Eligibility for Photoimmunotherapy in Patients with Unresectable Advanced or Recurrent Head and Neck Cancer and Changes before and after Systemic Therapy

Photoimmunotherapy is a novel cancer treatment that recently became covered by national health insurance in Japan, but treatment decision-making remains challenging for unresectable advanced or recurrent head and neck cancer. We aimed to clarify the characteristics of patients for whom photoimmunoth...
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Gespeichert in:

Autor*in:	Takeshi Shinozaki [verfasserIn] Kazuto Matsuura [verfasserIn] Wataru Okano [verfasserIn] Toshifumi Tomioka [verfasserIn] Yukio Nishiya [verfasserIn] Michiko Machida [verfasserIn] Ryuichi Hayashi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	photoimmunotherapy advanced head and neck cancer timing of photoimmunotherapy

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 15(2023), 15, p 3795
Übergeordnetes Werk:	volume:15 ; year:2023 ; number:15, p 3795

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers15153795

Katalog-ID:	DOAJ093717903

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allfieldsSound	10.3390/cancers15153795 doi (DE-627)DOAJ093717903 (DE-599)DOAJ4f9d6b742aa54722a2019bac20bfa91a DE-627 ger DE-627 rakwb eng RC254-282 Takeshi Shinozaki verfasserin aut Eligibility for Photoimmunotherapy in Patients with Unresectable Advanced or Recurrent Head and Neck Cancer and Changes before and after Systemic Therapy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Photoimmunotherapy is a novel cancer treatment that recently became covered by national health insurance in Japan, but treatment decision-making remains challenging for unresectable advanced or recurrent head and neck cancer. We aimed to clarify the characteristics of patients for whom photoimmunotherapy was indicated by a retrospective chart review. Patients aged ≥20 years diagnosed with advanced or recurrent head and neck cancer who started receiving systemic therapy at the National Cancer Center Hospital East from January 2016 through December 2020 were retrospectively analyzed. Before and after first-line systemic therapy, patients were classified into 3 groups according to eligibility for photoimmunotherapy: eligible, potentially eligible, and ineligible. In total, of 246 patients evaluated—194 after exclusions were analyzed—108 were deemed ineligible for treatment. Of the remaining 86 patients, 8 were considered potentially eligible and 9 eligible. Of the nine eligible patients, four became ineligible after receiving first-line systemic therapy due to disease progression. Our results suggest that the indication of photoimmunotherapy should be considered before, during, and after systemic therapy for unresectable locally advanced or recurrent head and neck cancer. photoimmunotherapy advanced head and neck cancer timing of photoimmunotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Kazuto Matsuura verfasserin aut Wataru Okano verfasserin aut Toshifumi Tomioka verfasserin aut Yukio Nishiya verfasserin aut Michiko Machida verfasserin aut Ryuichi Hayashi verfasserin aut In Cancers MDPI AG, 2010 15(2023), 15, p 3795 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:15, p 3795 https://doi.org/10.3390/cancers15153795 kostenfrei https://doaj.org/article/4f9d6b742aa54722a2019bac20bfa91a kostenfrei https://www.mdpi.com/2072-6694/15/15/3795 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 15, p 3795
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authorswithroles_txt_mv	Takeshi Shinozaki @@aut@@ Kazuto Matsuura @@aut@@ Wataru Okano @@aut@@ Toshifumi Tomioka @@aut@@ Yukio Nishiya @@aut@@ Michiko Machida @@aut@@ Ryuichi Hayashi @@aut@@
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callnumber-first	R - Medicine
author	Takeshi Shinozaki
spellingShingle	Takeshi Shinozaki misc RC254-282 misc photoimmunotherapy misc advanced head and neck cancer misc timing of photoimmunotherapy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Eligibility for Photoimmunotherapy in Patients with Unresectable Advanced or Recurrent Head and Neck Cancer and Changes before and after Systemic Therapy
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topic_title	RC254-282 Eligibility for Photoimmunotherapy in Patients with Unresectable Advanced or Recurrent Head and Neck Cancer and Changes before and after Systemic Therapy photoimmunotherapy advanced head and neck cancer timing of photoimmunotherapy
topic	misc RC254-282 misc photoimmunotherapy misc advanced head and neck cancer misc timing of photoimmunotherapy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc photoimmunotherapy misc advanced head and neck cancer misc timing of photoimmunotherapy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Eligibility for Photoimmunotherapy in Patients with Unresectable Advanced or Recurrent Head and Neck Cancer and Changes before and after Systemic Therapy
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title_full	Eligibility for Photoimmunotherapy in Patients with Unresectable Advanced or Recurrent Head and Neck Cancer and Changes before and after Systemic Therapy
author_sort	Takeshi Shinozaki
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author_browse	Takeshi Shinozaki Kazuto Matsuura Wataru Okano Toshifumi Tomioka Yukio Nishiya Michiko Machida Ryuichi Hayashi
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title_sort	eligibility for photoimmunotherapy in patients with unresectable advanced or recurrent head and neck cancer and changes before and after systemic therapy
callnumber	RC254-282
title_auth	Eligibility for Photoimmunotherapy in Patients with Unresectable Advanced or Recurrent Head and Neck Cancer and Changes before and after Systemic Therapy
abstract	Photoimmunotherapy is a novel cancer treatment that recently became covered by national health insurance in Japan, but treatment decision-making remains challenging for unresectable advanced or recurrent head and neck cancer. We aimed to clarify the characteristics of patients for whom photoimmunotherapy was indicated by a retrospective chart review. Patients aged ≥20 years diagnosed with advanced or recurrent head and neck cancer who started receiving systemic therapy at the National Cancer Center Hospital East from January 2016 through December 2020 were retrospectively analyzed. Before and after first-line systemic therapy, patients were classified into 3 groups according to eligibility for photoimmunotherapy: eligible, potentially eligible, and ineligible. In total, of 246 patients evaluated—194 after exclusions were analyzed—108 were deemed ineligible for treatment. Of the remaining 86 patients, 8 were considered potentially eligible and 9 eligible. Of the nine eligible patients, four became ineligible after receiving first-line systemic therapy due to disease progression. Our results suggest that the indication of photoimmunotherapy should be considered before, during, and after systemic therapy for unresectable locally advanced or recurrent head and neck cancer.
abstractGer	Photoimmunotherapy is a novel cancer treatment that recently became covered by national health insurance in Japan, but treatment decision-making remains challenging for unresectable advanced or recurrent head and neck cancer. We aimed to clarify the characteristics of patients for whom photoimmunotherapy was indicated by a retrospective chart review. Patients aged ≥20 years diagnosed with advanced or recurrent head and neck cancer who started receiving systemic therapy at the National Cancer Center Hospital East from January 2016 through December 2020 were retrospectively analyzed. Before and after first-line systemic therapy, patients were classified into 3 groups according to eligibility for photoimmunotherapy: eligible, potentially eligible, and ineligible. In total, of 246 patients evaluated—194 after exclusions were analyzed—108 were deemed ineligible for treatment. Of the remaining 86 patients, 8 were considered potentially eligible and 9 eligible. Of the nine eligible patients, four became ineligible after receiving first-line systemic therapy due to disease progression. Our results suggest that the indication of photoimmunotherapy should be considered before, during, and after systemic therapy for unresectable locally advanced or recurrent head and neck cancer.
abstract_unstemmed	Photoimmunotherapy is a novel cancer treatment that recently became covered by national health insurance in Japan, but treatment decision-making remains challenging for unresectable advanced or recurrent head and neck cancer. We aimed to clarify the characteristics of patients for whom photoimmunotherapy was indicated by a retrospective chart review. Patients aged ≥20 years diagnosed with advanced or recurrent head and neck cancer who started receiving systemic therapy at the National Cancer Center Hospital East from January 2016 through December 2020 were retrospectively analyzed. Before and after first-line systemic therapy, patients were classified into 3 groups according to eligibility for photoimmunotherapy: eligible, potentially eligible, and ineligible. In total, of 246 patients evaluated—194 after exclusions were analyzed—108 were deemed ineligible for treatment. Of the remaining 86 patients, 8 were considered potentially eligible and 9 eligible. Of the nine eligible patients, four became ineligible after receiving first-line systemic therapy due to disease progression. Our results suggest that the indication of photoimmunotherapy should be considered before, during, and after systemic therapy for unresectable locally advanced or recurrent head and neck cancer.
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title_short	Eligibility for Photoimmunotherapy in Patients with Unresectable Advanced or Recurrent Head and Neck Cancer and Changes before and after Systemic Therapy
url	https://doi.org/10.3390/cancers15153795 https://doaj.org/article/4f9d6b742aa54722a2019bac20bfa91a https://www.mdpi.com/2072-6694/15/15/3795 https://doaj.org/toc/2072-6694
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author2	Kazuto Matsuura Wataru Okano Toshifumi Tomioka Yukio Nishiya Michiko Machida Ryuichi Hayashi
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up_date	2024-07-03T18:59:55.610Z
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Eligibility for Photoimmunotherapy in Patients with Unresectable Advanced or Recurrent Head and Neck Cancer and Changes before and after Systemic Therapy

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