Validity of the Central Sensitization Inventory to Address Human Assumed Central Sensitization: Newly Proposed Clinically Relevant Values and Associations

Central sensitization cannot be directly demonstrated in humans and thus a gold standard is missing. Therefore, we used human assumed central sensitization (HACS) when associated with humans. The central sensitization inventory (CSI) is a screening questionnaire for addressing symptoms that are asso...
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Autor*in:	Ingrid Schuttert [verfasserIn] André P. Wolff [verfasserIn] Rita H. R. Schiphorst Preuper [verfasserIn] Alec G. G. A. Malmberg [verfasserIn] Michiel F. Reneman [verfasserIn] Hans Timmerman [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	chronic pain central sensitization inventory (CSI) central sensitization (CS) sensitization central sensitivity syndrome (CSS) human assumed central sensitization (HACS)

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 12(2023), 14, p 4849
Übergeordnetes Werk:	volume:12 ; year:2023 ; number:14, p 4849

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm12144849

Katalog-ID:	DOAJ093882513

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allfieldsSound	10.3390/jcm12144849 doi (DE-627)DOAJ093882513 (DE-599)DOAJa23cac35cced4a92a46541a0d17aae10 DE-627 ger DE-627 rakwb eng Ingrid Schuttert verfasserin aut Validity of the Central Sensitization Inventory to Address Human Assumed Central Sensitization: Newly Proposed Clinically Relevant Values and Associations 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Central sensitization cannot be directly demonstrated in humans and thus a gold standard is missing. Therefore, we used human assumed central sensitization (HACS) when associated with humans. The central sensitization inventory (CSI) is a screening questionnaire for addressing symptoms that are associated with HACS. This cross-sectional study compared patients with chronic pain and at least one central sensitivity syndrome with healthy, pain-free controls via ROC analyses. Analyses were performed for all participants together and for each sex separately. Regression analyses were performed on patients with chronic pain with and without central sensitivity syndromes. Based on 1730 patients and 250 healthy controls, cutoff values for the CSI for the total group were established at 30 points: women: 33 points; men: 25 points. Univariate and multivariate regression analyses were used to identify possible predictors for the CSI score in 2890 patients with chronic pain. The CSI score is associated with all independent factors and has a low association with pain severity in women and a low association with pain severity, age, and body mass index in men. The newly established CSI cutoff values are lower than in previous studies and different per sex, which might be of clinical relevance in daily practice and importance in research. chronic pain central sensitization inventory (CSI) central sensitization (CS) sensitization central sensitivity syndrome (CSS) human assumed central sensitization (HACS) Medicine R André P. Wolff verfasserin aut Rita H. R. Schiphorst Preuper verfasserin aut Alec G. G. A. Malmberg verfasserin aut Michiel F. Reneman verfasserin aut Hans Timmerman verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 14, p 4849 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:14, p 4849 https://doi.org/10.3390/jcm12144849 kostenfrei https://doaj.org/article/a23cac35cced4a92a46541a0d17aae10 kostenfrei https://www.mdpi.com/2077-0383/12/14/4849 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 14, p 4849
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author	Ingrid Schuttert
spellingShingle	Ingrid Schuttert misc chronic pain misc central sensitization inventory (CSI) misc central sensitization (CS) misc sensitization misc central sensitivity syndrome (CSS) misc human assumed central sensitization (HACS) misc Medicine misc R Validity of the Central Sensitization Inventory to Address Human Assumed Central Sensitization: Newly Proposed Clinically Relevant Values and Associations
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topic_title	Validity of the Central Sensitization Inventory to Address Human Assumed Central Sensitization: Newly Proposed Clinically Relevant Values and Associations chronic pain central sensitization inventory (CSI) central sensitization (CS) sensitization central sensitivity syndrome (CSS) human assumed central sensitization (HACS)
topic	misc chronic pain misc central sensitization inventory (CSI) misc central sensitization (CS) misc sensitization misc central sensitivity syndrome (CSS) misc human assumed central sensitization (HACS) misc Medicine misc R
topic_unstemmed	misc chronic pain misc central sensitization inventory (CSI) misc central sensitization (CS) misc sensitization misc central sensitivity syndrome (CSS) misc human assumed central sensitization (HACS) misc Medicine misc R
topic_browse	misc chronic pain misc central sensitization inventory (CSI) misc central sensitization (CS) misc sensitization misc central sensitivity syndrome (CSS) misc human assumed central sensitization (HACS) misc Medicine misc R
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title	Validity of the Central Sensitization Inventory to Address Human Assumed Central Sensitization: Newly Proposed Clinically Relevant Values and Associations
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title_full	Validity of the Central Sensitization Inventory to Address Human Assumed Central Sensitization: Newly Proposed Clinically Relevant Values and Associations
author_sort	Ingrid Schuttert
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author_browse	Ingrid Schuttert André P. Wolff Rita H. R. Schiphorst Preuper Alec G. G. A. Malmberg Michiel F. Reneman Hans Timmerman
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title_sort	validity of the central sensitization inventory to address human assumed central sensitization: newly proposed clinically relevant values and associations
title_auth	Validity of the Central Sensitization Inventory to Address Human Assumed Central Sensitization: Newly Proposed Clinically Relevant Values and Associations
abstract	Central sensitization cannot be directly demonstrated in humans and thus a gold standard is missing. Therefore, we used human assumed central sensitization (HACS) when associated with humans. The central sensitization inventory (CSI) is a screening questionnaire for addressing symptoms that are associated with HACS. This cross-sectional study compared patients with chronic pain and at least one central sensitivity syndrome with healthy, pain-free controls via ROC analyses. Analyses were performed for all participants together and for each sex separately. Regression analyses were performed on patients with chronic pain with and without central sensitivity syndromes. Based on 1730 patients and 250 healthy controls, cutoff values for the CSI for the total group were established at 30 points: women: 33 points; men: 25 points. Univariate and multivariate regression analyses were used to identify possible predictors for the CSI score in 2890 patients with chronic pain. The CSI score is associated with all independent factors and has a low association with pain severity in women and a low association with pain severity, age, and body mass index in men. The newly established CSI cutoff values are lower than in previous studies and different per sex, which might be of clinical relevance in daily practice and importance in research.
abstractGer	Central sensitization cannot be directly demonstrated in humans and thus a gold standard is missing. Therefore, we used human assumed central sensitization (HACS) when associated with humans. The central sensitization inventory (CSI) is a screening questionnaire for addressing symptoms that are associated with HACS. This cross-sectional study compared patients with chronic pain and at least one central sensitivity syndrome with healthy, pain-free controls via ROC analyses. Analyses were performed for all participants together and for each sex separately. Regression analyses were performed on patients with chronic pain with and without central sensitivity syndromes. Based on 1730 patients and 250 healthy controls, cutoff values for the CSI for the total group were established at 30 points: women: 33 points; men: 25 points. Univariate and multivariate regression analyses were used to identify possible predictors for the CSI score in 2890 patients with chronic pain. The CSI score is associated with all independent factors and has a low association with pain severity in women and a low association with pain severity, age, and body mass index in men. The newly established CSI cutoff values are lower than in previous studies and different per sex, which might be of clinical relevance in daily practice and importance in research.
abstract_unstemmed	Central sensitization cannot be directly demonstrated in humans and thus a gold standard is missing. Therefore, we used human assumed central sensitization (HACS) when associated with humans. The central sensitization inventory (CSI) is a screening questionnaire for addressing symptoms that are associated with HACS. This cross-sectional study compared patients with chronic pain and at least one central sensitivity syndrome with healthy, pain-free controls via ROC analyses. Analyses were performed for all participants together and for each sex separately. Regression analyses were performed on patients with chronic pain with and without central sensitivity syndromes. Based on 1730 patients and 250 healthy controls, cutoff values for the CSI for the total group were established at 30 points: women: 33 points; men: 25 points. Univariate and multivariate regression analyses were used to identify possible predictors for the CSI score in 2890 patients with chronic pain. The CSI score is associated with all independent factors and has a low association with pain severity in women and a low association with pain severity, age, and body mass index in men. The newly established CSI cutoff values are lower than in previous studies and different per sex, which might be of clinical relevance in daily practice and importance in research.
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title_short	Validity of the Central Sensitization Inventory to Address Human Assumed Central Sensitization: Newly Proposed Clinically Relevant Values and Associations
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author2	André P. Wolff Rita H. R. Schiphorst Preuper Alec G. G. A. Malmberg Michiel F. Reneman Hans Timmerman
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up_date	2024-07-03T19:57:09.036Z
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Validity of the Central Sensitization Inventory to Address Human Assumed Central Sensitization: Newly Proposed Clinically Relevant Values and Associations

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