Effectiveness of Immature Asian Pear Extract on Pulmonary Injury Caused by Particulate Matter in Mice

The use of natural products in developing respiratory-function-protective pharmaceuticals is actively progressing. However, in this context, the improvement effects of young Asian pear (<i<Pyrus pyrifolia</i< Nakai) extracts have not been evaluated yet. Thus, this study investigated the...
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Autor*in:	Mi-Ran Kim [verfasserIn] Jin-Hwa Lee [verfasserIn] Mo-Un Ku [verfasserIn] Ki-Young Kim [verfasserIn] Su Shin [verfasserIn] Eun-Jin Hong [verfasserIn] Sae-Kwang Ku [verfasserIn] Jae-Suk Choi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Asian pear lung injury PM mice anti-inflammatory activity

Übergeordnetes Werk:	In: Applied Sciences - MDPI AG, 2012, 13(2023), 17, p 9578
Übergeordnetes Werk:	volume:13 ; year:2023 ; number:17, p 9578

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/app13179578

Katalog-ID:	DOAJ093532059

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allfields	10.3390/app13179578 doi (DE-627)DOAJ093532059 (DE-599)DOAJe494830b4dfe40539f5605fd45770cd7 DE-627 ger DE-627 rakwb eng TA1-2040 QH301-705.5 QC1-999 QD1-999 Mi-Ran Kim verfasserin aut Effectiveness of Immature Asian Pear Extract on Pulmonary Injury Caused by Particulate Matter in Mice 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The use of natural products in developing respiratory-function-protective pharmaceuticals is actively progressing. However, in this context, the improvement effects of young Asian pear (<i<Pyrus pyrifolia</i< Nakai) extracts have not been evaluated yet. Thus, this study investigated the anti-inflammatory and lung damage improvement effects of immature Asian pear extract (IAP; 400, 200, and 100 mg/kg) using a particulate matter 2.5 μm (PM<sub<2.5</sub<)-induced sub-acute lung injury mouse model. The experimental results were compared with dexamethasone (0.75 mg/kg), used as a control drug. After two intranasal instillations of PM<sub<2.5</sub< and ten doses of IAP extract for eight days, changes in macroscopic lung autopsy, leukocyte fractionation from bronchoalveolar lavage fluid, lung antioxidant defense system, lung histopathology, and mRNA expression in lung tissue were confirmed. Stress-induced inflammatory lung damage through the increased expression of PM<sub<2.5</sub<-induced PI3K/Akt and p38 MAPK mRNA was significantly suppressed via the administration of IAP extract (400–100 mg/kg). Furthermore, IAP extract administration promoted serous fluid production in lung tissue, increased substance P and ACh levels, and decreased mucus-production-related expression of MUC5AC and MUC5B mRNA. Interestingly, the observed effects showed a dose-dependent manner without serious hepatotoxicity. The results of this study indicate that a proper oral administration of IAP extract could be helpful in protecting against lung diseases, positioning IAP extract as a potential candidate for an alternative agent to safeguard the respiratory system. Asian pear <i<Pyrus pyrifolia</i< lung injury PM<sub<2.5</sub< mice anti-inflammatory activity Technology T Engineering (General). Civil engineering (General) Biology (General) Physics Chemistry Jin-Hwa Lee verfasserin aut Mo-Un Ku verfasserin aut Ki-Young Kim verfasserin aut Su Shin verfasserin aut Eun-Jin Hong verfasserin aut Sae-Kwang Ku verfasserin aut Jae-Suk Choi verfasserin aut In Applied Sciences MDPI AG, 2012 13(2023), 17, p 9578 (DE-627)737287640 (DE-600)2704225-X 20763417 nnns volume:13 year:2023 number:17, p 9578 https://doi.org/10.3390/app13179578 kostenfrei https://doaj.org/article/e494830b4dfe40539f5605fd45770cd7 kostenfrei https://www.mdpi.com/2076-3417/13/17/9578 kostenfrei https://doaj.org/toc/2076-3417 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 17, p 9578
spelling	10.3390/app13179578 doi (DE-627)DOAJ093532059 (DE-599)DOAJe494830b4dfe40539f5605fd45770cd7 DE-627 ger DE-627 rakwb eng TA1-2040 QH301-705.5 QC1-999 QD1-999 Mi-Ran Kim verfasserin aut Effectiveness of Immature Asian Pear Extract on Pulmonary Injury Caused by Particulate Matter in Mice 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The use of natural products in developing respiratory-function-protective pharmaceuticals is actively progressing. However, in this context, the improvement effects of young Asian pear (<i<Pyrus pyrifolia</i< Nakai) extracts have not been evaluated yet. Thus, this study investigated the anti-inflammatory and lung damage improvement effects of immature Asian pear extract (IAP; 400, 200, and 100 mg/kg) using a particulate matter 2.5 μm (PM<sub<2.5</sub<)-induced sub-acute lung injury mouse model. The experimental results were compared with dexamethasone (0.75 mg/kg), used as a control drug. After two intranasal instillations of PM<sub<2.5</sub< and ten doses of IAP extract for eight days, changes in macroscopic lung autopsy, leukocyte fractionation from bronchoalveolar lavage fluid, lung antioxidant defense system, lung histopathology, and mRNA expression in lung tissue were confirmed. Stress-induced inflammatory lung damage through the increased expression of PM<sub<2.5</sub<-induced PI3K/Akt and p38 MAPK mRNA was significantly suppressed via the administration of IAP extract (400–100 mg/kg). Furthermore, IAP extract administration promoted serous fluid production in lung tissue, increased substance P and ACh levels, and decreased mucus-production-related expression of MUC5AC and MUC5B mRNA. Interestingly, the observed effects showed a dose-dependent manner without serious hepatotoxicity. The results of this study indicate that a proper oral administration of IAP extract could be helpful in protecting against lung diseases, positioning IAP extract as a potential candidate for an alternative agent to safeguard the respiratory system. Asian pear <i<Pyrus pyrifolia</i< lung injury PM<sub<2.5</sub< mice anti-inflammatory activity Technology T Engineering (General). Civil engineering (General) Biology (General) Physics Chemistry Jin-Hwa Lee verfasserin aut Mo-Un Ku verfasserin aut Ki-Young Kim verfasserin aut Su Shin verfasserin aut Eun-Jin Hong verfasserin aut Sae-Kwang Ku verfasserin aut Jae-Suk Choi verfasserin aut In Applied Sciences MDPI AG, 2012 13(2023), 17, p 9578 (DE-627)737287640 (DE-600)2704225-X 20763417 nnns volume:13 year:2023 number:17, p 9578 https://doi.org/10.3390/app13179578 kostenfrei https://doaj.org/article/e494830b4dfe40539f5605fd45770cd7 kostenfrei https://www.mdpi.com/2076-3417/13/17/9578 kostenfrei https://doaj.org/toc/2076-3417 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 17, p 9578
allfields_unstemmed	10.3390/app13179578 doi (DE-627)DOAJ093532059 (DE-599)DOAJe494830b4dfe40539f5605fd45770cd7 DE-627 ger DE-627 rakwb eng TA1-2040 QH301-705.5 QC1-999 QD1-999 Mi-Ran Kim verfasserin aut Effectiveness of Immature Asian Pear Extract on Pulmonary Injury Caused by Particulate Matter in Mice 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The use of natural products in developing respiratory-function-protective pharmaceuticals is actively progressing. However, in this context, the improvement effects of young Asian pear (<i<Pyrus pyrifolia</i< Nakai) extracts have not been evaluated yet. Thus, this study investigated the anti-inflammatory and lung damage improvement effects of immature Asian pear extract (IAP; 400, 200, and 100 mg/kg) using a particulate matter 2.5 μm (PM<sub<2.5</sub<)-induced sub-acute lung injury mouse model. The experimental results were compared with dexamethasone (0.75 mg/kg), used as a control drug. After two intranasal instillations of PM<sub<2.5</sub< and ten doses of IAP extract for eight days, changes in macroscopic lung autopsy, leukocyte fractionation from bronchoalveolar lavage fluid, lung antioxidant defense system, lung histopathology, and mRNA expression in lung tissue were confirmed. Stress-induced inflammatory lung damage through the increased expression of PM<sub<2.5</sub<-induced PI3K/Akt and p38 MAPK mRNA was significantly suppressed via the administration of IAP extract (400–100 mg/kg). Furthermore, IAP extract administration promoted serous fluid production in lung tissue, increased substance P and ACh levels, and decreased mucus-production-related expression of MUC5AC and MUC5B mRNA. Interestingly, the observed effects showed a dose-dependent manner without serious hepatotoxicity. The results of this study indicate that a proper oral administration of IAP extract could be helpful in protecting against lung diseases, positioning IAP extract as a potential candidate for an alternative agent to safeguard the respiratory system. Asian pear <i<Pyrus pyrifolia</i< lung injury PM<sub<2.5</sub< mice anti-inflammatory activity Technology T Engineering (General). Civil engineering (General) Biology (General) Physics Chemistry Jin-Hwa Lee verfasserin aut Mo-Un Ku verfasserin aut Ki-Young Kim verfasserin aut Su Shin verfasserin aut Eun-Jin Hong verfasserin aut Sae-Kwang Ku verfasserin aut Jae-Suk Choi verfasserin aut In Applied Sciences MDPI AG, 2012 13(2023), 17, p 9578 (DE-627)737287640 (DE-600)2704225-X 20763417 nnns volume:13 year:2023 number:17, p 9578 https://doi.org/10.3390/app13179578 kostenfrei https://doaj.org/article/e494830b4dfe40539f5605fd45770cd7 kostenfrei https://www.mdpi.com/2076-3417/13/17/9578 kostenfrei https://doaj.org/toc/2076-3417 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 17, p 9578
allfieldsGer	10.3390/app13179578 doi (DE-627)DOAJ093532059 (DE-599)DOAJe494830b4dfe40539f5605fd45770cd7 DE-627 ger DE-627 rakwb eng TA1-2040 QH301-705.5 QC1-999 QD1-999 Mi-Ran Kim verfasserin aut Effectiveness of Immature Asian Pear Extract on Pulmonary Injury Caused by Particulate Matter in Mice 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The use of natural products in developing respiratory-function-protective pharmaceuticals is actively progressing. However, in this context, the improvement effects of young Asian pear (<i<Pyrus pyrifolia</i< Nakai) extracts have not been evaluated yet. Thus, this study investigated the anti-inflammatory and lung damage improvement effects of immature Asian pear extract (IAP; 400, 200, and 100 mg/kg) using a particulate matter 2.5 μm (PM<sub<2.5</sub<)-induced sub-acute lung injury mouse model. The experimental results were compared with dexamethasone (0.75 mg/kg), used as a control drug. After two intranasal instillations of PM<sub<2.5</sub< and ten doses of IAP extract for eight days, changes in macroscopic lung autopsy, leukocyte fractionation from bronchoalveolar lavage fluid, lung antioxidant defense system, lung histopathology, and mRNA expression in lung tissue were confirmed. Stress-induced inflammatory lung damage through the increased expression of PM<sub<2.5</sub<-induced PI3K/Akt and p38 MAPK mRNA was significantly suppressed via the administration of IAP extract (400–100 mg/kg). Furthermore, IAP extract administration promoted serous fluid production in lung tissue, increased substance P and ACh levels, and decreased mucus-production-related expression of MUC5AC and MUC5B mRNA. Interestingly, the observed effects showed a dose-dependent manner without serious hepatotoxicity. The results of this study indicate that a proper oral administration of IAP extract could be helpful in protecting against lung diseases, positioning IAP extract as a potential candidate for an alternative agent to safeguard the respiratory system. Asian pear <i<Pyrus pyrifolia</i< lung injury PM<sub<2.5</sub< mice anti-inflammatory activity Technology T Engineering (General). Civil engineering (General) Biology (General) Physics Chemistry Jin-Hwa Lee verfasserin aut Mo-Un Ku verfasserin aut Ki-Young Kim verfasserin aut Su Shin verfasserin aut Eun-Jin Hong verfasserin aut Sae-Kwang Ku verfasserin aut Jae-Suk Choi verfasserin aut In Applied Sciences MDPI AG, 2012 13(2023), 17, p 9578 (DE-627)737287640 (DE-600)2704225-X 20763417 nnns volume:13 year:2023 number:17, p 9578 https://doi.org/10.3390/app13179578 kostenfrei https://doaj.org/article/e494830b4dfe40539f5605fd45770cd7 kostenfrei https://www.mdpi.com/2076-3417/13/17/9578 kostenfrei https://doaj.org/toc/2076-3417 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 17, p 9578
allfieldsSound	10.3390/app13179578 doi (DE-627)DOAJ093532059 (DE-599)DOAJe494830b4dfe40539f5605fd45770cd7 DE-627 ger DE-627 rakwb eng TA1-2040 QH301-705.5 QC1-999 QD1-999 Mi-Ran Kim verfasserin aut Effectiveness of Immature Asian Pear Extract on Pulmonary Injury Caused by Particulate Matter in Mice 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The use of natural products in developing respiratory-function-protective pharmaceuticals is actively progressing. However, in this context, the improvement effects of young Asian pear (<i<Pyrus pyrifolia</i< Nakai) extracts have not been evaluated yet. Thus, this study investigated the anti-inflammatory and lung damage improvement effects of immature Asian pear extract (IAP; 400, 200, and 100 mg/kg) using a particulate matter 2.5 μm (PM<sub<2.5</sub<)-induced sub-acute lung injury mouse model. The experimental results were compared with dexamethasone (0.75 mg/kg), used as a control drug. After two intranasal instillations of PM<sub<2.5</sub< and ten doses of IAP extract for eight days, changes in macroscopic lung autopsy, leukocyte fractionation from bronchoalveolar lavage fluid, lung antioxidant defense system, lung histopathology, and mRNA expression in lung tissue were confirmed. Stress-induced inflammatory lung damage through the increased expression of PM<sub<2.5</sub<-induced PI3K/Akt and p38 MAPK mRNA was significantly suppressed via the administration of IAP extract (400–100 mg/kg). Furthermore, IAP extract administration promoted serous fluid production in lung tissue, increased substance P and ACh levels, and decreased mucus-production-related expression of MUC5AC and MUC5B mRNA. Interestingly, the observed effects showed a dose-dependent manner without serious hepatotoxicity. The results of this study indicate that a proper oral administration of IAP extract could be helpful in protecting against lung diseases, positioning IAP extract as a potential candidate for an alternative agent to safeguard the respiratory system. Asian pear <i<Pyrus pyrifolia</i< lung injury PM<sub<2.5</sub< mice anti-inflammatory activity Technology T Engineering (General). Civil engineering (General) Biology (General) Physics Chemistry Jin-Hwa Lee verfasserin aut Mo-Un Ku verfasserin aut Ki-Young Kim verfasserin aut Su Shin verfasserin aut Eun-Jin Hong verfasserin aut Sae-Kwang Ku verfasserin aut Jae-Suk Choi verfasserin aut In Applied Sciences MDPI AG, 2012 13(2023), 17, p 9578 (DE-627)737287640 (DE-600)2704225-X 20763417 nnns volume:13 year:2023 number:17, p 9578 https://doi.org/10.3390/app13179578 kostenfrei https://doaj.org/article/e494830b4dfe40539f5605fd45770cd7 kostenfrei https://www.mdpi.com/2076-3417/13/17/9578 kostenfrei https://doaj.org/toc/2076-3417 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 17, p 9578
language	English
source	In Applied Sciences 13(2023), 17, p 9578 volume:13 year:2023 number:17, p 9578
sourceStr	In Applied Sciences 13(2023), 17, p 9578 volume:13 year:2023 number:17, p 9578
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Asian pear <i<Pyrus pyrifolia</i< lung injury PM<sub<2.5</sub< mice anti-inflammatory activity Technology T Engineering (General). Civil engineering (General) Biology (General) Physics Chemistry
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container_title	Applied Sciences
authorswithroles_txt_mv	Mi-Ran Kim @@aut@@ Jin-Hwa Lee @@aut@@ Mo-Un Ku @@aut@@ Ki-Young Kim @@aut@@ Su Shin @@aut@@ Eun-Jin Hong @@aut@@ Sae-Kwang Ku @@aut@@ Jae-Suk Choi @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	737287640
id	DOAJ093532059
language_de	englisch
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callnumber-first	T - Technology
author	Mi-Ran Kim
spellingShingle	Mi-Ran Kim misc TA1-2040 misc QH301-705.5 misc QC1-999 misc QD1-999 misc Asian pear misc <i<Pyrus pyrifolia</i< misc lung injury misc PM<sub<2.5</sub< misc mice misc anti-inflammatory activity misc Technology misc T misc Engineering (General). Civil engineering (General) misc Biology (General) misc Physics misc Chemistry Effectiveness of Immature Asian Pear Extract on Pulmonary Injury Caused by Particulate Matter in Mice
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topic_title	TA1-2040 QH301-705.5 QC1-999 QD1-999 Effectiveness of Immature Asian Pear Extract on Pulmonary Injury Caused by Particulate Matter in Mice Asian pear <i<Pyrus pyrifolia</i< lung injury PM<sub<2.5</sub< mice anti-inflammatory activity
topic	misc TA1-2040 misc QH301-705.5 misc QC1-999 misc QD1-999 misc Asian pear misc <i<Pyrus pyrifolia</i< misc lung injury misc PM<sub<2.5</sub< misc mice misc anti-inflammatory activity misc Technology misc T misc Engineering (General). Civil engineering (General) misc Biology (General) misc Physics misc Chemistry
topic_unstemmed	misc TA1-2040 misc QH301-705.5 misc QC1-999 misc QD1-999 misc Asian pear misc <i<Pyrus pyrifolia</i< misc lung injury misc PM<sub<2.5</sub< misc mice misc anti-inflammatory activity misc Technology misc T misc Engineering (General). Civil engineering (General) misc Biology (General) misc Physics misc Chemistry
topic_browse	misc TA1-2040 misc QH301-705.5 misc QC1-999 misc QD1-999 misc Asian pear misc <i<Pyrus pyrifolia</i< misc lung injury misc PM<sub<2.5</sub< misc mice misc anti-inflammatory activity misc Technology misc T misc Engineering (General). Civil engineering (General) misc Biology (General) misc Physics misc Chemistry
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title	Effectiveness of Immature Asian Pear Extract on Pulmonary Injury Caused by Particulate Matter in Mice
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title_full	Effectiveness of Immature Asian Pear Extract on Pulmonary Injury Caused by Particulate Matter in Mice
author_sort	Mi-Ran Kim
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author_browse	Mi-Ran Kim Jin-Hwa Lee Mo-Un Ku Ki-Young Kim Su Shin Eun-Jin Hong Sae-Kwang Ku Jae-Suk Choi
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title_sort	effectiveness of immature asian pear extract on pulmonary injury caused by particulate matter in mice
callnumber	TA1-2040
title_auth	Effectiveness of Immature Asian Pear Extract on Pulmonary Injury Caused by Particulate Matter in Mice
abstract	The use of natural products in developing respiratory-function-protective pharmaceuticals is actively progressing. However, in this context, the improvement effects of young Asian pear (<i<Pyrus pyrifolia</i< Nakai) extracts have not been evaluated yet. Thus, this study investigated the anti-inflammatory and lung damage improvement effects of immature Asian pear extract (IAP; 400, 200, and 100 mg/kg) using a particulate matter 2.5 μm (PM<sub<2.5</sub<)-induced sub-acute lung injury mouse model. The experimental results were compared with dexamethasone (0.75 mg/kg), used as a control drug. After two intranasal instillations of PM<sub<2.5</sub< and ten doses of IAP extract for eight days, changes in macroscopic lung autopsy, leukocyte fractionation from bronchoalveolar lavage fluid, lung antioxidant defense system, lung histopathology, and mRNA expression in lung tissue were confirmed. Stress-induced inflammatory lung damage through the increased expression of PM<sub<2.5</sub<-induced PI3K/Akt and p38 MAPK mRNA was significantly suppressed via the administration of IAP extract (400–100 mg/kg). Furthermore, IAP extract administration promoted serous fluid production in lung tissue, increased substance P and ACh levels, and decreased mucus-production-related expression of MUC5AC and MUC5B mRNA. Interestingly, the observed effects showed a dose-dependent manner without serious hepatotoxicity. The results of this study indicate that a proper oral administration of IAP extract could be helpful in protecting against lung diseases, positioning IAP extract as a potential candidate for an alternative agent to safeguard the respiratory system.
abstractGer	The use of natural products in developing respiratory-function-protective pharmaceuticals is actively progressing. However, in this context, the improvement effects of young Asian pear (<i<Pyrus pyrifolia</i< Nakai) extracts have not been evaluated yet. Thus, this study investigated the anti-inflammatory and lung damage improvement effects of immature Asian pear extract (IAP; 400, 200, and 100 mg/kg) using a particulate matter 2.5 μm (PM<sub<2.5</sub<)-induced sub-acute lung injury mouse model. The experimental results were compared with dexamethasone (0.75 mg/kg), used as a control drug. After two intranasal instillations of PM<sub<2.5</sub< and ten doses of IAP extract for eight days, changes in macroscopic lung autopsy, leukocyte fractionation from bronchoalveolar lavage fluid, lung antioxidant defense system, lung histopathology, and mRNA expression in lung tissue were confirmed. Stress-induced inflammatory lung damage through the increased expression of PM<sub<2.5</sub<-induced PI3K/Akt and p38 MAPK mRNA was significantly suppressed via the administration of IAP extract (400–100 mg/kg). Furthermore, IAP extract administration promoted serous fluid production in lung tissue, increased substance P and ACh levels, and decreased mucus-production-related expression of MUC5AC and MUC5B mRNA. Interestingly, the observed effects showed a dose-dependent manner without serious hepatotoxicity. The results of this study indicate that a proper oral administration of IAP extract could be helpful in protecting against lung diseases, positioning IAP extract as a potential candidate for an alternative agent to safeguard the respiratory system.
abstract_unstemmed	The use of natural products in developing respiratory-function-protective pharmaceuticals is actively progressing. However, in this context, the improvement effects of young Asian pear (<i<Pyrus pyrifolia</i< Nakai) extracts have not been evaluated yet. Thus, this study investigated the anti-inflammatory and lung damage improvement effects of immature Asian pear extract (IAP; 400, 200, and 100 mg/kg) using a particulate matter 2.5 μm (PM<sub<2.5</sub<)-induced sub-acute lung injury mouse model. The experimental results were compared with dexamethasone (0.75 mg/kg), used as a control drug. After two intranasal instillations of PM<sub<2.5</sub< and ten doses of IAP extract for eight days, changes in macroscopic lung autopsy, leukocyte fractionation from bronchoalveolar lavage fluid, lung antioxidant defense system, lung histopathology, and mRNA expression in lung tissue were confirmed. Stress-induced inflammatory lung damage through the increased expression of PM<sub<2.5</sub<-induced PI3K/Akt and p38 MAPK mRNA was significantly suppressed via the administration of IAP extract (400–100 mg/kg). Furthermore, IAP extract administration promoted serous fluid production in lung tissue, increased substance P and ACh levels, and decreased mucus-production-related expression of MUC5AC and MUC5B mRNA. Interestingly, the observed effects showed a dose-dependent manner without serious hepatotoxicity. The results of this study indicate that a proper oral administration of IAP extract could be helpful in protecting against lung diseases, positioning IAP extract as a potential candidate for an alternative agent to safeguard the respiratory system.
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container_issue	17, p 9578
title_short	Effectiveness of Immature Asian Pear Extract on Pulmonary Injury Caused by Particulate Matter in Mice
url	https://doi.org/10.3390/app13179578 https://doaj.org/article/e494830b4dfe40539f5605fd45770cd7 https://www.mdpi.com/2076-3417/13/17/9578 https://doaj.org/toc/2076-3417
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