Gender Influences Gut Microbiota among Patients with Irritable Bowel Syndrome

Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disease that affects approximately 11% of the general population. The gut microbiota, among other known factors, plays a substantial role in its pathogenesis. The study aimed to characterize the gut microbiota differences betwee...
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Autor*in:	Paulina Pecyna [verfasserIn] Marcin Gabryel [verfasserIn] Dorota Mankowska-Wierzbicka [verfasserIn] Dorota M. Nowak-Malczewska [verfasserIn] Katarzyna Jaskiewicz [verfasserIn] Marcelina M. Jaworska [verfasserIn] Hanna Tomczak [verfasserIn] Malgorzata Rydzanicz [verfasserIn] Rafal Ploski [verfasserIn] Marian Grzymislawski [verfasserIn] Agnieszka Dobrowolska [verfasserIn] Marzena Gajecka [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	microbiota composition alterations in IBS 16S rRNA sequencing gender influence gut microbiota

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 24(2023), 13, p 10424
Übergeordnetes Werk:	volume:24 ; year:2023 ; number:13, p 10424

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms241310424

Katalog-ID:	DOAJ094013772

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520			\|a Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disease that affects approximately 11% of the general population. The gut microbiota, among other known factors, plays a substantial role in its pathogenesis. The study aimed to characterize the gut microbiota differences between patients with IBS and unaffected individuals, taking into account the gender aspect of the patients and the types of IBS determined on the basis of the Rome IV Criteria, the IBS-C, IBS-D, IBS-M, and IBS-U. In total, 121 patients with IBS and 70 unaffected individuals participated in the study; the derived stool samples were subjected to 16S rRNA amplicon sequencing. The gut microbiota of patients with IBS was found to be more diverse in comparison to unaffected individuals, and the differences were observed primarily among <i<Clostridiales</i<, <i<Mogibacteriaceae</i<, <i<Synergistaceae</i<, <i<Coriobacteriaceae</i<, <i<Blautia</i< spp., and <i<Shuttleworthia</i< spp., depending on the study subgroup and patient gender. There was higher differentiation of females’ gut microbiota compared to males, regardless of the disease status. No correlation between the composition of the gut microbiota and the type of IBS was found. Patients with IBS were characterized by more diverse gut microbiota compared to unaffected individuals. The gender criterion should be considered in the characterization of the gut microbiota. The type of IBS did not determine the identified differences in gut microbiota.
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allfields	10.3390/ijms241310424 doi (DE-627)DOAJ094013772 (DE-599)DOAJ87efe05819be47bc96e69d32f4f1f8e8 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Paulina Pecyna verfasserin aut Gender Influences Gut Microbiota among Patients with Irritable Bowel Syndrome 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disease that affects approximately 11% of the general population. The gut microbiota, among other known factors, plays a substantial role in its pathogenesis. The study aimed to characterize the gut microbiota differences between patients with IBS and unaffected individuals, taking into account the gender aspect of the patients and the types of IBS determined on the basis of the Rome IV Criteria, the IBS-C, IBS-D, IBS-M, and IBS-U. In total, 121 patients with IBS and 70 unaffected individuals participated in the study; the derived stool samples were subjected to 16S rRNA amplicon sequencing. The gut microbiota of patients with IBS was found to be more diverse in comparison to unaffected individuals, and the differences were observed primarily among <i<Clostridiales</i<, <i<Mogibacteriaceae</i<, <i<Synergistaceae</i<, <i<Coriobacteriaceae</i<, <i<Blautia</i< spp., and <i<Shuttleworthia</i< spp., depending on the study subgroup and patient gender. There was higher differentiation of females’ gut microbiota compared to males, regardless of the disease status. No correlation between the composition of the gut microbiota and the type of IBS was found. Patients with IBS were characterized by more diverse gut microbiota compared to unaffected individuals. The gender criterion should be considered in the characterization of the gut microbiota. The type of IBS did not determine the identified differences in gut microbiota. microbiota composition alterations in IBS 16S rRNA sequencing gender influence gut microbiota Biology (General) Chemistry Marcin Gabryel verfasserin aut Dorota Mankowska-Wierzbicka verfasserin aut Dorota M. Nowak-Malczewska verfasserin aut Katarzyna Jaskiewicz verfasserin aut Marcelina M. Jaworska verfasserin aut Hanna Tomczak verfasserin aut Malgorzata Rydzanicz verfasserin aut Rafal Ploski verfasserin aut Marian Grzymislawski verfasserin aut Agnieszka Dobrowolska verfasserin aut Marzena Gajecka verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 13, p 10424 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:13, p 10424 https://doi.org/10.3390/ijms241310424 kostenfrei https://doaj.org/article/87efe05819be47bc96e69d32f4f1f8e8 kostenfrei https://www.mdpi.com/1422-0067/24/13/10424 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 13, p 10424
spelling	10.3390/ijms241310424 doi (DE-627)DOAJ094013772 (DE-599)DOAJ87efe05819be47bc96e69d32f4f1f8e8 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Paulina Pecyna verfasserin aut Gender Influences Gut Microbiota among Patients with Irritable Bowel Syndrome 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disease that affects approximately 11% of the general population. The gut microbiota, among other known factors, plays a substantial role in its pathogenesis. The study aimed to characterize the gut microbiota differences between patients with IBS and unaffected individuals, taking into account the gender aspect of the patients and the types of IBS determined on the basis of the Rome IV Criteria, the IBS-C, IBS-D, IBS-M, and IBS-U. In total, 121 patients with IBS and 70 unaffected individuals participated in the study; the derived stool samples were subjected to 16S rRNA amplicon sequencing. The gut microbiota of patients with IBS was found to be more diverse in comparison to unaffected individuals, and the differences were observed primarily among <i<Clostridiales</i<, <i<Mogibacteriaceae</i<, <i<Synergistaceae</i<, <i<Coriobacteriaceae</i<, <i<Blautia</i< spp., and <i<Shuttleworthia</i< spp., depending on the study subgroup and patient gender. There was higher differentiation of females’ gut microbiota compared to males, regardless of the disease status. No correlation between the composition of the gut microbiota and the type of IBS was found. Patients with IBS were characterized by more diverse gut microbiota compared to unaffected individuals. The gender criterion should be considered in the characterization of the gut microbiota. The type of IBS did not determine the identified differences in gut microbiota. microbiota composition alterations in IBS 16S rRNA sequencing gender influence gut microbiota Biology (General) Chemistry Marcin Gabryel verfasserin aut Dorota Mankowska-Wierzbicka verfasserin aut Dorota M. Nowak-Malczewska verfasserin aut Katarzyna Jaskiewicz verfasserin aut Marcelina M. Jaworska verfasserin aut Hanna Tomczak verfasserin aut Malgorzata Rydzanicz verfasserin aut Rafal Ploski verfasserin aut Marian Grzymislawski verfasserin aut Agnieszka Dobrowolska verfasserin aut Marzena Gajecka verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 13, p 10424 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:13, p 10424 https://doi.org/10.3390/ijms241310424 kostenfrei https://doaj.org/article/87efe05819be47bc96e69d32f4f1f8e8 kostenfrei https://www.mdpi.com/1422-0067/24/13/10424 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 13, p 10424
allfields_unstemmed	10.3390/ijms241310424 doi (DE-627)DOAJ094013772 (DE-599)DOAJ87efe05819be47bc96e69d32f4f1f8e8 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Paulina Pecyna verfasserin aut Gender Influences Gut Microbiota among Patients with Irritable Bowel Syndrome 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disease that affects approximately 11% of the general population. The gut microbiota, among other known factors, plays a substantial role in its pathogenesis. The study aimed to characterize the gut microbiota differences between patients with IBS and unaffected individuals, taking into account the gender aspect of the patients and the types of IBS determined on the basis of the Rome IV Criteria, the IBS-C, IBS-D, IBS-M, and IBS-U. In total, 121 patients with IBS and 70 unaffected individuals participated in the study; the derived stool samples were subjected to 16S rRNA amplicon sequencing. The gut microbiota of patients with IBS was found to be more diverse in comparison to unaffected individuals, and the differences were observed primarily among <i<Clostridiales</i<, <i<Mogibacteriaceae</i<, <i<Synergistaceae</i<, <i<Coriobacteriaceae</i<, <i<Blautia</i< spp., and <i<Shuttleworthia</i< spp., depending on the study subgroup and patient gender. There was higher differentiation of females’ gut microbiota compared to males, regardless of the disease status. No correlation between the composition of the gut microbiota and the type of IBS was found. Patients with IBS were characterized by more diverse gut microbiota compared to unaffected individuals. The gender criterion should be considered in the characterization of the gut microbiota. The type of IBS did not determine the identified differences in gut microbiota. microbiota composition alterations in IBS 16S rRNA sequencing gender influence gut microbiota Biology (General) Chemistry Marcin Gabryel verfasserin aut Dorota Mankowska-Wierzbicka verfasserin aut Dorota M. Nowak-Malczewska verfasserin aut Katarzyna Jaskiewicz verfasserin aut Marcelina M. Jaworska verfasserin aut Hanna Tomczak verfasserin aut Malgorzata Rydzanicz verfasserin aut Rafal Ploski verfasserin aut Marian Grzymislawski verfasserin aut Agnieszka Dobrowolska verfasserin aut Marzena Gajecka verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 13, p 10424 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:13, p 10424 https://doi.org/10.3390/ijms241310424 kostenfrei https://doaj.org/article/87efe05819be47bc96e69d32f4f1f8e8 kostenfrei https://www.mdpi.com/1422-0067/24/13/10424 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 13, p 10424
allfieldsGer	10.3390/ijms241310424 doi (DE-627)DOAJ094013772 (DE-599)DOAJ87efe05819be47bc96e69d32f4f1f8e8 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Paulina Pecyna verfasserin aut Gender Influences Gut Microbiota among Patients with Irritable Bowel Syndrome 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disease that affects approximately 11% of the general population. The gut microbiota, among other known factors, plays a substantial role in its pathogenesis. The study aimed to characterize the gut microbiota differences between patients with IBS and unaffected individuals, taking into account the gender aspect of the patients and the types of IBS determined on the basis of the Rome IV Criteria, the IBS-C, IBS-D, IBS-M, and IBS-U. In total, 121 patients with IBS and 70 unaffected individuals participated in the study; the derived stool samples were subjected to 16S rRNA amplicon sequencing. The gut microbiota of patients with IBS was found to be more diverse in comparison to unaffected individuals, and the differences were observed primarily among <i<Clostridiales</i<, <i<Mogibacteriaceae</i<, <i<Synergistaceae</i<, <i<Coriobacteriaceae</i<, <i<Blautia</i< spp., and <i<Shuttleworthia</i< spp., depending on the study subgroup and patient gender. There was higher differentiation of females’ gut microbiota compared to males, regardless of the disease status. No correlation between the composition of the gut microbiota and the type of IBS was found. Patients with IBS were characterized by more diverse gut microbiota compared to unaffected individuals. The gender criterion should be considered in the characterization of the gut microbiota. The type of IBS did not determine the identified differences in gut microbiota. microbiota composition alterations in IBS 16S rRNA sequencing gender influence gut microbiota Biology (General) Chemistry Marcin Gabryel verfasserin aut Dorota Mankowska-Wierzbicka verfasserin aut Dorota M. Nowak-Malczewska verfasserin aut Katarzyna Jaskiewicz verfasserin aut Marcelina M. Jaworska verfasserin aut Hanna Tomczak verfasserin aut Malgorzata Rydzanicz verfasserin aut Rafal Ploski verfasserin aut Marian Grzymislawski verfasserin aut Agnieszka Dobrowolska verfasserin aut Marzena Gajecka verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 13, p 10424 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:13, p 10424 https://doi.org/10.3390/ijms241310424 kostenfrei https://doaj.org/article/87efe05819be47bc96e69d32f4f1f8e8 kostenfrei https://www.mdpi.com/1422-0067/24/13/10424 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 13, p 10424
allfieldsSound	10.3390/ijms241310424 doi (DE-627)DOAJ094013772 (DE-599)DOAJ87efe05819be47bc96e69d32f4f1f8e8 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Paulina Pecyna verfasserin aut Gender Influences Gut Microbiota among Patients with Irritable Bowel Syndrome 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disease that affects approximately 11% of the general population. The gut microbiota, among other known factors, plays a substantial role in its pathogenesis. The study aimed to characterize the gut microbiota differences between patients with IBS and unaffected individuals, taking into account the gender aspect of the patients and the types of IBS determined on the basis of the Rome IV Criteria, the IBS-C, IBS-D, IBS-M, and IBS-U. In total, 121 patients with IBS and 70 unaffected individuals participated in the study; the derived stool samples were subjected to 16S rRNA amplicon sequencing. The gut microbiota of patients with IBS was found to be more diverse in comparison to unaffected individuals, and the differences were observed primarily among <i<Clostridiales</i<, <i<Mogibacteriaceae</i<, <i<Synergistaceae</i<, <i<Coriobacteriaceae</i<, <i<Blautia</i< spp., and <i<Shuttleworthia</i< spp., depending on the study subgroup and patient gender. There was higher differentiation of females’ gut microbiota compared to males, regardless of the disease status. No correlation between the composition of the gut microbiota and the type of IBS was found. Patients with IBS were characterized by more diverse gut microbiota compared to unaffected individuals. The gender criterion should be considered in the characterization of the gut microbiota. The type of IBS did not determine the identified differences in gut microbiota. microbiota composition alterations in IBS 16S rRNA sequencing gender influence gut microbiota Biology (General) Chemistry Marcin Gabryel verfasserin aut Dorota Mankowska-Wierzbicka verfasserin aut Dorota M. Nowak-Malczewska verfasserin aut Katarzyna Jaskiewicz verfasserin aut Marcelina M. Jaworska verfasserin aut Hanna Tomczak verfasserin aut Malgorzata Rydzanicz verfasserin aut Rafal Ploski verfasserin aut Marian Grzymislawski verfasserin aut Agnieszka Dobrowolska verfasserin aut Marzena Gajecka verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 13, p 10424 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:13, p 10424 https://doi.org/10.3390/ijms241310424 kostenfrei https://doaj.org/article/87efe05819be47bc96e69d32f4f1f8e8 kostenfrei https://www.mdpi.com/1422-0067/24/13/10424 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 13, p 10424
language	English
source	In International Journal of Molecular Sciences 24(2023), 13, p 10424 volume:24 year:2023 number:13, p 10424
sourceStr	In International Journal of Molecular Sciences 24(2023), 13, p 10424 volume:24 year:2023 number:13, p 10424
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	microbiota composition alterations in IBS 16S rRNA sequencing gender influence gut microbiota Biology (General) Chemistry
isfreeaccess_bool	true
container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Paulina Pecyna @@aut@@ Marcin Gabryel @@aut@@ Dorota Mankowska-Wierzbicka @@aut@@ Dorota M. Nowak-Malczewska @@aut@@ Katarzyna Jaskiewicz @@aut@@ Marcelina M. Jaworska @@aut@@ Hanna Tomczak @@aut@@ Malgorzata Rydzanicz @@aut@@ Rafal Ploski @@aut@@ Marian Grzymislawski @@aut@@ Agnieszka Dobrowolska @@aut@@ Marzena Gajecka @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	316340715
id	DOAJ094013772
language_de	englisch
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callnumber-first	Q - Science
author	Paulina Pecyna
spellingShingle	Paulina Pecyna misc QH301-705.5 misc QD1-999 misc microbiota composition alterations in IBS misc 16S rRNA sequencing misc gender influence misc gut microbiota misc Biology (General) misc Chemistry Gender Influences Gut Microbiota among Patients with Irritable Bowel Syndrome
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topic_title	QH301-705.5 QD1-999 Gender Influences Gut Microbiota among Patients with Irritable Bowel Syndrome microbiota composition alterations in IBS 16S rRNA sequencing gender influence gut microbiota
topic	misc QH301-705.5 misc QD1-999 misc microbiota composition alterations in IBS misc 16S rRNA sequencing misc gender influence misc gut microbiota misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc microbiota composition alterations in IBS misc 16S rRNA sequencing misc gender influence misc gut microbiota misc Biology (General) misc Chemistry
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title	Gender Influences Gut Microbiota among Patients with Irritable Bowel Syndrome
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title_full	Gender Influences Gut Microbiota among Patients with Irritable Bowel Syndrome
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author_browse	Paulina Pecyna Marcin Gabryel Dorota Mankowska-Wierzbicka Dorota M. Nowak-Malczewska Katarzyna Jaskiewicz Marcelina M. Jaworska Hanna Tomczak Malgorzata Rydzanicz Rafal Ploski Marian Grzymislawski Agnieszka Dobrowolska Marzena Gajecka
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title_sort	gender influences gut microbiota among patients with irritable bowel syndrome
callnumber	QH301-705.5
title_auth	Gender Influences Gut Microbiota among Patients with Irritable Bowel Syndrome
abstract	Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disease that affects approximately 11% of the general population. The gut microbiota, among other known factors, plays a substantial role in its pathogenesis. The study aimed to characterize the gut microbiota differences between patients with IBS and unaffected individuals, taking into account the gender aspect of the patients and the types of IBS determined on the basis of the Rome IV Criteria, the IBS-C, IBS-D, IBS-M, and IBS-U. In total, 121 patients with IBS and 70 unaffected individuals participated in the study; the derived stool samples were subjected to 16S rRNA amplicon sequencing. The gut microbiota of patients with IBS was found to be more diverse in comparison to unaffected individuals, and the differences were observed primarily among <i<Clostridiales</i<, <i<Mogibacteriaceae</i<, <i<Synergistaceae</i<, <i<Coriobacteriaceae</i<, <i<Blautia</i< spp., and <i<Shuttleworthia</i< spp., depending on the study subgroup and patient gender. There was higher differentiation of females’ gut microbiota compared to males, regardless of the disease status. No correlation between the composition of the gut microbiota and the type of IBS was found. Patients with IBS were characterized by more diverse gut microbiota compared to unaffected individuals. The gender criterion should be considered in the characterization of the gut microbiota. The type of IBS did not determine the identified differences in gut microbiota.
abstractGer	Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disease that affects approximately 11% of the general population. The gut microbiota, among other known factors, plays a substantial role in its pathogenesis. The study aimed to characterize the gut microbiota differences between patients with IBS and unaffected individuals, taking into account the gender aspect of the patients and the types of IBS determined on the basis of the Rome IV Criteria, the IBS-C, IBS-D, IBS-M, and IBS-U. In total, 121 patients with IBS and 70 unaffected individuals participated in the study; the derived stool samples were subjected to 16S rRNA amplicon sequencing. The gut microbiota of patients with IBS was found to be more diverse in comparison to unaffected individuals, and the differences were observed primarily among <i<Clostridiales</i<, <i<Mogibacteriaceae</i<, <i<Synergistaceae</i<, <i<Coriobacteriaceae</i<, <i<Blautia</i< spp., and <i<Shuttleworthia</i< spp., depending on the study subgroup and patient gender. There was higher differentiation of females’ gut microbiota compared to males, regardless of the disease status. No correlation between the composition of the gut microbiota and the type of IBS was found. Patients with IBS were characterized by more diverse gut microbiota compared to unaffected individuals. The gender criterion should be considered in the characterization of the gut microbiota. The type of IBS did not determine the identified differences in gut microbiota.
abstract_unstemmed	Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disease that affects approximately 11% of the general population. The gut microbiota, among other known factors, plays a substantial role in its pathogenesis. The study aimed to characterize the gut microbiota differences between patients with IBS and unaffected individuals, taking into account the gender aspect of the patients and the types of IBS determined on the basis of the Rome IV Criteria, the IBS-C, IBS-D, IBS-M, and IBS-U. In total, 121 patients with IBS and 70 unaffected individuals participated in the study; the derived stool samples were subjected to 16S rRNA amplicon sequencing. The gut microbiota of patients with IBS was found to be more diverse in comparison to unaffected individuals, and the differences were observed primarily among <i<Clostridiales</i<, <i<Mogibacteriaceae</i<, <i<Synergistaceae</i<, <i<Coriobacteriaceae</i<, <i<Blautia</i< spp., and <i<Shuttleworthia</i< spp., depending on the study subgroup and patient gender. There was higher differentiation of females’ gut microbiota compared to males, regardless of the disease status. No correlation between the composition of the gut microbiota and the type of IBS was found. Patients with IBS were characterized by more diverse gut microbiota compared to unaffected individuals. The gender criterion should be considered in the characterization of the gut microbiota. The type of IBS did not determine the identified differences in gut microbiota.
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title_short	Gender Influences Gut Microbiota among Patients with Irritable Bowel Syndrome
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