Novel Effect of <i<p</i<-Coumaric Acid on Hepatic Lipolysis: Inhibition of Hepatic Lipid-Droplets

<i<p</i<-coumaric acid (<i<p</i<-CA), a common plant phenolic acid with multiple bioactivities, has a lipid-lowering effect. As a dietary polyphenol, its low toxicity, with the advantages of prophylactic and long-term administration, makes it a potential drug for prophylaxis...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Zhiyi Yuan [verfasserIn] Xi Lu [verfasserIn] Fan Lei [verfasserIn] Hong Sun [verfasserIn] Jingfei Jiang [verfasserIn] Dongming Xing [verfasserIn] Lijun Du [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	hepatic lipase lipid droplet NAFLD PPAR

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 28(2023), 12, p 4641
Übergeordnetes Werk:	volume:28 ; year:2023 ; number:12, p 4641

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules28124641

Katalog-ID:	DOAJ094092036

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520			\|a <i<p</i<-coumaric acid (<i<p</i<-CA), a common plant phenolic acid with multiple bioactivities, has a lipid-lowering effect. As a dietary polyphenol, its low toxicity, with the advantages of prophylactic and long-term administration, makes it a potential drug for prophylaxis and the treatment of nonalcoholic fatty liver disease (NAFLD). However, the mechanism by which it regulates lipid metabolism is still unclear. In this study, we studied the effect of <i<p</i<-CA on the down-regulation of accumulated lipids in vivo and in vitro. <i<p</i<-CA increased a number of lipase expressions, including hormone-sensitive lipase (HSL), monoacylglycerol lipase (MGL) and hepatic triglyceride lipase (HTGL), as well as the expression of genes related to fatty acid oxidation, including long-chain fatty acyl-CoA synthetase 1 (ACSL1), carnitine palmitoyltransferase-1 (CPT1), by activating peroxisome proliferator-activated receptor α, and γ (PPARα and γ). Furthermore, <i<p</i<-CA promoted adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) phosphorylation and enhanced the expression of the mammalian suppressor of Sec4 (MSS4), a critical protein that can inhibit lipid droplet growth. Thus, <i<p</i<-CA can decrease lipid accumulation and inhibit lipid droplet fusion, which are correlated with the enhancement of liver lipases and genes related to fatty acid oxidation as an activator of PPARs. Therefore, <i<p</i<-CA is capable of regulating lipid metabolism and is a potential therapeutic drug or health care product for hyperlipidemia and fatty liver.
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allfields	10.3390/molecules28124641 doi (DE-627)DOAJ094092036 (DE-599)DOAJ9b76b2d4931644ba8e18a92131285e38 DE-627 ger DE-627 rakwb eng QD241-441 Zhiyi Yuan verfasserin aut Novel Effect of <i<p</i<-Coumaric Acid on Hepatic Lipolysis: Inhibition of Hepatic Lipid-Droplets 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<p</i<-coumaric acid (<i<p</i<-CA), a common plant phenolic acid with multiple bioactivities, has a lipid-lowering effect. As a dietary polyphenol, its low toxicity, with the advantages of prophylactic and long-term administration, makes it a potential drug for prophylaxis and the treatment of nonalcoholic fatty liver disease (NAFLD). However, the mechanism by which it regulates lipid metabolism is still unclear. In this study, we studied the effect of <i<p</i<-CA on the down-regulation of accumulated lipids in vivo and in vitro. <i<p</i<-CA increased a number of lipase expressions, including hormone-sensitive lipase (HSL), monoacylglycerol lipase (MGL) and hepatic triglyceride lipase (HTGL), as well as the expression of genes related to fatty acid oxidation, including long-chain fatty acyl-CoA synthetase 1 (ACSL1), carnitine palmitoyltransferase-1 (CPT1), by activating peroxisome proliferator-activated receptor α, and γ (PPARα and γ). Furthermore, <i<p</i<-CA promoted adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) phosphorylation and enhanced the expression of the mammalian suppressor of Sec4 (MSS4), a critical protein that can inhibit lipid droplet growth. Thus, <i<p</i<-CA can decrease lipid accumulation and inhibit lipid droplet fusion, which are correlated with the enhancement of liver lipases and genes related to fatty acid oxidation as an activator of PPARs. Therefore, <i<p</i<-CA is capable of regulating lipid metabolism and is a potential therapeutic drug or health care product for hyperlipidemia and fatty liver. <i<p</i<-coumaric acid hepatic lipase lipid droplet NAFLD PPAR Organic chemistry Xi Lu verfasserin aut Fan Lei verfasserin aut Hong Sun verfasserin aut Jingfei Jiang verfasserin aut Dongming Xing verfasserin aut Lijun Du verfasserin aut In Molecules MDPI AG, 2003 28(2023), 12, p 4641 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:28 year:2023 number:12, p 4641 https://doi.org/10.3390/molecules28124641 kostenfrei https://doaj.org/article/9b76b2d4931644ba8e18a92131285e38 kostenfrei https://www.mdpi.com/1420-3049/28/12/4641 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2023 12, p 4641
spelling	10.3390/molecules28124641 doi (DE-627)DOAJ094092036 (DE-599)DOAJ9b76b2d4931644ba8e18a92131285e38 DE-627 ger DE-627 rakwb eng QD241-441 Zhiyi Yuan verfasserin aut Novel Effect of <i<p</i<-Coumaric Acid on Hepatic Lipolysis: Inhibition of Hepatic Lipid-Droplets 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<p</i<-coumaric acid (<i<p</i<-CA), a common plant phenolic acid with multiple bioactivities, has a lipid-lowering effect. As a dietary polyphenol, its low toxicity, with the advantages of prophylactic and long-term administration, makes it a potential drug for prophylaxis and the treatment of nonalcoholic fatty liver disease (NAFLD). However, the mechanism by which it regulates lipid metabolism is still unclear. In this study, we studied the effect of <i<p</i<-CA on the down-regulation of accumulated lipids in vivo and in vitro. <i<p</i<-CA increased a number of lipase expressions, including hormone-sensitive lipase (HSL), monoacylglycerol lipase (MGL) and hepatic triglyceride lipase (HTGL), as well as the expression of genes related to fatty acid oxidation, including long-chain fatty acyl-CoA synthetase 1 (ACSL1), carnitine palmitoyltransferase-1 (CPT1), by activating peroxisome proliferator-activated receptor α, and γ (PPARα and γ). Furthermore, <i<p</i<-CA promoted adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) phosphorylation and enhanced the expression of the mammalian suppressor of Sec4 (MSS4), a critical protein that can inhibit lipid droplet growth. Thus, <i<p</i<-CA can decrease lipid accumulation and inhibit lipid droplet fusion, which are correlated with the enhancement of liver lipases and genes related to fatty acid oxidation as an activator of PPARs. Therefore, <i<p</i<-CA is capable of regulating lipid metabolism and is a potential therapeutic drug or health care product for hyperlipidemia and fatty liver. <i<p</i<-coumaric acid hepatic lipase lipid droplet NAFLD PPAR Organic chemistry Xi Lu verfasserin aut Fan Lei verfasserin aut Hong Sun verfasserin aut Jingfei Jiang verfasserin aut Dongming Xing verfasserin aut Lijun Du verfasserin aut In Molecules MDPI AG, 2003 28(2023), 12, p 4641 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:28 year:2023 number:12, p 4641 https://doi.org/10.3390/molecules28124641 kostenfrei https://doaj.org/article/9b76b2d4931644ba8e18a92131285e38 kostenfrei https://www.mdpi.com/1420-3049/28/12/4641 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2023 12, p 4641
allfields_unstemmed	10.3390/molecules28124641 doi (DE-627)DOAJ094092036 (DE-599)DOAJ9b76b2d4931644ba8e18a92131285e38 DE-627 ger DE-627 rakwb eng QD241-441 Zhiyi Yuan verfasserin aut Novel Effect of <i<p</i<-Coumaric Acid on Hepatic Lipolysis: Inhibition of Hepatic Lipid-Droplets 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<p</i<-coumaric acid (<i<p</i<-CA), a common plant phenolic acid with multiple bioactivities, has a lipid-lowering effect. As a dietary polyphenol, its low toxicity, with the advantages of prophylactic and long-term administration, makes it a potential drug for prophylaxis and the treatment of nonalcoholic fatty liver disease (NAFLD). However, the mechanism by which it regulates lipid metabolism is still unclear. In this study, we studied the effect of <i<p</i<-CA on the down-regulation of accumulated lipids in vivo and in vitro. <i<p</i<-CA increased a number of lipase expressions, including hormone-sensitive lipase (HSL), monoacylglycerol lipase (MGL) and hepatic triglyceride lipase (HTGL), as well as the expression of genes related to fatty acid oxidation, including long-chain fatty acyl-CoA synthetase 1 (ACSL1), carnitine palmitoyltransferase-1 (CPT1), by activating peroxisome proliferator-activated receptor α, and γ (PPARα and γ). Furthermore, <i<p</i<-CA promoted adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) phosphorylation and enhanced the expression of the mammalian suppressor of Sec4 (MSS4), a critical protein that can inhibit lipid droplet growth. Thus, <i<p</i<-CA can decrease lipid accumulation and inhibit lipid droplet fusion, which are correlated with the enhancement of liver lipases and genes related to fatty acid oxidation as an activator of PPARs. Therefore, <i<p</i<-CA is capable of regulating lipid metabolism and is a potential therapeutic drug or health care product for hyperlipidemia and fatty liver. <i<p</i<-coumaric acid hepatic lipase lipid droplet NAFLD PPAR Organic chemistry Xi Lu verfasserin aut Fan Lei verfasserin aut Hong Sun verfasserin aut Jingfei Jiang verfasserin aut Dongming Xing verfasserin aut Lijun Du verfasserin aut In Molecules MDPI AG, 2003 28(2023), 12, p 4641 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:28 year:2023 number:12, p 4641 https://doi.org/10.3390/molecules28124641 kostenfrei https://doaj.org/article/9b76b2d4931644ba8e18a92131285e38 kostenfrei https://www.mdpi.com/1420-3049/28/12/4641 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2023 12, p 4641
allfieldsGer	10.3390/molecules28124641 doi (DE-627)DOAJ094092036 (DE-599)DOAJ9b76b2d4931644ba8e18a92131285e38 DE-627 ger DE-627 rakwb eng QD241-441 Zhiyi Yuan verfasserin aut Novel Effect of <i<p</i<-Coumaric Acid on Hepatic Lipolysis: Inhibition of Hepatic Lipid-Droplets 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<p</i<-coumaric acid (<i<p</i<-CA), a common plant phenolic acid with multiple bioactivities, has a lipid-lowering effect. As a dietary polyphenol, its low toxicity, with the advantages of prophylactic and long-term administration, makes it a potential drug for prophylaxis and the treatment of nonalcoholic fatty liver disease (NAFLD). However, the mechanism by which it regulates lipid metabolism is still unclear. In this study, we studied the effect of <i<p</i<-CA on the down-regulation of accumulated lipids in vivo and in vitro. <i<p</i<-CA increased a number of lipase expressions, including hormone-sensitive lipase (HSL), monoacylglycerol lipase (MGL) and hepatic triglyceride lipase (HTGL), as well as the expression of genes related to fatty acid oxidation, including long-chain fatty acyl-CoA synthetase 1 (ACSL1), carnitine palmitoyltransferase-1 (CPT1), by activating peroxisome proliferator-activated receptor α, and γ (PPARα and γ). Furthermore, <i<p</i<-CA promoted adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) phosphorylation and enhanced the expression of the mammalian suppressor of Sec4 (MSS4), a critical protein that can inhibit lipid droplet growth. Thus, <i<p</i<-CA can decrease lipid accumulation and inhibit lipid droplet fusion, which are correlated with the enhancement of liver lipases and genes related to fatty acid oxidation as an activator of PPARs. Therefore, <i<p</i<-CA is capable of regulating lipid metabolism and is a potential therapeutic drug or health care product for hyperlipidemia and fatty liver. <i<p</i<-coumaric acid hepatic lipase lipid droplet NAFLD PPAR Organic chemistry Xi Lu verfasserin aut Fan Lei verfasserin aut Hong Sun verfasserin aut Jingfei Jiang verfasserin aut Dongming Xing verfasserin aut Lijun Du verfasserin aut In Molecules MDPI AG, 2003 28(2023), 12, p 4641 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:28 year:2023 number:12, p 4641 https://doi.org/10.3390/molecules28124641 kostenfrei https://doaj.org/article/9b76b2d4931644ba8e18a92131285e38 kostenfrei https://www.mdpi.com/1420-3049/28/12/4641 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2023 12, p 4641
allfieldsSound	10.3390/molecules28124641 doi (DE-627)DOAJ094092036 (DE-599)DOAJ9b76b2d4931644ba8e18a92131285e38 DE-627 ger DE-627 rakwb eng QD241-441 Zhiyi Yuan verfasserin aut Novel Effect of <i<p</i<-Coumaric Acid on Hepatic Lipolysis: Inhibition of Hepatic Lipid-Droplets 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<p</i<-coumaric acid (<i<p</i<-CA), a common plant phenolic acid with multiple bioactivities, has a lipid-lowering effect. As a dietary polyphenol, its low toxicity, with the advantages of prophylactic and long-term administration, makes it a potential drug for prophylaxis and the treatment of nonalcoholic fatty liver disease (NAFLD). However, the mechanism by which it regulates lipid metabolism is still unclear. In this study, we studied the effect of <i<p</i<-CA on the down-regulation of accumulated lipids in vivo and in vitro. <i<p</i<-CA increased a number of lipase expressions, including hormone-sensitive lipase (HSL), monoacylglycerol lipase (MGL) and hepatic triglyceride lipase (HTGL), as well as the expression of genes related to fatty acid oxidation, including long-chain fatty acyl-CoA synthetase 1 (ACSL1), carnitine palmitoyltransferase-1 (CPT1), by activating peroxisome proliferator-activated receptor α, and γ (PPARα and γ). Furthermore, <i<p</i<-CA promoted adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) phosphorylation and enhanced the expression of the mammalian suppressor of Sec4 (MSS4), a critical protein that can inhibit lipid droplet growth. Thus, <i<p</i<-CA can decrease lipid accumulation and inhibit lipid droplet fusion, which are correlated with the enhancement of liver lipases and genes related to fatty acid oxidation as an activator of PPARs. Therefore, <i<p</i<-CA is capable of regulating lipid metabolism and is a potential therapeutic drug or health care product for hyperlipidemia and fatty liver. <i<p</i<-coumaric acid hepatic lipase lipid droplet NAFLD PPAR Organic chemistry Xi Lu verfasserin aut Fan Lei verfasserin aut Hong Sun verfasserin aut Jingfei Jiang verfasserin aut Dongming Xing verfasserin aut Lijun Du verfasserin aut In Molecules MDPI AG, 2003 28(2023), 12, p 4641 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:28 year:2023 number:12, p 4641 https://doi.org/10.3390/molecules28124641 kostenfrei https://doaj.org/article/9b76b2d4931644ba8e18a92131285e38 kostenfrei https://www.mdpi.com/1420-3049/28/12/4641 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2023 12, p 4641
language	English
source	In Molecules 28(2023), 12, p 4641 volume:28 year:2023 number:12, p 4641
sourceStr	In Molecules 28(2023), 12, p 4641 volume:28 year:2023 number:12, p 4641
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topic_facet	<i<p</i<-coumaric acid hepatic lipase lipid droplet NAFLD PPAR Organic chemistry
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container_title	Molecules
authorswithroles_txt_mv	Zhiyi Yuan @@aut@@ Xi Lu @@aut@@ Fan Lei @@aut@@ Hong Sun @@aut@@ Jingfei Jiang @@aut@@ Dongming Xing @@aut@@ Lijun Du @@aut@@
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callnumber-first	Q - Science
author	Zhiyi Yuan
spellingShingle	Zhiyi Yuan misc QD241-441 misc <i<p</i<-coumaric acid misc hepatic lipase misc lipid droplet misc NAFLD misc PPAR misc Organic chemistry Novel Effect of <i<p</i<-Coumaric Acid on Hepatic Lipolysis: Inhibition of Hepatic Lipid-Droplets
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topic_title	QD241-441 Novel Effect of <i<p</i<-Coumaric Acid on Hepatic Lipolysis: Inhibition of Hepatic Lipid-Droplets <i<p</i<-coumaric acid hepatic lipase lipid droplet NAFLD PPAR
topic	misc QD241-441 misc <i<p</i<-coumaric acid misc hepatic lipase misc lipid droplet misc NAFLD misc PPAR misc Organic chemistry
topic_unstemmed	misc QD241-441 misc <i<p</i<-coumaric acid misc hepatic lipase misc lipid droplet misc NAFLD misc PPAR misc Organic chemistry
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title	Novel Effect of <i<p</i<-Coumaric Acid on Hepatic Lipolysis: Inhibition of Hepatic Lipid-Droplets
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title_full	Novel Effect of <i<p</i<-Coumaric Acid on Hepatic Lipolysis: Inhibition of Hepatic Lipid-Droplets
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author_browse	Zhiyi Yuan Xi Lu Fan Lei Hong Sun Jingfei Jiang Dongming Xing Lijun Du
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title_sort	novel effect of <i<p</i<-coumaric acid on hepatic lipolysis: inhibition of hepatic lipid-droplets
callnumber	QD241-441
title_auth	Novel Effect of <i<p</i<-Coumaric Acid on Hepatic Lipolysis: Inhibition of Hepatic Lipid-Droplets
abstract	<i<p</i<-coumaric acid (<i<p</i<-CA), a common plant phenolic acid with multiple bioactivities, has a lipid-lowering effect. As a dietary polyphenol, its low toxicity, with the advantages of prophylactic and long-term administration, makes it a potential drug for prophylaxis and the treatment of nonalcoholic fatty liver disease (NAFLD). However, the mechanism by which it regulates lipid metabolism is still unclear. In this study, we studied the effect of <i<p</i<-CA on the down-regulation of accumulated lipids in vivo and in vitro. <i<p</i<-CA increased a number of lipase expressions, including hormone-sensitive lipase (HSL), monoacylglycerol lipase (MGL) and hepatic triglyceride lipase (HTGL), as well as the expression of genes related to fatty acid oxidation, including long-chain fatty acyl-CoA synthetase 1 (ACSL1), carnitine palmitoyltransferase-1 (CPT1), by activating peroxisome proliferator-activated receptor α, and γ (PPARα and γ). Furthermore, <i<p</i<-CA promoted adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) phosphorylation and enhanced the expression of the mammalian suppressor of Sec4 (MSS4), a critical protein that can inhibit lipid droplet growth. Thus, <i<p</i<-CA can decrease lipid accumulation and inhibit lipid droplet fusion, which are correlated with the enhancement of liver lipases and genes related to fatty acid oxidation as an activator of PPARs. Therefore, <i<p</i<-CA is capable of regulating lipid metabolism and is a potential therapeutic drug or health care product for hyperlipidemia and fatty liver.
abstractGer	<i<p</i<-coumaric acid (<i<p</i<-CA), a common plant phenolic acid with multiple bioactivities, has a lipid-lowering effect. As a dietary polyphenol, its low toxicity, with the advantages of prophylactic and long-term administration, makes it a potential drug for prophylaxis and the treatment of nonalcoholic fatty liver disease (NAFLD). However, the mechanism by which it regulates lipid metabolism is still unclear. In this study, we studied the effect of <i<p</i<-CA on the down-regulation of accumulated lipids in vivo and in vitro. <i<p</i<-CA increased a number of lipase expressions, including hormone-sensitive lipase (HSL), monoacylglycerol lipase (MGL) and hepatic triglyceride lipase (HTGL), as well as the expression of genes related to fatty acid oxidation, including long-chain fatty acyl-CoA synthetase 1 (ACSL1), carnitine palmitoyltransferase-1 (CPT1), by activating peroxisome proliferator-activated receptor α, and γ (PPARα and γ). Furthermore, <i<p</i<-CA promoted adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) phosphorylation and enhanced the expression of the mammalian suppressor of Sec4 (MSS4), a critical protein that can inhibit lipid droplet growth. Thus, <i<p</i<-CA can decrease lipid accumulation and inhibit lipid droplet fusion, which are correlated with the enhancement of liver lipases and genes related to fatty acid oxidation as an activator of PPARs. Therefore, <i<p</i<-CA is capable of regulating lipid metabolism and is a potential therapeutic drug or health care product for hyperlipidemia and fatty liver.
abstract_unstemmed	<i<p</i<-coumaric acid (<i<p</i<-CA), a common plant phenolic acid with multiple bioactivities, has a lipid-lowering effect. As a dietary polyphenol, its low toxicity, with the advantages of prophylactic and long-term administration, makes it a potential drug for prophylaxis and the treatment of nonalcoholic fatty liver disease (NAFLD). However, the mechanism by which it regulates lipid metabolism is still unclear. In this study, we studied the effect of <i<p</i<-CA on the down-regulation of accumulated lipids in vivo and in vitro. <i<p</i<-CA increased a number of lipase expressions, including hormone-sensitive lipase (HSL), monoacylglycerol lipase (MGL) and hepatic triglyceride lipase (HTGL), as well as the expression of genes related to fatty acid oxidation, including long-chain fatty acyl-CoA synthetase 1 (ACSL1), carnitine palmitoyltransferase-1 (CPT1), by activating peroxisome proliferator-activated receptor α, and γ (PPARα and γ). Furthermore, <i<p</i<-CA promoted adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) phosphorylation and enhanced the expression of the mammalian suppressor of Sec4 (MSS4), a critical protein that can inhibit lipid droplet growth. Thus, <i<p</i<-CA can decrease lipid accumulation and inhibit lipid droplet fusion, which are correlated with the enhancement of liver lipases and genes related to fatty acid oxidation as an activator of PPARs. Therefore, <i<p</i<-CA is capable of regulating lipid metabolism and is a potential therapeutic drug or health care product for hyperlipidemia and fatty liver.
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container_issue	12, p 4641
title_short	Novel Effect of <i<p</i<-Coumaric Acid on Hepatic Lipolysis: Inhibition of Hepatic Lipid-Droplets
url	https://doi.org/10.3390/molecules28124641 https://doaj.org/article/9b76b2d4931644ba8e18a92131285e38 https://www.mdpi.com/1420-3049/28/12/4641 https://doaj.org/toc/1420-3049
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As a dietary polyphenol, its low toxicity, with the advantages of prophylactic and long-term administration, makes it a potential drug for prophylaxis and the treatment of nonalcoholic fatty liver disease (NAFLD). However, the mechanism by which it regulates lipid metabolism is still unclear. In this study, we studied the effect of <i<p</i<-CA on the down-regulation of accumulated lipids in vivo and in vitro. <i<p</i<-CA increased a number of lipase expressions, including hormone-sensitive lipase (HSL), monoacylglycerol lipase (MGL) and hepatic triglyceride lipase (HTGL), as well as the expression of genes related to fatty acid oxidation, including long-chain fatty acyl-CoA synthetase 1 (ACSL1), carnitine palmitoyltransferase-1 (CPT1), by activating peroxisome proliferator-activated receptor α, and γ (PPARα and γ). Furthermore, <i<p</i<-CA promoted adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) phosphorylation and enhanced the expression of the mammalian suppressor of Sec4 (MSS4), a critical protein that can inhibit lipid droplet growth. Thus, <i<p</i<-CA can decrease lipid accumulation and inhibit lipid droplet fusion, which are correlated with the enhancement of liver lipases and genes related to fatty acid oxidation as an activator of PPARs. 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Novel Effect of <i<p</i<-Coumaric Acid on Hepatic Lipolysis: Inhibition of Hepatic Lipid-Droplets

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