Characterization of <i<Arabidopsis thaliana</i< Coq9 in the CoQ Biosynthetic Pathway

Coenzyme Q, also known as ubiquinone, is a fat-soluble isoprene quinone that serves as a cofactor for numerous enzymes across all domains of life. However, the biosynthetic pathway for this important molecule in plants has been examined in only a limited number of studies. In yeast and mammals, Coq9...
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Autor*in:	Mei Hu [verfasserIn] Yan Jiang [verfasserIn] Jing-Jing Xu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	coenzyme Q plant metabolism Coq9 mitochondria

Übergeordnetes Werk:	In: Metabolites - MDPI AG, 2012, 13(2023), 7, p 813
Übergeordnetes Werk:	volume:13 ; year:2023 ; number:7, p 813

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/metabo13070813

Katalog-ID:	DOAJ093861303

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520			\|a Coenzyme Q, also known as ubiquinone, is a fat-soluble isoprene quinone that serves as a cofactor for numerous enzymes across all domains of life. However, the biosynthetic pathway for this important molecule in plants has been examined in only a limited number of studies. In yeast and mammals, Coq9, an isoprenoid-lipid-binding protein, is essential for CoQ biosynthesis. Previous studies showed that <i<Arabidopsis thaliana Coq9</i< failed to complement the fission yeast <i<Schizosaccharomyces pombe coq9</i< null mutant, and its function in plants remains unknown. In this study, we demonstrated that expression of <i<Arabidopsis Coq9</i< rescued the growth of a yeast temperature-sensitive <i<coq9</i< mutant and increased CoQ content. Phylogenetic analysis revealed that Coq9 is widely present in green plants. Green fluorescent protein (GFP) fusion experiments showed that <i<Arabidopsis</i< Coq9 is targeted to mitochondria. Disruption of the <i<Coq9</i< gene in <i<Arabidopsis</i< results in lower amounts of CoQ. Our work suggests that plant Coq9 is required for efficient CoQ biosynthesis. These findings provide new insights into the evolution of CoQ biosynthesis in plants. The identification of Coq9 as a key player in CoQ biosynthesis in plants opens up new avenues for understanding the regulation of this important metabolic pathway.
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allfieldsSound	10.3390/metabo13070813 doi (DE-627)DOAJ093861303 (DE-599)DOAJ028d9e6343434997847cead2f59a8e7f DE-627 ger DE-627 rakwb eng QR1-502 Mei Hu verfasserin aut Characterization of <i<Arabidopsis thaliana</i< Coq9 in the CoQ Biosynthetic Pathway 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Coenzyme Q, also known as ubiquinone, is a fat-soluble isoprene quinone that serves as a cofactor for numerous enzymes across all domains of life. However, the biosynthetic pathway for this important molecule in plants has been examined in only a limited number of studies. In yeast and mammals, Coq9, an isoprenoid-lipid-binding protein, is essential for CoQ biosynthesis. Previous studies showed that <i<Arabidopsis thaliana Coq9</i< failed to complement the fission yeast <i<Schizosaccharomyces pombe coq9</i< null mutant, and its function in plants remains unknown. In this study, we demonstrated that expression of <i<Arabidopsis Coq9</i< rescued the growth of a yeast temperature-sensitive <i<coq9</i< mutant and increased CoQ content. Phylogenetic analysis revealed that Coq9 is widely present in green plants. Green fluorescent protein (GFP) fusion experiments showed that <i<Arabidopsis</i< Coq9 is targeted to mitochondria. Disruption of the <i<Coq9</i< gene in <i<Arabidopsis</i< results in lower amounts of CoQ. Our work suggests that plant Coq9 is required for efficient CoQ biosynthesis. These findings provide new insights into the evolution of CoQ biosynthesis in plants. The identification of Coq9 as a key player in CoQ biosynthesis in plants opens up new avenues for understanding the regulation of this important metabolic pathway. coenzyme Q plant metabolism Coq9 <i<Arabidopsis</i< mitochondria Microbiology Yan Jiang verfasserin aut Jing-Jing Xu verfasserin aut In Metabolites MDPI AG, 2012 13(2023), 7, p 813 (DE-627)718627164 (DE-600)2662251-8 22181989 nnns volume:13 year:2023 number:7, p 813 https://doi.org/10.3390/metabo13070813 kostenfrei https://doaj.org/article/028d9e6343434997847cead2f59a8e7f kostenfrei https://www.mdpi.com/2218-1989/13/7/813 kostenfrei https://doaj.org/toc/2218-1989 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 7, p 813
language	English
source	In Metabolites 13(2023), 7, p 813 volume:13 year:2023 number:7, p 813
sourceStr	In Metabolites 13(2023), 7, p 813 volume:13 year:2023 number:7, p 813
format_phy_str_mv	Article
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topic_facet	coenzyme Q plant metabolism Coq9 <i<Arabidopsis</i< mitochondria Microbiology
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container_title	Metabolites
authorswithroles_txt_mv	Mei Hu @@aut@@ Yan Jiang @@aut@@ Jing-Jing Xu @@aut@@
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callnumber-first	Q - Science
author	Mei Hu
spellingShingle	Mei Hu misc QR1-502 misc coenzyme Q misc plant metabolism misc Coq9 misc <i<Arabidopsis</i< misc mitochondria misc Microbiology Characterization of <i<Arabidopsis thaliana</i< Coq9 in the CoQ Biosynthetic Pathway
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topic_title	QR1-502 Characterization of <i<Arabidopsis thaliana</i< Coq9 in the CoQ Biosynthetic Pathway coenzyme Q plant metabolism Coq9 <i<Arabidopsis</i< mitochondria
topic	misc QR1-502 misc coenzyme Q misc plant metabolism misc Coq9 misc <i<Arabidopsis</i< misc mitochondria misc Microbiology
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title	Characterization of <i<Arabidopsis thaliana</i< Coq9 in the CoQ Biosynthetic Pathway
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title_full	Characterization of <i<Arabidopsis thaliana</i< Coq9 in the CoQ Biosynthetic Pathway
author_sort	Mei Hu
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title_sort	characterization of <i<arabidopsis thaliana</i< coq9 in the coq biosynthetic pathway
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title_auth	Characterization of <i<Arabidopsis thaliana</i< Coq9 in the CoQ Biosynthetic Pathway
abstract	Coenzyme Q, also known as ubiquinone, is a fat-soluble isoprene quinone that serves as a cofactor for numerous enzymes across all domains of life. However, the biosynthetic pathway for this important molecule in plants has been examined in only a limited number of studies. In yeast and mammals, Coq9, an isoprenoid-lipid-binding protein, is essential for CoQ biosynthesis. Previous studies showed that <i<Arabidopsis thaliana Coq9</i< failed to complement the fission yeast <i<Schizosaccharomyces pombe coq9</i< null mutant, and its function in plants remains unknown. In this study, we demonstrated that expression of <i<Arabidopsis Coq9</i< rescued the growth of a yeast temperature-sensitive <i<coq9</i< mutant and increased CoQ content. Phylogenetic analysis revealed that Coq9 is widely present in green plants. Green fluorescent protein (GFP) fusion experiments showed that <i<Arabidopsis</i< Coq9 is targeted to mitochondria. Disruption of the <i<Coq9</i< gene in <i<Arabidopsis</i< results in lower amounts of CoQ. Our work suggests that plant Coq9 is required for efficient CoQ biosynthesis. These findings provide new insights into the evolution of CoQ biosynthesis in plants. The identification of Coq9 as a key player in CoQ biosynthesis in plants opens up new avenues for understanding the regulation of this important metabolic pathway.
abstractGer	Coenzyme Q, also known as ubiquinone, is a fat-soluble isoprene quinone that serves as a cofactor for numerous enzymes across all domains of life. However, the biosynthetic pathway for this important molecule in plants has been examined in only a limited number of studies. In yeast and mammals, Coq9, an isoprenoid-lipid-binding protein, is essential for CoQ biosynthesis. Previous studies showed that <i<Arabidopsis thaliana Coq9</i< failed to complement the fission yeast <i<Schizosaccharomyces pombe coq9</i< null mutant, and its function in plants remains unknown. In this study, we demonstrated that expression of <i<Arabidopsis Coq9</i< rescued the growth of a yeast temperature-sensitive <i<coq9</i< mutant and increased CoQ content. Phylogenetic analysis revealed that Coq9 is widely present in green plants. Green fluorescent protein (GFP) fusion experiments showed that <i<Arabidopsis</i< Coq9 is targeted to mitochondria. Disruption of the <i<Coq9</i< gene in <i<Arabidopsis</i< results in lower amounts of CoQ. Our work suggests that plant Coq9 is required for efficient CoQ biosynthesis. These findings provide new insights into the evolution of CoQ biosynthesis in plants. The identification of Coq9 as a key player in CoQ biosynthesis in plants opens up new avenues for understanding the regulation of this important metabolic pathway.
abstract_unstemmed	Coenzyme Q, also known as ubiquinone, is a fat-soluble isoprene quinone that serves as a cofactor for numerous enzymes across all domains of life. However, the biosynthetic pathway for this important molecule in plants has been examined in only a limited number of studies. In yeast and mammals, Coq9, an isoprenoid-lipid-binding protein, is essential for CoQ biosynthesis. Previous studies showed that <i<Arabidopsis thaliana Coq9</i< failed to complement the fission yeast <i<Schizosaccharomyces pombe coq9</i< null mutant, and its function in plants remains unknown. In this study, we demonstrated that expression of <i<Arabidopsis Coq9</i< rescued the growth of a yeast temperature-sensitive <i<coq9</i< mutant and increased CoQ content. Phylogenetic analysis revealed that Coq9 is widely present in green plants. Green fluorescent protein (GFP) fusion experiments showed that <i<Arabidopsis</i< Coq9 is targeted to mitochondria. Disruption of the <i<Coq9</i< gene in <i<Arabidopsis</i< results in lower amounts of CoQ. Our work suggests that plant Coq9 is required for efficient CoQ biosynthesis. These findings provide new insights into the evolution of CoQ biosynthesis in plants. The identification of Coq9 as a key player in CoQ biosynthesis in plants opens up new avenues for understanding the regulation of this important metabolic pathway.
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title_short	Characterization of <i<Arabidopsis thaliana</i< Coq9 in the CoQ Biosynthetic Pathway
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Characterization of <i<Arabidopsis thaliana</i< Coq9 in the CoQ Biosynthetic Pathway

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