Redox Regulation of Nrf2 in Cisplatin-Induced Kidney Injury

Cisplatin, a potent chemotherapeutic agent, is marred by severe nephrotoxicity that is governed by mechanisms involving oxidative stress, inflammation, and apoptosis pathways. The transcription factor Nrf2, pivotal in cellular defense against oxidative stress and inflammation, is the master regulato...
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Gespeichert in:

Autor*in:	Kranti A. Mapuskar [verfasserIn] Casey F. Pulliam [verfasserIn] Diana Zepeda-Orozco [verfasserIn] Benjamin R. Griffin [verfasserIn] Muhammad Furqan [verfasserIn] Douglas R. Spitz [verfasserIn] Bryan G. Allen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	oxidative stress reactive oxygen species Nrf2 chemotherapy kidney injury metabolism

Übergeordnetes Werk:	In: Antioxidants - MDPI AG, 2013, 12(2023), 1728, p 1728
Übergeordnetes Werk:	volume:12 ; year:2023 ; number:1728, p 1728

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/antiox12091728

Katalog-ID:	DOAJ093465785

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language	English
source	In Antioxidants 12(2023), 1728, p 1728 volume:12 year:2023 number:1728, p 1728
sourceStr	In Antioxidants 12(2023), 1728, p 1728 volume:12 year:2023 number:1728, p 1728
format_phy_str_mv	Article
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topic_facet	oxidative stress reactive oxygen species Nrf2 chemotherapy kidney injury metabolism Therapeutics. Pharmacology
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container_title	Antioxidants
authorswithroles_txt_mv	Kranti A. Mapuskar @@aut@@ Casey F. Pulliam @@aut@@ Diana Zepeda-Orozco @@aut@@ Benjamin R. Griffin @@aut@@ Muhammad Furqan @@aut@@ Douglas R. Spitz @@aut@@ Bryan G. Allen @@aut@@
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callnumber-first	R - Medicine
author	Kranti A. Mapuskar
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topic_title	RM1-950 Redox Regulation of Nrf2 in Cisplatin-Induced Kidney Injury oxidative stress reactive oxygen species Nrf2 chemotherapy kidney injury metabolism
topic	misc RM1-950 misc oxidative stress misc reactive oxygen species misc Nrf2 misc chemotherapy misc kidney injury misc metabolism misc Therapeutics. Pharmacology
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title	Redox Regulation of Nrf2 in Cisplatin-Induced Kidney Injury
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title_sort	redox regulation of nrf2 in cisplatin-induced kidney injury
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title_auth	Redox Regulation of Nrf2 in Cisplatin-Induced Kidney Injury
abstract	Cisplatin, a potent chemotherapeutic agent, is marred by severe nephrotoxicity that is governed by mechanisms involving oxidative stress, inflammation, and apoptosis pathways. The transcription factor Nrf2, pivotal in cellular defense against oxidative stress and inflammation, is the master regulator of the antioxidant response, upregulating antioxidants and cytoprotective genes under oxidative stress. This review discusses the mechanisms underlying chemotherapy-induced kidney injury, focusing on the role of Nrf2 in cancer therapy and its redox regulation in cisplatin-induced kidney injury. We also explore Nrf2's signaling pathways, post-translational modifications, and its involvement in autophagy, as well as examine redox-based strategies for modulating Nrf2 in cisplatin-induced kidney injury while considering the limitations and potential off-target effects of Nrf2 modulation. Understanding the redox regulation of Nrf2 in cisplatin-induced kidney injury holds significant promise for developing novel therapeutic interventions. This knowledge could provide valuable insights into potential strategies for mitigating the nephrotoxicity associated with cisplatin, ultimately enhancing the safety and efficacy of cancer treatment.
abstractGer	Cisplatin, a potent chemotherapeutic agent, is marred by severe nephrotoxicity that is governed by mechanisms involving oxidative stress, inflammation, and apoptosis pathways. The transcription factor Nrf2, pivotal in cellular defense against oxidative stress and inflammation, is the master regulator of the antioxidant response, upregulating antioxidants and cytoprotective genes under oxidative stress. This review discusses the mechanisms underlying chemotherapy-induced kidney injury, focusing on the role of Nrf2 in cancer therapy and its redox regulation in cisplatin-induced kidney injury. We also explore Nrf2's signaling pathways, post-translational modifications, and its involvement in autophagy, as well as examine redox-based strategies for modulating Nrf2 in cisplatin-induced kidney injury while considering the limitations and potential off-target effects of Nrf2 modulation. Understanding the redox regulation of Nrf2 in cisplatin-induced kidney injury holds significant promise for developing novel therapeutic interventions. This knowledge could provide valuable insights into potential strategies for mitigating the nephrotoxicity associated with cisplatin, ultimately enhancing the safety and efficacy of cancer treatment.
abstract_unstemmed	Cisplatin, a potent chemotherapeutic agent, is marred by severe nephrotoxicity that is governed by mechanisms involving oxidative stress, inflammation, and apoptosis pathways. The transcription factor Nrf2, pivotal in cellular defense against oxidative stress and inflammation, is the master regulator of the antioxidant response, upregulating antioxidants and cytoprotective genes under oxidative stress. This review discusses the mechanisms underlying chemotherapy-induced kidney injury, focusing on the role of Nrf2 in cancer therapy and its redox regulation in cisplatin-induced kidney injury. We also explore Nrf2's signaling pathways, post-translational modifications, and its involvement in autophagy, as well as examine redox-based strategies for modulating Nrf2 in cisplatin-induced kidney injury while considering the limitations and potential off-target effects of Nrf2 modulation. Understanding the redox regulation of Nrf2 in cisplatin-induced kidney injury holds significant promise for developing novel therapeutic interventions. This knowledge could provide valuable insights into potential strategies for mitigating the nephrotoxicity associated with cisplatin, ultimately enhancing the safety and efficacy of cancer treatment.
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title_short	Redox Regulation of Nrf2 in Cisplatin-Induced Kidney Injury
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