Effect of Particle Migration on the Stress Field in Microfluidic Flows of Blood Analog Fluids at High Reynolds Numbers

In the present paper, we investigate how the reductions in shear stresses and pressure losses in microfluidic gaps are directly linked to the local characteristics of cell-free layers (CFLs) at channel Reynolds numbers relevant to ventricular assist device (VAD) applications. For this, detailed stud...
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Autor*in:	Finn Knüppel [verfasserIn] Ang Sun [verfasserIn] Frank-Hendrik Wurm [verfasserIn] Jeanette Hussong [verfasserIn] Benjamin Torner [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	cell-free layer particulate blood analog fluid particle-laden flows wall shear stress astigmatism particle tracking velocimetry apparent viscosity

Übergeordnetes Werk:	In: Micromachines - MDPI AG, 2010, 14(2023), 8, p 1494
Übergeordnetes Werk:	volume:14 ; year:2023 ; number:8, p 1494

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/mi14081494

Katalog-ID:	DOAJ093579284

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520			\|a In the present paper, we investigate how the reductions in shear stresses and pressure losses in microfluidic gaps are directly linked to the local characteristics of cell-free layers (CFLs) at channel Reynolds numbers relevant to ventricular assist device (VAD) applications. For this, detailed studies of local particle distributions of a particulate blood analog fluid are combined with wall shear stress and pressure loss measurements in two complementary set-ups with identical flow geometry, bulk Reynolds numbers and particle Reynolds numbers. For all investigated particle volume fractions of up to <inline-formula<<math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"<<semantics<<mrow<<mn<5</mn<<mo<%</mo<</mrow<</semantics<</math<</inline-formula<, reductions in the stress and pressure loss were measured in comparison to a flow of an equivalent homogeneous fluid (without particles). We could explain this due to the formation of a CFL ranging from 10 to 20 <inline-formula<<math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"<<semantics<<mi mathvariant="sans-serif"<μ</mi<</semantics<</math<</inline-formula<m. Variations in the channel Reynolds number between <i<Re</i< = 50 and 150 did not lead to measurable changes in CFL heights or stress reductions for all investigated particle volume fractions. These measurements were used to describe the complete chain of how CFL formation leads to a stress reduction, which reduces the apparent viscosity of the suspension and results in the Fåhræus–Lindqvist effect. This chain of causes was investigated for the first time for flows with high Reynolds numbers (<inline-formula<<math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"<<semantics<<mrow<<mi<R</mi<<mi<e</mi<<mo<∼</mo<<mn<100</mn<</mrow<</semantics<</math<</inline-formula<), representing a flow regime which can be found in the narrow gaps of a VAD.
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spelling	10.3390/mi14081494 doi (DE-627)DOAJ093579284 (DE-599)DOAJd220d65dbffc4b63b2738b1b951f2a79 DE-627 ger DE-627 rakwb eng TJ1-1570 Finn Knüppel verfasserin aut Effect of Particle Migration on the Stress Field in Microfluidic Flows of Blood Analog Fluids at High Reynolds Numbers 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the present paper, we investigate how the reductions in shear stresses and pressure losses in microfluidic gaps are directly linked to the local characteristics of cell-free layers (CFLs) at channel Reynolds numbers relevant to ventricular assist device (VAD) applications. For this, detailed studies of local particle distributions of a particulate blood analog fluid are combined with wall shear stress and pressure loss measurements in two complementary set-ups with identical flow geometry, bulk Reynolds numbers and particle Reynolds numbers. For all investigated particle volume fractions of up to <inline-formula<<math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"<<semantics<<mrow<<mn<5</mn<<mo<%</mo<</mrow<</semantics<</math<</inline-formula<, reductions in the stress and pressure loss were measured in comparison to a flow of an equivalent homogeneous fluid (without particles). We could explain this due to the formation of a CFL ranging from 10 to 20 <inline-formula<<math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"<<semantics<<mi mathvariant="sans-serif"<μ</mi<</semantics<</math<</inline-formula<m. Variations in the channel Reynolds number between <i<Re</i< = 50 and 150 did not lead to measurable changes in CFL heights or stress reductions for all investigated particle volume fractions. These measurements were used to describe the complete chain of how CFL formation leads to a stress reduction, which reduces the apparent viscosity of the suspension and results in the Fåhræus–Lindqvist effect. This chain of causes was investigated for the first time for flows with high Reynolds numbers (<inline-formula<<math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"<<semantics<<mrow<<mi<R</mi<<mi<e</mi<<mo<∼</mo<<mn<100</mn<</mrow<</semantics<</math<</inline-formula<), representing a flow regime which can be found in the narrow gaps of a VAD. cell-free layer particulate blood analog fluid particle-laden flows wall shear stress astigmatism particle tracking velocimetry apparent viscosity Mechanical engineering and machinery Ang Sun verfasserin aut Frank-Hendrik Wurm verfasserin aut Jeanette Hussong verfasserin aut Benjamin Torner verfasserin aut In Micromachines MDPI AG, 2010 14(2023), 8, p 1494 (DE-627)665016069 (DE-600)2620864-7 2072666X nnns volume:14 year:2023 number:8, p 1494 https://doi.org/10.3390/mi14081494 kostenfrei https://doaj.org/article/d220d65dbffc4b63b2738b1b951f2a79 kostenfrei https://www.mdpi.com/2072-666X/14/8/1494 kostenfrei https://doaj.org/toc/2072-666X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 8, p 1494
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allfieldsGer	10.3390/mi14081494 doi (DE-627)DOAJ093579284 (DE-599)DOAJd220d65dbffc4b63b2738b1b951f2a79 DE-627 ger DE-627 rakwb eng TJ1-1570 Finn Knüppel verfasserin aut Effect of Particle Migration on the Stress Field in Microfluidic Flows of Blood Analog Fluids at High Reynolds Numbers 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the present paper, we investigate how the reductions in shear stresses and pressure losses in microfluidic gaps are directly linked to the local characteristics of cell-free layers (CFLs) at channel Reynolds numbers relevant to ventricular assist device (VAD) applications. For this, detailed studies of local particle distributions of a particulate blood analog fluid are combined with wall shear stress and pressure loss measurements in two complementary set-ups with identical flow geometry, bulk Reynolds numbers and particle Reynolds numbers. For all investigated particle volume fractions of up to <inline-formula<<math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"<<semantics<<mrow<<mn<5</mn<<mo<%</mo<</mrow<</semantics<</math<</inline-formula<, reductions in the stress and pressure loss were measured in comparison to a flow of an equivalent homogeneous fluid (without particles). We could explain this due to the formation of a CFL ranging from 10 to 20 <inline-formula<<math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"<<semantics<<mi mathvariant="sans-serif"<μ</mi<</semantics<</math<</inline-formula<m. Variations in the channel Reynolds number between <i<Re</i< = 50 and 150 did not lead to measurable changes in CFL heights or stress reductions for all investigated particle volume fractions. These measurements were used to describe the complete chain of how CFL formation leads to a stress reduction, which reduces the apparent viscosity of the suspension and results in the Fåhræus–Lindqvist effect. This chain of causes was investigated for the first time for flows with high Reynolds numbers (<inline-formula<<math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"<<semantics<<mrow<<mi<R</mi<<mi<e</mi<<mo<∼</mo<<mn<100</mn<</mrow<</semantics<</math<</inline-formula<), representing a flow regime which can be found in the narrow gaps of a VAD. cell-free layer particulate blood analog fluid particle-laden flows wall shear stress astigmatism particle tracking velocimetry apparent viscosity Mechanical engineering and machinery Ang Sun verfasserin aut Frank-Hendrik Wurm verfasserin aut Jeanette Hussong verfasserin aut Benjamin Torner verfasserin aut In Micromachines MDPI AG, 2010 14(2023), 8, p 1494 (DE-627)665016069 (DE-600)2620864-7 2072666X nnns volume:14 year:2023 number:8, p 1494 https://doi.org/10.3390/mi14081494 kostenfrei https://doaj.org/article/d220d65dbffc4b63b2738b1b951f2a79 kostenfrei https://www.mdpi.com/2072-666X/14/8/1494 kostenfrei https://doaj.org/toc/2072-666X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 8, p 1494
allfieldsSound	10.3390/mi14081494 doi (DE-627)DOAJ093579284 (DE-599)DOAJd220d65dbffc4b63b2738b1b951f2a79 DE-627 ger DE-627 rakwb eng TJ1-1570 Finn Knüppel verfasserin aut Effect of Particle Migration on the Stress Field in Microfluidic Flows of Blood Analog Fluids at High Reynolds Numbers 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the present paper, we investigate how the reductions in shear stresses and pressure losses in microfluidic gaps are directly linked to the local characteristics of cell-free layers (CFLs) at channel Reynolds numbers relevant to ventricular assist device (VAD) applications. For this, detailed studies of local particle distributions of a particulate blood analog fluid are combined with wall shear stress and pressure loss measurements in two complementary set-ups with identical flow geometry, bulk Reynolds numbers and particle Reynolds numbers. For all investigated particle volume fractions of up to <inline-formula<<math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"<<semantics<<mrow<<mn<5</mn<<mo<%</mo<</mrow<</semantics<</math<</inline-formula<, reductions in the stress and pressure loss were measured in comparison to a flow of an equivalent homogeneous fluid (without particles). We could explain this due to the formation of a CFL ranging from 10 to 20 <inline-formula<<math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"<<semantics<<mi mathvariant="sans-serif"<μ</mi<</semantics<</math<</inline-formula<m. Variations in the channel Reynolds number between <i<Re</i< = 50 and 150 did not lead to measurable changes in CFL heights or stress reductions for all investigated particle volume fractions. These measurements were used to describe the complete chain of how CFL formation leads to a stress reduction, which reduces the apparent viscosity of the suspension and results in the Fåhræus–Lindqvist effect. This chain of causes was investigated for the first time for flows with high Reynolds numbers (<inline-formula<<math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"<<semantics<<mrow<<mi<R</mi<<mi<e</mi<<mo<∼</mo<<mn<100</mn<</mrow<</semantics<</math<</inline-formula<), representing a flow regime which can be found in the narrow gaps of a VAD. cell-free layer particulate blood analog fluid particle-laden flows wall shear stress astigmatism particle tracking velocimetry apparent viscosity Mechanical engineering and machinery Ang Sun verfasserin aut Frank-Hendrik Wurm verfasserin aut Jeanette Hussong verfasserin aut Benjamin Torner verfasserin aut In Micromachines MDPI AG, 2010 14(2023), 8, p 1494 (DE-627)665016069 (DE-600)2620864-7 2072666X nnns volume:14 year:2023 number:8, p 1494 https://doi.org/10.3390/mi14081494 kostenfrei https://doaj.org/article/d220d65dbffc4b63b2738b1b951f2a79 kostenfrei https://www.mdpi.com/2072-666X/14/8/1494 kostenfrei https://doaj.org/toc/2072-666X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 8, p 1494
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source	In Micromachines 14(2023), 8, p 1494 volume:14 year:2023 number:8, p 1494
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authorswithroles_txt_mv	Finn Knüppel @@aut@@ Ang Sun @@aut@@ Frank-Hendrik Wurm @@aut@@ Jeanette Hussong @@aut@@ Benjamin Torner @@aut@@
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author	Finn Knüppel
spellingShingle	Finn Knüppel misc TJ1-1570 misc cell-free layer misc particulate blood analog fluid misc particle-laden flows misc wall shear stress misc astigmatism particle tracking velocimetry misc apparent viscosity misc Mechanical engineering and machinery Effect of Particle Migration on the Stress Field in Microfluidic Flows of Blood Analog Fluids at High Reynolds Numbers
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topic_title	TJ1-1570 Effect of Particle Migration on the Stress Field in Microfluidic Flows of Blood Analog Fluids at High Reynolds Numbers cell-free layer particulate blood analog fluid particle-laden flows wall shear stress astigmatism particle tracking velocimetry apparent viscosity
topic	misc TJ1-1570 misc cell-free layer misc particulate blood analog fluid misc particle-laden flows misc wall shear stress misc astigmatism particle tracking velocimetry misc apparent viscosity misc Mechanical engineering and machinery
topic_unstemmed	misc TJ1-1570 misc cell-free layer misc particulate blood analog fluid misc particle-laden flows misc wall shear stress misc astigmatism particle tracking velocimetry misc apparent viscosity misc Mechanical engineering and machinery
topic_browse	misc TJ1-1570 misc cell-free layer misc particulate blood analog fluid misc particle-laden flows misc wall shear stress misc astigmatism particle tracking velocimetry misc apparent viscosity misc Mechanical engineering and machinery
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title	Effect of Particle Migration on the Stress Field in Microfluidic Flows of Blood Analog Fluids at High Reynolds Numbers
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title_full	Effect of Particle Migration on the Stress Field in Microfluidic Flows of Blood Analog Fluids at High Reynolds Numbers
author_sort	Finn Knüppel
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author_browse	Finn Knüppel Ang Sun Frank-Hendrik Wurm Jeanette Hussong Benjamin Torner
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title_sort	effect of particle migration on the stress field in microfluidic flows of blood analog fluids at high reynolds numbers
callnumber	TJ1-1570
title_auth	Effect of Particle Migration on the Stress Field in Microfluidic Flows of Blood Analog Fluids at High Reynolds Numbers
abstract	In the present paper, we investigate how the reductions in shear stresses and pressure losses in microfluidic gaps are directly linked to the local characteristics of cell-free layers (CFLs) at channel Reynolds numbers relevant to ventricular assist device (VAD) applications. For this, detailed studies of local particle distributions of a particulate blood analog fluid are combined with wall shear stress and pressure loss measurements in two complementary set-ups with identical flow geometry, bulk Reynolds numbers and particle Reynolds numbers. For all investigated particle volume fractions of up to <inline-formula<<math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"<<semantics<<mrow<<mn<5</mn<<mo<%</mo<</mrow<</semantics<</math<</inline-formula<, reductions in the stress and pressure loss were measured in comparison to a flow of an equivalent homogeneous fluid (without particles). We could explain this due to the formation of a CFL ranging from 10 to 20 <inline-formula<<math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"<<semantics<<mi mathvariant="sans-serif"<μ</mi<</semantics<</math<</inline-formula<m. Variations in the channel Reynolds number between <i<Re</i< = 50 and 150 did not lead to measurable changes in CFL heights or stress reductions for all investigated particle volume fractions. These measurements were used to describe the complete chain of how CFL formation leads to a stress reduction, which reduces the apparent viscosity of the suspension and results in the Fåhræus–Lindqvist effect. This chain of causes was investigated for the first time for flows with high Reynolds numbers (<inline-formula<<math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"<<semantics<<mrow<<mi<R</mi<<mi<e</mi<<mo<∼</mo<<mn<100</mn<</mrow<</semantics<</math<</inline-formula<), representing a flow regime which can be found in the narrow gaps of a VAD.
abstractGer	In the present paper, we investigate how the reductions in shear stresses and pressure losses in microfluidic gaps are directly linked to the local characteristics of cell-free layers (CFLs) at channel Reynolds numbers relevant to ventricular assist device (VAD) applications. For this, detailed studies of local particle distributions of a particulate blood analog fluid are combined with wall shear stress and pressure loss measurements in two complementary set-ups with identical flow geometry, bulk Reynolds numbers and particle Reynolds numbers. For all investigated particle volume fractions of up to <inline-formula<<math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"<<semantics<<mrow<<mn<5</mn<<mo<%</mo<</mrow<</semantics<</math<</inline-formula<, reductions in the stress and pressure loss were measured in comparison to a flow of an equivalent homogeneous fluid (without particles). We could explain this due to the formation of a CFL ranging from 10 to 20 <inline-formula<<math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"<<semantics<<mi mathvariant="sans-serif"<μ</mi<</semantics<</math<</inline-formula<m. Variations in the channel Reynolds number between <i<Re</i< = 50 and 150 did not lead to measurable changes in CFL heights or stress reductions for all investigated particle volume fractions. These measurements were used to describe the complete chain of how CFL formation leads to a stress reduction, which reduces the apparent viscosity of the suspension and results in the Fåhræus–Lindqvist effect. This chain of causes was investigated for the first time for flows with high Reynolds numbers (<inline-formula<<math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"<<semantics<<mrow<<mi<R</mi<<mi<e</mi<<mo<∼</mo<<mn<100</mn<</mrow<</semantics<</math<</inline-formula<), representing a flow regime which can be found in the narrow gaps of a VAD.
abstract_unstemmed	In the present paper, we investigate how the reductions in shear stresses and pressure losses in microfluidic gaps are directly linked to the local characteristics of cell-free layers (CFLs) at channel Reynolds numbers relevant to ventricular assist device (VAD) applications. For this, detailed studies of local particle distributions of a particulate blood analog fluid are combined with wall shear stress and pressure loss measurements in two complementary set-ups with identical flow geometry, bulk Reynolds numbers and particle Reynolds numbers. For all investigated particle volume fractions of up to <inline-formula<<math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"<<semantics<<mrow<<mn<5</mn<<mo<%</mo<</mrow<</semantics<</math<</inline-formula<, reductions in the stress and pressure loss were measured in comparison to a flow of an equivalent homogeneous fluid (without particles). We could explain this due to the formation of a CFL ranging from 10 to 20 <inline-formula<<math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"<<semantics<<mi mathvariant="sans-serif"<μ</mi<</semantics<</math<</inline-formula<m. Variations in the channel Reynolds number between <i<Re</i< = 50 and 150 did not lead to measurable changes in CFL heights or stress reductions for all investigated particle volume fractions. These measurements were used to describe the complete chain of how CFL formation leads to a stress reduction, which reduces the apparent viscosity of the suspension and results in the Fåhræus–Lindqvist effect. This chain of causes was investigated for the first time for flows with high Reynolds numbers (<inline-formula<<math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"<<semantics<<mrow<<mi<R</mi<<mi<e</mi<<mo<∼</mo<<mn<100</mn<</mrow<</semantics<</math<</inline-formula<), representing a flow regime which can be found in the narrow gaps of a VAD.
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title_short	Effect of Particle Migration on the Stress Field in Microfluidic Flows of Blood Analog Fluids at High Reynolds Numbers
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