Clinical Profiles in Multiple Sclerosis: Cognitive Reserve and Motor Impairment along Disease Duration

(i) Background: Cognitive impairment in people with multiple sclerosis (MS) has been studied in relation to certain clinical variables (e.g., motor disability and disease duration) and lifestyle factors such as cognitive reserve (CR). However, only very few studies have considered the interaction of...
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Autor*in:	Sabrina Maffezzini [verfasserIn] Veronica Pucci [verfasserIn] Alice Riccardi [verfasserIn] Sonia Montemurro [verfasserIn] Marco Puthenparampil [verfasserIn] Paola Perini [verfasserIn] Francesca Rinaldi [verfasserIn] Paolo Gallo [verfasserIn] Giorgio Arcara [verfasserIn] Sara Mondini [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	multiple sclerosis cognitive impairment motor impairment disease duration cognitive reserve generalised additive models

Übergeordnetes Werk:	In: Behavioral Sciences - MDPI AG, 2012, 13(2023), 708, p 708
Übergeordnetes Werk:	volume:13 ; year:2023 ; number:708, p 708

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/bs13090708

Katalog-ID:	DOAJ093454961

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520			\|a (i) Background: Cognitive impairment in people with multiple sclerosis (MS) has been studied in relation to certain clinical variables (e.g., motor disability and disease duration) and lifestyle factors such as cognitive reserve (CR). However, only very few studies have considered the interaction of clinical variables and cognitive reserve in preserving the integrity of the neuropsychological profile. In this paper, we hypothesised that a higher level of CR might predict good cognitive efficiency by modulating the clinical outcome of the disease. (ii) Methods: A sample of 100 participants with MS (age range 30–74), was recruited and assessed remotely with a questionnaire to measure CR and a cognitive screening test. Data were analysed through generalized additive models. (iii) Results: We found that the model analysing the interaction between CR and disease duration, and between CR and motor disability, was able to explain a significant percentage of cognitive performance. In particular, higher levels of CR predicted a better cognitive performance despite a long disease duration, unless the motor disability was severe. (iv) Conclusion: This study highlights the crucial role of CR in modulating cognitive efficiency in people with MS.
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allfields	10.3390/bs13090708 doi (DE-627)DOAJ093454961 (DE-599)DOAJ0c255768ca804b65aa8a0ffe02f803b4 DE-627 ger DE-627 rakwb eng BF1-990 Sabrina Maffezzini verfasserin aut Clinical Profiles in Multiple Sclerosis: Cognitive Reserve and Motor Impairment along Disease Duration 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier (i) Background: Cognitive impairment in people with multiple sclerosis (MS) has been studied in relation to certain clinical variables (e.g., motor disability and disease duration) and lifestyle factors such as cognitive reserve (CR). However, only very few studies have considered the interaction of clinical variables and cognitive reserve in preserving the integrity of the neuropsychological profile. In this paper, we hypothesised that a higher level of CR might predict good cognitive efficiency by modulating the clinical outcome of the disease. (ii) Methods: A sample of 100 participants with MS (age range 30–74), was recruited and assessed remotely with a questionnaire to measure CR and a cognitive screening test. Data were analysed through generalized additive models. (iii) Results: We found that the model analysing the interaction between CR and disease duration, and between CR and motor disability, was able to explain a significant percentage of cognitive performance. In particular, higher levels of CR predicted a better cognitive performance despite a long disease duration, unless the motor disability was severe. (iv) Conclusion: This study highlights the crucial role of CR in modulating cognitive efficiency in people with MS. multiple sclerosis cognitive impairment motor impairment disease duration cognitive reserve generalised additive models Psychology Veronica Pucci verfasserin aut Alice Riccardi verfasserin aut Sonia Montemurro verfasserin aut Marco Puthenparampil verfasserin aut Paola Perini verfasserin aut Francesca Rinaldi verfasserin aut Paolo Gallo verfasserin aut Giorgio Arcara verfasserin aut Sara Mondini verfasserin aut In Behavioral Sciences MDPI AG, 2012 13(2023), 708, p 708 (DE-627)687718163 (DE-600)2651997-5 2076328X nnns volume:13 year:2023 number:708, p 708 https://doi.org/10.3390/bs13090708 kostenfrei https://doaj.org/article/0c255768ca804b65aa8a0ffe02f803b4 kostenfrei https://www.mdpi.com/2076-328X/13/9/708 kostenfrei https://doaj.org/toc/2076-328X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2086 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 708, p 708
spelling	10.3390/bs13090708 doi (DE-627)DOAJ093454961 (DE-599)DOAJ0c255768ca804b65aa8a0ffe02f803b4 DE-627 ger DE-627 rakwb eng BF1-990 Sabrina Maffezzini verfasserin aut Clinical Profiles in Multiple Sclerosis: Cognitive Reserve and Motor Impairment along Disease Duration 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier (i) Background: Cognitive impairment in people with multiple sclerosis (MS) has been studied in relation to certain clinical variables (e.g., motor disability and disease duration) and lifestyle factors such as cognitive reserve (CR). However, only very few studies have considered the interaction of clinical variables and cognitive reserve in preserving the integrity of the neuropsychological profile. In this paper, we hypothesised that a higher level of CR might predict good cognitive efficiency by modulating the clinical outcome of the disease. (ii) Methods: A sample of 100 participants with MS (age range 30–74), was recruited and assessed remotely with a questionnaire to measure CR and a cognitive screening test. Data were analysed through generalized additive models. (iii) Results: We found that the model analysing the interaction between CR and disease duration, and between CR and motor disability, was able to explain a significant percentage of cognitive performance. In particular, higher levels of CR predicted a better cognitive performance despite a long disease duration, unless the motor disability was severe. (iv) Conclusion: This study highlights the crucial role of CR in modulating cognitive efficiency in people with MS. multiple sclerosis cognitive impairment motor impairment disease duration cognitive reserve generalised additive models Psychology Veronica Pucci verfasserin aut Alice Riccardi verfasserin aut Sonia Montemurro verfasserin aut Marco Puthenparampil verfasserin aut Paola Perini verfasserin aut Francesca Rinaldi verfasserin aut Paolo Gallo verfasserin aut Giorgio Arcara verfasserin aut Sara Mondini verfasserin aut In Behavioral Sciences MDPI AG, 2012 13(2023), 708, p 708 (DE-627)687718163 (DE-600)2651997-5 2076328X nnns volume:13 year:2023 number:708, p 708 https://doi.org/10.3390/bs13090708 kostenfrei https://doaj.org/article/0c255768ca804b65aa8a0ffe02f803b4 kostenfrei https://www.mdpi.com/2076-328X/13/9/708 kostenfrei https://doaj.org/toc/2076-328X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2086 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 708, p 708
allfields_unstemmed	10.3390/bs13090708 doi (DE-627)DOAJ093454961 (DE-599)DOAJ0c255768ca804b65aa8a0ffe02f803b4 DE-627 ger DE-627 rakwb eng BF1-990 Sabrina Maffezzini verfasserin aut Clinical Profiles in Multiple Sclerosis: Cognitive Reserve and Motor Impairment along Disease Duration 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier (i) Background: Cognitive impairment in people with multiple sclerosis (MS) has been studied in relation to certain clinical variables (e.g., motor disability and disease duration) and lifestyle factors such as cognitive reserve (CR). However, only very few studies have considered the interaction of clinical variables and cognitive reserve in preserving the integrity of the neuropsychological profile. In this paper, we hypothesised that a higher level of CR might predict good cognitive efficiency by modulating the clinical outcome of the disease. (ii) Methods: A sample of 100 participants with MS (age range 30–74), was recruited and assessed remotely with a questionnaire to measure CR and a cognitive screening test. Data were analysed through generalized additive models. (iii) Results: We found that the model analysing the interaction between CR and disease duration, and between CR and motor disability, was able to explain a significant percentage of cognitive performance. In particular, higher levels of CR predicted a better cognitive performance despite a long disease duration, unless the motor disability was severe. (iv) Conclusion: This study highlights the crucial role of CR in modulating cognitive efficiency in people with MS. multiple sclerosis cognitive impairment motor impairment disease duration cognitive reserve generalised additive models Psychology Veronica Pucci verfasserin aut Alice Riccardi verfasserin aut Sonia Montemurro verfasserin aut Marco Puthenparampil verfasserin aut Paola Perini verfasserin aut Francesca Rinaldi verfasserin aut Paolo Gallo verfasserin aut Giorgio Arcara verfasserin aut Sara Mondini verfasserin aut In Behavioral Sciences MDPI AG, 2012 13(2023), 708, p 708 (DE-627)687718163 (DE-600)2651997-5 2076328X nnns volume:13 year:2023 number:708, p 708 https://doi.org/10.3390/bs13090708 kostenfrei https://doaj.org/article/0c255768ca804b65aa8a0ffe02f803b4 kostenfrei https://www.mdpi.com/2076-328X/13/9/708 kostenfrei https://doaj.org/toc/2076-328X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2086 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 708, p 708
allfieldsGer	10.3390/bs13090708 doi (DE-627)DOAJ093454961 (DE-599)DOAJ0c255768ca804b65aa8a0ffe02f803b4 DE-627 ger DE-627 rakwb eng BF1-990 Sabrina Maffezzini verfasserin aut Clinical Profiles in Multiple Sclerosis: Cognitive Reserve and Motor Impairment along Disease Duration 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier (i) Background: Cognitive impairment in people with multiple sclerosis (MS) has been studied in relation to certain clinical variables (e.g., motor disability and disease duration) and lifestyle factors such as cognitive reserve (CR). However, only very few studies have considered the interaction of clinical variables and cognitive reserve in preserving the integrity of the neuropsychological profile. In this paper, we hypothesised that a higher level of CR might predict good cognitive efficiency by modulating the clinical outcome of the disease. (ii) Methods: A sample of 100 participants with MS (age range 30–74), was recruited and assessed remotely with a questionnaire to measure CR and a cognitive screening test. Data were analysed through generalized additive models. (iii) Results: We found that the model analysing the interaction between CR and disease duration, and between CR and motor disability, was able to explain a significant percentage of cognitive performance. In particular, higher levels of CR predicted a better cognitive performance despite a long disease duration, unless the motor disability was severe. (iv) Conclusion: This study highlights the crucial role of CR in modulating cognitive efficiency in people with MS. multiple sclerosis cognitive impairment motor impairment disease duration cognitive reserve generalised additive models Psychology Veronica Pucci verfasserin aut Alice Riccardi verfasserin aut Sonia Montemurro verfasserin aut Marco Puthenparampil verfasserin aut Paola Perini verfasserin aut Francesca Rinaldi verfasserin aut Paolo Gallo verfasserin aut Giorgio Arcara verfasserin aut Sara Mondini verfasserin aut In Behavioral Sciences MDPI AG, 2012 13(2023), 708, p 708 (DE-627)687718163 (DE-600)2651997-5 2076328X nnns volume:13 year:2023 number:708, p 708 https://doi.org/10.3390/bs13090708 kostenfrei https://doaj.org/article/0c255768ca804b65aa8a0ffe02f803b4 kostenfrei https://www.mdpi.com/2076-328X/13/9/708 kostenfrei https://doaj.org/toc/2076-328X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2086 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 708, p 708
allfieldsSound	10.3390/bs13090708 doi (DE-627)DOAJ093454961 (DE-599)DOAJ0c255768ca804b65aa8a0ffe02f803b4 DE-627 ger DE-627 rakwb eng BF1-990 Sabrina Maffezzini verfasserin aut Clinical Profiles in Multiple Sclerosis: Cognitive Reserve and Motor Impairment along Disease Duration 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier (i) Background: Cognitive impairment in people with multiple sclerosis (MS) has been studied in relation to certain clinical variables (e.g., motor disability and disease duration) and lifestyle factors such as cognitive reserve (CR). However, only very few studies have considered the interaction of clinical variables and cognitive reserve in preserving the integrity of the neuropsychological profile. In this paper, we hypothesised that a higher level of CR might predict good cognitive efficiency by modulating the clinical outcome of the disease. (ii) Methods: A sample of 100 participants with MS (age range 30–74), was recruited and assessed remotely with a questionnaire to measure CR and a cognitive screening test. Data were analysed through generalized additive models. (iii) Results: We found that the model analysing the interaction between CR and disease duration, and between CR and motor disability, was able to explain a significant percentage of cognitive performance. In particular, higher levels of CR predicted a better cognitive performance despite a long disease duration, unless the motor disability was severe. (iv) Conclusion: This study highlights the crucial role of CR in modulating cognitive efficiency in people with MS. multiple sclerosis cognitive impairment motor impairment disease duration cognitive reserve generalised additive models Psychology Veronica Pucci verfasserin aut Alice Riccardi verfasserin aut Sonia Montemurro verfasserin aut Marco Puthenparampil verfasserin aut Paola Perini verfasserin aut Francesca Rinaldi verfasserin aut Paolo Gallo verfasserin aut Giorgio Arcara verfasserin aut Sara Mondini verfasserin aut In Behavioral Sciences MDPI AG, 2012 13(2023), 708, p 708 (DE-627)687718163 (DE-600)2651997-5 2076328X nnns volume:13 year:2023 number:708, p 708 https://doi.org/10.3390/bs13090708 kostenfrei https://doaj.org/article/0c255768ca804b65aa8a0ffe02f803b4 kostenfrei https://www.mdpi.com/2076-328X/13/9/708 kostenfrei https://doaj.org/toc/2076-328X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2086 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 708, p 708
language	English
source	In Behavioral Sciences 13(2023), 708, p 708 volume:13 year:2023 number:708, p 708
sourceStr	In Behavioral Sciences 13(2023), 708, p 708 volume:13 year:2023 number:708, p 708
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	multiple sclerosis cognitive impairment motor impairment disease duration cognitive reserve generalised additive models Psychology
isfreeaccess_bool	true
container_title	Behavioral Sciences
authorswithroles_txt_mv	Sabrina Maffezzini @@aut@@ Veronica Pucci @@aut@@ Alice Riccardi @@aut@@ Sonia Montemurro @@aut@@ Marco Puthenparampil @@aut@@ Paola Perini @@aut@@ Francesca Rinaldi @@aut@@ Paolo Gallo @@aut@@ Giorgio Arcara @@aut@@ Sara Mondini @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	687718163
id	DOAJ093454961
language_de	englisch
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callnumber-first	B - Philosophy, Psychology, Religion
author	Sabrina Maffezzini
spellingShingle	Sabrina Maffezzini misc BF1-990 misc multiple sclerosis misc cognitive impairment misc motor impairment misc disease duration misc cognitive reserve misc generalised additive models misc Psychology Clinical Profiles in Multiple Sclerosis: Cognitive Reserve and Motor Impairment along Disease Duration
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topic_title	BF1-990 Clinical Profiles in Multiple Sclerosis: Cognitive Reserve and Motor Impairment along Disease Duration multiple sclerosis cognitive impairment motor impairment disease duration cognitive reserve generalised additive models
topic	misc BF1-990 misc multiple sclerosis misc cognitive impairment misc motor impairment misc disease duration misc cognitive reserve misc generalised additive models misc Psychology
topic_unstemmed	misc BF1-990 misc multiple sclerosis misc cognitive impairment misc motor impairment misc disease duration misc cognitive reserve misc generalised additive models misc Psychology
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title	Clinical Profiles in Multiple Sclerosis: Cognitive Reserve and Motor Impairment along Disease Duration
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title_full	Clinical Profiles in Multiple Sclerosis: Cognitive Reserve and Motor Impairment along Disease Duration
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author_browse	Sabrina Maffezzini Veronica Pucci Alice Riccardi Sonia Montemurro Marco Puthenparampil Paola Perini Francesca Rinaldi Paolo Gallo Giorgio Arcara Sara Mondini
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title_sort	clinical profiles in multiple sclerosis: cognitive reserve and motor impairment along disease duration
callnumber	BF1-990
title_auth	Clinical Profiles in Multiple Sclerosis: Cognitive Reserve and Motor Impairment along Disease Duration
abstract	(i) Background: Cognitive impairment in people with multiple sclerosis (MS) has been studied in relation to certain clinical variables (e.g., motor disability and disease duration) and lifestyle factors such as cognitive reserve (CR). However, only very few studies have considered the interaction of clinical variables and cognitive reserve in preserving the integrity of the neuropsychological profile. In this paper, we hypothesised that a higher level of CR might predict good cognitive efficiency by modulating the clinical outcome of the disease. (ii) Methods: A sample of 100 participants with MS (age range 30–74), was recruited and assessed remotely with a questionnaire to measure CR and a cognitive screening test. Data were analysed through generalized additive models. (iii) Results: We found that the model analysing the interaction between CR and disease duration, and between CR and motor disability, was able to explain a significant percentage of cognitive performance. In particular, higher levels of CR predicted a better cognitive performance despite a long disease duration, unless the motor disability was severe. (iv) Conclusion: This study highlights the crucial role of CR in modulating cognitive efficiency in people with MS.
abstractGer	(i) Background: Cognitive impairment in people with multiple sclerosis (MS) has been studied in relation to certain clinical variables (e.g., motor disability and disease duration) and lifestyle factors such as cognitive reserve (CR). However, only very few studies have considered the interaction of clinical variables and cognitive reserve in preserving the integrity of the neuropsychological profile. In this paper, we hypothesised that a higher level of CR might predict good cognitive efficiency by modulating the clinical outcome of the disease. (ii) Methods: A sample of 100 participants with MS (age range 30–74), was recruited and assessed remotely with a questionnaire to measure CR and a cognitive screening test. Data were analysed through generalized additive models. (iii) Results: We found that the model analysing the interaction between CR and disease duration, and between CR and motor disability, was able to explain a significant percentage of cognitive performance. In particular, higher levels of CR predicted a better cognitive performance despite a long disease duration, unless the motor disability was severe. (iv) Conclusion: This study highlights the crucial role of CR in modulating cognitive efficiency in people with MS.
abstract_unstemmed	(i) Background: Cognitive impairment in people with multiple sclerosis (MS) has been studied in relation to certain clinical variables (e.g., motor disability and disease duration) and lifestyle factors such as cognitive reserve (CR). However, only very few studies have considered the interaction of clinical variables and cognitive reserve in preserving the integrity of the neuropsychological profile. In this paper, we hypothesised that a higher level of CR might predict good cognitive efficiency by modulating the clinical outcome of the disease. (ii) Methods: A sample of 100 participants with MS (age range 30–74), was recruited and assessed remotely with a questionnaire to measure CR and a cognitive screening test. Data were analysed through generalized additive models. (iii) Results: We found that the model analysing the interaction between CR and disease duration, and between CR and motor disability, was able to explain a significant percentage of cognitive performance. In particular, higher levels of CR predicted a better cognitive performance despite a long disease duration, unless the motor disability was severe. (iv) Conclusion: This study highlights the crucial role of CR in modulating cognitive efficiency in people with MS.
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title_short	Clinical Profiles in Multiple Sclerosis: Cognitive Reserve and Motor Impairment along Disease Duration
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Clinical Profiles in Multiple Sclerosis: Cognitive Reserve and Motor Impairment along Disease Duration

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