Oral Semaglutide under Human Protocols and Doses Regulates Food Intake, Body Weight, and Glycemia in Diet-Induced Obese Mice

The first oral form of the glucagon-like peptide-1 receptor agonist, oral semaglutide, has recently been launched and potently controls glycemia and body weight in subjects with type 2 diabetes. This drug carries the absorption enhancer and requires specific protocols of administration. The mechanis...
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Gespeichert in:

Autor*in:	Yermek Rakhat [verfasserIn] Lei Wang [verfasserIn] Wanxin Han [verfasserIn] Aktolkyn Rustemova [verfasserIn] Nazymgul Kulzhanova [verfasserIn] Yuichiro Yamada [verfasserIn] Daisuke Yabe [verfasserIn] Yutaka Seino [verfasserIn] Toshihiko Yada [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	oral semaglutide GLP-1 receptor agonist obesity diabetes food intake body weight

Übergeordnetes Werk:	In: Nutrients - MDPI AG, 2009, 15(2023), 17, p 3765
Übergeordnetes Werk:	volume:15 ; year:2023 ; number:17, p 3765

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/nu15173765

Katalog-ID:	DOAJ09349548X

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callnumber-first	T - Technology
author	Yermek Rakhat
spellingShingle	Yermek Rakhat misc TX341-641 misc oral semaglutide misc GLP-1 receptor agonist misc obesity misc diabetes misc food intake misc body weight misc Nutrition. Foods and food supply Oral Semaglutide under Human Protocols and Doses Regulates Food Intake, Body Weight, and Glycemia in Diet-Induced Obese Mice
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topic_title	TX341-641 Oral Semaglutide under Human Protocols and Doses Regulates Food Intake, Body Weight, and Glycemia in Diet-Induced Obese Mice oral semaglutide GLP-1 receptor agonist obesity diabetes food intake body weight
topic	misc TX341-641 misc oral semaglutide misc GLP-1 receptor agonist misc obesity misc diabetes misc food intake misc body weight misc Nutrition. Foods and food supply
topic_unstemmed	misc TX341-641 misc oral semaglutide misc GLP-1 receptor agonist misc obesity misc diabetes misc food intake misc body weight misc Nutrition. Foods and food supply
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title	Oral Semaglutide under Human Protocols and Doses Regulates Food Intake, Body Weight, and Glycemia in Diet-Induced Obese Mice
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title_full	Oral Semaglutide under Human Protocols and Doses Regulates Food Intake, Body Weight, and Glycemia in Diet-Induced Obese Mice
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title_sort	oral semaglutide under human protocols and doses regulates food intake, body weight, and glycemia in diet-induced obese mice
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title_auth	Oral Semaglutide under Human Protocols and Doses Regulates Food Intake, Body Weight, and Glycemia in Diet-Induced Obese Mice
abstract	The first oral form of the glucagon-like peptide-1 receptor agonist, oral semaglutide, has recently been launched and potently controls glycemia and body weight in subjects with type 2 diabetes. This drug carries the absorption enhancer and requires specific protocols of administration. The mechanism of action of oral semaglutide is not fully understood, for which an appropriate experimental model is required. This study explores the metabolic effects of oral semaglutide in mice under human protocols and doses. Oral semaglutide was bolus and once daily injected into high-fat diet-induced obese (DIO) mice under human protocols, followed by monitoring blood glucose, food intake, and body weight. Oral semaglutide 0.23 mg/kg, a comparable human dose (14 mg) in a small volume of water under human protocols rapidly decreased blood glucose and food intake and continuously reduced food intake and weight gain for 3 days in DIO mice. At 0.7 mg/kg (42 mg), this drug was somewhat more potent. Oral semaglutide with human protocols and doses rapidly reduces blood glucose and food intake and continuously suppresses feeding and weight in DIO mice. This study establishes mice as a model suitable for analyzing the mechanism of anti-obesity/diabetes actions of oral semaglutide.
abstractGer	The first oral form of the glucagon-like peptide-1 receptor agonist, oral semaglutide, has recently been launched and potently controls glycemia and body weight in subjects with type 2 diabetes. This drug carries the absorption enhancer and requires specific protocols of administration. The mechanism of action of oral semaglutide is not fully understood, for which an appropriate experimental model is required. This study explores the metabolic effects of oral semaglutide in mice under human protocols and doses. Oral semaglutide was bolus and once daily injected into high-fat diet-induced obese (DIO) mice under human protocols, followed by monitoring blood glucose, food intake, and body weight. Oral semaglutide 0.23 mg/kg, a comparable human dose (14 mg) in a small volume of water under human protocols rapidly decreased blood glucose and food intake and continuously reduced food intake and weight gain for 3 days in DIO mice. At 0.7 mg/kg (42 mg), this drug was somewhat more potent. Oral semaglutide with human protocols and doses rapidly reduces blood glucose and food intake and continuously suppresses feeding and weight in DIO mice. This study establishes mice as a model suitable for analyzing the mechanism of anti-obesity/diabetes actions of oral semaglutide.
abstract_unstemmed	The first oral form of the glucagon-like peptide-1 receptor agonist, oral semaglutide, has recently been launched and potently controls glycemia and body weight in subjects with type 2 diabetes. This drug carries the absorption enhancer and requires specific protocols of administration. The mechanism of action of oral semaglutide is not fully understood, for which an appropriate experimental model is required. This study explores the metabolic effects of oral semaglutide in mice under human protocols and doses. Oral semaglutide was bolus and once daily injected into high-fat diet-induced obese (DIO) mice under human protocols, followed by monitoring blood glucose, food intake, and body weight. Oral semaglutide 0.23 mg/kg, a comparable human dose (14 mg) in a small volume of water under human protocols rapidly decreased blood glucose and food intake and continuously reduced food intake and weight gain for 3 days in DIO mice. At 0.7 mg/kg (42 mg), this drug was somewhat more potent. Oral semaglutide with human protocols and doses rapidly reduces blood glucose and food intake and continuously suppresses feeding and weight in DIO mice. This study establishes mice as a model suitable for analyzing the mechanism of anti-obesity/diabetes actions of oral semaglutide.
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title_short	Oral Semaglutide under Human Protocols and Doses Regulates Food Intake, Body Weight, and Glycemia in Diet-Induced Obese Mice
url	https://doi.org/10.3390/nu15173765 https://doaj.org/article/fa8e5c411a884009a7f97c5ccc486deb https://www.mdpi.com/2072-6643/15/17/3765 https://doaj.org/toc/2072-6643
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author2	Lei Wang Wanxin Han Aktolkyn Rustemova Nazymgul Kulzhanova Yuichiro Yamada Daisuke Yabe Yutaka Seino Toshihiko Yada
author2Str	Lei Wang Wanxin Han Aktolkyn Rustemova Nazymgul Kulzhanova Yuichiro Yamada Daisuke Yabe Yutaka Seino Toshihiko Yada
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up_date	2024-07-03T17:39:51.312Z
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Oral Semaglutide under Human Protocols and Doses Regulates Food Intake, Body Weight, and Glycemia in Diet-Induced Obese Mice

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