A Case of Prostatic Signet-Ring Cell-like Carcinoma with Pagetoid Spread and Intraductal Carcinoma and Long-Term Survival: PD-L1 and Mismatch Repair System Proteins (MMR) Immunohistochemical Evaluation with Systematic Literature Review
Prostatic adenocarcinoma (PA) is the second most common malignancy in men globally. Signet-ring cell-like adenocarcinoma (SRCC) is a very rare PA subtype, with around 200 cases reported in the English literature. Histologically, the tumor cells show a vacuole compressing the nucleus to the periphery...
Ausführliche Beschreibung
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| Autor*in: |
Nektarios Koufopoulos [verfasserIn] Argyro-Ioanna Ieronimaki [verfasserIn] Andriani Zacharatou [verfasserIn] Alina Roxana Gouloumis [verfasserIn] Danai Leventakou [verfasserIn] Ioannis Boutas [verfasserIn] Dionysios T. Dimas [verfasserIn] Adamantia Kontogeorgi [verfasserIn] Kyparissia Sitara [verfasserIn] Lubna Khaldi [verfasserIn] Magda Zanelli [verfasserIn] Andrea Palicelli [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Journal of Personalized Medicine - MDPI AG, 2012, 13(2023), 6, p 1016 |
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| Übergeordnetes Werk: |
volume:13 ; year:2023 ; number:6, p 1016 |
| Links: |
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| DOI / URN: |
10.3390/jpm13061016 |
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| Katalog-ID: |
DOAJ094118361 |
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| 520 | |a Prostatic adenocarcinoma (PA) is the second most common malignancy in men globally. Signet-ring cell-like adenocarcinoma (SRCC) is a very rare PA subtype, with around 200 cases reported in the English literature. Histologically, the tumor cells show a vacuole compressing the nucleus to the periphery. Pagetoid spread in acini and ducts is usually related to metastases from urothelial or colorectal carcinomas, less commonly associated with intraductal carcinoma (IC); histologically, the tumor cells grow between the acinar secretory and basal cell layers. To our knowledge, we report the first prostatic SRCC (Gleason score 10, stage pT3b) associated with IC and pagetoid spread to prostatic acini and seminal vesicles. To our systematic literature review (PRISMA guidelines), it is the first tested case for both PD-L1 (<1% of positive tumor cells, clone 22C3) and mismatch repair system proteins (MMR) (MLH1+/MSH2+/PMS2+/MSH6+). We found no SRCC previously tested for MMR, while only four previous cases showed high expression of another PD-L1 clone (28-8). Finally, we discussed the differential diagnoses of prostatic SRCC. | ||
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10.3390/jpm13061016 doi (DE-627)DOAJ094118361 (DE-599)DOAJf4cf0d3728d04f9a8df5a77af215baa2 DE-627 ger DE-627 rakwb eng Nektarios Koufopoulos verfasserin aut A Case of Prostatic Signet-Ring Cell-like Carcinoma with Pagetoid Spread and Intraductal Carcinoma and Long-Term Survival: PD-L1 and Mismatch Repair System Proteins (MMR) Immunohistochemical Evaluation with Systematic Literature Review 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Prostatic adenocarcinoma (PA) is the second most common malignancy in men globally. Signet-ring cell-like adenocarcinoma (SRCC) is a very rare PA subtype, with around 200 cases reported in the English literature. Histologically, the tumor cells show a vacuole compressing the nucleus to the periphery. Pagetoid spread in acini and ducts is usually related to metastases from urothelial or colorectal carcinomas, less commonly associated with intraductal carcinoma (IC); histologically, the tumor cells grow between the acinar secretory and basal cell layers. To our knowledge, we report the first prostatic SRCC (Gleason score 10, stage pT3b) associated with IC and pagetoid spread to prostatic acini and seminal vesicles. To our systematic literature review (PRISMA guidelines), it is the first tested case for both PD-L1 (<1% of positive tumor cells, clone 22C3) and mismatch repair system proteins (MMR) (MLH1+/MSH2+/PMS2+/MSH6+). We found no SRCC previously tested for MMR, while only four previous cases showed high expression of another PD-L1 clone (28-8). Finally, we discussed the differential diagnoses of prostatic SRCC. prostatic carcinoma signet ring cell carcinoma intraductal carcinoma pagetoid spread metastasis PD-L1 Medicine R Argyro-Ioanna Ieronimaki verfasserin aut Andriani Zacharatou verfasserin aut Alina Roxana Gouloumis verfasserin aut Danai Leventakou verfasserin aut Ioannis Boutas verfasserin aut Dionysios T. Dimas verfasserin aut Adamantia Kontogeorgi verfasserin aut Kyparissia Sitara verfasserin aut Lubna Khaldi verfasserin aut Magda Zanelli verfasserin aut Andrea Palicelli verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 13(2023), 6, p 1016 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:13 year:2023 number:6, p 1016 https://doi.org/10.3390/jpm13061016 kostenfrei https://doaj.org/article/f4cf0d3728d04f9a8df5a77af215baa2 kostenfrei https://www.mdpi.com/2075-4426/13/6/1016 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 6, p 1016 |
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10.3390/jpm13061016 doi (DE-627)DOAJ094118361 (DE-599)DOAJf4cf0d3728d04f9a8df5a77af215baa2 DE-627 ger DE-627 rakwb eng Nektarios Koufopoulos verfasserin aut A Case of Prostatic Signet-Ring Cell-like Carcinoma with Pagetoid Spread and Intraductal Carcinoma and Long-Term Survival: PD-L1 and Mismatch Repair System Proteins (MMR) Immunohistochemical Evaluation with Systematic Literature Review 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Prostatic adenocarcinoma (PA) is the second most common malignancy in men globally. Signet-ring cell-like adenocarcinoma (SRCC) is a very rare PA subtype, with around 200 cases reported in the English literature. Histologically, the tumor cells show a vacuole compressing the nucleus to the periphery. Pagetoid spread in acini and ducts is usually related to metastases from urothelial or colorectal carcinomas, less commonly associated with intraductal carcinoma (IC); histologically, the tumor cells grow between the acinar secretory and basal cell layers. To our knowledge, we report the first prostatic SRCC (Gleason score 10, stage pT3b) associated with IC and pagetoid spread to prostatic acini and seminal vesicles. To our systematic literature review (PRISMA guidelines), it is the first tested case for both PD-L1 (<1% of positive tumor cells, clone 22C3) and mismatch repair system proteins (MMR) (MLH1+/MSH2+/PMS2+/MSH6+). We found no SRCC previously tested for MMR, while only four previous cases showed high expression of another PD-L1 clone (28-8). Finally, we discussed the differential diagnoses of prostatic SRCC. prostatic carcinoma signet ring cell carcinoma intraductal carcinoma pagetoid spread metastasis PD-L1 Medicine R Argyro-Ioanna Ieronimaki verfasserin aut Andriani Zacharatou verfasserin aut Alina Roxana Gouloumis verfasserin aut Danai Leventakou verfasserin aut Ioannis Boutas verfasserin aut Dionysios T. Dimas verfasserin aut Adamantia Kontogeorgi verfasserin aut Kyparissia Sitara verfasserin aut Lubna Khaldi verfasserin aut Magda Zanelli verfasserin aut Andrea Palicelli verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 13(2023), 6, p 1016 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:13 year:2023 number:6, p 1016 https://doi.org/10.3390/jpm13061016 kostenfrei https://doaj.org/article/f4cf0d3728d04f9a8df5a77af215baa2 kostenfrei https://www.mdpi.com/2075-4426/13/6/1016 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 6, p 1016 |
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10.3390/jpm13061016 doi (DE-627)DOAJ094118361 (DE-599)DOAJf4cf0d3728d04f9a8df5a77af215baa2 DE-627 ger DE-627 rakwb eng Nektarios Koufopoulos verfasserin aut A Case of Prostatic Signet-Ring Cell-like Carcinoma with Pagetoid Spread and Intraductal Carcinoma and Long-Term Survival: PD-L1 and Mismatch Repair System Proteins (MMR) Immunohistochemical Evaluation with Systematic Literature Review 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Prostatic adenocarcinoma (PA) is the second most common malignancy in men globally. Signet-ring cell-like adenocarcinoma (SRCC) is a very rare PA subtype, with around 200 cases reported in the English literature. Histologically, the tumor cells show a vacuole compressing the nucleus to the periphery. Pagetoid spread in acini and ducts is usually related to metastases from urothelial or colorectal carcinomas, less commonly associated with intraductal carcinoma (IC); histologically, the tumor cells grow between the acinar secretory and basal cell layers. To our knowledge, we report the first prostatic SRCC (Gleason score 10, stage pT3b) associated with IC and pagetoid spread to prostatic acini and seminal vesicles. To our systematic literature review (PRISMA guidelines), it is the first tested case for both PD-L1 (<1% of positive tumor cells, clone 22C3) and mismatch repair system proteins (MMR) (MLH1+/MSH2+/PMS2+/MSH6+). We found no SRCC previously tested for MMR, while only four previous cases showed high expression of another PD-L1 clone (28-8). Finally, we discussed the differential diagnoses of prostatic SRCC. prostatic carcinoma signet ring cell carcinoma intraductal carcinoma pagetoid spread metastasis PD-L1 Medicine R Argyro-Ioanna Ieronimaki verfasserin aut Andriani Zacharatou verfasserin aut Alina Roxana Gouloumis verfasserin aut Danai Leventakou verfasserin aut Ioannis Boutas verfasserin aut Dionysios T. Dimas verfasserin aut Adamantia Kontogeorgi verfasserin aut Kyparissia Sitara verfasserin aut Lubna Khaldi verfasserin aut Magda Zanelli verfasserin aut Andrea Palicelli verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 13(2023), 6, p 1016 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:13 year:2023 number:6, p 1016 https://doi.org/10.3390/jpm13061016 kostenfrei https://doaj.org/article/f4cf0d3728d04f9a8df5a77af215baa2 kostenfrei https://www.mdpi.com/2075-4426/13/6/1016 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 6, p 1016 |
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10.3390/jpm13061016 doi (DE-627)DOAJ094118361 (DE-599)DOAJf4cf0d3728d04f9a8df5a77af215baa2 DE-627 ger DE-627 rakwb eng Nektarios Koufopoulos verfasserin aut A Case of Prostatic Signet-Ring Cell-like Carcinoma with Pagetoid Spread and Intraductal Carcinoma and Long-Term Survival: PD-L1 and Mismatch Repair System Proteins (MMR) Immunohistochemical Evaluation with Systematic Literature Review 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Prostatic adenocarcinoma (PA) is the second most common malignancy in men globally. Signet-ring cell-like adenocarcinoma (SRCC) is a very rare PA subtype, with around 200 cases reported in the English literature. Histologically, the tumor cells show a vacuole compressing the nucleus to the periphery. Pagetoid spread in acini and ducts is usually related to metastases from urothelial or colorectal carcinomas, less commonly associated with intraductal carcinoma (IC); histologically, the tumor cells grow between the acinar secretory and basal cell layers. To our knowledge, we report the first prostatic SRCC (Gleason score 10, stage pT3b) associated with IC and pagetoid spread to prostatic acini and seminal vesicles. To our systematic literature review (PRISMA guidelines), it is the first tested case for both PD-L1 (<1% of positive tumor cells, clone 22C3) and mismatch repair system proteins (MMR) (MLH1+/MSH2+/PMS2+/MSH6+). We found no SRCC previously tested for MMR, while only four previous cases showed high expression of another PD-L1 clone (28-8). Finally, we discussed the differential diagnoses of prostatic SRCC. prostatic carcinoma signet ring cell carcinoma intraductal carcinoma pagetoid spread metastasis PD-L1 Medicine R Argyro-Ioanna Ieronimaki verfasserin aut Andriani Zacharatou verfasserin aut Alina Roxana Gouloumis verfasserin aut Danai Leventakou verfasserin aut Ioannis Boutas verfasserin aut Dionysios T. Dimas verfasserin aut Adamantia Kontogeorgi verfasserin aut Kyparissia Sitara verfasserin aut Lubna Khaldi verfasserin aut Magda Zanelli verfasserin aut Andrea Palicelli verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 13(2023), 6, p 1016 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:13 year:2023 number:6, p 1016 https://doi.org/10.3390/jpm13061016 kostenfrei https://doaj.org/article/f4cf0d3728d04f9a8df5a77af215baa2 kostenfrei https://www.mdpi.com/2075-4426/13/6/1016 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 6, p 1016 |
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10.3390/jpm13061016 doi (DE-627)DOAJ094118361 (DE-599)DOAJf4cf0d3728d04f9a8df5a77af215baa2 DE-627 ger DE-627 rakwb eng Nektarios Koufopoulos verfasserin aut A Case of Prostatic Signet-Ring Cell-like Carcinoma with Pagetoid Spread and Intraductal Carcinoma and Long-Term Survival: PD-L1 and Mismatch Repair System Proteins (MMR) Immunohistochemical Evaluation with Systematic Literature Review 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Prostatic adenocarcinoma (PA) is the second most common malignancy in men globally. Signet-ring cell-like adenocarcinoma (SRCC) is a very rare PA subtype, with around 200 cases reported in the English literature. Histologically, the tumor cells show a vacuole compressing the nucleus to the periphery. Pagetoid spread in acini and ducts is usually related to metastases from urothelial or colorectal carcinomas, less commonly associated with intraductal carcinoma (IC); histologically, the tumor cells grow between the acinar secretory and basal cell layers. To our knowledge, we report the first prostatic SRCC (Gleason score 10, stage pT3b) associated with IC and pagetoid spread to prostatic acini and seminal vesicles. To our systematic literature review (PRISMA guidelines), it is the first tested case for both PD-L1 (<1% of positive tumor cells, clone 22C3) and mismatch repair system proteins (MMR) (MLH1+/MSH2+/PMS2+/MSH6+). We found no SRCC previously tested for MMR, while only four previous cases showed high expression of another PD-L1 clone (28-8). Finally, we discussed the differential diagnoses of prostatic SRCC. prostatic carcinoma signet ring cell carcinoma intraductal carcinoma pagetoid spread metastasis PD-L1 Medicine R Argyro-Ioanna Ieronimaki verfasserin aut Andriani Zacharatou verfasserin aut Alina Roxana Gouloumis verfasserin aut Danai Leventakou verfasserin aut Ioannis Boutas verfasserin aut Dionysios T. Dimas verfasserin aut Adamantia Kontogeorgi verfasserin aut Kyparissia Sitara verfasserin aut Lubna Khaldi verfasserin aut Magda Zanelli verfasserin aut Andrea Palicelli verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 13(2023), 6, p 1016 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:13 year:2023 number:6, p 1016 https://doi.org/10.3390/jpm13061016 kostenfrei https://doaj.org/article/f4cf0d3728d04f9a8df5a77af215baa2 kostenfrei https://www.mdpi.com/2075-4426/13/6/1016 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 6, p 1016 |
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A Case of Prostatic Signet-Ring Cell-like Carcinoma with Pagetoid Spread and Intraductal Carcinoma and Long-Term Survival: PD-L1 and Mismatch Repair System Proteins (MMR) Immunohistochemical Evaluation with Systematic Literature Review |
| abstract |
Prostatic adenocarcinoma (PA) is the second most common malignancy in men globally. Signet-ring cell-like adenocarcinoma (SRCC) is a very rare PA subtype, with around 200 cases reported in the English literature. Histologically, the tumor cells show a vacuole compressing the nucleus to the periphery. Pagetoid spread in acini and ducts is usually related to metastases from urothelial or colorectal carcinomas, less commonly associated with intraductal carcinoma (IC); histologically, the tumor cells grow between the acinar secretory and basal cell layers. To our knowledge, we report the first prostatic SRCC (Gleason score 10, stage pT3b) associated with IC and pagetoid spread to prostatic acini and seminal vesicles. To our systematic literature review (PRISMA guidelines), it is the first tested case for both PD-L1 (<1% of positive tumor cells, clone 22C3) and mismatch repair system proteins (MMR) (MLH1+/MSH2+/PMS2+/MSH6+). We found no SRCC previously tested for MMR, while only four previous cases showed high expression of another PD-L1 clone (28-8). Finally, we discussed the differential diagnoses of prostatic SRCC. |
| abstractGer |
Prostatic adenocarcinoma (PA) is the second most common malignancy in men globally. Signet-ring cell-like adenocarcinoma (SRCC) is a very rare PA subtype, with around 200 cases reported in the English literature. Histologically, the tumor cells show a vacuole compressing the nucleus to the periphery. Pagetoid spread in acini and ducts is usually related to metastases from urothelial or colorectal carcinomas, less commonly associated with intraductal carcinoma (IC); histologically, the tumor cells grow between the acinar secretory and basal cell layers. To our knowledge, we report the first prostatic SRCC (Gleason score 10, stage pT3b) associated with IC and pagetoid spread to prostatic acini and seminal vesicles. To our systematic literature review (PRISMA guidelines), it is the first tested case for both PD-L1 (<1% of positive tumor cells, clone 22C3) and mismatch repair system proteins (MMR) (MLH1+/MSH2+/PMS2+/MSH6+). We found no SRCC previously tested for MMR, while only four previous cases showed high expression of another PD-L1 clone (28-8). Finally, we discussed the differential diagnoses of prostatic SRCC. |
| abstract_unstemmed |
Prostatic adenocarcinoma (PA) is the second most common malignancy in men globally. Signet-ring cell-like adenocarcinoma (SRCC) is a very rare PA subtype, with around 200 cases reported in the English literature. Histologically, the tumor cells show a vacuole compressing the nucleus to the periphery. Pagetoid spread in acini and ducts is usually related to metastases from urothelial or colorectal carcinomas, less commonly associated with intraductal carcinoma (IC); histologically, the tumor cells grow between the acinar secretory and basal cell layers. To our knowledge, we report the first prostatic SRCC (Gleason score 10, stage pT3b) associated with IC and pagetoid spread to prostatic acini and seminal vesicles. To our systematic literature review (PRISMA guidelines), it is the first tested case for both PD-L1 (<1% of positive tumor cells, clone 22C3) and mismatch repair system proteins (MMR) (MLH1+/MSH2+/PMS2+/MSH6+). We found no SRCC previously tested for MMR, while only four previous cases showed high expression of another PD-L1 clone (28-8). Finally, we discussed the differential diagnoses of prostatic SRCC. |
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6, p 1016 |
| title_short |
A Case of Prostatic Signet-Ring Cell-like Carcinoma with Pagetoid Spread and Intraductal Carcinoma and Long-Term Survival: PD-L1 and Mismatch Repair System Proteins (MMR) Immunohistochemical Evaluation with Systematic Literature Review |
| url |
https://doi.org/10.3390/jpm13061016 https://doaj.org/article/f4cf0d3728d04f9a8df5a77af215baa2 https://www.mdpi.com/2075-4426/13/6/1016 https://doaj.org/toc/2075-4426 |
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Argyro-Ioanna Ieronimaki Andriani Zacharatou Alina Roxana Gouloumis Danai Leventakou Ioannis Boutas Dionysios T. Dimas Adamantia Kontogeorgi Kyparissia Sitara Lubna Khaldi Magda Zanelli Andrea Palicelli |
| author2Str |
Argyro-Ioanna Ieronimaki Andriani Zacharatou Alina Roxana Gouloumis Danai Leventakou Ioannis Boutas Dionysios T. Dimas Adamantia Kontogeorgi Kyparissia Sitara Lubna Khaldi Magda Zanelli Andrea Palicelli |
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| doi_str |
10.3390/jpm13061016 |
| up_date |
2024-07-03T21:21:47.662Z |
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