Retinal Photoreceptors and Microvascular Changes in the Assessment of Diabetic Retinopathy Progression: A Two-Year Follow-Up Study

Background: With the increasing global incidence of diabetes mellitus (DM), diabetic retinopathy (DR) has become one of the leading causes of blindness in developed countries. DR leads to changes in retinal neurons and microcirculation. Rtx1<sup<TM</sup< (Imagine Eyes, Orsay, France) is...
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Gespeichert in:

Autor*in:	Magdalena Kupis [verfasserIn] Zbigniew M. Wawrzyniak [verfasserIn] Jacek P. Szaflik [verfasserIn] Anna Zaleska-Żmijewska [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	diabetic retinopathy adaptive optics rtx-1 technology cone morphology retinal microcirculation

Übergeordnetes Werk:	In: Diagnostics - MDPI AG, 2012, 13(2023), 15, p 2513
Übergeordnetes Werk:	volume:13 ; year:2023 ; number:15, p 2513

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/diagnostics13152513

Katalog-ID:	DOAJ093714149

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allfields	10.3390/diagnostics13152513 doi (DE-627)DOAJ093714149 (DE-599)DOAJ9f7ba2ae1cab439a8bcde6341b93c715 DE-627 ger DE-627 rakwb eng R5-920 Magdalena Kupis verfasserin aut Retinal Photoreceptors and Microvascular Changes in the Assessment of Diabetic Retinopathy Progression: A Two-Year Follow-Up Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: With the increasing global incidence of diabetes mellitus (DM), diabetic retinopathy (DR) has become one of the leading causes of blindness in developed countries. DR leads to changes in retinal neurons and microcirculation. Rtx1<sup<TM</sup< (Imagine Eyes, Orsay, France) is a retinal camera that allows histological visualisations of cones and retinal microcirculation throughout the DM duration. Objective: This study aimed to analyse the cones and retinal microvascular changes in 50 diabetic individuals and 18 healthy volunteers. The patients participated in the initial visit and two follow-up appointments, one and two years after the study, beginning with Rtx1<sup<TM</sup< image acquisition, visual acuity assessment, macular OCT scans and blood measurements. Results: The study revealed significant differences in the cone density, mosaic arrangement and vascular morphology between healthy and diabetic patients. The final measurements showed decreased photoreceptor and microvascular parameters in the DR group compared with the control group. Furthermore, in the 2-year follow-up, both groups’ Rtx1<sup<TM</sup<-acquired morphological changes were statistically significant. Conclusions: Rtx1<sup<TM</sup< technology was successfully used as a non-invasive method of photoreceptors and retinal vasculature assessment over time in patients with diabetic retinopathy. The study revealed a trend toward more vascular morphological changes occurring over time in diabetic patients. diabetic retinopathy adaptive optics rtx-1 technology cone morphology retinal microcirculation Medicine (General) Zbigniew M. Wawrzyniak verfasserin aut Jacek P. Szaflik verfasserin aut Anna Zaleska-Żmijewska verfasserin aut In Diagnostics MDPI AG, 2012 13(2023), 15, p 2513 (DE-627)718627814 (DE-600)2662336-5 20754418 nnns volume:13 year:2023 number:15, p 2513 https://doi.org/10.3390/diagnostics13152513 kostenfrei https://doaj.org/article/9f7ba2ae1cab439a8bcde6341b93c715 kostenfrei https://www.mdpi.com/2075-4418/13/15/2513 kostenfrei https://doaj.org/toc/2075-4418 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 15, p 2513
spelling	10.3390/diagnostics13152513 doi (DE-627)DOAJ093714149 (DE-599)DOAJ9f7ba2ae1cab439a8bcde6341b93c715 DE-627 ger DE-627 rakwb eng R5-920 Magdalena Kupis verfasserin aut Retinal Photoreceptors and Microvascular Changes in the Assessment of Diabetic Retinopathy Progression: A Two-Year Follow-Up Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: With the increasing global incidence of diabetes mellitus (DM), diabetic retinopathy (DR) has become one of the leading causes of blindness in developed countries. DR leads to changes in retinal neurons and microcirculation. Rtx1<sup<TM</sup< (Imagine Eyes, Orsay, France) is a retinal camera that allows histological visualisations of cones and retinal microcirculation throughout the DM duration. Objective: This study aimed to analyse the cones and retinal microvascular changes in 50 diabetic individuals and 18 healthy volunteers. The patients participated in the initial visit and two follow-up appointments, one and two years after the study, beginning with Rtx1<sup<TM</sup< image acquisition, visual acuity assessment, macular OCT scans and blood measurements. Results: The study revealed significant differences in the cone density, mosaic arrangement and vascular morphology between healthy and diabetic patients. The final measurements showed decreased photoreceptor and microvascular parameters in the DR group compared with the control group. Furthermore, in the 2-year follow-up, both groups’ Rtx1<sup<TM</sup<-acquired morphological changes were statistically significant. Conclusions: Rtx1<sup<TM</sup< technology was successfully used as a non-invasive method of photoreceptors and retinal vasculature assessment over time in patients with diabetic retinopathy. The study revealed a trend toward more vascular morphological changes occurring over time in diabetic patients. diabetic retinopathy adaptive optics rtx-1 technology cone morphology retinal microcirculation Medicine (General) Zbigniew M. Wawrzyniak verfasserin aut Jacek P. Szaflik verfasserin aut Anna Zaleska-Żmijewska verfasserin aut In Diagnostics MDPI AG, 2012 13(2023), 15, p 2513 (DE-627)718627814 (DE-600)2662336-5 20754418 nnns volume:13 year:2023 number:15, p 2513 https://doi.org/10.3390/diagnostics13152513 kostenfrei https://doaj.org/article/9f7ba2ae1cab439a8bcde6341b93c715 kostenfrei https://www.mdpi.com/2075-4418/13/15/2513 kostenfrei https://doaj.org/toc/2075-4418 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 15, p 2513
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allfieldsGer	10.3390/diagnostics13152513 doi (DE-627)DOAJ093714149 (DE-599)DOAJ9f7ba2ae1cab439a8bcde6341b93c715 DE-627 ger DE-627 rakwb eng R5-920 Magdalena Kupis verfasserin aut Retinal Photoreceptors and Microvascular Changes in the Assessment of Diabetic Retinopathy Progression: A Two-Year Follow-Up Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: With the increasing global incidence of diabetes mellitus (DM), diabetic retinopathy (DR) has become one of the leading causes of blindness in developed countries. DR leads to changes in retinal neurons and microcirculation. Rtx1<sup<TM</sup< (Imagine Eyes, Orsay, France) is a retinal camera that allows histological visualisations of cones and retinal microcirculation throughout the DM duration. Objective: This study aimed to analyse the cones and retinal microvascular changes in 50 diabetic individuals and 18 healthy volunteers. The patients participated in the initial visit and two follow-up appointments, one and two years after the study, beginning with Rtx1<sup<TM</sup< image acquisition, visual acuity assessment, macular OCT scans and blood measurements. Results: The study revealed significant differences in the cone density, mosaic arrangement and vascular morphology between healthy and diabetic patients. The final measurements showed decreased photoreceptor and microvascular parameters in the DR group compared with the control group. Furthermore, in the 2-year follow-up, both groups’ Rtx1<sup<TM</sup<-acquired morphological changes were statistically significant. Conclusions: Rtx1<sup<TM</sup< technology was successfully used as a non-invasive method of photoreceptors and retinal vasculature assessment over time in patients with diabetic retinopathy. The study revealed a trend toward more vascular morphological changes occurring over time in diabetic patients. diabetic retinopathy adaptive optics rtx-1 technology cone morphology retinal microcirculation Medicine (General) Zbigniew M. Wawrzyniak verfasserin aut Jacek P. Szaflik verfasserin aut Anna Zaleska-Żmijewska verfasserin aut In Diagnostics MDPI AG, 2012 13(2023), 15, p 2513 (DE-627)718627814 (DE-600)2662336-5 20754418 nnns volume:13 year:2023 number:15, p 2513 https://doi.org/10.3390/diagnostics13152513 kostenfrei https://doaj.org/article/9f7ba2ae1cab439a8bcde6341b93c715 kostenfrei https://www.mdpi.com/2075-4418/13/15/2513 kostenfrei https://doaj.org/toc/2075-4418 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 15, p 2513
allfieldsSound	10.3390/diagnostics13152513 doi (DE-627)DOAJ093714149 (DE-599)DOAJ9f7ba2ae1cab439a8bcde6341b93c715 DE-627 ger DE-627 rakwb eng R5-920 Magdalena Kupis verfasserin aut Retinal Photoreceptors and Microvascular Changes in the Assessment of Diabetic Retinopathy Progression: A Two-Year Follow-Up Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: With the increasing global incidence of diabetes mellitus (DM), diabetic retinopathy (DR) has become one of the leading causes of blindness in developed countries. DR leads to changes in retinal neurons and microcirculation. Rtx1<sup<TM</sup< (Imagine Eyes, Orsay, France) is a retinal camera that allows histological visualisations of cones and retinal microcirculation throughout the DM duration. Objective: This study aimed to analyse the cones and retinal microvascular changes in 50 diabetic individuals and 18 healthy volunteers. The patients participated in the initial visit and two follow-up appointments, one and two years after the study, beginning with Rtx1<sup<TM</sup< image acquisition, visual acuity assessment, macular OCT scans and blood measurements. Results: The study revealed significant differences in the cone density, mosaic arrangement and vascular morphology between healthy and diabetic patients. The final measurements showed decreased photoreceptor and microvascular parameters in the DR group compared with the control group. Furthermore, in the 2-year follow-up, both groups’ Rtx1<sup<TM</sup<-acquired morphological changes were statistically significant. Conclusions: Rtx1<sup<TM</sup< technology was successfully used as a non-invasive method of photoreceptors and retinal vasculature assessment over time in patients with diabetic retinopathy. The study revealed a trend toward more vascular morphological changes occurring over time in diabetic patients. diabetic retinopathy adaptive optics rtx-1 technology cone morphology retinal microcirculation Medicine (General) Zbigniew M. Wawrzyniak verfasserin aut Jacek P. Szaflik verfasserin aut Anna Zaleska-Żmijewska verfasserin aut In Diagnostics MDPI AG, 2012 13(2023), 15, p 2513 (DE-627)718627814 (DE-600)2662336-5 20754418 nnns volume:13 year:2023 number:15, p 2513 https://doi.org/10.3390/diagnostics13152513 kostenfrei https://doaj.org/article/9f7ba2ae1cab439a8bcde6341b93c715 kostenfrei https://www.mdpi.com/2075-4418/13/15/2513 kostenfrei https://doaj.org/toc/2075-4418 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 15, p 2513
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authorswithroles_txt_mv	Magdalena Kupis @@aut@@ Zbigniew M. Wawrzyniak @@aut@@ Jacek P. Szaflik @@aut@@ Anna Zaleska-Żmijewska @@aut@@
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callnumber-first	R - Medicine
author	Magdalena Kupis
spellingShingle	Magdalena Kupis misc R5-920 misc diabetic retinopathy misc adaptive optics misc rtx-1 technology misc cone morphology misc retinal microcirculation misc Medicine (General) Retinal Photoreceptors and Microvascular Changes in the Assessment of Diabetic Retinopathy Progression: A Two-Year Follow-Up Study
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topic_title	R5-920 Retinal Photoreceptors and Microvascular Changes in the Assessment of Diabetic Retinopathy Progression: A Two-Year Follow-Up Study diabetic retinopathy adaptive optics rtx-1 technology cone morphology retinal microcirculation
topic	misc R5-920 misc diabetic retinopathy misc adaptive optics misc rtx-1 technology misc cone morphology misc retinal microcirculation misc Medicine (General)
topic_unstemmed	misc R5-920 misc diabetic retinopathy misc adaptive optics misc rtx-1 technology misc cone morphology misc retinal microcirculation misc Medicine (General)
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title	Retinal Photoreceptors and Microvascular Changes in the Assessment of Diabetic Retinopathy Progression: A Two-Year Follow-Up Study
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title_full	Retinal Photoreceptors and Microvascular Changes in the Assessment of Diabetic Retinopathy Progression: A Two-Year Follow-Up Study
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author_browse	Magdalena Kupis Zbigniew M. Wawrzyniak Jacek P. Szaflik Anna Zaleska-Żmijewska
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title_sort	retinal photoreceptors and microvascular changes in the assessment of diabetic retinopathy progression: a two-year follow-up study
callnumber	R5-920
title_auth	Retinal Photoreceptors and Microvascular Changes in the Assessment of Diabetic Retinopathy Progression: A Two-Year Follow-Up Study
abstract	Background: With the increasing global incidence of diabetes mellitus (DM), diabetic retinopathy (DR) has become one of the leading causes of blindness in developed countries. DR leads to changes in retinal neurons and microcirculation. Rtx1<sup<TM</sup< (Imagine Eyes, Orsay, France) is a retinal camera that allows histological visualisations of cones and retinal microcirculation throughout the DM duration. Objective: This study aimed to analyse the cones and retinal microvascular changes in 50 diabetic individuals and 18 healthy volunteers. The patients participated in the initial visit and two follow-up appointments, one and two years after the study, beginning with Rtx1<sup<TM</sup< image acquisition, visual acuity assessment, macular OCT scans and blood measurements. Results: The study revealed significant differences in the cone density, mosaic arrangement and vascular morphology between healthy and diabetic patients. The final measurements showed decreased photoreceptor and microvascular parameters in the DR group compared with the control group. Furthermore, in the 2-year follow-up, both groups’ Rtx1<sup<TM</sup<-acquired morphological changes were statistically significant. Conclusions: Rtx1<sup<TM</sup< technology was successfully used as a non-invasive method of photoreceptors and retinal vasculature assessment over time in patients with diabetic retinopathy. The study revealed a trend toward more vascular morphological changes occurring over time in diabetic patients.
abstractGer	Background: With the increasing global incidence of diabetes mellitus (DM), diabetic retinopathy (DR) has become one of the leading causes of blindness in developed countries. DR leads to changes in retinal neurons and microcirculation. Rtx1<sup<TM</sup< (Imagine Eyes, Orsay, France) is a retinal camera that allows histological visualisations of cones and retinal microcirculation throughout the DM duration. Objective: This study aimed to analyse the cones and retinal microvascular changes in 50 diabetic individuals and 18 healthy volunteers. The patients participated in the initial visit and two follow-up appointments, one and two years after the study, beginning with Rtx1<sup<TM</sup< image acquisition, visual acuity assessment, macular OCT scans and blood measurements. Results: The study revealed significant differences in the cone density, mosaic arrangement and vascular morphology between healthy and diabetic patients. The final measurements showed decreased photoreceptor and microvascular parameters in the DR group compared with the control group. Furthermore, in the 2-year follow-up, both groups’ Rtx1<sup<TM</sup<-acquired morphological changes were statistically significant. Conclusions: Rtx1<sup<TM</sup< technology was successfully used as a non-invasive method of photoreceptors and retinal vasculature assessment over time in patients with diabetic retinopathy. The study revealed a trend toward more vascular morphological changes occurring over time in diabetic patients.
abstract_unstemmed	Background: With the increasing global incidence of diabetes mellitus (DM), diabetic retinopathy (DR) has become one of the leading causes of blindness in developed countries. DR leads to changes in retinal neurons and microcirculation. Rtx1<sup<TM</sup< (Imagine Eyes, Orsay, France) is a retinal camera that allows histological visualisations of cones and retinal microcirculation throughout the DM duration. Objective: This study aimed to analyse the cones and retinal microvascular changes in 50 diabetic individuals and 18 healthy volunteers. The patients participated in the initial visit and two follow-up appointments, one and two years after the study, beginning with Rtx1<sup<TM</sup< image acquisition, visual acuity assessment, macular OCT scans and blood measurements. Results: The study revealed significant differences in the cone density, mosaic arrangement and vascular morphology between healthy and diabetic patients. The final measurements showed decreased photoreceptor and microvascular parameters in the DR group compared with the control group. Furthermore, in the 2-year follow-up, both groups’ Rtx1<sup<TM</sup<-acquired morphological changes were statistically significant. Conclusions: Rtx1<sup<TM</sup< technology was successfully used as a non-invasive method of photoreceptors and retinal vasculature assessment over time in patients with diabetic retinopathy. The study revealed a trend toward more vascular morphological changes occurring over time in diabetic patients.
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title_short	Retinal Photoreceptors and Microvascular Changes in the Assessment of Diabetic Retinopathy Progression: A Two-Year Follow-Up Study
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author2	Zbigniew M. Wawrzyniak Jacek P. Szaflik Anna Zaleska-Żmijewska
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up_date	2024-07-03T18:58:28.862Z
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Retinal Photoreceptors and Microvascular Changes in the Assessment of Diabetic Retinopathy Progression: A Two-Year Follow-Up Study

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