A Higher Dose of <i<Staphylococcus aureus</i< Enterotoxin B Led to More Th1 and Lower Th2/Th1 Ratio in Th Cells

Exposure to <i<Staphylococcus aureus</i< enterotoxin B (SEB) is one of the causes of food poisoning and is associated with several immune diseases due to its superantigen capability. This study aimed to characterize the differentiations of naïve Th cells stimulated with different doses o...
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Autor*in:	Jin Yuan [verfasserIn] Xiaoqian Xu [verfasserIn] Zhongliang Wang [verfasserIn] Ping Tong [verfasserIn] Xuanyi Meng [verfasserIn] Yong Wu [verfasserIn] Xin Li [verfasserIn] Jinyan Gao [verfasserIn] Hongbing Chen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	T helper cell naïve Th cell cytokine dendritic cell

Übergeordnetes Werk:	In: Toxins - MDPI AG, 2010, 15(2023), 6, p 363
Übergeordnetes Werk:	volume:15 ; year:2023 ; number:6, p 363

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/toxins15060363

Katalog-ID:	DOAJ094047480

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allfieldsSound	10.3390/toxins15060363 doi (DE-627)DOAJ094047480 (DE-599)DOAJe469dd3cefeb4bc58449d6f1199beec3 DE-627 ger DE-627 rakwb eng Jin Yuan verfasserin aut A Higher Dose of <i<Staphylococcus aureus</i< Enterotoxin B Led to More Th1 and Lower Th2/Th1 Ratio in Th Cells 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Exposure to <i<Staphylococcus aureus</i< enterotoxin B (SEB) is one of the causes of food poisoning and is associated with several immune diseases due to its superantigen capability. This study aimed to characterize the differentiations of naïve Th cells stimulated with different doses of SEB. The expression of T-bet, GATA-3, and Foxp3 or secretion of IFN-γ, IL-4, IL-5, IL-13, and IL-10 were evaluated in wild-type (WT) or DO11.10 CD4 T cells co-cultured with bone marrow dendritic cells (BMDCs). We found that the balance of Th1/Th2 could be dominated by the doses of SEB stimulation. A higher SEB dose could induce more Th1 and a lower Th2/Th1 ratio in Th cells co-cultured with BMDCs. This different tendency of Th cell differentiation induced by the SEB complements the existing knowledge about SEB acting as a superantigen to activate Th cells. Additionally, it is also helpful in managing the colonization of <i<S. aureus</i< and food contamination of SEB. <i<Staphylococcus aureus</i< enterotoxin B T helper cell naïve Th cell cytokine dendritic cell Medicine R Xiaoqian Xu verfasserin aut Zhongliang Wang verfasserin aut Ping Tong verfasserin aut Xuanyi Meng verfasserin aut Yong Wu verfasserin aut Xin Li verfasserin aut Jinyan Gao verfasserin aut Hongbing Chen verfasserin aut In Toxins MDPI AG, 2010 15(2023), 6, p 363 (DE-627)610604236 (DE-600)2518395-3 20726651 nnns volume:15 year:2023 number:6, p 363 https://doi.org/10.3390/toxins15060363 kostenfrei https://doaj.org/article/e469dd3cefeb4bc58449d6f1199beec3 kostenfrei https://www.mdpi.com/2072-6651/15/6/363 kostenfrei https://doaj.org/toc/2072-6651 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 6, p 363
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author	Jin Yuan
spellingShingle	Jin Yuan misc <i<Staphylococcus aureus</i< enterotoxin B misc T helper cell misc naïve Th cell misc cytokine misc dendritic cell misc Medicine misc R A Higher Dose of <i<Staphylococcus aureus</i< Enterotoxin B Led to More Th1 and Lower Th2/Th1 Ratio in Th Cells
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topic_title	A Higher Dose of <i<Staphylococcus aureus</i< Enterotoxin B Led to More Th1 and Lower Th2/Th1 Ratio in Th Cells <i<Staphylococcus aureus</i< enterotoxin B T helper cell naïve Th cell cytokine dendritic cell
topic	misc <i<Staphylococcus aureus</i< enterotoxin B misc T helper cell misc naïve Th cell misc cytokine misc dendritic cell misc Medicine misc R
topic_unstemmed	misc <i<Staphylococcus aureus</i< enterotoxin B misc T helper cell misc naïve Th cell misc cytokine misc dendritic cell misc Medicine misc R
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title	A Higher Dose of <i<Staphylococcus aureus</i< Enterotoxin B Led to More Th1 and Lower Th2/Th1 Ratio in Th Cells
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title_full	A Higher Dose of <i<Staphylococcus aureus</i< Enterotoxin B Led to More Th1 and Lower Th2/Th1 Ratio in Th Cells
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author_browse	Jin Yuan Xiaoqian Xu Zhongliang Wang Ping Tong Xuanyi Meng Yong Wu Xin Li Jinyan Gao Hongbing Chen
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title_sort	higher dose of <i<staphylococcus aureus</i< enterotoxin b led to more th1 and lower th2/th1 ratio in th cells
title_auth	A Higher Dose of <i<Staphylococcus aureus</i< Enterotoxin B Led to More Th1 and Lower Th2/Th1 Ratio in Th Cells
abstract	Exposure to <i<Staphylococcus aureus</i< enterotoxin B (SEB) is one of the causes of food poisoning and is associated with several immune diseases due to its superantigen capability. This study aimed to characterize the differentiations of naïve Th cells stimulated with different doses of SEB. The expression of T-bet, GATA-3, and Foxp3 or secretion of IFN-γ, IL-4, IL-5, IL-13, and IL-10 were evaluated in wild-type (WT) or DO11.10 CD4 T cells co-cultured with bone marrow dendritic cells (BMDCs). We found that the balance of Th1/Th2 could be dominated by the doses of SEB stimulation. A higher SEB dose could induce more Th1 and a lower Th2/Th1 ratio in Th cells co-cultured with BMDCs. This different tendency of Th cell differentiation induced by the SEB complements the existing knowledge about SEB acting as a superantigen to activate Th cells. Additionally, it is also helpful in managing the colonization of <i<S. aureus</i< and food contamination of SEB.
abstractGer	Exposure to <i<Staphylococcus aureus</i< enterotoxin B (SEB) is one of the causes of food poisoning and is associated with several immune diseases due to its superantigen capability. This study aimed to characterize the differentiations of naïve Th cells stimulated with different doses of SEB. The expression of T-bet, GATA-3, and Foxp3 or secretion of IFN-γ, IL-4, IL-5, IL-13, and IL-10 were evaluated in wild-type (WT) or DO11.10 CD4 T cells co-cultured with bone marrow dendritic cells (BMDCs). We found that the balance of Th1/Th2 could be dominated by the doses of SEB stimulation. A higher SEB dose could induce more Th1 and a lower Th2/Th1 ratio in Th cells co-cultured with BMDCs. This different tendency of Th cell differentiation induced by the SEB complements the existing knowledge about SEB acting as a superantigen to activate Th cells. Additionally, it is also helpful in managing the colonization of <i<S. aureus</i< and food contamination of SEB.
abstract_unstemmed	Exposure to <i<Staphylococcus aureus</i< enterotoxin B (SEB) is one of the causes of food poisoning and is associated with several immune diseases due to its superantigen capability. This study aimed to characterize the differentiations of naïve Th cells stimulated with different doses of SEB. The expression of T-bet, GATA-3, and Foxp3 or secretion of IFN-γ, IL-4, IL-5, IL-13, and IL-10 were evaluated in wild-type (WT) or DO11.10 CD4 T cells co-cultured with bone marrow dendritic cells (BMDCs). We found that the balance of Th1/Th2 could be dominated by the doses of SEB stimulation. A higher SEB dose could induce more Th1 and a lower Th2/Th1 ratio in Th cells co-cultured with BMDCs. This different tendency of Th cell differentiation induced by the SEB complements the existing knowledge about SEB acting as a superantigen to activate Th cells. Additionally, it is also helpful in managing the colonization of <i<S. aureus</i< and food contamination of SEB.
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container_issue	6, p 363
title_short	A Higher Dose of <i<Staphylococcus aureus</i< Enterotoxin B Led to More Th1 and Lower Th2/Th1 Ratio in Th Cells
url	https://doi.org/10.3390/toxins15060363 https://doaj.org/article/e469dd3cefeb4bc58449d6f1199beec3 https://www.mdpi.com/2072-6651/15/6/363 https://doaj.org/toc/2072-6651
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up_date	2024-07-03T20:57:08.527Z
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A Higher Dose of <i<Staphylococcus aureus</i< Enterotoxin B Led to More Th1 and Lower Th2/Th1 Ratio in Th Cells

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