The Effect of Metformin on Plasma Prolactin Levels in Young Women with Autoimmune Thyroiditis

Metformin decreases elevated prolactin levels, which are frequently found in patients with thyroid disorders. The aim of this study was to investigate whether thyroid autoimmunity modulates the impact of metformin on lactotrope secretory function. This study compared two matched groups of young wome...
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Autor*in:	Robert Krysiak [verfasserIn] Karolina Kowalcze [verfasserIn] Andrzej Madej [verfasserIn] Bogusław Okopień [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	autoimmune thyroiditis hyperprolactinemia insulin resistance lactotrope secretory function

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 12(2023), 11, p 3769
Übergeordnetes Werk:	volume:12 ; year:2023 ; number:11, p 3769

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm12113769

Katalog-ID:	DOAJ094261784

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source	In Journal of Clinical Medicine 12(2023), 11, p 3769 volume:12 year:2023 number:11, p 3769
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author	Robert Krysiak
spellingShingle	Robert Krysiak misc autoimmune thyroiditis misc hyperprolactinemia misc insulin resistance misc lactotrope secretory function misc Medicine misc R The Effect of Metformin on Plasma Prolactin Levels in Young Women with Autoimmune Thyroiditis
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topic_title	The Effect of Metformin on Plasma Prolactin Levels in Young Women with Autoimmune Thyroiditis autoimmune thyroiditis hyperprolactinemia insulin resistance lactotrope secretory function
topic	misc autoimmune thyroiditis misc hyperprolactinemia misc insulin resistance misc lactotrope secretory function misc Medicine misc R
topic_unstemmed	misc autoimmune thyroiditis misc hyperprolactinemia misc insulin resistance misc lactotrope secretory function misc Medicine misc R
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title	The Effect of Metformin on Plasma Prolactin Levels in Young Women with Autoimmune Thyroiditis
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title_full	The Effect of Metformin on Plasma Prolactin Levels in Young Women with Autoimmune Thyroiditis
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title_sort	effect of metformin on plasma prolactin levels in young women with autoimmune thyroiditis
title_auth	The Effect of Metformin on Plasma Prolactin Levels in Young Women with Autoimmune Thyroiditis
abstract	Metformin decreases elevated prolactin levels, which are frequently found in patients with thyroid disorders. The aim of this study was to investigate whether thyroid autoimmunity modulates the impact of metformin on lactotrope secretory function. This study compared two matched groups of young women with prediabetes and mild-to-moderate prolactin excess: 28 subjects with coexisting euthyroid autoimmune thyroiditis (group 1) and 28 individuals without thyroid disorders (group 2), treated for six months with metformin (3 g daily). Thyroid antibody titers, glucose homeostasis markers, prolactin, thyrotropin, free thyroid hormones, FSH, LH, ACTH, IGF-1 and hsCRP were assessed at the beginning and at the end of the study. At entry, the study groups differed in antibody titers and hsCRP levels. Although the improvement in glucose homeostasis and the decrease in hsCRP levels were observed in both study groups, they were more pronounced in group 2. Only in group 2 did metformin reduce circulating prolactin levels (both total and monomeric). Prolactin-lowering properties of metformin positively correlated with baseline prolactin levels, baseline antibody titers (in group 1) and with the degree of reduction in hsCRP levels. The obtained results suggest that autoimmune thyroiditis may attenuate the impact of metformin on lactotrope secretory function.
abstractGer	Metformin decreases elevated prolactin levels, which are frequently found in patients with thyroid disorders. The aim of this study was to investigate whether thyroid autoimmunity modulates the impact of metformin on lactotrope secretory function. This study compared two matched groups of young women with prediabetes and mild-to-moderate prolactin excess: 28 subjects with coexisting euthyroid autoimmune thyroiditis (group 1) and 28 individuals without thyroid disorders (group 2), treated for six months with metformin (3 g daily). Thyroid antibody titers, glucose homeostasis markers, prolactin, thyrotropin, free thyroid hormones, FSH, LH, ACTH, IGF-1 and hsCRP were assessed at the beginning and at the end of the study. At entry, the study groups differed in antibody titers and hsCRP levels. Although the improvement in glucose homeostasis and the decrease in hsCRP levels were observed in both study groups, they were more pronounced in group 2. Only in group 2 did metformin reduce circulating prolactin levels (both total and monomeric). Prolactin-lowering properties of metformin positively correlated with baseline prolactin levels, baseline antibody titers (in group 1) and with the degree of reduction in hsCRP levels. The obtained results suggest that autoimmune thyroiditis may attenuate the impact of metformin on lactotrope secretory function.
abstract_unstemmed	Metformin decreases elevated prolactin levels, which are frequently found in patients with thyroid disorders. The aim of this study was to investigate whether thyroid autoimmunity modulates the impact of metformin on lactotrope secretory function. This study compared two matched groups of young women with prediabetes and mild-to-moderate prolactin excess: 28 subjects with coexisting euthyroid autoimmune thyroiditis (group 1) and 28 individuals without thyroid disorders (group 2), treated for six months with metformin (3 g daily). Thyroid antibody titers, glucose homeostasis markers, prolactin, thyrotropin, free thyroid hormones, FSH, LH, ACTH, IGF-1 and hsCRP were assessed at the beginning and at the end of the study. At entry, the study groups differed in antibody titers and hsCRP levels. Although the improvement in glucose homeostasis and the decrease in hsCRP levels were observed in both study groups, they were more pronounced in group 2. Only in group 2 did metformin reduce circulating prolactin levels (both total and monomeric). Prolactin-lowering properties of metformin positively correlated with baseline prolactin levels, baseline antibody titers (in group 1) and with the degree of reduction in hsCRP levels. The obtained results suggest that autoimmune thyroiditis may attenuate the impact of metformin on lactotrope secretory function.
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title_short	The Effect of Metformin on Plasma Prolactin Levels in Young Women with Autoimmune Thyroiditis
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