G Protein-Coupled Receptors and the Rise of Type 2 Diabetes in Children

The human genome counts hundreds of GPCRs specialized to sense thousands of different extracellular cues, including light, odorants and nutrients in addition to hormones. Primordial GPCRs were likely glucose transporters that became sensors to monitor the abundance of nutrients and direct the cell t...
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Gespeichert in:

Autor*in:	Alessia Dallatana [verfasserIn] Linda Cremonesi [verfasserIn] Maddalena Trombetta [verfasserIn] Giulio Fracasso [verfasserIn] Riccardo Nocini [verfasserIn] Luca Giacomello [verfasserIn] Giulio Innamorati [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	type 2 diabetes diabetes in youth GPCRs β cells glucose homeostasis

Übergeordnetes Werk:	In: Biomedicines - MDPI AG, 2014, 11(2023), 6, p 1576
Übergeordnetes Werk:	volume:11 ; year:2023 ; number:6, p 1576

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/biomedicines11061576

Katalog-ID:	DOAJ094203814

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source	In Biomedicines 11(2023), 6, p 1576 volume:11 year:2023 number:6, p 1576
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authorswithroles_txt_mv	Alessia Dallatana @@aut@@ Linda Cremonesi @@aut@@ Maddalena Trombetta @@aut@@ Giulio Fracasso @@aut@@ Riccardo Nocini @@aut@@ Luca Giacomello @@aut@@ Giulio Innamorati @@aut@@
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callnumber-first	Q - Science
author	Alessia Dallatana
spellingShingle	Alessia Dallatana misc QH301-705.5 misc type 2 diabetes misc diabetes in youth misc GPCRs misc β cells misc glucose homeostasis misc Biology (General) G Protein-Coupled Receptors and the Rise of Type 2 Diabetes in Children
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topic	misc QH301-705.5 misc type 2 diabetes misc diabetes in youth misc GPCRs misc β cells misc glucose homeostasis misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc type 2 diabetes misc diabetes in youth misc GPCRs misc β cells misc glucose homeostasis misc Biology (General)
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title	G Protein-Coupled Receptors and the Rise of Type 2 Diabetes in Children
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title_sort	g protein-coupled receptors and the rise of type 2 diabetes in children
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title_auth	G Protein-Coupled Receptors and the Rise of Type 2 Diabetes in Children
abstract	The human genome counts hundreds of GPCRs specialized to sense thousands of different extracellular cues, including light, odorants and nutrients in addition to hormones. Primordial GPCRs were likely glucose transporters that became sensors to monitor the abundance of nutrients and direct the cell to switch from aerobic metabolism to fermentation. Human β cells express multiple GPCRs that contribute to regulate glucose homeostasis, cooperating with many others expressed by a variety of cell types and tissues. These GPCRs are intensely studied as pharmacological targets to treat type 2 diabetes in adults. The dramatic rise of type 2 diabetes incidence in pediatric age is likely correlated to the rapidly evolving lifestyle of children and adolescents of the new century. Current pharmacological treatments are based on therapies designed for adults, while youth and puberty are characterized by a different hormonal balance related to glucose metabolism. This review focuses on GPCRs functional traits that are relevant for β cells function, with an emphasis on aspects that could help to differentiate new treatments specifically addressed to young type 2 diabetes patients.
abstractGer	The human genome counts hundreds of GPCRs specialized to sense thousands of different extracellular cues, including light, odorants and nutrients in addition to hormones. Primordial GPCRs were likely glucose transporters that became sensors to monitor the abundance of nutrients and direct the cell to switch from aerobic metabolism to fermentation. Human β cells express multiple GPCRs that contribute to regulate glucose homeostasis, cooperating with many others expressed by a variety of cell types and tissues. These GPCRs are intensely studied as pharmacological targets to treat type 2 diabetes in adults. The dramatic rise of type 2 diabetes incidence in pediatric age is likely correlated to the rapidly evolving lifestyle of children and adolescents of the new century. Current pharmacological treatments are based on therapies designed for adults, while youth and puberty are characterized by a different hormonal balance related to glucose metabolism. This review focuses on GPCRs functional traits that are relevant for β cells function, with an emphasis on aspects that could help to differentiate new treatments specifically addressed to young type 2 diabetes patients.
abstract_unstemmed	The human genome counts hundreds of GPCRs specialized to sense thousands of different extracellular cues, including light, odorants and nutrients in addition to hormones. Primordial GPCRs were likely glucose transporters that became sensors to monitor the abundance of nutrients and direct the cell to switch from aerobic metabolism to fermentation. Human β cells express multiple GPCRs that contribute to regulate glucose homeostasis, cooperating with many others expressed by a variety of cell types and tissues. These GPCRs are intensely studied as pharmacological targets to treat type 2 diabetes in adults. The dramatic rise of type 2 diabetes incidence in pediatric age is likely correlated to the rapidly evolving lifestyle of children and adolescents of the new century. Current pharmacological treatments are based on therapies designed for adults, while youth and puberty are characterized by a different hormonal balance related to glucose metabolism. This review focuses on GPCRs functional traits that are relevant for β cells function, with an emphasis on aspects that could help to differentiate new treatments specifically addressed to young type 2 diabetes patients.
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title_short	G Protein-Coupled Receptors and the Rise of Type 2 Diabetes in Children
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