Dual-Ligand Synergistic Targeting Anti-Tumor Nanoplatforms with Cascade-Responsive Drug Release

Dual-ligand targeting drug delivery nanoplatforms are considered a promising tool for enhancing the specificity of chemotherapy. However, serious off-target delivery has been observed in current dual-ligand targeting nanoplatforms, as each ligand can independently recognize receptors on the cell mem...
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Gespeichert in:

Autor*in:	Fang Luo [verfasserIn] Ting Zhong [verfasserIn] Ying Chen [verfasserIn] Qianqian Guo [verfasserIn] Ling Tao [verfasserIn] Xiangchun Shen [verfasserIn] Yanhua Fan [verfasserIn] Xingjie Wu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	synergistic targeting specific treatment drug delivery controlled release tumor chemotherapy

Übergeordnetes Werk:	In: Pharmaceutics - MDPI AG, 2010, 15(2023), 7, p 2014
Übergeordnetes Werk:	volume:15 ; year:2023 ; number:7, p 2014

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/pharmaceutics15072014

Katalog-ID:	DOAJ093841051

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spelling	10.3390/pharmaceutics15072014 doi (DE-627)DOAJ093841051 (DE-599)DOAJ2f28c294f2b74763aed39742239975e8 DE-627 ger DE-627 rakwb eng RS1-441 Fang Luo verfasserin aut Dual-Ligand Synergistic Targeting Anti-Tumor Nanoplatforms with Cascade-Responsive Drug Release 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Dual-ligand targeting drug delivery nanoplatforms are considered a promising tool for enhancing the specificity of chemotherapy. However, serious off-target delivery has been observed in current dual-ligand targeting nanoplatforms, as each ligand can independently recognize receptors on the cell membrane surface and guide drug nanocarriers to different cells. To overcome this barrier, a dual-ligand synergistic targeting (DLST) nanoplatform is developed, which can guide chemotherapy treatment specifically to cancer cells simultaneously overexpressing two receptors. This nanoplatform consists of a singlet oxygen (<sup<1</sup<O<sub<2</sub<) photosensitizer-loaded nanocarrier and a drug-loaded nanocarrier with <sup<1</sup<O<sub<2</sub< responsiveness, which were, respectively, decorated with a pair of complementary DNA sequences and two different ligands. For cancer cells overexpressing both receptors, two nanocarriers can be internalized in larger quantities to cause DNA hybridization-induced nanocarrier aggregation, which further activates <sup<1</sup<O<sub<2</sub<-triggered drug release under light irradiation. For cells overexpressing a single receptor, only one type of nanocarrier can be internalized in a large quantity, leading to blocked drug release due to the ultrashort action radius of <sup<1</sup<O<sub<2</sub<. In vivo evaluation showed this DLST nanoplatform displayed highly specific tumor treatment with minimized long-term toxicity. This is a highly efficient drug delivery system for DLST chemotherapy, holding great potential for clinical applications. synergistic targeting specific treatment drug delivery controlled release tumor chemotherapy Pharmacy and materia medica Ting Zhong verfasserin aut Ying Chen verfasserin aut Qianqian Guo verfasserin aut Ling Tao verfasserin aut Xiangchun Shen verfasserin aut Yanhua Fan verfasserin aut Xingjie Wu verfasserin aut In Pharmaceutics MDPI AG, 2010 15(2023), 7, p 2014 (DE-627)614096529 (DE-600)2527217-2 19994923 nnns volume:15 year:2023 number:7, p 2014 https://doi.org/10.3390/pharmaceutics15072014 kostenfrei https://doaj.org/article/2f28c294f2b74763aed39742239975e8 kostenfrei https://www.mdpi.com/1999-4923/15/7/2014 kostenfrei https://doaj.org/toc/1999-4923 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 7, p 2014
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allfieldsGer	10.3390/pharmaceutics15072014 doi (DE-627)DOAJ093841051 (DE-599)DOAJ2f28c294f2b74763aed39742239975e8 DE-627 ger DE-627 rakwb eng RS1-441 Fang Luo verfasserin aut Dual-Ligand Synergistic Targeting Anti-Tumor Nanoplatforms with Cascade-Responsive Drug Release 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Dual-ligand targeting drug delivery nanoplatforms are considered a promising tool for enhancing the specificity of chemotherapy. However, serious off-target delivery has been observed in current dual-ligand targeting nanoplatforms, as each ligand can independently recognize receptors on the cell membrane surface and guide drug nanocarriers to different cells. To overcome this barrier, a dual-ligand synergistic targeting (DLST) nanoplatform is developed, which can guide chemotherapy treatment specifically to cancer cells simultaneously overexpressing two receptors. This nanoplatform consists of a singlet oxygen (<sup<1</sup<O<sub<2</sub<) photosensitizer-loaded nanocarrier and a drug-loaded nanocarrier with <sup<1</sup<O<sub<2</sub< responsiveness, which were, respectively, decorated with a pair of complementary DNA sequences and two different ligands. For cancer cells overexpressing both receptors, two nanocarriers can be internalized in larger quantities to cause DNA hybridization-induced nanocarrier aggregation, which further activates <sup<1</sup<O<sub<2</sub<-triggered drug release under light irradiation. For cells overexpressing a single receptor, only one type of nanocarrier can be internalized in a large quantity, leading to blocked drug release due to the ultrashort action radius of <sup<1</sup<O<sub<2</sub<. In vivo evaluation showed this DLST nanoplatform displayed highly specific tumor treatment with minimized long-term toxicity. This is a highly efficient drug delivery system for DLST chemotherapy, holding great potential for clinical applications. synergistic targeting specific treatment drug delivery controlled release tumor chemotherapy Pharmacy and materia medica Ting Zhong verfasserin aut Ying Chen verfasserin aut Qianqian Guo verfasserin aut Ling Tao verfasserin aut Xiangchun Shen verfasserin aut Yanhua Fan verfasserin aut Xingjie Wu verfasserin aut In Pharmaceutics MDPI AG, 2010 15(2023), 7, p 2014 (DE-627)614096529 (DE-600)2527217-2 19994923 nnns volume:15 year:2023 number:7, p 2014 https://doi.org/10.3390/pharmaceutics15072014 kostenfrei https://doaj.org/article/2f28c294f2b74763aed39742239975e8 kostenfrei https://www.mdpi.com/1999-4923/15/7/2014 kostenfrei https://doaj.org/toc/1999-4923 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 7, p 2014
allfieldsSound	10.3390/pharmaceutics15072014 doi (DE-627)DOAJ093841051 (DE-599)DOAJ2f28c294f2b74763aed39742239975e8 DE-627 ger DE-627 rakwb eng RS1-441 Fang Luo verfasserin aut Dual-Ligand Synergistic Targeting Anti-Tumor Nanoplatforms with Cascade-Responsive Drug Release 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Dual-ligand targeting drug delivery nanoplatforms are considered a promising tool for enhancing the specificity of chemotherapy. However, serious off-target delivery has been observed in current dual-ligand targeting nanoplatforms, as each ligand can independently recognize receptors on the cell membrane surface and guide drug nanocarriers to different cells. To overcome this barrier, a dual-ligand synergistic targeting (DLST) nanoplatform is developed, which can guide chemotherapy treatment specifically to cancer cells simultaneously overexpressing two receptors. This nanoplatform consists of a singlet oxygen (<sup<1</sup<O<sub<2</sub<) photosensitizer-loaded nanocarrier and a drug-loaded nanocarrier with <sup<1</sup<O<sub<2</sub< responsiveness, which were, respectively, decorated with a pair of complementary DNA sequences and two different ligands. For cancer cells overexpressing both receptors, two nanocarriers can be internalized in larger quantities to cause DNA hybridization-induced nanocarrier aggregation, which further activates <sup<1</sup<O<sub<2</sub<-triggered drug release under light irradiation. For cells overexpressing a single receptor, only one type of nanocarrier can be internalized in a large quantity, leading to blocked drug release due to the ultrashort action radius of <sup<1</sup<O<sub<2</sub<. In vivo evaluation showed this DLST nanoplatform displayed highly specific tumor treatment with minimized long-term toxicity. This is a highly efficient drug delivery system for DLST chemotherapy, holding great potential for clinical applications. synergistic targeting specific treatment drug delivery controlled release tumor chemotherapy Pharmacy and materia medica Ting Zhong verfasserin aut Ying Chen verfasserin aut Qianqian Guo verfasserin aut Ling Tao verfasserin aut Xiangchun Shen verfasserin aut Yanhua Fan verfasserin aut Xingjie Wu verfasserin aut In Pharmaceutics MDPI AG, 2010 15(2023), 7, p 2014 (DE-627)614096529 (DE-600)2527217-2 19994923 nnns volume:15 year:2023 number:7, p 2014 https://doi.org/10.3390/pharmaceutics15072014 kostenfrei https://doaj.org/article/2f28c294f2b74763aed39742239975e8 kostenfrei https://www.mdpi.com/1999-4923/15/7/2014 kostenfrei https://doaj.org/toc/1999-4923 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 7, p 2014
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source	In Pharmaceutics 15(2023), 7, p 2014 volume:15 year:2023 number:7, p 2014
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callnumber-first	R - Medicine
author	Fang Luo
spellingShingle	Fang Luo misc RS1-441 misc synergistic targeting misc specific treatment misc drug delivery misc controlled release misc tumor chemotherapy misc Pharmacy and materia medica Dual-Ligand Synergistic Targeting Anti-Tumor Nanoplatforms with Cascade-Responsive Drug Release
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topic_title	RS1-441 Dual-Ligand Synergistic Targeting Anti-Tumor Nanoplatforms with Cascade-Responsive Drug Release synergistic targeting specific treatment drug delivery controlled release tumor chemotherapy
topic	misc RS1-441 misc synergistic targeting misc specific treatment misc drug delivery misc controlled release misc tumor chemotherapy misc Pharmacy and materia medica
topic_unstemmed	misc RS1-441 misc synergistic targeting misc specific treatment misc drug delivery misc controlled release misc tumor chemotherapy misc Pharmacy and materia medica
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title	Dual-Ligand Synergistic Targeting Anti-Tumor Nanoplatforms with Cascade-Responsive Drug Release
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title_sort	dual-ligand synergistic targeting anti-tumor nanoplatforms with cascade-responsive drug release
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title_auth	Dual-Ligand Synergistic Targeting Anti-Tumor Nanoplatforms with Cascade-Responsive Drug Release
abstract	Dual-ligand targeting drug delivery nanoplatforms are considered a promising tool for enhancing the specificity of chemotherapy. However, serious off-target delivery has been observed in current dual-ligand targeting nanoplatforms, as each ligand can independently recognize receptors on the cell membrane surface and guide drug nanocarriers to different cells. To overcome this barrier, a dual-ligand synergistic targeting (DLST) nanoplatform is developed, which can guide chemotherapy treatment specifically to cancer cells simultaneously overexpressing two receptors. This nanoplatform consists of a singlet oxygen (<sup<1</sup<O<sub<2</sub<) photosensitizer-loaded nanocarrier and a drug-loaded nanocarrier with <sup<1</sup<O<sub<2</sub< responsiveness, which were, respectively, decorated with a pair of complementary DNA sequences and two different ligands. For cancer cells overexpressing both receptors, two nanocarriers can be internalized in larger quantities to cause DNA hybridization-induced nanocarrier aggregation, which further activates <sup<1</sup<O<sub<2</sub<-triggered drug release under light irradiation. For cells overexpressing a single receptor, only one type of nanocarrier can be internalized in a large quantity, leading to blocked drug release due to the ultrashort action radius of <sup<1</sup<O<sub<2</sub<. In vivo evaluation showed this DLST nanoplatform displayed highly specific tumor treatment with minimized long-term toxicity. This is a highly efficient drug delivery system for DLST chemotherapy, holding great potential for clinical applications.
abstractGer	Dual-ligand targeting drug delivery nanoplatforms are considered a promising tool for enhancing the specificity of chemotherapy. However, serious off-target delivery has been observed in current dual-ligand targeting nanoplatforms, as each ligand can independently recognize receptors on the cell membrane surface and guide drug nanocarriers to different cells. To overcome this barrier, a dual-ligand synergistic targeting (DLST) nanoplatform is developed, which can guide chemotherapy treatment specifically to cancer cells simultaneously overexpressing two receptors. This nanoplatform consists of a singlet oxygen (<sup<1</sup<O<sub<2</sub<) photosensitizer-loaded nanocarrier and a drug-loaded nanocarrier with <sup<1</sup<O<sub<2</sub< responsiveness, which were, respectively, decorated with a pair of complementary DNA sequences and two different ligands. For cancer cells overexpressing both receptors, two nanocarriers can be internalized in larger quantities to cause DNA hybridization-induced nanocarrier aggregation, which further activates <sup<1</sup<O<sub<2</sub<-triggered drug release under light irradiation. For cells overexpressing a single receptor, only one type of nanocarrier can be internalized in a large quantity, leading to blocked drug release due to the ultrashort action radius of <sup<1</sup<O<sub<2</sub<. In vivo evaluation showed this DLST nanoplatform displayed highly specific tumor treatment with minimized long-term toxicity. This is a highly efficient drug delivery system for DLST chemotherapy, holding great potential for clinical applications.
abstract_unstemmed	Dual-ligand targeting drug delivery nanoplatforms are considered a promising tool for enhancing the specificity of chemotherapy. However, serious off-target delivery has been observed in current dual-ligand targeting nanoplatforms, as each ligand can independently recognize receptors on the cell membrane surface and guide drug nanocarriers to different cells. To overcome this barrier, a dual-ligand synergistic targeting (DLST) nanoplatform is developed, which can guide chemotherapy treatment specifically to cancer cells simultaneously overexpressing two receptors. This nanoplatform consists of a singlet oxygen (<sup<1</sup<O<sub<2</sub<) photosensitizer-loaded nanocarrier and a drug-loaded nanocarrier with <sup<1</sup<O<sub<2</sub< responsiveness, which were, respectively, decorated with a pair of complementary DNA sequences and two different ligands. For cancer cells overexpressing both receptors, two nanocarriers can be internalized in larger quantities to cause DNA hybridization-induced nanocarrier aggregation, which further activates <sup<1</sup<O<sub<2</sub<-triggered drug release under light irradiation. For cells overexpressing a single receptor, only one type of nanocarrier can be internalized in a large quantity, leading to blocked drug release due to the ultrashort action radius of <sup<1</sup<O<sub<2</sub<. In vivo evaluation showed this DLST nanoplatform displayed highly specific tumor treatment with minimized long-term toxicity. This is a highly efficient drug delivery system for DLST chemotherapy, holding great potential for clinical applications.
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title_short	Dual-Ligand Synergistic Targeting Anti-Tumor Nanoplatforms with Cascade-Responsive Drug Release
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up_date	2024-07-03T19:41:57.706Z
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Dual-Ligand Synergistic Targeting Anti-Tumor Nanoplatforms with Cascade-Responsive Drug Release

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