New Insights into NF-κB Signaling in Innate Immunity: Focus on Immunometabolic Crosstalks

The nuclear factor kappa B (NF-κB) is a family of transcription factors that, beyond their numberless functions in various cell processes, play a pivotal role in regulating immune cell activation. Two main pathways—canonical and non-canonical—are responsible for NF-κB activation and heterodimer tran...
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Autor*in:	Dominga Iacobazzi [verfasserIn] Paolo Convertini [verfasserIn] Simona Todisco [verfasserIn] Anna Santarsiero [verfasserIn] Vito Iacobazzi [verfasserIn] Vittoria Infantino [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	NF-κB innate immunity macrophages immunometabolism gene expression

Übergeordnetes Werk:	In: Biology - MDPI AG, 2012, 12(2023), 6, p 776
Übergeordnetes Werk:	volume:12 ; year:2023 ; number:6, p 776

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/biology12060776

Katalog-ID:	DOAJ094205957

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language	English
source	In Biology 12(2023), 6, p 776 volume:12 year:2023 number:6, p 776
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author	Dominga Iacobazzi
spellingShingle	Dominga Iacobazzi misc QH301-705.5 misc NF-κB misc innate immunity misc macrophages misc immunometabolism misc gene expression misc Biology (General) New Insights into NF-κB Signaling in Innate Immunity: Focus on Immunometabolic Crosstalks
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topic_title	QH301-705.5 New Insights into NF-κB Signaling in Innate Immunity: Focus on Immunometabolic Crosstalks NF-κB innate immunity macrophages immunometabolism gene expression
topic	misc QH301-705.5 misc NF-κB misc innate immunity misc macrophages misc immunometabolism misc gene expression misc Biology (General)
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title	New Insights into NF-κB Signaling in Innate Immunity: Focus on Immunometabolic Crosstalks
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title_auth	New Insights into NF-κB Signaling in Innate Immunity: Focus on Immunometabolic Crosstalks
abstract	The nuclear factor kappa B (NF-κB) is a family of transcription factors that, beyond their numberless functions in various cell processes, play a pivotal role in regulating immune cell activation. Two main pathways—canonical and non-canonical—are responsible for NF-κB activation and heterodimer translocation into the nucleus. A complex crosstalk between NF-κB signaling and metabolism is emerging in innate immunity. Metabolic enzymes and metabolites regulate NF-κB activity in many cases through post-translational modifications such as acetylation and phosphorylation. On the other hand, NF-κB affects immunometabolic pathways, including the citrate pathway, thereby building an intricate network. In this review, the emerging findings about NF-κB function in innate immunity and the interplay between NF-κB and immunometabolism have been discussed. These outcomes allow for a deeper comprehension of the molecular mechanisms underlying NF-κB function in innate immune cells. Moreover, the new insights are important in order to perceive NF-κB signaling as a potential therapeutic target for inflammatory/immune chronic diseases.
abstractGer	The nuclear factor kappa B (NF-κB) is a family of transcription factors that, beyond their numberless functions in various cell processes, play a pivotal role in regulating immune cell activation. Two main pathways—canonical and non-canonical—are responsible for NF-κB activation and heterodimer translocation into the nucleus. A complex crosstalk between NF-κB signaling and metabolism is emerging in innate immunity. Metabolic enzymes and metabolites regulate NF-κB activity in many cases through post-translational modifications such as acetylation and phosphorylation. On the other hand, NF-κB affects immunometabolic pathways, including the citrate pathway, thereby building an intricate network. In this review, the emerging findings about NF-κB function in innate immunity and the interplay between NF-κB and immunometabolism have been discussed. These outcomes allow for a deeper comprehension of the molecular mechanisms underlying NF-κB function in innate immune cells. Moreover, the new insights are important in order to perceive NF-κB signaling as a potential therapeutic target for inflammatory/immune chronic diseases.
abstract_unstemmed	The nuclear factor kappa B (NF-κB) is a family of transcription factors that, beyond their numberless functions in various cell processes, play a pivotal role in regulating immune cell activation. Two main pathways—canonical and non-canonical—are responsible for NF-κB activation and heterodimer translocation into the nucleus. A complex crosstalk between NF-κB signaling and metabolism is emerging in innate immunity. Metabolic enzymes and metabolites regulate NF-κB activity in many cases through post-translational modifications such as acetylation and phosphorylation. On the other hand, NF-κB affects immunometabolic pathways, including the citrate pathway, thereby building an intricate network. In this review, the emerging findings about NF-κB function in innate immunity and the interplay between NF-κB and immunometabolism have been discussed. These outcomes allow for a deeper comprehension of the molecular mechanisms underlying NF-κB function in innate immune cells. Moreover, the new insights are important in order to perceive NF-κB signaling as a potential therapeutic target for inflammatory/immune chronic diseases.
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