Characterization of Health Beneficial Components in Discarded Leaves of Three Escarole (<i<Cichorium endivia</i< L.) Cultivar and Study of Their Antioxidant and Anti-Inflammatory Activities

Plants of genus <i<Cichorium</i< (Asteraceae) can be used as vegetables with higher nutritional value and as medicinal plants. This genus has beneficial properties owing to the presence of a number of specialized metabolites such as alkaloids, sesquiterpene lactones, coumarins, unsaturated fatty acids, flavonoids, saponins, and tannins. <i<Cichorium endivia</i< L., known as escarole, has achieved a common food status due to its nutritionary value, bitter taste, and the presence of healthy components, and is eaten cooked or raw in salads. Presently, wastes derived from the horticultural crops supply chain are generated in very large amounts. Vegetable waste comprises the discarded leaves of food sources produced during collection, handling, transportation, and processing. The external leaves of <i<Cichorium endivia</i< L. are a horticultural crop that is discarded. In this work, the phytochemical profile, antioxidant, and anti-inflammatory activities of hydroalcoholic extract obtained from discarded leaves of three cultivars of escarole (<i<C. endivia</i< var. <i<crispum</i< ‘Capriccio’, <i<C. endivia</i< var. <i<latifolium</i< ‘Performance’ and ‘Leonida’) typical horticultural crop of the Campania region were investigated. In order to describe a metabolite profile of <i<C. endivia</i< cultivars, the extracts were analysed by HR/ESI/Qexactive/MS/MS and NMR. The careful analysis of the accurate masses, the ESI/MS spectra, and the <sup<1</sup<H NMR chemical shifts allowed for the identification of small molecules belonging to phenolic, flavonoid, sesquiterpene, amino acids, and unsaturated fatty acid classes. In addition, the antioxidant potential of the extracts was evaluated using cell-free and cell-based assays, as well as their cytotoxic and anti-inflammatory activity. All the extracts showed similar radical-scavenging ability while significant differences between the three investigated cultivars emerged in the cell-based assays. The obtained data were ascribed to the content of polyphenols and sesquiterpenes in the extracts. Accordingly, <i<C. endivia</i< by-products can be deemed an interesting material for healthy product formulations. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Giuliana Donadio [verfasserIn] Maria Laura Bellone [verfasserIn] Francesca Mensitieri [verfasserIn] Valentina Parisi [verfasserIn] Valentina Santoro [verfasserIn] Maria Vitiello [verfasserIn] Fabrizio Dal Piaz [verfasserIn] Nunziatina De Tommasi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	cultivar NMR HRESIMS anti-inflammatory antioxidant

Übergeordnetes Werk:	In: Antioxidants - MDPI AG, 2013, 12(2023), 7, p 1402
Übergeordnetes Werk:	volume:12 ; year:2023 ; number:7, p 1402

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/antiox12071402

Katalog-ID:	DOAJ093955243

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allfields	10.3390/antiox12071402 doi (DE-627)DOAJ093955243 (DE-599)DOAJ3fdc41fa99624582aac0ebde7791145b DE-627 ger DE-627 rakwb eng RM1-950 Giuliana Donadio verfasserin aut Characterization of Health Beneficial Components in Discarded Leaves of Three Escarole (<i<Cichorium endivia</i< L.) Cultivar and Study of Their Antioxidant and Anti-Inflammatory Activities 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plants of genus <i<Cichorium</i< (Asteraceae) can be used as vegetables with higher nutritional value and as medicinal plants. This genus has beneficial properties owing to the presence of a number of specialized metabolites such as alkaloids, sesquiterpene lactones, coumarins, unsaturated fatty acids, flavonoids, saponins, and tannins. <i<Cichorium endivia</i< L., known as escarole, has achieved a common food status due to its nutritionary value, bitter taste, and the presence of healthy components, and is eaten cooked or raw in salads. Presently, wastes derived from the horticultural crops supply chain are generated in very large amounts. Vegetable waste comprises the discarded leaves of food sources produced during collection, handling, transportation, and processing. The external leaves of <i<Cichorium endivia</i< L. are a horticultural crop that is discarded. In this work, the phytochemical profile, antioxidant, and anti-inflammatory activities of hydroalcoholic extract obtained from discarded leaves of three cultivars of escarole (<i<C. endivia</i< var. <i<crispum</i< ‘Capriccio’, <i<C. endivia</i< var. <i<latifolium</i< ‘Performance’ and ‘Leonida’) typical horticultural crop of the Campania region were investigated. In order to describe a metabolite profile of <i<C. endivia</i< cultivars, the extracts were analysed by HR/ESI/Qexactive/MS/MS and NMR. The careful analysis of the accurate masses, the ESI/MS spectra, and the <sup<1</sup<H NMR chemical shifts allowed for the identification of small molecules belonging to phenolic, flavonoid, sesquiterpene, amino acids, and unsaturated fatty acid classes. In addition, the antioxidant potential of the extracts was evaluated using cell-free and cell-based assays, as well as their cytotoxic and anti-inflammatory activity. All the extracts showed similar radical-scavenging ability while significant differences between the three investigated cultivars emerged in the cell-based assays. The obtained data were ascribed to the content of polyphenols and sesquiterpenes in the extracts. Accordingly, <i<C. endivia</i< by-products can be deemed an interesting material for healthy product formulations. <i<Cichorium endivia</i< L. cultivar NMR HRESIMS anti-inflammatory antioxidant Therapeutics. Pharmacology Maria Laura Bellone verfasserin aut Francesca Mensitieri verfasserin aut Valentina Parisi verfasserin aut Valentina Santoro verfasserin aut Maria Vitiello verfasserin aut Fabrizio Dal Piaz verfasserin aut Nunziatina De Tommasi verfasserin aut In Antioxidants MDPI AG, 2013 12(2023), 7, p 1402 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:12 year:2023 number:7, p 1402 https://doi.org/10.3390/antiox12071402 kostenfrei https://doaj.org/article/3fdc41fa99624582aac0ebde7791145b kostenfrei https://www.mdpi.com/2076-3921/12/7/1402 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 7, p 1402
spelling	10.3390/antiox12071402 doi (DE-627)DOAJ093955243 (DE-599)DOAJ3fdc41fa99624582aac0ebde7791145b DE-627 ger DE-627 rakwb eng RM1-950 Giuliana Donadio verfasserin aut Characterization of Health Beneficial Components in Discarded Leaves of Three Escarole (<i<Cichorium endivia</i< L.) Cultivar and Study of Their Antioxidant and Anti-Inflammatory Activities 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plants of genus <i<Cichorium</i< (Asteraceae) can be used as vegetables with higher nutritional value and as medicinal plants. This genus has beneficial properties owing to the presence of a number of specialized metabolites such as alkaloids, sesquiterpene lactones, coumarins, unsaturated fatty acids, flavonoids, saponins, and tannins. <i<Cichorium endivia</i< L., known as escarole, has achieved a common food status due to its nutritionary value, bitter taste, and the presence of healthy components, and is eaten cooked or raw in salads. Presently, wastes derived from the horticultural crops supply chain are generated in very large amounts. Vegetable waste comprises the discarded leaves of food sources produced during collection, handling, transportation, and processing. The external leaves of <i<Cichorium endivia</i< L. are a horticultural crop that is discarded. In this work, the phytochemical profile, antioxidant, and anti-inflammatory activities of hydroalcoholic extract obtained from discarded leaves of three cultivars of escarole (<i<C. endivia</i< var. <i<crispum</i< ‘Capriccio’, <i<C. endivia</i< var. <i<latifolium</i< ‘Performance’ and ‘Leonida’) typical horticultural crop of the Campania region were investigated. In order to describe a metabolite profile of <i<C. endivia</i< cultivars, the extracts were analysed by HR/ESI/Qexactive/MS/MS and NMR. The careful analysis of the accurate masses, the ESI/MS spectra, and the <sup<1</sup<H NMR chemical shifts allowed for the identification of small molecules belonging to phenolic, flavonoid, sesquiterpene, amino acids, and unsaturated fatty acid classes. In addition, the antioxidant potential of the extracts was evaluated using cell-free and cell-based assays, as well as their cytotoxic and anti-inflammatory activity. All the extracts showed similar radical-scavenging ability while significant differences between the three investigated cultivars emerged in the cell-based assays. The obtained data were ascribed to the content of polyphenols and sesquiterpenes in the extracts. Accordingly, <i<C. endivia</i< by-products can be deemed an interesting material for healthy product formulations. <i<Cichorium endivia</i< L. cultivar NMR HRESIMS anti-inflammatory antioxidant Therapeutics. Pharmacology Maria Laura Bellone verfasserin aut Francesca Mensitieri verfasserin aut Valentina Parisi verfasserin aut Valentina Santoro verfasserin aut Maria Vitiello verfasserin aut Fabrizio Dal Piaz verfasserin aut Nunziatina De Tommasi verfasserin aut In Antioxidants MDPI AG, 2013 12(2023), 7, p 1402 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:12 year:2023 number:7, p 1402 https://doi.org/10.3390/antiox12071402 kostenfrei https://doaj.org/article/3fdc41fa99624582aac0ebde7791145b kostenfrei https://www.mdpi.com/2076-3921/12/7/1402 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 7, p 1402
allfields_unstemmed	10.3390/antiox12071402 doi (DE-627)DOAJ093955243 (DE-599)DOAJ3fdc41fa99624582aac0ebde7791145b DE-627 ger DE-627 rakwb eng RM1-950 Giuliana Donadio verfasserin aut Characterization of Health Beneficial Components in Discarded Leaves of Three Escarole (<i<Cichorium endivia</i< L.) Cultivar and Study of Their Antioxidant and Anti-Inflammatory Activities 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plants of genus <i<Cichorium</i< (Asteraceae) can be used as vegetables with higher nutritional value and as medicinal plants. This genus has beneficial properties owing to the presence of a number of specialized metabolites such as alkaloids, sesquiterpene lactones, coumarins, unsaturated fatty acids, flavonoids, saponins, and tannins. <i<Cichorium endivia</i< L., known as escarole, has achieved a common food status due to its nutritionary value, bitter taste, and the presence of healthy components, and is eaten cooked or raw in salads. Presently, wastes derived from the horticultural crops supply chain are generated in very large amounts. Vegetable waste comprises the discarded leaves of food sources produced during collection, handling, transportation, and processing. The external leaves of <i<Cichorium endivia</i< L. are a horticultural crop that is discarded. In this work, the phytochemical profile, antioxidant, and anti-inflammatory activities of hydroalcoholic extract obtained from discarded leaves of three cultivars of escarole (<i<C. endivia</i< var. <i<crispum</i< ‘Capriccio’, <i<C. endivia</i< var. <i<latifolium</i< ‘Performance’ and ‘Leonida’) typical horticultural crop of the Campania region were investigated. In order to describe a metabolite profile of <i<C. endivia</i< cultivars, the extracts were analysed by HR/ESI/Qexactive/MS/MS and NMR. The careful analysis of the accurate masses, the ESI/MS spectra, and the <sup<1</sup<H NMR chemical shifts allowed for the identification of small molecules belonging to phenolic, flavonoid, sesquiterpene, amino acids, and unsaturated fatty acid classes. In addition, the antioxidant potential of the extracts was evaluated using cell-free and cell-based assays, as well as their cytotoxic and anti-inflammatory activity. All the extracts showed similar radical-scavenging ability while significant differences between the three investigated cultivars emerged in the cell-based assays. The obtained data were ascribed to the content of polyphenols and sesquiterpenes in the extracts. Accordingly, <i<C. endivia</i< by-products can be deemed an interesting material for healthy product formulations. <i<Cichorium endivia</i< L. cultivar NMR HRESIMS anti-inflammatory antioxidant Therapeutics. Pharmacology Maria Laura Bellone verfasserin aut Francesca Mensitieri verfasserin aut Valentina Parisi verfasserin aut Valentina Santoro verfasserin aut Maria Vitiello verfasserin aut Fabrizio Dal Piaz verfasserin aut Nunziatina De Tommasi verfasserin aut In Antioxidants MDPI AG, 2013 12(2023), 7, p 1402 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:12 year:2023 number:7, p 1402 https://doi.org/10.3390/antiox12071402 kostenfrei https://doaj.org/article/3fdc41fa99624582aac0ebde7791145b kostenfrei https://www.mdpi.com/2076-3921/12/7/1402 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 7, p 1402
allfieldsGer	10.3390/antiox12071402 doi (DE-627)DOAJ093955243 (DE-599)DOAJ3fdc41fa99624582aac0ebde7791145b DE-627 ger DE-627 rakwb eng RM1-950 Giuliana Donadio verfasserin aut Characterization of Health Beneficial Components in Discarded Leaves of Three Escarole (<i<Cichorium endivia</i< L.) Cultivar and Study of Their Antioxidant and Anti-Inflammatory Activities 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plants of genus <i<Cichorium</i< (Asteraceae) can be used as vegetables with higher nutritional value and as medicinal plants. This genus has beneficial properties owing to the presence of a number of specialized metabolites such as alkaloids, sesquiterpene lactones, coumarins, unsaturated fatty acids, flavonoids, saponins, and tannins. <i<Cichorium endivia</i< L., known as escarole, has achieved a common food status due to its nutritionary value, bitter taste, and the presence of healthy components, and is eaten cooked or raw in salads. Presently, wastes derived from the horticultural crops supply chain are generated in very large amounts. Vegetable waste comprises the discarded leaves of food sources produced during collection, handling, transportation, and processing. The external leaves of <i<Cichorium endivia</i< L. are a horticultural crop that is discarded. In this work, the phytochemical profile, antioxidant, and anti-inflammatory activities of hydroalcoholic extract obtained from discarded leaves of three cultivars of escarole (<i<C. endivia</i< var. <i<crispum</i< ‘Capriccio’, <i<C. endivia</i< var. <i<latifolium</i< ‘Performance’ and ‘Leonida’) typical horticultural crop of the Campania region were investigated. In order to describe a metabolite profile of <i<C. endivia</i< cultivars, the extracts were analysed by HR/ESI/Qexactive/MS/MS and NMR. The careful analysis of the accurate masses, the ESI/MS spectra, and the <sup<1</sup<H NMR chemical shifts allowed for the identification of small molecules belonging to phenolic, flavonoid, sesquiterpene, amino acids, and unsaturated fatty acid classes. In addition, the antioxidant potential of the extracts was evaluated using cell-free and cell-based assays, as well as their cytotoxic and anti-inflammatory activity. All the extracts showed similar radical-scavenging ability while significant differences between the three investigated cultivars emerged in the cell-based assays. The obtained data were ascribed to the content of polyphenols and sesquiterpenes in the extracts. Accordingly, <i<C. endivia</i< by-products can be deemed an interesting material for healthy product formulations. <i<Cichorium endivia</i< L. cultivar NMR HRESIMS anti-inflammatory antioxidant Therapeutics. Pharmacology Maria Laura Bellone verfasserin aut Francesca Mensitieri verfasserin aut Valentina Parisi verfasserin aut Valentina Santoro verfasserin aut Maria Vitiello verfasserin aut Fabrizio Dal Piaz verfasserin aut Nunziatina De Tommasi verfasserin aut In Antioxidants MDPI AG, 2013 12(2023), 7, p 1402 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:12 year:2023 number:7, p 1402 https://doi.org/10.3390/antiox12071402 kostenfrei https://doaj.org/article/3fdc41fa99624582aac0ebde7791145b kostenfrei https://www.mdpi.com/2076-3921/12/7/1402 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 7, p 1402
allfieldsSound	10.3390/antiox12071402 doi (DE-627)DOAJ093955243 (DE-599)DOAJ3fdc41fa99624582aac0ebde7791145b DE-627 ger DE-627 rakwb eng RM1-950 Giuliana Donadio verfasserin aut Characterization of Health Beneficial Components in Discarded Leaves of Three Escarole (<i<Cichorium endivia</i< L.) Cultivar and Study of Their Antioxidant and Anti-Inflammatory Activities 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plants of genus <i<Cichorium</i< (Asteraceae) can be used as vegetables with higher nutritional value and as medicinal plants. This genus has beneficial properties owing to the presence of a number of specialized metabolites such as alkaloids, sesquiterpene lactones, coumarins, unsaturated fatty acids, flavonoids, saponins, and tannins. <i<Cichorium endivia</i< L., known as escarole, has achieved a common food status due to its nutritionary value, bitter taste, and the presence of healthy components, and is eaten cooked or raw in salads. Presently, wastes derived from the horticultural crops supply chain are generated in very large amounts. Vegetable waste comprises the discarded leaves of food sources produced during collection, handling, transportation, and processing. The external leaves of <i<Cichorium endivia</i< L. are a horticultural crop that is discarded. In this work, the phytochemical profile, antioxidant, and anti-inflammatory activities of hydroalcoholic extract obtained from discarded leaves of three cultivars of escarole (<i<C. endivia</i< var. <i<crispum</i< ‘Capriccio’, <i<C. endivia</i< var. <i<latifolium</i< ‘Performance’ and ‘Leonida’) typical horticultural crop of the Campania region were investigated. In order to describe a metabolite profile of <i<C. endivia</i< cultivars, the extracts were analysed by HR/ESI/Qexactive/MS/MS and NMR. The careful analysis of the accurate masses, the ESI/MS spectra, and the <sup<1</sup<H NMR chemical shifts allowed for the identification of small molecules belonging to phenolic, flavonoid, sesquiterpene, amino acids, and unsaturated fatty acid classes. In addition, the antioxidant potential of the extracts was evaluated using cell-free and cell-based assays, as well as their cytotoxic and anti-inflammatory activity. All the extracts showed similar radical-scavenging ability while significant differences between the three investigated cultivars emerged in the cell-based assays. The obtained data were ascribed to the content of polyphenols and sesquiterpenes in the extracts. Accordingly, <i<C. endivia</i< by-products can be deemed an interesting material for healthy product formulations. <i<Cichorium endivia</i< L. cultivar NMR HRESIMS anti-inflammatory antioxidant Therapeutics. Pharmacology Maria Laura Bellone verfasserin aut Francesca Mensitieri verfasserin aut Valentina Parisi verfasserin aut Valentina Santoro verfasserin aut Maria Vitiello verfasserin aut Fabrizio Dal Piaz verfasserin aut Nunziatina De Tommasi verfasserin aut In Antioxidants MDPI AG, 2013 12(2023), 7, p 1402 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:12 year:2023 number:7, p 1402 https://doi.org/10.3390/antiox12071402 kostenfrei https://doaj.org/article/3fdc41fa99624582aac0ebde7791145b kostenfrei https://www.mdpi.com/2076-3921/12/7/1402 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 7, p 1402
language	English
source	In Antioxidants 12(2023), 7, p 1402 volume:12 year:2023 number:7, p 1402
sourceStr	In Antioxidants 12(2023), 7, p 1402 volume:12 year:2023 number:7, p 1402
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	<i<Cichorium endivia</i< L. cultivar NMR HRESIMS anti-inflammatory antioxidant Therapeutics. Pharmacology
isfreeaccess_bool	true
container_title	Antioxidants
authorswithroles_txt_mv	Giuliana Donadio @@aut@@ Maria Laura Bellone @@aut@@ Francesca Mensitieri @@aut@@ Valentina Parisi @@aut@@ Valentina Santoro @@aut@@ Maria Vitiello @@aut@@ Fabrizio Dal Piaz @@aut@@ Nunziatina De Tommasi @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	737287578
id	DOAJ093955243
language_de	englisch
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callnumber-first	R - Medicine
author	Giuliana Donadio
spellingShingle	Giuliana Donadio misc RM1-950 misc <i<Cichorium endivia</i< L. misc cultivar misc NMR misc HRESIMS misc anti-inflammatory misc antioxidant misc Therapeutics. Pharmacology Characterization of Health Beneficial Components in Discarded Leaves of Three Escarole (<i<Cichorium endivia</i< L.) Cultivar and Study of Their Antioxidant and Anti-Inflammatory Activities
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topic_title	RM1-950 Characterization of Health Beneficial Components in Discarded Leaves of Three Escarole (<i<Cichorium endivia</i< L.) Cultivar and Study of Their Antioxidant and Anti-Inflammatory Activities <i<Cichorium endivia</i< L. cultivar NMR HRESIMS anti-inflammatory antioxidant
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title	Characterization of Health Beneficial Components in Discarded Leaves of Three Escarole (<i<Cichorium endivia</i< L.) Cultivar and Study of Their Antioxidant and Anti-Inflammatory Activities
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title_full	Characterization of Health Beneficial Components in Discarded Leaves of Three Escarole (<i<Cichorium endivia</i< L.) Cultivar and Study of Their Antioxidant and Anti-Inflammatory Activities
author_sort	Giuliana Donadio
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author_browse	Giuliana Donadio Maria Laura Bellone Francesca Mensitieri Valentina Parisi Valentina Santoro Maria Vitiello Fabrizio Dal Piaz Nunziatina De Tommasi
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author-letter	Giuliana Donadio
doi_str_mv	10.3390/antiox12071402
author2-role	verfasserin
title_sort	characterization of health beneficial components in discarded leaves of three escarole (<i<cichorium endivia</i< l.) cultivar and study of their antioxidant and anti-inflammatory activities
callnumber	RM1-950
title_auth	Characterization of Health Beneficial Components in Discarded Leaves of Three Escarole (<i<Cichorium endivia</i< L.) Cultivar and Study of Their Antioxidant and Anti-Inflammatory Activities
abstract	Plants of genus <i<Cichorium</i< (Asteraceae) can be used as vegetables with higher nutritional value and as medicinal plants. This genus has beneficial properties owing to the presence of a number of specialized metabolites such as alkaloids, sesquiterpene lactones, coumarins, unsaturated fatty acids, flavonoids, saponins, and tannins. <i<Cichorium endivia</i< L., known as escarole, has achieved a common food status due to its nutritionary value, bitter taste, and the presence of healthy components, and is eaten cooked or raw in salads. Presently, wastes derived from the horticultural crops supply chain are generated in very large amounts. Vegetable waste comprises the discarded leaves of food sources produced during collection, handling, transportation, and processing. The external leaves of <i<Cichorium endivia</i< L. are a horticultural crop that is discarded. In this work, the phytochemical profile, antioxidant, and anti-inflammatory activities of hydroalcoholic extract obtained from discarded leaves of three cultivars of escarole (<i<C. endivia</i< var. <i<crispum</i< ‘Capriccio’, <i<C. endivia</i< var. <i<latifolium</i< ‘Performance’ and ‘Leonida’) typical horticultural crop of the Campania region were investigated. In order to describe a metabolite profile of <i<C. endivia</i< cultivars, the extracts were analysed by HR/ESI/Qexactive/MS/MS and NMR. The careful analysis of the accurate masses, the ESI/MS spectra, and the <sup<1</sup<H NMR chemical shifts allowed for the identification of small molecules belonging to phenolic, flavonoid, sesquiterpene, amino acids, and unsaturated fatty acid classes. In addition, the antioxidant potential of the extracts was evaluated using cell-free and cell-based assays, as well as their cytotoxic and anti-inflammatory activity. All the extracts showed similar radical-scavenging ability while significant differences between the three investigated cultivars emerged in the cell-based assays. The obtained data were ascribed to the content of polyphenols and sesquiterpenes in the extracts. Accordingly, <i<C. endivia</i< by-products can be deemed an interesting material for healthy product formulations.
abstractGer	Plants of genus <i<Cichorium</i< (Asteraceae) can be used as vegetables with higher nutritional value and as medicinal plants. This genus has beneficial properties owing to the presence of a number of specialized metabolites such as alkaloids, sesquiterpene lactones, coumarins, unsaturated fatty acids, flavonoids, saponins, and tannins. <i<Cichorium endivia</i< L., known as escarole, has achieved a common food status due to its nutritionary value, bitter taste, and the presence of healthy components, and is eaten cooked or raw in salads. Presently, wastes derived from the horticultural crops supply chain are generated in very large amounts. Vegetable waste comprises the discarded leaves of food sources produced during collection, handling, transportation, and processing. The external leaves of <i<Cichorium endivia</i< L. are a horticultural crop that is discarded. In this work, the phytochemical profile, antioxidant, and anti-inflammatory activities of hydroalcoholic extract obtained from discarded leaves of three cultivars of escarole (<i<C. endivia</i< var. <i<crispum</i< ‘Capriccio’, <i<C. endivia</i< var. <i<latifolium</i< ‘Performance’ and ‘Leonida’) typical horticultural crop of the Campania region were investigated. In order to describe a metabolite profile of <i<C. endivia</i< cultivars, the extracts were analysed by HR/ESI/Qexactive/MS/MS and NMR. The careful analysis of the accurate masses, the ESI/MS spectra, and the <sup<1</sup<H NMR chemical shifts allowed for the identification of small molecules belonging to phenolic, flavonoid, sesquiterpene, amino acids, and unsaturated fatty acid classes. In addition, the antioxidant potential of the extracts was evaluated using cell-free and cell-based assays, as well as their cytotoxic and anti-inflammatory activity. All the extracts showed similar radical-scavenging ability while significant differences between the three investigated cultivars emerged in the cell-based assays. The obtained data were ascribed to the content of polyphenols and sesquiterpenes in the extracts. Accordingly, <i<C. endivia</i< by-products can be deemed an interesting material for healthy product formulations.
abstract_unstemmed	Plants of genus <i<Cichorium</i< (Asteraceae) can be used as vegetables with higher nutritional value and as medicinal plants. This genus has beneficial properties owing to the presence of a number of specialized metabolites such as alkaloids, sesquiterpene lactones, coumarins, unsaturated fatty acids, flavonoids, saponins, and tannins. <i<Cichorium endivia</i< L., known as escarole, has achieved a common food status due to its nutritionary value, bitter taste, and the presence of healthy components, and is eaten cooked or raw in salads. Presently, wastes derived from the horticultural crops supply chain are generated in very large amounts. Vegetable waste comprises the discarded leaves of food sources produced during collection, handling, transportation, and processing. The external leaves of <i<Cichorium endivia</i< L. are a horticultural crop that is discarded. In this work, the phytochemical profile, antioxidant, and anti-inflammatory activities of hydroalcoholic extract obtained from discarded leaves of three cultivars of escarole (<i<C. endivia</i< var. <i<crispum</i< ‘Capriccio’, <i<C. endivia</i< var. <i<latifolium</i< ‘Performance’ and ‘Leonida’) typical horticultural crop of the Campania region were investigated. In order to describe a metabolite profile of <i<C. endivia</i< cultivars, the extracts were analysed by HR/ESI/Qexactive/MS/MS and NMR. The careful analysis of the accurate masses, the ESI/MS spectra, and the <sup<1</sup<H NMR chemical shifts allowed for the identification of small molecules belonging to phenolic, flavonoid, sesquiterpene, amino acids, and unsaturated fatty acid classes. In addition, the antioxidant potential of the extracts was evaluated using cell-free and cell-based assays, as well as their cytotoxic and anti-inflammatory activity. All the extracts showed similar radical-scavenging ability while significant differences between the three investigated cultivars emerged in the cell-based assays. The obtained data were ascribed to the content of polyphenols and sesquiterpenes in the extracts. Accordingly, <i<C. endivia</i< by-products can be deemed an interesting material for healthy product formulations.
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title_short	Characterization of Health Beneficial Components in Discarded Leaves of Three Escarole (<i<Cichorium endivia</i< L.) Cultivar and Study of Their Antioxidant and Anti-Inflammatory Activities
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Characterization of Health Beneficial Components in Discarded Leaves of Three Escarole (<i<Cichorium endivia</i< L.) Cultivar and Study of Their Antioxidant and Anti-Inflammatory Activities

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