAD<sup<+</sup</sirtuin signaling. In this chapter, we summarize the evidence for impairment of the NAD<sup<+</sup</sirtuin pathway in obesity, not only in white adipose tissue but also in brown adipose tissue and during the process of beiging, together with correlative evidence from human studies. We also describe the role of PARPs and CD38 as important NAD<sup<+</sup< consumers and discuss findings from experimental studies that investigated potential NAD<sup<+</sup< boosting strategies and their efficacy in restoring impaired NAD<sup<+</sup< metabolism in dysfunctional obese adipose tissue. In sum, these studies suggest a critical role of NAD<sup<+</sup< metabolism in adipose biology and provide a basis for the potential development of strategies to restore metabolic health in obesity. sirtuin PARP CD38 nicotinamide nicotinamide riboside nicotinamide mononucleotide Biology (General) David A. Bernlohr verfasserin aut In Biomedicines MDPI AG, 2014 11(2023), 2560, p 2560 (DE-627)750370483 (DE-600)2720867-9 22279059 nnns volume:11 year:2023 number:2560, p 2560 https://doi.org/10.3390/biomedicines11092560 kostenfrei https://doaj.org/article/8ce7704be96f432baf856bca1e0ff696 kostenfrei https://www.mdpi.com/2227-9059/11/9/2560 kostenfrei https://doaj.org/toc/2227-9059 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2023 2560, p 2560
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allfieldsGer	10.3390/biomedicines11092560 doi (DE-627)DOAJ093448910 (DE-599)DOAJ8ce7704be96f432baf856bca1e0ff696 DE-627 ger DE-627 rakwb eng QH301-705.5 Tatjana Ruskovska verfasserin aut The Role of NAD<sup<+</sup< in Metabolic Regulation of Adipose Tissue: Implications for Obesity-Induced Insulin Resistance 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Obesity-induced insulin resistance is among the key factors in the development of type 2 diabetes, atherogenic dyslipidemia and cardiovascular disease. Adipose tissue plays a key role in the regulation of whole-body metabolism and insulin sensitivity. In obesity, adipose tissue becomes inflamed and dysfunctional, exhibiting a modified biochemical signature and adipokine secretion pattern that promotes insulin resistance in peripheral tissues. An important hallmark of dysfunctional obese adipose tissue is impaired NAD<sup<+</sup</sirtuin signaling. In this chapter, we summarize the evidence for impairment of the NAD<sup<+</sup</sirtuin pathway in obesity, not only in white adipose tissue but also in brown adipose tissue and during the process of beiging, together with correlative evidence from human studies. We also describe the role of PARPs and CD38 as important NAD<sup<+</sup< consumers and discuss findings from experimental studies that investigated potential NAD<sup<+</sup< boosting strategies and their efficacy in restoring impaired NAD<sup<+</sup< metabolism in dysfunctional obese adipose tissue. In sum, these studies suggest a critical role of NAD<sup<+</sup< metabolism in adipose biology and provide a basis for the potential development of strategies to restore metabolic health in obesity. sirtuin PARP CD38 nicotinamide nicotinamide riboside nicotinamide mononucleotide Biology (General) David A. Bernlohr verfasserin aut In Biomedicines MDPI AG, 2014 11(2023), 2560, p 2560 (DE-627)750370483 (DE-600)2720867-9 22279059 nnns volume:11 year:2023 number:2560, p 2560 https://doi.org/10.3390/biomedicines11092560 kostenfrei https://doaj.org/article/8ce7704be96f432baf856bca1e0ff696 kostenfrei https://www.mdpi.com/2227-9059/11/9/2560 kostenfrei https://doaj.org/toc/2227-9059 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2023 2560, p 2560
allfieldsSound	10.3390/biomedicines11092560 doi (DE-627)DOAJ093448910 (DE-599)DOAJ8ce7704be96f432baf856bca1e0ff696 DE-627 ger DE-627 rakwb eng QH301-705.5 Tatjana Ruskovska verfasserin aut The Role of NAD<sup<+</sup< in Metabolic Regulation of Adipose Tissue: Implications for Obesity-Induced Insulin Resistance 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Obesity-induced insulin resistance is among the key factors in the development of type 2 diabetes, atherogenic dyslipidemia and cardiovascular disease. Adipose tissue plays a key role in the regulation of whole-body metabolism and insulin sensitivity. In obesity, adipose tissue becomes inflamed and dysfunctional, exhibiting a modified biochemical signature and adipokine secretion pattern that promotes insulin resistance in peripheral tissues. An important hallmark of dysfunctional obese adipose tissue is impaired NAD<sup<+</sup</sirtuin signaling. In this chapter, we summarize the evidence for impairment of the NAD<sup<+</sup</sirtuin pathway in obesity, not only in white adipose tissue but also in brown adipose tissue and during the process of beiging, together with correlative evidence from human studies. We also describe the role of PARPs and CD38 as important NAD<sup<+</sup< consumers and discuss findings from experimental studies that investigated potential NAD<sup<+</sup< boosting strategies and their efficacy in restoring impaired NAD<sup<+</sup< metabolism in dysfunctional obese adipose tissue. In sum, these studies suggest a critical role of NAD<sup<+</sup< metabolism in adipose biology and provide a basis for the potential development of strategies to restore metabolic health in obesity. sirtuin PARP CD38 nicotinamide nicotinamide riboside nicotinamide mononucleotide Biology (General) David A. Bernlohr verfasserin aut In Biomedicines MDPI AG, 2014 11(2023), 2560, p 2560 (DE-627)750370483 (DE-600)2720867-9 22279059 nnns volume:11 year:2023 number:2560, p 2560 https://doi.org/10.3390/biomedicines11092560 kostenfrei https://doaj.org/article/8ce7704be96f432baf856bca1e0ff696 kostenfrei https://www.mdpi.com/2227-9059/11/9/2560 kostenfrei https://doaj.org/toc/2227-9059 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2023 2560, p 2560
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author	Tatjana Ruskovska
spellingShingle	Tatjana Ruskovska misc QH301-705.5 misc sirtuin misc PARP misc CD38 misc nicotinamide misc nicotinamide riboside misc nicotinamide mononucleotide misc Biology (General) The Role of NAD<sup<+</sup< in Metabolic Regulation of Adipose Tissue: Implications for Obesity-Induced Insulin Resistance
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title	The Role of NAD<sup<+</sup< in Metabolic Regulation of Adipose Tissue: Implications for Obesity-Induced Insulin Resistance
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title_full	The Role of NAD<sup<+</sup< in Metabolic Regulation of Adipose Tissue: Implications for Obesity-Induced Insulin Resistance
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title_sort	role of nad<sup<+</sup< in metabolic regulation of adipose tissue: implications for obesity-induced insulin resistance
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title_auth	The Role of NAD<sup<+</sup< in Metabolic Regulation of Adipose Tissue: Implications for Obesity-Induced Insulin Resistance
abstract	Obesity-induced insulin resistance is among the key factors in the development of type 2 diabetes, atherogenic dyslipidemia and cardiovascular disease. Adipose tissue plays a key role in the regulation of whole-body metabolism and insulin sensitivity. In obesity, adipose tissue becomes inflamed and dysfunctional, exhibiting a modified biochemical signature and adipokine secretion pattern that promotes insulin resistance in peripheral tissues. An important hallmark of dysfunctional obese adipose tissue is impaired NAD<sup<+</sup</sirtuin signaling. In this chapter, we summarize the evidence for impairment of the NAD<sup<+</sup</sirtuin pathway in obesity, not only in white adipose tissue but also in brown adipose tissue and during the process of beiging, together with correlative evidence from human studies. We also describe the role of PARPs and CD38 as important NAD<sup<+</sup< consumers and discuss findings from experimental studies that investigated potential NAD<sup<+</sup< boosting strategies and their efficacy in restoring impaired NAD<sup<+</sup< metabolism in dysfunctional obese adipose tissue. In sum, these studies suggest a critical role of NAD<sup<+</sup< metabolism in adipose biology and provide a basis for the potential development of strategies to restore metabolic health in obesity.
abstractGer	Obesity-induced insulin resistance is among the key factors in the development of type 2 diabetes, atherogenic dyslipidemia and cardiovascular disease. Adipose tissue plays a key role in the regulation of whole-body metabolism and insulin sensitivity. In obesity, adipose tissue becomes inflamed and dysfunctional, exhibiting a modified biochemical signature and adipokine secretion pattern that promotes insulin resistance in peripheral tissues. An important hallmark of dysfunctional obese adipose tissue is impaired NAD<sup<+</sup</sirtuin signaling. In this chapter, we summarize the evidence for impairment of the NAD<sup<+</sup</sirtuin pathway in obesity, not only in white adipose tissue but also in brown adipose tissue and during the process of beiging, together with correlative evidence from human studies. We also describe the role of PARPs and CD38 as important NAD<sup<+</sup< consumers and discuss findings from experimental studies that investigated potential NAD<sup<+</sup< boosting strategies and their efficacy in restoring impaired NAD<sup<+</sup< metabolism in dysfunctional obese adipose tissue. In sum, these studies suggest a critical role of NAD<sup<+</sup< metabolism in adipose biology and provide a basis for the potential development of strategies to restore metabolic health in obesity.
abstract_unstemmed	Obesity-induced insulin resistance is among the key factors in the development of type 2 diabetes, atherogenic dyslipidemia and cardiovascular disease. Adipose tissue plays a key role in the regulation of whole-body metabolism and insulin sensitivity. In obesity, adipose tissue becomes inflamed and dysfunctional, exhibiting a modified biochemical signature and adipokine secretion pattern that promotes insulin resistance in peripheral tissues. An important hallmark of dysfunctional obese adipose tissue is impaired NAD<sup<+</sup</sirtuin signaling. In this chapter, we summarize the evidence for impairment of the NAD<sup<+</sup</sirtuin pathway in obesity, not only in white adipose tissue but also in brown adipose tissue and during the process of beiging, together with correlative evidence from human studies. We also describe the role of PARPs and CD38 as important NAD<sup<+</sup< consumers and discuss findings from experimental studies that investigated potential NAD<sup<+</sup< boosting strategies and their efficacy in restoring impaired NAD<sup<+</sup< metabolism in dysfunctional obese adipose tissue. In sum, these studies suggest a critical role of NAD<sup<+</sup< metabolism in adipose biology and provide a basis for the potential development of strategies to restore metabolic health in obesity.
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title_short	The Role of NAD<sup<+</sup< in Metabolic Regulation of Adipose Tissue: Implications for Obesity-Induced Insulin Resistance
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