Alpha-Synuclein in Peripheral Tissues as a Possible Marker for Neurological Diseases and Other Medical Conditions

The possible usefulness of alpha-synuclein (aSyn) determinations in peripheral tissues (blood cells, salivary gland biopsies, olfactory mucosa, digestive tract, skin) and in biological fluids, except for cerebrospinal fluid (serum, plasma, saliva, feces, urine), as a marker of several diseases, has...
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Autor*in:	Félix Javier Jiménez-Jiménez [verfasserIn] Hortensia Alonso-Navarro [verfasserIn] Elena García-Martín [verfasserIn] Diego Santos-García [verfasserIn] Iván Martínez-Valbuena [verfasserIn] José A. G. Agúndez [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	alpha-synuclein peripheral tissues parkinson’s disease alpha-synucleinopathies biological markers

Übergeordnetes Werk:	In: Biomolecules - MDPI AG, 2013, 13(2023), 8, p 1263
Übergeordnetes Werk:	volume:13 ; year:2023 ; number:8, p 1263

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/biom13081263

Katalog-ID:	DOAJ09364423X

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spelling	10.3390/biom13081263 doi (DE-627)DOAJ09364423X (DE-599)DOAJ0871ad702ccd47f0aacc4d136906292d DE-627 ger DE-627 rakwb eng QR1-502 Félix Javier Jiménez-Jiménez verfasserin aut Alpha-Synuclein in Peripheral Tissues as a Possible Marker for Neurological Diseases and Other Medical Conditions 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The possible usefulness of alpha-synuclein (aSyn) determinations in peripheral tissues (blood cells, salivary gland biopsies, olfactory mucosa, digestive tract, skin) and in biological fluids, except for cerebrospinal fluid (serum, plasma, saliva, feces, urine), as a marker of several diseases, has been the subject of numerous publications. This narrative review summarizes data from studies trying to determine the role of total, oligomeric, and phosphorylated aSyn determinations as a marker of various diseases, especially PD and other alpha-synucleinopathies. In summary, the results of studies addressing the determinations of aSyn in its different forms in peripheral tissues (especially in platelets, skin, and digestive tract, but also salivary glands and olfactory mucosa), in combination with other potential biomarkers, could be a useful tool to discriminate PD from controls and from other causes of parkinsonisms, including synucleinopathies. alpha-synuclein peripheral tissues parkinson’s disease alpha-synucleinopathies biological markers Microbiology Hortensia Alonso-Navarro verfasserin aut Elena García-Martín verfasserin aut Diego Santos-García verfasserin aut Iván Martínez-Valbuena verfasserin aut José A. G. Agúndez verfasserin aut In Biomolecules MDPI AG, 2013 13(2023), 8, p 1263 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:13 year:2023 number:8, p 1263 https://doi.org/10.3390/biom13081263 kostenfrei https://doaj.org/article/0871ad702ccd47f0aacc4d136906292d kostenfrei https://www.mdpi.com/2218-273X/13/8/1263 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 8, p 1263
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source	In Biomolecules 13(2023), 8, p 1263 volume:13 year:2023 number:8, p 1263
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authorswithroles_txt_mv	Félix Javier Jiménez-Jiménez @@aut@@ Hortensia Alonso-Navarro @@aut@@ Elena García-Martín @@aut@@ Diego Santos-García @@aut@@ Iván Martínez-Valbuena @@aut@@ José A. G. Agúndez @@aut@@
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callnumber-first	Q - Science
author	Félix Javier Jiménez-Jiménez
spellingShingle	Félix Javier Jiménez-Jiménez misc QR1-502 misc alpha-synuclein misc peripheral tissues misc parkinson’s disease misc alpha-synucleinopathies misc biological markers misc Microbiology Alpha-Synuclein in Peripheral Tissues as a Possible Marker for Neurological Diseases and Other Medical Conditions
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topic	misc QR1-502 misc alpha-synuclein misc peripheral tissues misc parkinson’s disease misc alpha-synucleinopathies misc biological markers misc Microbiology
topic_unstemmed	misc QR1-502 misc alpha-synuclein misc peripheral tissues misc parkinson’s disease misc alpha-synucleinopathies misc biological markers misc Microbiology
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title	Alpha-Synuclein in Peripheral Tissues as a Possible Marker for Neurological Diseases and Other Medical Conditions
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title_sort	alpha-synuclein in peripheral tissues as a possible marker for neurological diseases and other medical conditions
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title_auth	Alpha-Synuclein in Peripheral Tissues as a Possible Marker for Neurological Diseases and Other Medical Conditions
abstract	The possible usefulness of alpha-synuclein (aSyn) determinations in peripheral tissues (blood cells, salivary gland biopsies, olfactory mucosa, digestive tract, skin) and in biological fluids, except for cerebrospinal fluid (serum, plasma, saliva, feces, urine), as a marker of several diseases, has been the subject of numerous publications. This narrative review summarizes data from studies trying to determine the role of total, oligomeric, and phosphorylated aSyn determinations as a marker of various diseases, especially PD and other alpha-synucleinopathies. In summary, the results of studies addressing the determinations of aSyn in its different forms in peripheral tissues (especially in platelets, skin, and digestive tract, but also salivary glands and olfactory mucosa), in combination with other potential biomarkers, could be a useful tool to discriminate PD from controls and from other causes of parkinsonisms, including synucleinopathies.
abstractGer	The possible usefulness of alpha-synuclein (aSyn) determinations in peripheral tissues (blood cells, salivary gland biopsies, olfactory mucosa, digestive tract, skin) and in biological fluids, except for cerebrospinal fluid (serum, plasma, saliva, feces, urine), as a marker of several diseases, has been the subject of numerous publications. This narrative review summarizes data from studies trying to determine the role of total, oligomeric, and phosphorylated aSyn determinations as a marker of various diseases, especially PD and other alpha-synucleinopathies. In summary, the results of studies addressing the determinations of aSyn in its different forms in peripheral tissues (especially in platelets, skin, and digestive tract, but also salivary glands and olfactory mucosa), in combination with other potential biomarkers, could be a useful tool to discriminate PD from controls and from other causes of parkinsonisms, including synucleinopathies.
abstract_unstemmed	The possible usefulness of alpha-synuclein (aSyn) determinations in peripheral tissues (blood cells, salivary gland biopsies, olfactory mucosa, digestive tract, skin) and in biological fluids, except for cerebrospinal fluid (serum, plasma, saliva, feces, urine), as a marker of several diseases, has been the subject of numerous publications. This narrative review summarizes data from studies trying to determine the role of total, oligomeric, and phosphorylated aSyn determinations as a marker of various diseases, especially PD and other alpha-synucleinopathies. In summary, the results of studies addressing the determinations of aSyn in its different forms in peripheral tissues (especially in platelets, skin, and digestive tract, but also salivary glands and olfactory mucosa), in combination with other potential biomarkers, could be a useful tool to discriminate PD from controls and from other causes of parkinsonisms, including synucleinopathies.
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title_short	Alpha-Synuclein in Peripheral Tissues as a Possible Marker for Neurological Diseases and Other Medical Conditions
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