35 Years of TFAM Research: Old Protein, New Puzzles

Transcription Factor A Mitochondrial (TFAM), through its contributions to mtDNA maintenance and expression, is essential for cellular bioenergetics and, therefore, for the very survival of cells. Thirty-five years of research on TFAM structure and function generated a considerable body of experiment...
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Autor*in:	Natalya Kozhukhar [verfasserIn] Mikhail F. Alexeyev [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	mitochondria mitochondrial transcription factor A (TFAM) mitochondrial DNA mitochondrial DNA transcription mitochondrial DNA replication mitochondrial biogenesis

Übergeordnetes Werk:	In: Biology - MDPI AG, 2012, 12(2023), 6, p 823
Übergeordnetes Werk:	volume:12 ; year:2023 ; number:6, p 823

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/biology12060823

Katalog-ID:	DOAJ094205477

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allfields	10.3390/biology12060823 doi (DE-627)DOAJ094205477 (DE-599)DOAJ3c335891db3c4e2db889fff17e55fad1 DE-627 ger DE-627 rakwb eng QH301-705.5 Natalya Kozhukhar verfasserin aut 35 Years of TFAM Research: Old Protein, New Puzzles 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Transcription Factor A Mitochondrial (TFAM), through its contributions to mtDNA maintenance and expression, is essential for cellular bioenergetics and, therefore, for the very survival of cells. Thirty-five years of research on TFAM structure and function generated a considerable body of experimental evidence, some of which remains to be fully reconciled. Recent advancements allowed an unprecedented glimpse into the structure of TFAM complexed with promoter DNA and TFAM within the open promoter complexes. These novel insights, however, raise new questions about the function of this remarkable protein. In our review, we compile the available literature on TFAM structure and function and provide some critical analysis of the available data. mitochondria mitochondrial transcription factor A (TFAM) mitochondrial DNA mitochondrial DNA transcription mitochondrial DNA replication mitochondrial biogenesis Biology (General) Mikhail F. Alexeyev verfasserin aut In Biology MDPI AG, 2012 12(2023), 6, p 823 (DE-627)718622073 (DE-600)2661517-4 20797737 nnns volume:12 year:2023 number:6, p 823 https://doi.org/10.3390/biology12060823 kostenfrei https://doaj.org/article/3c335891db3c4e2db889fff17e55fad1 kostenfrei https://www.mdpi.com/2079-7737/12/6/823 kostenfrei https://doaj.org/toc/2079-7737 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 6, p 823
spelling	10.3390/biology12060823 doi (DE-627)DOAJ094205477 (DE-599)DOAJ3c335891db3c4e2db889fff17e55fad1 DE-627 ger DE-627 rakwb eng QH301-705.5 Natalya Kozhukhar verfasserin aut 35 Years of TFAM Research: Old Protein, New Puzzles 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Transcription Factor A Mitochondrial (TFAM), through its contributions to mtDNA maintenance and expression, is essential for cellular bioenergetics and, therefore, for the very survival of cells. Thirty-five years of research on TFAM structure and function generated a considerable body of experimental evidence, some of which remains to be fully reconciled. Recent advancements allowed an unprecedented glimpse into the structure of TFAM complexed with promoter DNA and TFAM within the open promoter complexes. These novel insights, however, raise new questions about the function of this remarkable protein. In our review, we compile the available literature on TFAM structure and function and provide some critical analysis of the available data. mitochondria mitochondrial transcription factor A (TFAM) mitochondrial DNA mitochondrial DNA transcription mitochondrial DNA replication mitochondrial biogenesis Biology (General) Mikhail F. Alexeyev verfasserin aut In Biology MDPI AG, 2012 12(2023), 6, p 823 (DE-627)718622073 (DE-600)2661517-4 20797737 nnns volume:12 year:2023 number:6, p 823 https://doi.org/10.3390/biology12060823 kostenfrei https://doaj.org/article/3c335891db3c4e2db889fff17e55fad1 kostenfrei https://www.mdpi.com/2079-7737/12/6/823 kostenfrei https://doaj.org/toc/2079-7737 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 6, p 823
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callnumber-first	Q - Science
author	Natalya Kozhukhar
spellingShingle	Natalya Kozhukhar misc QH301-705.5 misc mitochondria misc mitochondrial transcription factor A (TFAM) misc mitochondrial DNA misc mitochondrial DNA transcription misc mitochondrial DNA replication misc mitochondrial biogenesis misc Biology (General) 35 Years of TFAM Research: Old Protein, New Puzzles
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topic_title	QH301-705.5 35 Years of TFAM Research: Old Protein, New Puzzles mitochondria mitochondrial transcription factor A (TFAM) mitochondrial DNA mitochondrial DNA transcription mitochondrial DNA replication mitochondrial biogenesis
topic	misc QH301-705.5 misc mitochondria misc mitochondrial transcription factor A (TFAM) misc mitochondrial DNA misc mitochondrial DNA transcription misc mitochondrial DNA replication misc mitochondrial biogenesis misc Biology (General)
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title	35 Years of TFAM Research: Old Protein, New Puzzles
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title_sort	35 years of tfam research: old protein, new puzzles
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title_auth	35 Years of TFAM Research: Old Protein, New Puzzles
abstract	Transcription Factor A Mitochondrial (TFAM), through its contributions to mtDNA maintenance and expression, is essential for cellular bioenergetics and, therefore, for the very survival of cells. Thirty-five years of research on TFAM structure and function generated a considerable body of experimental evidence, some of which remains to be fully reconciled. Recent advancements allowed an unprecedented glimpse into the structure of TFAM complexed with promoter DNA and TFAM within the open promoter complexes. These novel insights, however, raise new questions about the function of this remarkable protein. In our review, we compile the available literature on TFAM structure and function and provide some critical analysis of the available data.
abstractGer	Transcription Factor A Mitochondrial (TFAM), through its contributions to mtDNA maintenance and expression, is essential for cellular bioenergetics and, therefore, for the very survival of cells. Thirty-five years of research on TFAM structure and function generated a considerable body of experimental evidence, some of which remains to be fully reconciled. Recent advancements allowed an unprecedented glimpse into the structure of TFAM complexed with promoter DNA and TFAM within the open promoter complexes. These novel insights, however, raise new questions about the function of this remarkable protein. In our review, we compile the available literature on TFAM structure and function and provide some critical analysis of the available data.
abstract_unstemmed	Transcription Factor A Mitochondrial (TFAM), through its contributions to mtDNA maintenance and expression, is essential for cellular bioenergetics and, therefore, for the very survival of cells. Thirty-five years of research on TFAM structure and function generated a considerable body of experimental evidence, some of which remains to be fully reconciled. Recent advancements allowed an unprecedented glimpse into the structure of TFAM complexed with promoter DNA and TFAM within the open promoter complexes. These novel insights, however, raise new questions about the function of this remarkable protein. In our review, we compile the available literature on TFAM structure and function and provide some critical analysis of the available data.
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title_short	35 Years of TFAM Research: Old Protein, New Puzzles
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