Effects on Right Ventricular Function One Year after COVID-19-Related Pulmonary Embolism

The aim of this study was to investigate the presence of subclinical cardiac dysfunction in recovered coronavirus disease 2019 (COVID-19) patients, who were stratified according to a previous diagnosis of pulmonary embolism (PE) as a complication of COVID-19 pneumonia. Out of 68 patients with SARS-C...
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Autor*in:	Federica Ilardi [verfasserIn] Mario Crisci [verfasserIn] Cecilia Calabrese [verfasserIn] Anna Scognamiglio [verfasserIn] Fortunato Arenga [verfasserIn] Rachele Manzo [verfasserIn] Domenica F. Mariniello [verfasserIn] Valentino Allocca [verfasserIn] Anna Annunziata [verfasserIn] Antonello D’Andrea [verfasserIn] Raffaele Merenda [verfasserIn] Vittorio Monda [verfasserIn] Giovanni Esposito [verfasserIn] Giuseppe Fiorentino [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	COVID-19 pulmonary embolism right-ventricle global longitudinal strain right-ventricle free wall longitudinal strain right-ventricle dysfunction

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 12(2023), 11, p 3611
Übergeordnetes Werk:	volume:12 ; year:2023 ; number:11, p 3611

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm12113611

Katalog-ID:	DOAJ094263345

Internformat


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520			\|a The aim of this study was to investigate the presence of subclinical cardiac dysfunction in recovered coronavirus disease 2019 (COVID-19) patients, who were stratified according to a previous diagnosis of pulmonary embolism (PE) as a complication of COVID-19 pneumonia. Out of 68 patients with SARS-CoV-2 pneumonia followed up for one year, 44 patients (mean age 58.4 ± 13.3, 70% males) without known cardiopulmonary disease were divided in two groups (PE+ and PE−, each comprising 22 patients) and underwent clinical and transthoracic echocardiographic examination, including right-ventricle global longitudinal strain (RV-GLS), and RV free wall longitudinal strain (RV-FWLS). While no significant differences were found in the left- or right-heart chambers’ dimensions between the two study groups, the PE+ patients showed a significant reduction in RV-GLS (−16.4 ± 2.9 vs. −21.6 ± 4.3%, <i<p</i< < 0.001) and RV-FWLS (−18.9 ± 4 vs. −24.6 ± 5.12%, <i<p</i< < 0.001) values compared to the PE- patients. According to the ROC-curve analysis, RV-FWLS < 21% was the best cut-off with which to predict PE diagnosis in patients after SARS-CoV-2 pneumonia (sensitivity 74%, specificity 89%, area under the curve = 0.819, <i<p</i< < 0.001). According to the multivariate logistic regression model, RV-FWLS < 21% was independently associated with PE (HR 34.96, 95% CI:3.24–377.09, <i<p</i< = 0.003) and obesity (HR 10.34, 95% CI:1.05–101.68, <i<p</i< = 0.045). In conclusion, in recovered COVID-19 patients with a history of PE+, there is a persistence of subclinical RV dysfunction one year after the acute phase of the disease, detectable by a significant impairment in RV-GLS and RV-FWLS. A reduction in RV-FWLS of lower than 21% is independently associated with COVID-related PE.
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allfields	10.3390/jcm12113611 doi (DE-627)DOAJ094263345 (DE-599)DOAJcedbfd8e2b464ff7946de6705c8baab6 DE-627 ger DE-627 rakwb eng Federica Ilardi verfasserin aut Effects on Right Ventricular Function One Year after COVID-19-Related Pulmonary Embolism 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to investigate the presence of subclinical cardiac dysfunction in recovered coronavirus disease 2019 (COVID-19) patients, who were stratified according to a previous diagnosis of pulmonary embolism (PE) as a complication of COVID-19 pneumonia. Out of 68 patients with SARS-CoV-2 pneumonia followed up for one year, 44 patients (mean age 58.4 ± 13.3, 70% males) without known cardiopulmonary disease were divided in two groups (PE+ and PE−, each comprising 22 patients) and underwent clinical and transthoracic echocardiographic examination, including right-ventricle global longitudinal strain (RV-GLS), and RV free wall longitudinal strain (RV-FWLS). While no significant differences were found in the left- or right-heart chambers’ dimensions between the two study groups, the PE+ patients showed a significant reduction in RV-GLS (−16.4 ± 2.9 vs. −21.6 ± 4.3%, <i<p</i< < 0.001) and RV-FWLS (−18.9 ± 4 vs. −24.6 ± 5.12%, <i<p</i< < 0.001) values compared to the PE- patients. According to the ROC-curve analysis, RV-FWLS < 21% was the best cut-off with which to predict PE diagnosis in patients after SARS-CoV-2 pneumonia (sensitivity 74%, specificity 89%, area under the curve = 0.819, <i<p</i< < 0.001). According to the multivariate logistic regression model, RV-FWLS < 21% was independently associated with PE (HR 34.96, 95% CI:3.24–377.09, <i<p</i< = 0.003) and obesity (HR 10.34, 95% CI:1.05–101.68, <i<p</i< = 0.045). In conclusion, in recovered COVID-19 patients with a history of PE+, there is a persistence of subclinical RV dysfunction one year after the acute phase of the disease, detectable by a significant impairment in RV-GLS and RV-FWLS. A reduction in RV-FWLS of lower than 21% is independently associated with COVID-related PE. COVID-19 pulmonary embolism right-ventricle global longitudinal strain right-ventricle free wall longitudinal strain right-ventricle dysfunction Medicine R Mario Crisci verfasserin aut Cecilia Calabrese verfasserin aut Anna Scognamiglio verfasserin aut Fortunato Arenga verfasserin aut Rachele Manzo verfasserin aut Domenica F. Mariniello verfasserin aut Valentino Allocca verfasserin aut Anna Annunziata verfasserin aut Antonello D’Andrea verfasserin aut Raffaele Merenda verfasserin aut Vittorio Monda verfasserin aut Giovanni Esposito verfasserin aut Giuseppe Fiorentino verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 11, p 3611 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:11, p 3611 https://doi.org/10.3390/jcm12113611 kostenfrei https://doaj.org/article/cedbfd8e2b464ff7946de6705c8baab6 kostenfrei https://www.mdpi.com/2077-0383/12/11/3611 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 11, p 3611
spelling	10.3390/jcm12113611 doi (DE-627)DOAJ094263345 (DE-599)DOAJcedbfd8e2b464ff7946de6705c8baab6 DE-627 ger DE-627 rakwb eng Federica Ilardi verfasserin aut Effects on Right Ventricular Function One Year after COVID-19-Related Pulmonary Embolism 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to investigate the presence of subclinical cardiac dysfunction in recovered coronavirus disease 2019 (COVID-19) patients, who were stratified according to a previous diagnosis of pulmonary embolism (PE) as a complication of COVID-19 pneumonia. Out of 68 patients with SARS-CoV-2 pneumonia followed up for one year, 44 patients (mean age 58.4 ± 13.3, 70% males) without known cardiopulmonary disease were divided in two groups (PE+ and PE−, each comprising 22 patients) and underwent clinical and transthoracic echocardiographic examination, including right-ventricle global longitudinal strain (RV-GLS), and RV free wall longitudinal strain (RV-FWLS). While no significant differences were found in the left- or right-heart chambers’ dimensions between the two study groups, the PE+ patients showed a significant reduction in RV-GLS (−16.4 ± 2.9 vs. −21.6 ± 4.3%, <i<p</i< < 0.001) and RV-FWLS (−18.9 ± 4 vs. −24.6 ± 5.12%, <i<p</i< < 0.001) values compared to the PE- patients. According to the ROC-curve analysis, RV-FWLS < 21% was the best cut-off with which to predict PE diagnosis in patients after SARS-CoV-2 pneumonia (sensitivity 74%, specificity 89%, area under the curve = 0.819, <i<p</i< < 0.001). According to the multivariate logistic regression model, RV-FWLS < 21% was independently associated with PE (HR 34.96, 95% CI:3.24–377.09, <i<p</i< = 0.003) and obesity (HR 10.34, 95% CI:1.05–101.68, <i<p</i< = 0.045). In conclusion, in recovered COVID-19 patients with a history of PE+, there is a persistence of subclinical RV dysfunction one year after the acute phase of the disease, detectable by a significant impairment in RV-GLS and RV-FWLS. A reduction in RV-FWLS of lower than 21% is independently associated with COVID-related PE. COVID-19 pulmonary embolism right-ventricle global longitudinal strain right-ventricle free wall longitudinal strain right-ventricle dysfunction Medicine R Mario Crisci verfasserin aut Cecilia Calabrese verfasserin aut Anna Scognamiglio verfasserin aut Fortunato Arenga verfasserin aut Rachele Manzo verfasserin aut Domenica F. Mariniello verfasserin aut Valentino Allocca verfasserin aut Anna Annunziata verfasserin aut Antonello D’Andrea verfasserin aut Raffaele Merenda verfasserin aut Vittorio Monda verfasserin aut Giovanni Esposito verfasserin aut Giuseppe Fiorentino verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 11, p 3611 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:11, p 3611 https://doi.org/10.3390/jcm12113611 kostenfrei https://doaj.org/article/cedbfd8e2b464ff7946de6705c8baab6 kostenfrei https://www.mdpi.com/2077-0383/12/11/3611 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 11, p 3611
allfields_unstemmed	10.3390/jcm12113611 doi (DE-627)DOAJ094263345 (DE-599)DOAJcedbfd8e2b464ff7946de6705c8baab6 DE-627 ger DE-627 rakwb eng Federica Ilardi verfasserin aut Effects on Right Ventricular Function One Year after COVID-19-Related Pulmonary Embolism 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to investigate the presence of subclinical cardiac dysfunction in recovered coronavirus disease 2019 (COVID-19) patients, who were stratified according to a previous diagnosis of pulmonary embolism (PE) as a complication of COVID-19 pneumonia. Out of 68 patients with SARS-CoV-2 pneumonia followed up for one year, 44 patients (mean age 58.4 ± 13.3, 70% males) without known cardiopulmonary disease were divided in two groups (PE+ and PE−, each comprising 22 patients) and underwent clinical and transthoracic echocardiographic examination, including right-ventricle global longitudinal strain (RV-GLS), and RV free wall longitudinal strain (RV-FWLS). While no significant differences were found in the left- or right-heart chambers’ dimensions between the two study groups, the PE+ patients showed a significant reduction in RV-GLS (−16.4 ± 2.9 vs. −21.6 ± 4.3%, <i<p</i< < 0.001) and RV-FWLS (−18.9 ± 4 vs. −24.6 ± 5.12%, <i<p</i< < 0.001) values compared to the PE- patients. According to the ROC-curve analysis, RV-FWLS < 21% was the best cut-off with which to predict PE diagnosis in patients after SARS-CoV-2 pneumonia (sensitivity 74%, specificity 89%, area under the curve = 0.819, <i<p</i< < 0.001). According to the multivariate logistic regression model, RV-FWLS < 21% was independently associated with PE (HR 34.96, 95% CI:3.24–377.09, <i<p</i< = 0.003) and obesity (HR 10.34, 95% CI:1.05–101.68, <i<p</i< = 0.045). In conclusion, in recovered COVID-19 patients with a history of PE+, there is a persistence of subclinical RV dysfunction one year after the acute phase of the disease, detectable by a significant impairment in RV-GLS and RV-FWLS. A reduction in RV-FWLS of lower than 21% is independently associated with COVID-related PE. COVID-19 pulmonary embolism right-ventricle global longitudinal strain right-ventricle free wall longitudinal strain right-ventricle dysfunction Medicine R Mario Crisci verfasserin aut Cecilia Calabrese verfasserin aut Anna Scognamiglio verfasserin aut Fortunato Arenga verfasserin aut Rachele Manzo verfasserin aut Domenica F. Mariniello verfasserin aut Valentino Allocca verfasserin aut Anna Annunziata verfasserin aut Antonello D’Andrea verfasserin aut Raffaele Merenda verfasserin aut Vittorio Monda verfasserin aut Giovanni Esposito verfasserin aut Giuseppe Fiorentino verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 11, p 3611 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:11, p 3611 https://doi.org/10.3390/jcm12113611 kostenfrei https://doaj.org/article/cedbfd8e2b464ff7946de6705c8baab6 kostenfrei https://www.mdpi.com/2077-0383/12/11/3611 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 11, p 3611
allfieldsGer	10.3390/jcm12113611 doi (DE-627)DOAJ094263345 (DE-599)DOAJcedbfd8e2b464ff7946de6705c8baab6 DE-627 ger DE-627 rakwb eng Federica Ilardi verfasserin aut Effects on Right Ventricular Function One Year after COVID-19-Related Pulmonary Embolism 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to investigate the presence of subclinical cardiac dysfunction in recovered coronavirus disease 2019 (COVID-19) patients, who were stratified according to a previous diagnosis of pulmonary embolism (PE) as a complication of COVID-19 pneumonia. Out of 68 patients with SARS-CoV-2 pneumonia followed up for one year, 44 patients (mean age 58.4 ± 13.3, 70% males) without known cardiopulmonary disease were divided in two groups (PE+ and PE−, each comprising 22 patients) and underwent clinical and transthoracic echocardiographic examination, including right-ventricle global longitudinal strain (RV-GLS), and RV free wall longitudinal strain (RV-FWLS). While no significant differences were found in the left- or right-heart chambers’ dimensions between the two study groups, the PE+ patients showed a significant reduction in RV-GLS (−16.4 ± 2.9 vs. −21.6 ± 4.3%, <i<p</i< < 0.001) and RV-FWLS (−18.9 ± 4 vs. −24.6 ± 5.12%, <i<p</i< < 0.001) values compared to the PE- patients. According to the ROC-curve analysis, RV-FWLS < 21% was the best cut-off with which to predict PE diagnosis in patients after SARS-CoV-2 pneumonia (sensitivity 74%, specificity 89%, area under the curve = 0.819, <i<p</i< < 0.001). According to the multivariate logistic regression model, RV-FWLS < 21% was independently associated with PE (HR 34.96, 95% CI:3.24–377.09, <i<p</i< = 0.003) and obesity (HR 10.34, 95% CI:1.05–101.68, <i<p</i< = 0.045). In conclusion, in recovered COVID-19 patients with a history of PE+, there is a persistence of subclinical RV dysfunction one year after the acute phase of the disease, detectable by a significant impairment in RV-GLS and RV-FWLS. A reduction in RV-FWLS of lower than 21% is independently associated with COVID-related PE. COVID-19 pulmonary embolism right-ventricle global longitudinal strain right-ventricle free wall longitudinal strain right-ventricle dysfunction Medicine R Mario Crisci verfasserin aut Cecilia Calabrese verfasserin aut Anna Scognamiglio verfasserin aut Fortunato Arenga verfasserin aut Rachele Manzo verfasserin aut Domenica F. Mariniello verfasserin aut Valentino Allocca verfasserin aut Anna Annunziata verfasserin aut Antonello D’Andrea verfasserin aut Raffaele Merenda verfasserin aut Vittorio Monda verfasserin aut Giovanni Esposito verfasserin aut Giuseppe Fiorentino verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 11, p 3611 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:11, p 3611 https://doi.org/10.3390/jcm12113611 kostenfrei https://doaj.org/article/cedbfd8e2b464ff7946de6705c8baab6 kostenfrei https://www.mdpi.com/2077-0383/12/11/3611 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 11, p 3611
allfieldsSound	10.3390/jcm12113611 doi (DE-627)DOAJ094263345 (DE-599)DOAJcedbfd8e2b464ff7946de6705c8baab6 DE-627 ger DE-627 rakwb eng Federica Ilardi verfasserin aut Effects on Right Ventricular Function One Year after COVID-19-Related Pulmonary Embolism 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to investigate the presence of subclinical cardiac dysfunction in recovered coronavirus disease 2019 (COVID-19) patients, who were stratified according to a previous diagnosis of pulmonary embolism (PE) as a complication of COVID-19 pneumonia. Out of 68 patients with SARS-CoV-2 pneumonia followed up for one year, 44 patients (mean age 58.4 ± 13.3, 70% males) without known cardiopulmonary disease were divided in two groups (PE+ and PE−, each comprising 22 patients) and underwent clinical and transthoracic echocardiographic examination, including right-ventricle global longitudinal strain (RV-GLS), and RV free wall longitudinal strain (RV-FWLS). While no significant differences were found in the left- or right-heart chambers’ dimensions between the two study groups, the PE+ patients showed a significant reduction in RV-GLS (−16.4 ± 2.9 vs. −21.6 ± 4.3%, <i<p</i< < 0.001) and RV-FWLS (−18.9 ± 4 vs. −24.6 ± 5.12%, <i<p</i< < 0.001) values compared to the PE- patients. According to the ROC-curve analysis, RV-FWLS < 21% was the best cut-off with which to predict PE diagnosis in patients after SARS-CoV-2 pneumonia (sensitivity 74%, specificity 89%, area under the curve = 0.819, <i<p</i< < 0.001). According to the multivariate logistic regression model, RV-FWLS < 21% was independently associated with PE (HR 34.96, 95% CI:3.24–377.09, <i<p</i< = 0.003) and obesity (HR 10.34, 95% CI:1.05–101.68, <i<p</i< = 0.045). In conclusion, in recovered COVID-19 patients with a history of PE+, there is a persistence of subclinical RV dysfunction one year after the acute phase of the disease, detectable by a significant impairment in RV-GLS and RV-FWLS. A reduction in RV-FWLS of lower than 21% is independently associated with COVID-related PE. COVID-19 pulmonary embolism right-ventricle global longitudinal strain right-ventricle free wall longitudinal strain right-ventricle dysfunction Medicine R Mario Crisci verfasserin aut Cecilia Calabrese verfasserin aut Anna Scognamiglio verfasserin aut Fortunato Arenga verfasserin aut Rachele Manzo verfasserin aut Domenica F. Mariniello verfasserin aut Valentino Allocca verfasserin aut Anna Annunziata verfasserin aut Antonello D’Andrea verfasserin aut Raffaele Merenda verfasserin aut Vittorio Monda verfasserin aut Giovanni Esposito verfasserin aut Giuseppe Fiorentino verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 11, p 3611 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:11, p 3611 https://doi.org/10.3390/jcm12113611 kostenfrei https://doaj.org/article/cedbfd8e2b464ff7946de6705c8baab6 kostenfrei https://www.mdpi.com/2077-0383/12/11/3611 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 11, p 3611
language	English
source	In Journal of Clinical Medicine 12(2023), 11, p 3611 volume:12 year:2023 number:11, p 3611
sourceStr	In Journal of Clinical Medicine 12(2023), 11, p 3611 volume:12 year:2023 number:11, p 3611
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	COVID-19 pulmonary embolism right-ventricle global longitudinal strain right-ventricle free wall longitudinal strain right-ventricle dysfunction Medicine R
isfreeaccess_bool	true
container_title	Journal of Clinical Medicine
authorswithroles_txt_mv	Federica Ilardi @@aut@@ Mario Crisci @@aut@@ Cecilia Calabrese @@aut@@ Anna Scognamiglio @@aut@@ Fortunato Arenga @@aut@@ Rachele Manzo @@aut@@ Domenica F. Mariniello @@aut@@ Valentino Allocca @@aut@@ Anna Annunziata @@aut@@ Antonello D’Andrea @@aut@@ Raffaele Merenda @@aut@@ Vittorio Monda @@aut@@ Giovanni Esposito @@aut@@ Giuseppe Fiorentino @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	718632478
id	DOAJ094263345
language_de	englisch
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author	Federica Ilardi
spellingShingle	Federica Ilardi misc COVID-19 misc pulmonary embolism misc right-ventricle global longitudinal strain misc right-ventricle free wall longitudinal strain misc right-ventricle dysfunction misc Medicine misc R Effects on Right Ventricular Function One Year after COVID-19-Related Pulmonary Embolism
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topic_title	Effects on Right Ventricular Function One Year after COVID-19-Related Pulmonary Embolism COVID-19 pulmonary embolism right-ventricle global longitudinal strain right-ventricle free wall longitudinal strain right-ventricle dysfunction
topic	misc COVID-19 misc pulmonary embolism misc right-ventricle global longitudinal strain misc right-ventricle free wall longitudinal strain misc right-ventricle dysfunction misc Medicine misc R
topic_unstemmed	misc COVID-19 misc pulmonary embolism misc right-ventricle global longitudinal strain misc right-ventricle free wall longitudinal strain misc right-ventricle dysfunction misc Medicine misc R
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title	Effects on Right Ventricular Function One Year after COVID-19-Related Pulmonary Embolism
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title_full	Effects on Right Ventricular Function One Year after COVID-19-Related Pulmonary Embolism
author_sort	Federica Ilardi
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author_browse	Federica Ilardi Mario Crisci Cecilia Calabrese Anna Scognamiglio Fortunato Arenga Rachele Manzo Domenica F. Mariniello Valentino Allocca Anna Annunziata Antonello D’Andrea Raffaele Merenda Vittorio Monda Giovanni Esposito Giuseppe Fiorentino
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author-letter	Federica Ilardi
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title_sort	effects on right ventricular function one year after covid-19-related pulmonary embolism
title_auth	Effects on Right Ventricular Function One Year after COVID-19-Related Pulmonary Embolism
abstract	The aim of this study was to investigate the presence of subclinical cardiac dysfunction in recovered coronavirus disease 2019 (COVID-19) patients, who were stratified according to a previous diagnosis of pulmonary embolism (PE) as a complication of COVID-19 pneumonia. Out of 68 patients with SARS-CoV-2 pneumonia followed up for one year, 44 patients (mean age 58.4 ± 13.3, 70% males) without known cardiopulmonary disease were divided in two groups (PE+ and PE−, each comprising 22 patients) and underwent clinical and transthoracic echocardiographic examination, including right-ventricle global longitudinal strain (RV-GLS), and RV free wall longitudinal strain (RV-FWLS). While no significant differences were found in the left- or right-heart chambers’ dimensions between the two study groups, the PE+ patients showed a significant reduction in RV-GLS (−16.4 ± 2.9 vs. −21.6 ± 4.3%, <i<p</i< < 0.001) and RV-FWLS (−18.9 ± 4 vs. −24.6 ± 5.12%, <i<p</i< < 0.001) values compared to the PE- patients. According to the ROC-curve analysis, RV-FWLS < 21% was the best cut-off with which to predict PE diagnosis in patients after SARS-CoV-2 pneumonia (sensitivity 74%, specificity 89%, area under the curve = 0.819, <i<p</i< < 0.001). According to the multivariate logistic regression model, RV-FWLS < 21% was independently associated with PE (HR 34.96, 95% CI:3.24–377.09, <i<p</i< = 0.003) and obesity (HR 10.34, 95% CI:1.05–101.68, <i<p</i< = 0.045). In conclusion, in recovered COVID-19 patients with a history of PE+, there is a persistence of subclinical RV dysfunction one year after the acute phase of the disease, detectable by a significant impairment in RV-GLS and RV-FWLS. A reduction in RV-FWLS of lower than 21% is independently associated with COVID-related PE.
abstractGer	The aim of this study was to investigate the presence of subclinical cardiac dysfunction in recovered coronavirus disease 2019 (COVID-19) patients, who were stratified according to a previous diagnosis of pulmonary embolism (PE) as a complication of COVID-19 pneumonia. Out of 68 patients with SARS-CoV-2 pneumonia followed up for one year, 44 patients (mean age 58.4 ± 13.3, 70% males) without known cardiopulmonary disease were divided in two groups (PE+ and PE−, each comprising 22 patients) and underwent clinical and transthoracic echocardiographic examination, including right-ventricle global longitudinal strain (RV-GLS), and RV free wall longitudinal strain (RV-FWLS). While no significant differences were found in the left- or right-heart chambers’ dimensions between the two study groups, the PE+ patients showed a significant reduction in RV-GLS (−16.4 ± 2.9 vs. −21.6 ± 4.3%, <i<p</i< < 0.001) and RV-FWLS (−18.9 ± 4 vs. −24.6 ± 5.12%, <i<p</i< < 0.001) values compared to the PE- patients. According to the ROC-curve analysis, RV-FWLS < 21% was the best cut-off with which to predict PE diagnosis in patients after SARS-CoV-2 pneumonia (sensitivity 74%, specificity 89%, area under the curve = 0.819, <i<p</i< < 0.001). According to the multivariate logistic regression model, RV-FWLS < 21% was independently associated with PE (HR 34.96, 95% CI:3.24–377.09, <i<p</i< = 0.003) and obesity (HR 10.34, 95% CI:1.05–101.68, <i<p</i< = 0.045). In conclusion, in recovered COVID-19 patients with a history of PE+, there is a persistence of subclinical RV dysfunction one year after the acute phase of the disease, detectable by a significant impairment in RV-GLS and RV-FWLS. A reduction in RV-FWLS of lower than 21% is independently associated with COVID-related PE.
abstract_unstemmed	The aim of this study was to investigate the presence of subclinical cardiac dysfunction in recovered coronavirus disease 2019 (COVID-19) patients, who were stratified according to a previous diagnosis of pulmonary embolism (PE) as a complication of COVID-19 pneumonia. Out of 68 patients with SARS-CoV-2 pneumonia followed up for one year, 44 patients (mean age 58.4 ± 13.3, 70% males) without known cardiopulmonary disease were divided in two groups (PE+ and PE−, each comprising 22 patients) and underwent clinical and transthoracic echocardiographic examination, including right-ventricle global longitudinal strain (RV-GLS), and RV free wall longitudinal strain (RV-FWLS). While no significant differences were found in the left- or right-heart chambers’ dimensions between the two study groups, the PE+ patients showed a significant reduction in RV-GLS (−16.4 ± 2.9 vs. −21.6 ± 4.3%, <i<p</i< < 0.001) and RV-FWLS (−18.9 ± 4 vs. −24.6 ± 5.12%, <i<p</i< < 0.001) values compared to the PE- patients. According to the ROC-curve analysis, RV-FWLS < 21% was the best cut-off with which to predict PE diagnosis in patients after SARS-CoV-2 pneumonia (sensitivity 74%, specificity 89%, area under the curve = 0.819, <i<p</i< < 0.001). According to the multivariate logistic regression model, RV-FWLS < 21% was independently associated with PE (HR 34.96, 95% CI:3.24–377.09, <i<p</i< = 0.003) and obesity (HR 10.34, 95% CI:1.05–101.68, <i<p</i< = 0.045). In conclusion, in recovered COVID-19 patients with a history of PE+, there is a persistence of subclinical RV dysfunction one year after the acute phase of the disease, detectable by a significant impairment in RV-GLS and RV-FWLS. A reduction in RV-FWLS of lower than 21% is independently associated with COVID-related PE.
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title_short	Effects on Right Ventricular Function One Year after COVID-19-Related Pulmonary Embolism
url	https://doi.org/10.3390/jcm12113611 https://doaj.org/article/cedbfd8e2b464ff7946de6705c8baab6 https://www.mdpi.com/2077-0383/12/11/3611 https://doaj.org/toc/2077-0383
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author2	Mario Crisci Cecilia Calabrese Anna Scognamiglio Fortunato Arenga Rachele Manzo Domenica F. Mariniello Valentino Allocca Anna Annunziata Antonello D’Andrea Raffaele Merenda Vittorio Monda Giovanni Esposito Giuseppe Fiorentino
author2Str	Mario Crisci Cecilia Calabrese Anna Scognamiglio Fortunato Arenga Rachele Manzo Domenica F. Mariniello Valentino Allocca Anna Annunziata Antonello D’Andrea Raffaele Merenda Vittorio Monda Giovanni Esposito Giuseppe Fiorentino
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up_date	2024-07-03T22:11:47.994Z
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