Disrupted Topological Organization of Brain Network in Rats with Spatial Memory Impairments Induced by Acute Microwave Radiation

Previous studies have suggested that microwave (MW) radiation with certain parameters can induce spatial memory deficits. However, the effect of MW on the topological organization of the brain network is still unknown. This work aimed to investigate the topological organization of the brain network...
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Autor*in:	Haoyu Wang [verfasserIn] Haixia Zhao [verfasserIn] Chunfang Li [verfasserIn] Ji Dong [verfasserIn] Jianghao Zhao [verfasserIn] Hanlin Yue [verfasserIn] Yunfei Lai [verfasserIn] Li Zhao [verfasserIn] Hui Wang [verfasserIn] Jing Zhang [verfasserIn] Xinping Xu [verfasserIn] Binwei Yao [verfasserIn] Hongmei Zhou [verfasserIn] Binbin Nie [verfasserIn] Xiumin Du [verfasserIn] Ruiyun Peng [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	microwave radiation topological organization brain network spatial memory resting-state fMRI rat

Übergeordnetes Werk:	In: Brain Sciences - MDPI AG, 2012, 13(2023), 7, p 1006
Übergeordnetes Werk:	volume:13 ; year:2023 ; number:7, p 1006

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/brainsci13071006

Katalog-ID:	DOAJ093935447

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allfields	10.3390/brainsci13071006 doi (DE-627)DOAJ093935447 (DE-599)DOAJ46d04fbe5d8d4031a97e3a55a389174e DE-627 ger DE-627 rakwb eng RC321-571 Haoyu Wang verfasserin aut Disrupted Topological Organization of Brain Network in Rats with Spatial Memory Impairments Induced by Acute Microwave Radiation 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Previous studies have suggested that microwave (MW) radiation with certain parameters can induce spatial memory deficits. However, the effect of MW on the topological organization of the brain network is still unknown. This work aimed to investigate the topological organization of the brain network in rats with spatial memory impairments induced by acute microwave (MW) radiation. The Morris water maze (MWM) test and resting-state functional magnetic resonance imaging were performed to estimate the spatial memory ability and brain network topological organization of the rats after MW exposure. Compared with the sham group, the rats exposed to 30 mW/cm<sup<2</sup< 1.5 GHz MW radiation exhibited a significantly decreased normalized clustering coefficient (γ) (<i<p</i< = 0.002) 1 d after the exposure and a prolonged average escape latency (AEL) (<i<p</i< = 0.014) 3 d after the exposure. Moreover, after 10 mW/cm<sup<2</sup< 1.5 GHz MW radiation, a significantly decreased γ (<i<p</i< = 0.003) was also observed in the rats, without any changes in AEL. In contrast, no adverse effects on AEL or topological parameters were observed after 9.375 GHz MW radiation. In conclusion, the rats with spatial memory deficits induced by MW radiation exhibited disruptions in the topological organization of the brain network. Moreover, these topological organization disruptions emerged earlier than behavioral symptom onset and could even be found in the rats without a decline in the performance of the spatial memory task. Therefore, it is possible to use the topological parameters of the brain network as early and sensitive indicators of the spatial memory impairments induced by acute MW radiation. microwave radiation topological organization brain network spatial memory resting-state fMRI rat Neurosciences. Biological psychiatry. Neuropsychiatry Haixia Zhao verfasserin aut Chunfang Li verfasserin aut Ji Dong verfasserin aut Jianghao Zhao verfasserin aut Hanlin Yue verfasserin aut Yunfei Lai verfasserin aut Li Zhao verfasserin aut Hui Wang verfasserin aut Jing Zhang verfasserin aut Xinping Xu verfasserin aut Binwei Yao verfasserin aut Hongmei Zhou verfasserin aut Binbin Nie verfasserin aut Xiumin Du verfasserin aut Ruiyun Peng verfasserin aut In Brain Sciences MDPI AG, 2012 13(2023), 7, p 1006 (DE-627)687718139 (DE-600)2651993-8 20763425 nnns volume:13 year:2023 number:7, p 1006 https://doi.org/10.3390/brainsci13071006 kostenfrei https://doaj.org/article/46d04fbe5d8d4031a97e3a55a389174e kostenfrei https://www.mdpi.com/2076-3425/13/7/1006 kostenfrei https://doaj.org/toc/2076-3425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 7, p 1006
spelling	10.3390/brainsci13071006 doi (DE-627)DOAJ093935447 (DE-599)DOAJ46d04fbe5d8d4031a97e3a55a389174e DE-627 ger DE-627 rakwb eng RC321-571 Haoyu Wang verfasserin aut Disrupted Topological Organization of Brain Network in Rats with Spatial Memory Impairments Induced by Acute Microwave Radiation 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Previous studies have suggested that microwave (MW) radiation with certain parameters can induce spatial memory deficits. However, the effect of MW on the topological organization of the brain network is still unknown. This work aimed to investigate the topological organization of the brain network in rats with spatial memory impairments induced by acute microwave (MW) radiation. The Morris water maze (MWM) test and resting-state functional magnetic resonance imaging were performed to estimate the spatial memory ability and brain network topological organization of the rats after MW exposure. Compared with the sham group, the rats exposed to 30 mW/cm<sup<2</sup< 1.5 GHz MW radiation exhibited a significantly decreased normalized clustering coefficient (γ) (<i<p</i< = 0.002) 1 d after the exposure and a prolonged average escape latency (AEL) (<i<p</i< = 0.014) 3 d after the exposure. Moreover, after 10 mW/cm<sup<2</sup< 1.5 GHz MW radiation, a significantly decreased γ (<i<p</i< = 0.003) was also observed in the rats, without any changes in AEL. In contrast, no adverse effects on AEL or topological parameters were observed after 9.375 GHz MW radiation. In conclusion, the rats with spatial memory deficits induced by MW radiation exhibited disruptions in the topological organization of the brain network. Moreover, these topological organization disruptions emerged earlier than behavioral symptom onset and could even be found in the rats without a decline in the performance of the spatial memory task. Therefore, it is possible to use the topological parameters of the brain network as early and sensitive indicators of the spatial memory impairments induced by acute MW radiation. microwave radiation topological organization brain network spatial memory resting-state fMRI rat Neurosciences. Biological psychiatry. Neuropsychiatry Haixia Zhao verfasserin aut Chunfang Li verfasserin aut Ji Dong verfasserin aut Jianghao Zhao verfasserin aut Hanlin Yue verfasserin aut Yunfei Lai verfasserin aut Li Zhao verfasserin aut Hui Wang verfasserin aut Jing Zhang verfasserin aut Xinping Xu verfasserin aut Binwei Yao verfasserin aut Hongmei Zhou verfasserin aut Binbin Nie verfasserin aut Xiumin Du verfasserin aut Ruiyun Peng verfasserin aut In Brain Sciences MDPI AG, 2012 13(2023), 7, p 1006 (DE-627)687718139 (DE-600)2651993-8 20763425 nnns volume:13 year:2023 number:7, p 1006 https://doi.org/10.3390/brainsci13071006 kostenfrei https://doaj.org/article/46d04fbe5d8d4031a97e3a55a389174e kostenfrei https://www.mdpi.com/2076-3425/13/7/1006 kostenfrei https://doaj.org/toc/2076-3425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 7, p 1006
allfields_unstemmed	10.3390/brainsci13071006 doi (DE-627)DOAJ093935447 (DE-599)DOAJ46d04fbe5d8d4031a97e3a55a389174e DE-627 ger DE-627 rakwb eng RC321-571 Haoyu Wang verfasserin aut Disrupted Topological Organization of Brain Network in Rats with Spatial Memory Impairments Induced by Acute Microwave Radiation 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Previous studies have suggested that microwave (MW) radiation with certain parameters can induce spatial memory deficits. However, the effect of MW on the topological organization of the brain network is still unknown. This work aimed to investigate the topological organization of the brain network in rats with spatial memory impairments induced by acute microwave (MW) radiation. The Morris water maze (MWM) test and resting-state functional magnetic resonance imaging were performed to estimate the spatial memory ability and brain network topological organization of the rats after MW exposure. Compared with the sham group, the rats exposed to 30 mW/cm<sup<2</sup< 1.5 GHz MW radiation exhibited a significantly decreased normalized clustering coefficient (γ) (<i<p</i< = 0.002) 1 d after the exposure and a prolonged average escape latency (AEL) (<i<p</i< = 0.014) 3 d after the exposure. Moreover, after 10 mW/cm<sup<2</sup< 1.5 GHz MW radiation, a significantly decreased γ (<i<p</i< = 0.003) was also observed in the rats, without any changes in AEL. In contrast, no adverse effects on AEL or topological parameters were observed after 9.375 GHz MW radiation. In conclusion, the rats with spatial memory deficits induced by MW radiation exhibited disruptions in the topological organization of the brain network. Moreover, these topological organization disruptions emerged earlier than behavioral symptom onset and could even be found in the rats without a decline in the performance of the spatial memory task. Therefore, it is possible to use the topological parameters of the brain network as early and sensitive indicators of the spatial memory impairments induced by acute MW radiation. microwave radiation topological organization brain network spatial memory resting-state fMRI rat Neurosciences. Biological psychiatry. Neuropsychiatry Haixia Zhao verfasserin aut Chunfang Li verfasserin aut Ji Dong verfasserin aut Jianghao Zhao verfasserin aut Hanlin Yue verfasserin aut Yunfei Lai verfasserin aut Li Zhao verfasserin aut Hui Wang verfasserin aut Jing Zhang verfasserin aut Xinping Xu verfasserin aut Binwei Yao verfasserin aut Hongmei Zhou verfasserin aut Binbin Nie verfasserin aut Xiumin Du verfasserin aut Ruiyun Peng verfasserin aut In Brain Sciences MDPI AG, 2012 13(2023), 7, p 1006 (DE-627)687718139 (DE-600)2651993-8 20763425 nnns volume:13 year:2023 number:7, p 1006 https://doi.org/10.3390/brainsci13071006 kostenfrei https://doaj.org/article/46d04fbe5d8d4031a97e3a55a389174e kostenfrei https://www.mdpi.com/2076-3425/13/7/1006 kostenfrei https://doaj.org/toc/2076-3425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 7, p 1006
allfieldsGer	10.3390/brainsci13071006 doi (DE-627)DOAJ093935447 (DE-599)DOAJ46d04fbe5d8d4031a97e3a55a389174e DE-627 ger DE-627 rakwb eng RC321-571 Haoyu Wang verfasserin aut Disrupted Topological Organization of Brain Network in Rats with Spatial Memory Impairments Induced by Acute Microwave Radiation 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Previous studies have suggested that microwave (MW) radiation with certain parameters can induce spatial memory deficits. However, the effect of MW on the topological organization of the brain network is still unknown. This work aimed to investigate the topological organization of the brain network in rats with spatial memory impairments induced by acute microwave (MW) radiation. The Morris water maze (MWM) test and resting-state functional magnetic resonance imaging were performed to estimate the spatial memory ability and brain network topological organization of the rats after MW exposure. Compared with the sham group, the rats exposed to 30 mW/cm<sup<2</sup< 1.5 GHz MW radiation exhibited a significantly decreased normalized clustering coefficient (γ) (<i<p</i< = 0.002) 1 d after the exposure and a prolonged average escape latency (AEL) (<i<p</i< = 0.014) 3 d after the exposure. Moreover, after 10 mW/cm<sup<2</sup< 1.5 GHz MW radiation, a significantly decreased γ (<i<p</i< = 0.003) was also observed in the rats, without any changes in AEL. In contrast, no adverse effects on AEL or topological parameters were observed after 9.375 GHz MW radiation. In conclusion, the rats with spatial memory deficits induced by MW radiation exhibited disruptions in the topological organization of the brain network. Moreover, these topological organization disruptions emerged earlier than behavioral symptom onset and could even be found in the rats without a decline in the performance of the spatial memory task. Therefore, it is possible to use the topological parameters of the brain network as early and sensitive indicators of the spatial memory impairments induced by acute MW radiation. microwave radiation topological organization brain network spatial memory resting-state fMRI rat Neurosciences. Biological psychiatry. Neuropsychiatry Haixia Zhao verfasserin aut Chunfang Li verfasserin aut Ji Dong verfasserin aut Jianghao Zhao verfasserin aut Hanlin Yue verfasserin aut Yunfei Lai verfasserin aut Li Zhao verfasserin aut Hui Wang verfasserin aut Jing Zhang verfasserin aut Xinping Xu verfasserin aut Binwei Yao verfasserin aut Hongmei Zhou verfasserin aut Binbin Nie verfasserin aut Xiumin Du verfasserin aut Ruiyun Peng verfasserin aut In Brain Sciences MDPI AG, 2012 13(2023), 7, p 1006 (DE-627)687718139 (DE-600)2651993-8 20763425 nnns volume:13 year:2023 number:7, p 1006 https://doi.org/10.3390/brainsci13071006 kostenfrei https://doaj.org/article/46d04fbe5d8d4031a97e3a55a389174e kostenfrei https://www.mdpi.com/2076-3425/13/7/1006 kostenfrei https://doaj.org/toc/2076-3425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 7, p 1006
allfieldsSound	10.3390/brainsci13071006 doi (DE-627)DOAJ093935447 (DE-599)DOAJ46d04fbe5d8d4031a97e3a55a389174e DE-627 ger DE-627 rakwb eng RC321-571 Haoyu Wang verfasserin aut Disrupted Topological Organization of Brain Network in Rats with Spatial Memory Impairments Induced by Acute Microwave Radiation 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Previous studies have suggested that microwave (MW) radiation with certain parameters can induce spatial memory deficits. However, the effect of MW on the topological organization of the brain network is still unknown. This work aimed to investigate the topological organization of the brain network in rats with spatial memory impairments induced by acute microwave (MW) radiation. The Morris water maze (MWM) test and resting-state functional magnetic resonance imaging were performed to estimate the spatial memory ability and brain network topological organization of the rats after MW exposure. Compared with the sham group, the rats exposed to 30 mW/cm<sup<2</sup< 1.5 GHz MW radiation exhibited a significantly decreased normalized clustering coefficient (γ) (<i<p</i< = 0.002) 1 d after the exposure and a prolonged average escape latency (AEL) (<i<p</i< = 0.014) 3 d after the exposure. Moreover, after 10 mW/cm<sup<2</sup< 1.5 GHz MW radiation, a significantly decreased γ (<i<p</i< = 0.003) was also observed in the rats, without any changes in AEL. In contrast, no adverse effects on AEL or topological parameters were observed after 9.375 GHz MW radiation. In conclusion, the rats with spatial memory deficits induced by MW radiation exhibited disruptions in the topological organization of the brain network. Moreover, these topological organization disruptions emerged earlier than behavioral symptom onset and could even be found in the rats without a decline in the performance of the spatial memory task. Therefore, it is possible to use the topological parameters of the brain network as early and sensitive indicators of the spatial memory impairments induced by acute MW radiation. microwave radiation topological organization brain network spatial memory resting-state fMRI rat Neurosciences. Biological psychiatry. Neuropsychiatry Haixia Zhao verfasserin aut Chunfang Li verfasserin aut Ji Dong verfasserin aut Jianghao Zhao verfasserin aut Hanlin Yue verfasserin aut Yunfei Lai verfasserin aut Li Zhao verfasserin aut Hui Wang verfasserin aut Jing Zhang verfasserin aut Xinping Xu verfasserin aut Binwei Yao verfasserin aut Hongmei Zhou verfasserin aut Binbin Nie verfasserin aut Xiumin Du verfasserin aut Ruiyun Peng verfasserin aut In Brain Sciences MDPI AG, 2012 13(2023), 7, p 1006 (DE-627)687718139 (DE-600)2651993-8 20763425 nnns volume:13 year:2023 number:7, p 1006 https://doi.org/10.3390/brainsci13071006 kostenfrei https://doaj.org/article/46d04fbe5d8d4031a97e3a55a389174e kostenfrei https://www.mdpi.com/2076-3425/13/7/1006 kostenfrei https://doaj.org/toc/2076-3425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 7, p 1006
language	English
source	In Brain Sciences 13(2023), 7, p 1006 volume:13 year:2023 number:7, p 1006
sourceStr	In Brain Sciences 13(2023), 7, p 1006 volume:13 year:2023 number:7, p 1006
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	microwave radiation topological organization brain network spatial memory resting-state fMRI rat Neurosciences. Biological psychiatry. Neuropsychiatry
isfreeaccess_bool	true
container_title	Brain Sciences
authorswithroles_txt_mv	Haoyu Wang @@aut@@ Haixia Zhao @@aut@@ Chunfang Li @@aut@@ Ji Dong @@aut@@ Jianghao Zhao @@aut@@ Hanlin Yue @@aut@@ Yunfei Lai @@aut@@ Li Zhao @@aut@@ Hui Wang @@aut@@ Jing Zhang @@aut@@ Xinping Xu @@aut@@ Binwei Yao @@aut@@ Hongmei Zhou @@aut@@ Binbin Nie @@aut@@ Xiumin Du @@aut@@ Ruiyun Peng @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	687718139
id	DOAJ093935447
language_de	englisch
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However, the effect of MW on the topological organization of the brain network is still unknown. This work aimed to investigate the topological organization of the brain network in rats with spatial memory impairments induced by acute microwave (MW) radiation. The Morris water maze (MWM) test and resting-state functional magnetic resonance imaging were performed to estimate the spatial memory ability and brain network topological organization of the rats after MW exposure. Compared with the sham group, the rats exposed to 30 mW/cm<sup<2</sup< 1.5 GHz MW radiation exhibited a significantly decreased normalized clustering coefficient (γ) (<i<p</i< = 0.002) 1 d after the exposure and a prolonged average escape latency (AEL) (<i<p</i< = 0.014) 3 d after the exposure. Moreover, after 10 mW/cm<sup<2</sup< 1.5 GHz MW radiation, a significantly decreased γ (<i<p</i< = 0.003) was also observed in the rats, without any changes in AEL. 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callnumber-first	R - Medicine
author	Haoyu Wang
spellingShingle	Haoyu Wang misc RC321-571 misc microwave radiation misc topological organization misc brain network misc spatial memory misc resting-state fMRI misc rat misc Neurosciences. Biological psychiatry. Neuropsychiatry Disrupted Topological Organization of Brain Network in Rats with Spatial Memory Impairments Induced by Acute Microwave Radiation
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topic_title	RC321-571 Disrupted Topological Organization of Brain Network in Rats with Spatial Memory Impairments Induced by Acute Microwave Radiation microwave radiation topological organization brain network spatial memory resting-state fMRI rat
topic	misc RC321-571 misc microwave radiation misc topological organization misc brain network misc spatial memory misc resting-state fMRI misc rat misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc microwave radiation misc topological organization misc brain network misc spatial memory misc resting-state fMRI misc rat misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_browse	misc RC321-571 misc microwave radiation misc topological organization misc brain network misc spatial memory misc resting-state fMRI misc rat misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Disrupted Topological Organization of Brain Network in Rats with Spatial Memory Impairments Induced by Acute Microwave Radiation
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title_full	Disrupted Topological Organization of Brain Network in Rats with Spatial Memory Impairments Induced by Acute Microwave Radiation
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author_browse	Haoyu Wang Haixia Zhao Chunfang Li Ji Dong Jianghao Zhao Hanlin Yue Yunfei Lai Li Zhao Hui Wang Jing Zhang Xinping Xu Binwei Yao Hongmei Zhou Binbin Nie Xiumin Du Ruiyun Peng
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title_sort	disrupted topological organization of brain network in rats with spatial memory impairments induced by acute microwave radiation
callnumber	RC321-571
title_auth	Disrupted Topological Organization of Brain Network in Rats with Spatial Memory Impairments Induced by Acute Microwave Radiation
abstract	Previous studies have suggested that microwave (MW) radiation with certain parameters can induce spatial memory deficits. However, the effect of MW on the topological organization of the brain network is still unknown. This work aimed to investigate the topological organization of the brain network in rats with spatial memory impairments induced by acute microwave (MW) radiation. The Morris water maze (MWM) test and resting-state functional magnetic resonance imaging were performed to estimate the spatial memory ability and brain network topological organization of the rats after MW exposure. Compared with the sham group, the rats exposed to 30 mW/cm<sup<2</sup< 1.5 GHz MW radiation exhibited a significantly decreased normalized clustering coefficient (γ) (<i<p</i< = 0.002) 1 d after the exposure and a prolonged average escape latency (AEL) (<i<p</i< = 0.014) 3 d after the exposure. Moreover, after 10 mW/cm<sup<2</sup< 1.5 GHz MW radiation, a significantly decreased γ (<i<p</i< = 0.003) was also observed in the rats, without any changes in AEL. In contrast, no adverse effects on AEL or topological parameters were observed after 9.375 GHz MW radiation. In conclusion, the rats with spatial memory deficits induced by MW radiation exhibited disruptions in the topological organization of the brain network. Moreover, these topological organization disruptions emerged earlier than behavioral symptom onset and could even be found in the rats without a decline in the performance of the spatial memory task. Therefore, it is possible to use the topological parameters of the brain network as early and sensitive indicators of the spatial memory impairments induced by acute MW radiation.
abstractGer	Previous studies have suggested that microwave (MW) radiation with certain parameters can induce spatial memory deficits. However, the effect of MW on the topological organization of the brain network is still unknown. This work aimed to investigate the topological organization of the brain network in rats with spatial memory impairments induced by acute microwave (MW) radiation. The Morris water maze (MWM) test and resting-state functional magnetic resonance imaging were performed to estimate the spatial memory ability and brain network topological organization of the rats after MW exposure. Compared with the sham group, the rats exposed to 30 mW/cm<sup<2</sup< 1.5 GHz MW radiation exhibited a significantly decreased normalized clustering coefficient (γ) (<i<p</i< = 0.002) 1 d after the exposure and a prolonged average escape latency (AEL) (<i<p</i< = 0.014) 3 d after the exposure. Moreover, after 10 mW/cm<sup<2</sup< 1.5 GHz MW radiation, a significantly decreased γ (<i<p</i< = 0.003) was also observed in the rats, without any changes in AEL. In contrast, no adverse effects on AEL or topological parameters were observed after 9.375 GHz MW radiation. In conclusion, the rats with spatial memory deficits induced by MW radiation exhibited disruptions in the topological organization of the brain network. Moreover, these topological organization disruptions emerged earlier than behavioral symptom onset and could even be found in the rats without a decline in the performance of the spatial memory task. Therefore, it is possible to use the topological parameters of the brain network as early and sensitive indicators of the spatial memory impairments induced by acute MW radiation.
abstract_unstemmed	Previous studies have suggested that microwave (MW) radiation with certain parameters can induce spatial memory deficits. However, the effect of MW on the topological organization of the brain network is still unknown. This work aimed to investigate the topological organization of the brain network in rats with spatial memory impairments induced by acute microwave (MW) radiation. The Morris water maze (MWM) test and resting-state functional magnetic resonance imaging were performed to estimate the spatial memory ability and brain network topological organization of the rats after MW exposure. Compared with the sham group, the rats exposed to 30 mW/cm<sup<2</sup< 1.5 GHz MW radiation exhibited a significantly decreased normalized clustering coefficient (γ) (<i<p</i< = 0.002) 1 d after the exposure and a prolonged average escape latency (AEL) (<i<p</i< = 0.014) 3 d after the exposure. Moreover, after 10 mW/cm<sup<2</sup< 1.5 GHz MW radiation, a significantly decreased γ (<i<p</i< = 0.003) was also observed in the rats, without any changes in AEL. In contrast, no adverse effects on AEL or topological parameters were observed after 9.375 GHz MW radiation. In conclusion, the rats with spatial memory deficits induced by MW radiation exhibited disruptions in the topological organization of the brain network. Moreover, these topological organization disruptions emerged earlier than behavioral symptom onset and could even be found in the rats without a decline in the performance of the spatial memory task. Therefore, it is possible to use the topological parameters of the brain network as early and sensitive indicators of the spatial memory impairments induced by acute MW radiation.
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title_short	Disrupted Topological Organization of Brain Network in Rats with Spatial Memory Impairments Induced by Acute Microwave Radiation
url	https://doi.org/10.3390/brainsci13071006 https://doaj.org/article/46d04fbe5d8d4031a97e3a55a389174e https://www.mdpi.com/2076-3425/13/7/1006 https://doaj.org/toc/2076-3425
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Disrupted Topological Organization of Brain Network in Rats with Spatial Memory Impairments Induced by Acute Microwave Radiation

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