Antioxidant and Anticancer Assessment and Phytochemical Investigation of Three Varieties of Date Fruits

Date palm (<i<Phoenix dactylifera</i< L.) fruits contain high concentrations of phenolic compounds, particularly flavonoids and other micronutrients, which impact human health due to their potent antioxidant, anti-inflammatory, and anticancer characteristics. In the present study, the effect of ethyl acetate, hydroethanol, hydromethanol, and aqueous extract from three date palm varieties (i.e., Ajwa, Siwi, and Sukkari) on phytochemical profiles and antioxidant and anticancer activities was investigated. Fruit extracts were screened for their antioxidant activity using the DPPH· method. Phenolic constituents were quantified and identified using HPLC-DAD. Extracts (ethyl acetate, hydroethanol, and hydromethanol) were assessed for cytotoxicity on nine human cancer cell lines, i.e., MG-63, HCT116, MCF7, MDA-MB-231, HEPG2, HUH7, A549, H460, and HFB4, using the sulphorhodamine-B (SRB) assay. Results showed that the ethyl acetate extract of the Sukkari fruits has the greatest antioxidant potential with an IC<sub<50</sub< value of 132.4 ± 0.3 μg·mL<sup<−1</sup<, while the aqueous extract of Ajwa date fruits exhibited the lowest antioxidant effect with an IC<sub<50</sub< value of 867.1 ± 0.3 μg·mL<sup<−1</sup<. The extracts exhibited potent to moderate anticancer activities against the investigated cancer cell line in a source-dependent manner. Methanol extract of Siwi fruits exhibited the most potent anticancer activity (IC<sub<50</sub< = 99 ± 1.6 µg·mL<sup<−1</sup<), followed by the same extract of Sukkari fruits with an IC<sub<50</sub< value of 119 ± 3.5 µg·mL<sup<−1</sup< against the cell line of human breast cancer (MDA-MB-231). Additionally, principal component analysis (PCA) was investigated to determine the relationship among the investigated traits and treatments. Our findings reveal that date palm fruit-derived extracts are excellent sources of biologically active constituents and substantiate their potential use in new anticancer strategies from natural resources. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Ahmed S. Abdelbaky [verfasserIn] Mohamed A. Tammam [verfasserIn] Mohamed Yassin Ali [verfasserIn] Marwa Sharaky [verfasserIn] Khaled Selim [verfasserIn] Wael M. Semida [verfasserIn] Taia A. Abd El-Mageed [verfasserIn] Mohamed Fawzy Ramadan [verfasserIn] Hesham F. Oraby [verfasserIn] Yasser M. Diab [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	antioxidants cancer cell lines HPLC-DAD phenolics ethyl acetate extract

Übergeordnetes Werk:	In: Metabolites - MDPI AG, 2012, 13(2023), 7, p 816
Übergeordnetes Werk:	volume:13 ; year:2023 ; number:7, p 816

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/metabo13070816

Katalog-ID:	DOAJ093861273

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allfields	10.3390/metabo13070816 doi (DE-627)DOAJ093861273 (DE-599)DOAJ65f60d3b30a74f3fa0a23bea0ee2347d DE-627 ger DE-627 rakwb eng QR1-502 Ahmed S. Abdelbaky verfasserin aut Antioxidant and Anticancer Assessment and Phytochemical Investigation of Three Varieties of Date Fruits 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Date palm (<i<Phoenix dactylifera</i< L.) fruits contain high concentrations of phenolic compounds, particularly flavonoids and other micronutrients, which impact human health due to their potent antioxidant, anti-inflammatory, and anticancer characteristics. In the present study, the effect of ethyl acetate, hydroethanol, hydromethanol, and aqueous extract from three date palm varieties (i.e., Ajwa, Siwi, and Sukkari) on phytochemical profiles and antioxidant and anticancer activities was investigated. Fruit extracts were screened for their antioxidant activity using the DPPH· method. Phenolic constituents were quantified and identified using HPLC-DAD. Extracts (ethyl acetate, hydroethanol, and hydromethanol) were assessed for cytotoxicity on nine human cancer cell lines, i.e., MG-63, HCT116, MCF7, MDA-MB-231, HEPG2, HUH7, A549, H460, and HFB4, using the sulphorhodamine-B (SRB) assay. Results showed that the ethyl acetate extract of the Sukkari fruits has the greatest antioxidant potential with an IC<sub<50</sub< value of 132.4 ± 0.3 μg·mL<sup<−1</sup<, while the aqueous extract of Ajwa date fruits exhibited the lowest antioxidant effect with an IC<sub<50</sub< value of 867.1 ± 0.3 μg·mL<sup<−1</sup<. The extracts exhibited potent to moderate anticancer activities against the investigated cancer cell line in a source-dependent manner. Methanol extract of Siwi fruits exhibited the most potent anticancer activity (IC<sub<50</sub< = 99 ± 1.6 µg·mL<sup<−1</sup<), followed by the same extract of Sukkari fruits with an IC<sub<50</sub< value of 119 ± 3.5 µg·mL<sup<−1</sup< against the cell line of human breast cancer (MDA-MB-231). Additionally, principal component analysis (PCA) was investigated to determine the relationship among the investigated traits and treatments. Our findings reveal that date palm fruit-derived extracts are excellent sources of biologically active constituents and substantiate their potential use in new anticancer strategies from natural resources. <i<Phoenix dactylifera</i< L. antioxidants cancer cell lines HPLC-DAD phenolics ethyl acetate extract Microbiology Mohamed A. Tammam verfasserin aut Mohamed Yassin Ali verfasserin aut Marwa Sharaky verfasserin aut Khaled Selim verfasserin aut Wael M. Semida verfasserin aut Taia A. Abd El-Mageed verfasserin aut Mohamed Fawzy Ramadan verfasserin aut Hesham F. Oraby verfasserin aut Yasser M. Diab verfasserin aut In Metabolites MDPI AG, 2012 13(2023), 7, p 816 (DE-627)718627164 (DE-600)2662251-8 22181989 nnns volume:13 year:2023 number:7, p 816 https://doi.org/10.3390/metabo13070816 kostenfrei https://doaj.org/article/65f60d3b30a74f3fa0a23bea0ee2347d kostenfrei https://www.mdpi.com/2218-1989/13/7/816 kostenfrei https://doaj.org/toc/2218-1989 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 7, p 816
spelling	10.3390/metabo13070816 doi (DE-627)DOAJ093861273 (DE-599)DOAJ65f60d3b30a74f3fa0a23bea0ee2347d DE-627 ger DE-627 rakwb eng QR1-502 Ahmed S. Abdelbaky verfasserin aut Antioxidant and Anticancer Assessment and Phytochemical Investigation of Three Varieties of Date Fruits 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Date palm (<i<Phoenix dactylifera</i< L.) fruits contain high concentrations of phenolic compounds, particularly flavonoids and other micronutrients, which impact human health due to their potent antioxidant, anti-inflammatory, and anticancer characteristics. In the present study, the effect of ethyl acetate, hydroethanol, hydromethanol, and aqueous extract from three date palm varieties (i.e., Ajwa, Siwi, and Sukkari) on phytochemical profiles and antioxidant and anticancer activities was investigated. Fruit extracts were screened for their antioxidant activity using the DPPH· method. Phenolic constituents were quantified and identified using HPLC-DAD. Extracts (ethyl acetate, hydroethanol, and hydromethanol) were assessed for cytotoxicity on nine human cancer cell lines, i.e., MG-63, HCT116, MCF7, MDA-MB-231, HEPG2, HUH7, A549, H460, and HFB4, using the sulphorhodamine-B (SRB) assay. Results showed that the ethyl acetate extract of the Sukkari fruits has the greatest antioxidant potential with an IC<sub<50</sub< value of 132.4 ± 0.3 μg·mL<sup<−1</sup<, while the aqueous extract of Ajwa date fruits exhibited the lowest antioxidant effect with an IC<sub<50</sub< value of 867.1 ± 0.3 μg·mL<sup<−1</sup<. The extracts exhibited potent to moderate anticancer activities against the investigated cancer cell line in a source-dependent manner. Methanol extract of Siwi fruits exhibited the most potent anticancer activity (IC<sub<50</sub< = 99 ± 1.6 µg·mL<sup<−1</sup<), followed by the same extract of Sukkari fruits with an IC<sub<50</sub< value of 119 ± 3.5 µg·mL<sup<−1</sup< against the cell line of human breast cancer (MDA-MB-231). Additionally, principal component analysis (PCA) was investigated to determine the relationship among the investigated traits and treatments. Our findings reveal that date palm fruit-derived extracts are excellent sources of biologically active constituents and substantiate their potential use in new anticancer strategies from natural resources. <i<Phoenix dactylifera</i< L. antioxidants cancer cell lines HPLC-DAD phenolics ethyl acetate extract Microbiology Mohamed A. Tammam verfasserin aut Mohamed Yassin Ali verfasserin aut Marwa Sharaky verfasserin aut Khaled Selim verfasserin aut Wael M. Semida verfasserin aut Taia A. Abd El-Mageed verfasserin aut Mohamed Fawzy Ramadan verfasserin aut Hesham F. Oraby verfasserin aut Yasser M. Diab verfasserin aut In Metabolites MDPI AG, 2012 13(2023), 7, p 816 (DE-627)718627164 (DE-600)2662251-8 22181989 nnns volume:13 year:2023 number:7, p 816 https://doi.org/10.3390/metabo13070816 kostenfrei https://doaj.org/article/65f60d3b30a74f3fa0a23bea0ee2347d kostenfrei https://www.mdpi.com/2218-1989/13/7/816 kostenfrei https://doaj.org/toc/2218-1989 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 7, p 816
allfields_unstemmed	10.3390/metabo13070816 doi (DE-627)DOAJ093861273 (DE-599)DOAJ65f60d3b30a74f3fa0a23bea0ee2347d DE-627 ger DE-627 rakwb eng QR1-502 Ahmed S. Abdelbaky verfasserin aut Antioxidant and Anticancer Assessment and Phytochemical Investigation of Three Varieties of Date Fruits 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Date palm (<i<Phoenix dactylifera</i< L.) fruits contain high concentrations of phenolic compounds, particularly flavonoids and other micronutrients, which impact human health due to their potent antioxidant, anti-inflammatory, and anticancer characteristics. In the present study, the effect of ethyl acetate, hydroethanol, hydromethanol, and aqueous extract from three date palm varieties (i.e., Ajwa, Siwi, and Sukkari) on phytochemical profiles and antioxidant and anticancer activities was investigated. Fruit extracts were screened for their antioxidant activity using the DPPH· method. Phenolic constituents were quantified and identified using HPLC-DAD. Extracts (ethyl acetate, hydroethanol, and hydromethanol) were assessed for cytotoxicity on nine human cancer cell lines, i.e., MG-63, HCT116, MCF7, MDA-MB-231, HEPG2, HUH7, A549, H460, and HFB4, using the sulphorhodamine-B (SRB) assay. Results showed that the ethyl acetate extract of the Sukkari fruits has the greatest antioxidant potential with an IC<sub<50</sub< value of 132.4 ± 0.3 μg·mL<sup<−1</sup<, while the aqueous extract of Ajwa date fruits exhibited the lowest antioxidant effect with an IC<sub<50</sub< value of 867.1 ± 0.3 μg·mL<sup<−1</sup<. The extracts exhibited potent to moderate anticancer activities against the investigated cancer cell line in a source-dependent manner. Methanol extract of Siwi fruits exhibited the most potent anticancer activity (IC<sub<50</sub< = 99 ± 1.6 µg·mL<sup<−1</sup<), followed by the same extract of Sukkari fruits with an IC<sub<50</sub< value of 119 ± 3.5 µg·mL<sup<−1</sup< against the cell line of human breast cancer (MDA-MB-231). Additionally, principal component analysis (PCA) was investigated to determine the relationship among the investigated traits and treatments. Our findings reveal that date palm fruit-derived extracts are excellent sources of biologically active constituents and substantiate their potential use in new anticancer strategies from natural resources. <i<Phoenix dactylifera</i< L. antioxidants cancer cell lines HPLC-DAD phenolics ethyl acetate extract Microbiology Mohamed A. Tammam verfasserin aut Mohamed Yassin Ali verfasserin aut Marwa Sharaky verfasserin aut Khaled Selim verfasserin aut Wael M. Semida verfasserin aut Taia A. Abd El-Mageed verfasserin aut Mohamed Fawzy Ramadan verfasserin aut Hesham F. Oraby verfasserin aut Yasser M. Diab verfasserin aut In Metabolites MDPI AG, 2012 13(2023), 7, p 816 (DE-627)718627164 (DE-600)2662251-8 22181989 nnns volume:13 year:2023 number:7, p 816 https://doi.org/10.3390/metabo13070816 kostenfrei https://doaj.org/article/65f60d3b30a74f3fa0a23bea0ee2347d kostenfrei https://www.mdpi.com/2218-1989/13/7/816 kostenfrei https://doaj.org/toc/2218-1989 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 7, p 816
allfieldsGer	10.3390/metabo13070816 doi (DE-627)DOAJ093861273 (DE-599)DOAJ65f60d3b30a74f3fa0a23bea0ee2347d DE-627 ger DE-627 rakwb eng QR1-502 Ahmed S. Abdelbaky verfasserin aut Antioxidant and Anticancer Assessment and Phytochemical Investigation of Three Varieties of Date Fruits 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Date palm (<i<Phoenix dactylifera</i< L.) fruits contain high concentrations of phenolic compounds, particularly flavonoids and other micronutrients, which impact human health due to their potent antioxidant, anti-inflammatory, and anticancer characteristics. In the present study, the effect of ethyl acetate, hydroethanol, hydromethanol, and aqueous extract from three date palm varieties (i.e., Ajwa, Siwi, and Sukkari) on phytochemical profiles and antioxidant and anticancer activities was investigated. Fruit extracts were screened for their antioxidant activity using the DPPH· method. Phenolic constituents were quantified and identified using HPLC-DAD. Extracts (ethyl acetate, hydroethanol, and hydromethanol) were assessed for cytotoxicity on nine human cancer cell lines, i.e., MG-63, HCT116, MCF7, MDA-MB-231, HEPG2, HUH7, A549, H460, and HFB4, using the sulphorhodamine-B (SRB) assay. Results showed that the ethyl acetate extract of the Sukkari fruits has the greatest antioxidant potential with an IC<sub<50</sub< value of 132.4 ± 0.3 μg·mL<sup<−1</sup<, while the aqueous extract of Ajwa date fruits exhibited the lowest antioxidant effect with an IC<sub<50</sub< value of 867.1 ± 0.3 μg·mL<sup<−1</sup<. The extracts exhibited potent to moderate anticancer activities against the investigated cancer cell line in a source-dependent manner. Methanol extract of Siwi fruits exhibited the most potent anticancer activity (IC<sub<50</sub< = 99 ± 1.6 µg·mL<sup<−1</sup<), followed by the same extract of Sukkari fruits with an IC<sub<50</sub< value of 119 ± 3.5 µg·mL<sup<−1</sup< against the cell line of human breast cancer (MDA-MB-231). Additionally, principal component analysis (PCA) was investigated to determine the relationship among the investigated traits and treatments. Our findings reveal that date palm fruit-derived extracts are excellent sources of biologically active constituents and substantiate their potential use in new anticancer strategies from natural resources. <i<Phoenix dactylifera</i< L. antioxidants cancer cell lines HPLC-DAD phenolics ethyl acetate extract Microbiology Mohamed A. Tammam verfasserin aut Mohamed Yassin Ali verfasserin aut Marwa Sharaky verfasserin aut Khaled Selim verfasserin aut Wael M. Semida verfasserin aut Taia A. Abd El-Mageed verfasserin aut Mohamed Fawzy Ramadan verfasserin aut Hesham F. Oraby verfasserin aut Yasser M. Diab verfasserin aut In Metabolites MDPI AG, 2012 13(2023), 7, p 816 (DE-627)718627164 (DE-600)2662251-8 22181989 nnns volume:13 year:2023 number:7, p 816 https://doi.org/10.3390/metabo13070816 kostenfrei https://doaj.org/article/65f60d3b30a74f3fa0a23bea0ee2347d kostenfrei https://www.mdpi.com/2218-1989/13/7/816 kostenfrei https://doaj.org/toc/2218-1989 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 7, p 816
allfieldsSound	10.3390/metabo13070816 doi (DE-627)DOAJ093861273 (DE-599)DOAJ65f60d3b30a74f3fa0a23bea0ee2347d DE-627 ger DE-627 rakwb eng QR1-502 Ahmed S. Abdelbaky verfasserin aut Antioxidant and Anticancer Assessment and Phytochemical Investigation of Three Varieties of Date Fruits 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Date palm (<i<Phoenix dactylifera</i< L.) fruits contain high concentrations of phenolic compounds, particularly flavonoids and other micronutrients, which impact human health due to their potent antioxidant, anti-inflammatory, and anticancer characteristics. In the present study, the effect of ethyl acetate, hydroethanol, hydromethanol, and aqueous extract from three date palm varieties (i.e., Ajwa, Siwi, and Sukkari) on phytochemical profiles and antioxidant and anticancer activities was investigated. Fruit extracts were screened for their antioxidant activity using the DPPH· method. Phenolic constituents were quantified and identified using HPLC-DAD. Extracts (ethyl acetate, hydroethanol, and hydromethanol) were assessed for cytotoxicity on nine human cancer cell lines, i.e., MG-63, HCT116, MCF7, MDA-MB-231, HEPG2, HUH7, A549, H460, and HFB4, using the sulphorhodamine-B (SRB) assay. Results showed that the ethyl acetate extract of the Sukkari fruits has the greatest antioxidant potential with an IC<sub<50</sub< value of 132.4 ± 0.3 μg·mL<sup<−1</sup<, while the aqueous extract of Ajwa date fruits exhibited the lowest antioxidant effect with an IC<sub<50</sub< value of 867.1 ± 0.3 μg·mL<sup<−1</sup<. The extracts exhibited potent to moderate anticancer activities against the investigated cancer cell line in a source-dependent manner. Methanol extract of Siwi fruits exhibited the most potent anticancer activity (IC<sub<50</sub< = 99 ± 1.6 µg·mL<sup<−1</sup<), followed by the same extract of Sukkari fruits with an IC<sub<50</sub< value of 119 ± 3.5 µg·mL<sup<−1</sup< against the cell line of human breast cancer (MDA-MB-231). Additionally, principal component analysis (PCA) was investigated to determine the relationship among the investigated traits and treatments. Our findings reveal that date palm fruit-derived extracts are excellent sources of biologically active constituents and substantiate their potential use in new anticancer strategies from natural resources. <i<Phoenix dactylifera</i< L. antioxidants cancer cell lines HPLC-DAD phenolics ethyl acetate extract Microbiology Mohamed A. Tammam verfasserin aut Mohamed Yassin Ali verfasserin aut Marwa Sharaky verfasserin aut Khaled Selim verfasserin aut Wael M. Semida verfasserin aut Taia A. Abd El-Mageed verfasserin aut Mohamed Fawzy Ramadan verfasserin aut Hesham F. Oraby verfasserin aut Yasser M. Diab verfasserin aut In Metabolites MDPI AG, 2012 13(2023), 7, p 816 (DE-627)718627164 (DE-600)2662251-8 22181989 nnns volume:13 year:2023 number:7, p 816 https://doi.org/10.3390/metabo13070816 kostenfrei https://doaj.org/article/65f60d3b30a74f3fa0a23bea0ee2347d kostenfrei https://www.mdpi.com/2218-1989/13/7/816 kostenfrei https://doaj.org/toc/2218-1989 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 7, p 816
language	English
source	In Metabolites 13(2023), 7, p 816 volume:13 year:2023 number:7, p 816
sourceStr	In Metabolites 13(2023), 7, p 816 volume:13 year:2023 number:7, p 816
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	<i<Phoenix dactylifera</i< L. antioxidants cancer cell lines HPLC-DAD phenolics ethyl acetate extract Microbiology
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container_title	Metabolites
authorswithroles_txt_mv	Ahmed S. Abdelbaky @@aut@@ Mohamed A. Tammam @@aut@@ Mohamed Yassin Ali @@aut@@ Marwa Sharaky @@aut@@ Khaled Selim @@aut@@ Wael M. Semida @@aut@@ Taia A. Abd El-Mageed @@aut@@ Mohamed Fawzy Ramadan @@aut@@ Hesham F. Oraby @@aut@@ Yasser M. Diab @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
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id	DOAJ093861273
language_de	englisch
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author	Ahmed S. Abdelbaky
spellingShingle	Ahmed S. Abdelbaky misc QR1-502 misc <i<Phoenix dactylifera</i< L. misc antioxidants misc cancer cell lines misc HPLC-DAD misc phenolics misc ethyl acetate extract misc Microbiology Antioxidant and Anticancer Assessment and Phytochemical Investigation of Three Varieties of Date Fruits
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topic_title	QR1-502 Antioxidant and Anticancer Assessment and Phytochemical Investigation of Three Varieties of Date Fruits <i<Phoenix dactylifera</i< L. antioxidants cancer cell lines HPLC-DAD phenolics ethyl acetate extract
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title	Antioxidant and Anticancer Assessment and Phytochemical Investigation of Three Varieties of Date Fruits
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title_full	Antioxidant and Anticancer Assessment and Phytochemical Investigation of Three Varieties of Date Fruits
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author_browse	Ahmed S. Abdelbaky Mohamed A. Tammam Mohamed Yassin Ali Marwa Sharaky Khaled Selim Wael M. Semida Taia A. Abd El-Mageed Mohamed Fawzy Ramadan Hesham F. Oraby Yasser M. Diab
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title_sort	antioxidant and anticancer assessment and phytochemical investigation of three varieties of date fruits
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title_auth	Antioxidant and Anticancer Assessment and Phytochemical Investigation of Three Varieties of Date Fruits
abstract	Date palm (<i<Phoenix dactylifera</i< L.) fruits contain high concentrations of phenolic compounds, particularly flavonoids and other micronutrients, which impact human health due to their potent antioxidant, anti-inflammatory, and anticancer characteristics. In the present study, the effect of ethyl acetate, hydroethanol, hydromethanol, and aqueous extract from three date palm varieties (i.e., Ajwa, Siwi, and Sukkari) on phytochemical profiles and antioxidant and anticancer activities was investigated. Fruit extracts were screened for their antioxidant activity using the DPPH· method. Phenolic constituents were quantified and identified using HPLC-DAD. Extracts (ethyl acetate, hydroethanol, and hydromethanol) were assessed for cytotoxicity on nine human cancer cell lines, i.e., MG-63, HCT116, MCF7, MDA-MB-231, HEPG2, HUH7, A549, H460, and HFB4, using the sulphorhodamine-B (SRB) assay. Results showed that the ethyl acetate extract of the Sukkari fruits has the greatest antioxidant potential with an IC<sub<50</sub< value of 132.4 ± 0.3 μg·mL<sup<−1</sup<, while the aqueous extract of Ajwa date fruits exhibited the lowest antioxidant effect with an IC<sub<50</sub< value of 867.1 ± 0.3 μg·mL<sup<−1</sup<. The extracts exhibited potent to moderate anticancer activities against the investigated cancer cell line in a source-dependent manner. Methanol extract of Siwi fruits exhibited the most potent anticancer activity (IC<sub<50</sub< = 99 ± 1.6 µg·mL<sup<−1</sup<), followed by the same extract of Sukkari fruits with an IC<sub<50</sub< value of 119 ± 3.5 µg·mL<sup<−1</sup< against the cell line of human breast cancer (MDA-MB-231). Additionally, principal component analysis (PCA) was investigated to determine the relationship among the investigated traits and treatments. Our findings reveal that date palm fruit-derived extracts are excellent sources of biologically active constituents and substantiate their potential use in new anticancer strategies from natural resources.
abstractGer	Date palm (<i<Phoenix dactylifera</i< L.) fruits contain high concentrations of phenolic compounds, particularly flavonoids and other micronutrients, which impact human health due to their potent antioxidant, anti-inflammatory, and anticancer characteristics. In the present study, the effect of ethyl acetate, hydroethanol, hydromethanol, and aqueous extract from three date palm varieties (i.e., Ajwa, Siwi, and Sukkari) on phytochemical profiles and antioxidant and anticancer activities was investigated. Fruit extracts were screened for their antioxidant activity using the DPPH· method. Phenolic constituents were quantified and identified using HPLC-DAD. Extracts (ethyl acetate, hydroethanol, and hydromethanol) were assessed for cytotoxicity on nine human cancer cell lines, i.e., MG-63, HCT116, MCF7, MDA-MB-231, HEPG2, HUH7, A549, H460, and HFB4, using the sulphorhodamine-B (SRB) assay. Results showed that the ethyl acetate extract of the Sukkari fruits has the greatest antioxidant potential with an IC<sub<50</sub< value of 132.4 ± 0.3 μg·mL<sup<−1</sup<, while the aqueous extract of Ajwa date fruits exhibited the lowest antioxidant effect with an IC<sub<50</sub< value of 867.1 ± 0.3 μg·mL<sup<−1</sup<. The extracts exhibited potent to moderate anticancer activities against the investigated cancer cell line in a source-dependent manner. Methanol extract of Siwi fruits exhibited the most potent anticancer activity (IC<sub<50</sub< = 99 ± 1.6 µg·mL<sup<−1</sup<), followed by the same extract of Sukkari fruits with an IC<sub<50</sub< value of 119 ± 3.5 µg·mL<sup<−1</sup< against the cell line of human breast cancer (MDA-MB-231). Additionally, principal component analysis (PCA) was investigated to determine the relationship among the investigated traits and treatments. Our findings reveal that date palm fruit-derived extracts are excellent sources of biologically active constituents and substantiate their potential use in new anticancer strategies from natural resources.
abstract_unstemmed	Date palm (<i<Phoenix dactylifera</i< L.) fruits contain high concentrations of phenolic compounds, particularly flavonoids and other micronutrients, which impact human health due to their potent antioxidant, anti-inflammatory, and anticancer characteristics. In the present study, the effect of ethyl acetate, hydroethanol, hydromethanol, and aqueous extract from three date palm varieties (i.e., Ajwa, Siwi, and Sukkari) on phytochemical profiles and antioxidant and anticancer activities was investigated. Fruit extracts were screened for their antioxidant activity using the DPPH· method. Phenolic constituents were quantified and identified using HPLC-DAD. Extracts (ethyl acetate, hydroethanol, and hydromethanol) were assessed for cytotoxicity on nine human cancer cell lines, i.e., MG-63, HCT116, MCF7, MDA-MB-231, HEPG2, HUH7, A549, H460, and HFB4, using the sulphorhodamine-B (SRB) assay. Results showed that the ethyl acetate extract of the Sukkari fruits has the greatest antioxidant potential with an IC<sub<50</sub< value of 132.4 ± 0.3 μg·mL<sup<−1</sup<, while the aqueous extract of Ajwa date fruits exhibited the lowest antioxidant effect with an IC<sub<50</sub< value of 867.1 ± 0.3 μg·mL<sup<−1</sup<. The extracts exhibited potent to moderate anticancer activities against the investigated cancer cell line in a source-dependent manner. Methanol extract of Siwi fruits exhibited the most potent anticancer activity (IC<sub<50</sub< = 99 ± 1.6 µg·mL<sup<−1</sup<), followed by the same extract of Sukkari fruits with an IC<sub<50</sub< value of 119 ± 3.5 µg·mL<sup<−1</sup< against the cell line of human breast cancer (MDA-MB-231). Additionally, principal component analysis (PCA) was investigated to determine the relationship among the investigated traits and treatments. Our findings reveal that date palm fruit-derived extracts are excellent sources of biologically active constituents and substantiate their potential use in new anticancer strategies from natural resources.
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title_short	Antioxidant and Anticancer Assessment and Phytochemical Investigation of Three Varieties of Date Fruits
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Antioxidant and Anticancer Assessment and Phytochemical Investigation of Three Varieties of Date Fruits

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