Semi-solid extrusion 3D-printing of eucalypt extract-loaded polyethylene oxide gels intended for pharmaceutical applications
In pharmaceutics, 3D printing is considered as a promising future technology for fabricating more complex patient-specific drug delivery systems (DDSs). An anti-staphylococcal herbal preparation, “Chlorophyllipt”, is produced mainly in a liquid form by the pharmaceutical industry in Ukraine, and it...
Ausführliche Beschreibung
Autor*in: |
Oleh Koshovyi [verfasserIn] Jyrki Heinämäki [verfasserIn] Ivo Laidmäe [verfasserIn] Niklas Sandler Topelius [verfasserIn] Andriy Grytsyk [verfasserIn] Ain Raal [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2023 |
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Schlagwörter: |
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Übergeordnetes Werk: |
In: Annals of 3D Printed Medicine - Elsevier, 2021, 12(2023), Seite 100123- |
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Übergeordnetes Werk: |
volume:12 ; year:2023 ; pages:100123- |
Links: |
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DOI / URN: |
10.1016/j.stlm.2023.100123 |
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Katalog-ID: |
DOAJ093534922 |
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520 | |a In pharmaceutics, 3D printing is considered as a promising future technology for fabricating more complex patient-specific drug delivery systems (DDSs). An anti-staphylococcal herbal preparation, “Chlorophyllipt”, is produced mainly in a liquid form by the pharmaceutical industry in Ukraine, and it is composed of an ethanolic eucalypt extract (EE). Since staphylococcal infections have become a true challenge for the health care in all over the world, it would be relevant and justified to develop the aqueous gels of the present EE applicable for the 3D printing of the corresponding solid DDSs. The aim of the present study was to develop a novel polyethylene oxide (PEO) gel loaded with EE for a semi-solid extrusion (SSE) 3D printing and to print the corresponding oral solid DDSs with different sizes and shapes. For SSE 3D printing, we prepared and tested total ten (10) different aqueous PEO gel formulations loaded with EE. Prior to 3D printing, the physical appearance, homogeneity, injection force and viscosity of the gels were investigated. The EE-PEO gels were printed to lattice- and round-shaped solid DDSs with the head speed of 0.5 mm/s, and the weight (mass uniformity) and effective surface area of the printed systems were determined. The most feasible EE-PEO gel for SSE 3D printing comprised of 10 mg/ml of EE, 30 mg/ml of eumulgin and 20 mg/ml of ascorbic acid in a 20-% aqueous PEO gel. The key process parameters of the SSE 3D printing were identified and verified. The printing quality of EE-PEO DDSs were very good, thus showing compatibility of a plant extract and carrier polymer. Such 3D-printed antimicrobial DDSs can be used for example in the treatment of skin wounds and infections of the oral cavity. | ||
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10.1016/j.stlm.2023.100123 doi (DE-627)DOAJ093534922 (DE-599)DOAJba0cdbad9bcc4100ac620bdab30c2100 DE-627 ger DE-627 rakwb eng R855-855.5 Oleh Koshovyi verfasserin aut Semi-solid extrusion 3D-printing of eucalypt extract-loaded polyethylene oxide gels intended for pharmaceutical applications 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In pharmaceutics, 3D printing is considered as a promising future technology for fabricating more complex patient-specific drug delivery systems (DDSs). An anti-staphylococcal herbal preparation, “Chlorophyllipt”, is produced mainly in a liquid form by the pharmaceutical industry in Ukraine, and it is composed of an ethanolic eucalypt extract (EE). Since staphylococcal infections have become a true challenge for the health care in all over the world, it would be relevant and justified to develop the aqueous gels of the present EE applicable for the 3D printing of the corresponding solid DDSs. The aim of the present study was to develop a novel polyethylene oxide (PEO) gel loaded with EE for a semi-solid extrusion (SSE) 3D printing and to print the corresponding oral solid DDSs with different sizes and shapes. For SSE 3D printing, we prepared and tested total ten (10) different aqueous PEO gel formulations loaded with EE. Prior to 3D printing, the physical appearance, homogeneity, injection force and viscosity of the gels were investigated. The EE-PEO gels were printed to lattice- and round-shaped solid DDSs with the head speed of 0.5 mm/s, and the weight (mass uniformity) and effective surface area of the printed systems were determined. The most feasible EE-PEO gel for SSE 3D printing comprised of 10 mg/ml of EE, 30 mg/ml of eumulgin and 20 mg/ml of ascorbic acid in a 20-% aqueous PEO gel. The key process parameters of the SSE 3D printing were identified and verified. The printing quality of EE-PEO DDSs were very good, thus showing compatibility of a plant extract and carrier polymer. Such 3D-printed antimicrobial DDSs can be used for example in the treatment of skin wounds and infections of the oral cavity. Eucalypt leaves extract (EE) Polyethylene oxide (PEO) Aqueous gel Semi-solid extrusion (SSE) 3D printing Pharmaceutical delivery system Medical technology Jyrki Heinämäki verfasserin aut Ivo Laidmäe verfasserin aut Niklas Sandler Topelius verfasserin aut Andriy Grytsyk verfasserin aut Ain Raal verfasserin aut In Annals of 3D Printed Medicine Elsevier, 2021 12(2023), Seite 100123- (DE-627)1759893900 26669641 nnns volume:12 year:2023 pages:100123- https://doi.org/10.1016/j.stlm.2023.100123 kostenfrei https://doaj.org/article/ba0cdbad9bcc4100ac620bdab30c2100 kostenfrei http://www.sciencedirect.com/science/article/pii/S2666964123000243 kostenfrei https://doaj.org/toc/2666-9641 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 12 2023 100123- |
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10.1016/j.stlm.2023.100123 doi (DE-627)DOAJ093534922 (DE-599)DOAJba0cdbad9bcc4100ac620bdab30c2100 DE-627 ger DE-627 rakwb eng R855-855.5 Oleh Koshovyi verfasserin aut Semi-solid extrusion 3D-printing of eucalypt extract-loaded polyethylene oxide gels intended for pharmaceutical applications 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In pharmaceutics, 3D printing is considered as a promising future technology for fabricating more complex patient-specific drug delivery systems (DDSs). An anti-staphylococcal herbal preparation, “Chlorophyllipt”, is produced mainly in a liquid form by the pharmaceutical industry in Ukraine, and it is composed of an ethanolic eucalypt extract (EE). Since staphylococcal infections have become a true challenge for the health care in all over the world, it would be relevant and justified to develop the aqueous gels of the present EE applicable for the 3D printing of the corresponding solid DDSs. The aim of the present study was to develop a novel polyethylene oxide (PEO) gel loaded with EE for a semi-solid extrusion (SSE) 3D printing and to print the corresponding oral solid DDSs with different sizes and shapes. For SSE 3D printing, we prepared and tested total ten (10) different aqueous PEO gel formulations loaded with EE. Prior to 3D printing, the physical appearance, homogeneity, injection force and viscosity of the gels were investigated. The EE-PEO gels were printed to lattice- and round-shaped solid DDSs with the head speed of 0.5 mm/s, and the weight (mass uniformity) and effective surface area of the printed systems were determined. The most feasible EE-PEO gel for SSE 3D printing comprised of 10 mg/ml of EE, 30 mg/ml of eumulgin and 20 mg/ml of ascorbic acid in a 20-% aqueous PEO gel. The key process parameters of the SSE 3D printing were identified and verified. The printing quality of EE-PEO DDSs were very good, thus showing compatibility of a plant extract and carrier polymer. Such 3D-printed antimicrobial DDSs can be used for example in the treatment of skin wounds and infections of the oral cavity. Eucalypt leaves extract (EE) Polyethylene oxide (PEO) Aqueous gel Semi-solid extrusion (SSE) 3D printing Pharmaceutical delivery system Medical technology Jyrki Heinämäki verfasserin aut Ivo Laidmäe verfasserin aut Niklas Sandler Topelius verfasserin aut Andriy Grytsyk verfasserin aut Ain Raal verfasserin aut In Annals of 3D Printed Medicine Elsevier, 2021 12(2023), Seite 100123- (DE-627)1759893900 26669641 nnns volume:12 year:2023 pages:100123- https://doi.org/10.1016/j.stlm.2023.100123 kostenfrei https://doaj.org/article/ba0cdbad9bcc4100ac620bdab30c2100 kostenfrei http://www.sciencedirect.com/science/article/pii/S2666964123000243 kostenfrei https://doaj.org/toc/2666-9641 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 12 2023 100123- |
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10.1016/j.stlm.2023.100123 doi (DE-627)DOAJ093534922 (DE-599)DOAJba0cdbad9bcc4100ac620bdab30c2100 DE-627 ger DE-627 rakwb eng R855-855.5 Oleh Koshovyi verfasserin aut Semi-solid extrusion 3D-printing of eucalypt extract-loaded polyethylene oxide gels intended for pharmaceutical applications 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In pharmaceutics, 3D printing is considered as a promising future technology for fabricating more complex patient-specific drug delivery systems (DDSs). An anti-staphylococcal herbal preparation, “Chlorophyllipt”, is produced mainly in a liquid form by the pharmaceutical industry in Ukraine, and it is composed of an ethanolic eucalypt extract (EE). Since staphylococcal infections have become a true challenge for the health care in all over the world, it would be relevant and justified to develop the aqueous gels of the present EE applicable for the 3D printing of the corresponding solid DDSs. The aim of the present study was to develop a novel polyethylene oxide (PEO) gel loaded with EE for a semi-solid extrusion (SSE) 3D printing and to print the corresponding oral solid DDSs with different sizes and shapes. For SSE 3D printing, we prepared and tested total ten (10) different aqueous PEO gel formulations loaded with EE. Prior to 3D printing, the physical appearance, homogeneity, injection force and viscosity of the gels were investigated. The EE-PEO gels were printed to lattice- and round-shaped solid DDSs with the head speed of 0.5 mm/s, and the weight (mass uniformity) and effective surface area of the printed systems were determined. The most feasible EE-PEO gel for SSE 3D printing comprised of 10 mg/ml of EE, 30 mg/ml of eumulgin and 20 mg/ml of ascorbic acid in a 20-% aqueous PEO gel. The key process parameters of the SSE 3D printing were identified and verified. The printing quality of EE-PEO DDSs were very good, thus showing compatibility of a plant extract and carrier polymer. Such 3D-printed antimicrobial DDSs can be used for example in the treatment of skin wounds and infections of the oral cavity. Eucalypt leaves extract (EE) Polyethylene oxide (PEO) Aqueous gel Semi-solid extrusion (SSE) 3D printing Pharmaceutical delivery system Medical technology Jyrki Heinämäki verfasserin aut Ivo Laidmäe verfasserin aut Niklas Sandler Topelius verfasserin aut Andriy Grytsyk verfasserin aut Ain Raal verfasserin aut In Annals of 3D Printed Medicine Elsevier, 2021 12(2023), Seite 100123- (DE-627)1759893900 26669641 nnns volume:12 year:2023 pages:100123- https://doi.org/10.1016/j.stlm.2023.100123 kostenfrei https://doaj.org/article/ba0cdbad9bcc4100ac620bdab30c2100 kostenfrei http://www.sciencedirect.com/science/article/pii/S2666964123000243 kostenfrei https://doaj.org/toc/2666-9641 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 12 2023 100123- |
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10.1016/j.stlm.2023.100123 doi (DE-627)DOAJ093534922 (DE-599)DOAJba0cdbad9bcc4100ac620bdab30c2100 DE-627 ger DE-627 rakwb eng R855-855.5 Oleh Koshovyi verfasserin aut Semi-solid extrusion 3D-printing of eucalypt extract-loaded polyethylene oxide gels intended for pharmaceutical applications 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In pharmaceutics, 3D printing is considered as a promising future technology for fabricating more complex patient-specific drug delivery systems (DDSs). An anti-staphylococcal herbal preparation, “Chlorophyllipt”, is produced mainly in a liquid form by the pharmaceutical industry in Ukraine, and it is composed of an ethanolic eucalypt extract (EE). Since staphylococcal infections have become a true challenge for the health care in all over the world, it would be relevant and justified to develop the aqueous gels of the present EE applicable for the 3D printing of the corresponding solid DDSs. The aim of the present study was to develop a novel polyethylene oxide (PEO) gel loaded with EE for a semi-solid extrusion (SSE) 3D printing and to print the corresponding oral solid DDSs with different sizes and shapes. For SSE 3D printing, we prepared and tested total ten (10) different aqueous PEO gel formulations loaded with EE. Prior to 3D printing, the physical appearance, homogeneity, injection force and viscosity of the gels were investigated. The EE-PEO gels were printed to lattice- and round-shaped solid DDSs with the head speed of 0.5 mm/s, and the weight (mass uniformity) and effective surface area of the printed systems were determined. The most feasible EE-PEO gel for SSE 3D printing comprised of 10 mg/ml of EE, 30 mg/ml of eumulgin and 20 mg/ml of ascorbic acid in a 20-% aqueous PEO gel. The key process parameters of the SSE 3D printing were identified and verified. The printing quality of EE-PEO DDSs were very good, thus showing compatibility of a plant extract and carrier polymer. Such 3D-printed antimicrobial DDSs can be used for example in the treatment of skin wounds and infections of the oral cavity. Eucalypt leaves extract (EE) Polyethylene oxide (PEO) Aqueous gel Semi-solid extrusion (SSE) 3D printing Pharmaceutical delivery system Medical technology Jyrki Heinämäki verfasserin aut Ivo Laidmäe verfasserin aut Niklas Sandler Topelius verfasserin aut Andriy Grytsyk verfasserin aut Ain Raal verfasserin aut In Annals of 3D Printed Medicine Elsevier, 2021 12(2023), Seite 100123- (DE-627)1759893900 26669641 nnns volume:12 year:2023 pages:100123- https://doi.org/10.1016/j.stlm.2023.100123 kostenfrei https://doaj.org/article/ba0cdbad9bcc4100ac620bdab30c2100 kostenfrei http://www.sciencedirect.com/science/article/pii/S2666964123000243 kostenfrei https://doaj.org/toc/2666-9641 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 12 2023 100123- |
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Oleh Koshovyi misc R855-855.5 misc Eucalypt leaves extract (EE) misc Polyethylene oxide (PEO) misc Aqueous gel misc Semi-solid extrusion (SSE) 3D printing misc Pharmaceutical delivery system misc Medical technology Semi-solid extrusion 3D-printing of eucalypt extract-loaded polyethylene oxide gels intended for pharmaceutical applications |
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R855-855.5 Semi-solid extrusion 3D-printing of eucalypt extract-loaded polyethylene oxide gels intended for pharmaceutical applications Eucalypt leaves extract (EE) Polyethylene oxide (PEO) Aqueous gel Semi-solid extrusion (SSE) 3D printing Pharmaceutical delivery system |
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Oleh Koshovyi Jyrki Heinämäki Ivo Laidmäe Niklas Sandler Topelius Andriy Grytsyk Ain Raal |
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semi-solid extrusion 3d-printing of eucalypt extract-loaded polyethylene oxide gels intended for pharmaceutical applications |
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Semi-solid extrusion 3D-printing of eucalypt extract-loaded polyethylene oxide gels intended for pharmaceutical applications |
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In pharmaceutics, 3D printing is considered as a promising future technology for fabricating more complex patient-specific drug delivery systems (DDSs). An anti-staphylococcal herbal preparation, “Chlorophyllipt”, is produced mainly in a liquid form by the pharmaceutical industry in Ukraine, and it is composed of an ethanolic eucalypt extract (EE). Since staphylococcal infections have become a true challenge for the health care in all over the world, it would be relevant and justified to develop the aqueous gels of the present EE applicable for the 3D printing of the corresponding solid DDSs. The aim of the present study was to develop a novel polyethylene oxide (PEO) gel loaded with EE for a semi-solid extrusion (SSE) 3D printing and to print the corresponding oral solid DDSs with different sizes and shapes. For SSE 3D printing, we prepared and tested total ten (10) different aqueous PEO gel formulations loaded with EE. Prior to 3D printing, the physical appearance, homogeneity, injection force and viscosity of the gels were investigated. The EE-PEO gels were printed to lattice- and round-shaped solid DDSs with the head speed of 0.5 mm/s, and the weight (mass uniformity) and effective surface area of the printed systems were determined. The most feasible EE-PEO gel for SSE 3D printing comprised of 10 mg/ml of EE, 30 mg/ml of eumulgin and 20 mg/ml of ascorbic acid in a 20-% aqueous PEO gel. The key process parameters of the SSE 3D printing were identified and verified. The printing quality of EE-PEO DDSs were very good, thus showing compatibility of a plant extract and carrier polymer. Such 3D-printed antimicrobial DDSs can be used for example in the treatment of skin wounds and infections of the oral cavity. |
abstractGer |
In pharmaceutics, 3D printing is considered as a promising future technology for fabricating more complex patient-specific drug delivery systems (DDSs). An anti-staphylococcal herbal preparation, “Chlorophyllipt”, is produced mainly in a liquid form by the pharmaceutical industry in Ukraine, and it is composed of an ethanolic eucalypt extract (EE). Since staphylococcal infections have become a true challenge for the health care in all over the world, it would be relevant and justified to develop the aqueous gels of the present EE applicable for the 3D printing of the corresponding solid DDSs. The aim of the present study was to develop a novel polyethylene oxide (PEO) gel loaded with EE for a semi-solid extrusion (SSE) 3D printing and to print the corresponding oral solid DDSs with different sizes and shapes. For SSE 3D printing, we prepared and tested total ten (10) different aqueous PEO gel formulations loaded with EE. Prior to 3D printing, the physical appearance, homogeneity, injection force and viscosity of the gels were investigated. The EE-PEO gels were printed to lattice- and round-shaped solid DDSs with the head speed of 0.5 mm/s, and the weight (mass uniformity) and effective surface area of the printed systems were determined. The most feasible EE-PEO gel for SSE 3D printing comprised of 10 mg/ml of EE, 30 mg/ml of eumulgin and 20 mg/ml of ascorbic acid in a 20-% aqueous PEO gel. The key process parameters of the SSE 3D printing were identified and verified. The printing quality of EE-PEO DDSs were very good, thus showing compatibility of a plant extract and carrier polymer. Such 3D-printed antimicrobial DDSs can be used for example in the treatment of skin wounds and infections of the oral cavity. |
abstract_unstemmed |
In pharmaceutics, 3D printing is considered as a promising future technology for fabricating more complex patient-specific drug delivery systems (DDSs). An anti-staphylococcal herbal preparation, “Chlorophyllipt”, is produced mainly in a liquid form by the pharmaceutical industry in Ukraine, and it is composed of an ethanolic eucalypt extract (EE). Since staphylococcal infections have become a true challenge for the health care in all over the world, it would be relevant and justified to develop the aqueous gels of the present EE applicable for the 3D printing of the corresponding solid DDSs. The aim of the present study was to develop a novel polyethylene oxide (PEO) gel loaded with EE for a semi-solid extrusion (SSE) 3D printing and to print the corresponding oral solid DDSs with different sizes and shapes. For SSE 3D printing, we prepared and tested total ten (10) different aqueous PEO gel formulations loaded with EE. Prior to 3D printing, the physical appearance, homogeneity, injection force and viscosity of the gels were investigated. The EE-PEO gels were printed to lattice- and round-shaped solid DDSs with the head speed of 0.5 mm/s, and the weight (mass uniformity) and effective surface area of the printed systems were determined. The most feasible EE-PEO gel for SSE 3D printing comprised of 10 mg/ml of EE, 30 mg/ml of eumulgin and 20 mg/ml of ascorbic acid in a 20-% aqueous PEO gel. The key process parameters of the SSE 3D printing were identified and verified. The printing quality of EE-PEO DDSs were very good, thus showing compatibility of a plant extract and carrier polymer. Such 3D-printed antimicrobial DDSs can be used for example in the treatment of skin wounds and infections of the oral cavity. |
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Semi-solid extrusion 3D-printing of eucalypt extract-loaded polyethylene oxide gels intended for pharmaceutical applications |
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https://doi.org/10.1016/j.stlm.2023.100123 https://doaj.org/article/ba0cdbad9bcc4100ac620bdab30c2100 http://www.sciencedirect.com/science/article/pii/S2666964123000243 https://doaj.org/toc/2666-9641 |
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The EE-PEO gels were printed to lattice- and round-shaped solid DDSs with the head speed of 0.5 mm/s, and the weight (mass uniformity) and effective surface area of the printed systems were determined. The most feasible EE-PEO gel for SSE 3D printing comprised of 10 mg/ml of EE, 30 mg/ml of eumulgin and 20 mg/ml of ascorbic acid in a 20-% aqueous PEO gel. The key process parameters of the SSE 3D printing were identified and verified. The printing quality of EE-PEO DDSs were very good, thus showing compatibility of a plant extract and carrier polymer. 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